MOJ immunology最新文献_第8页

The Immune Response Against Oryzatensin Increase VEGF and MMP-9 Experssion in HEP-G2 Cell Line 抗Oryzatensin的免疫反应增加了HEP-G2细胞中VEGF和MMP-9的表达

MOJ immunology Pub Date : 2017-03-23 DOI: 10.15406/moji.2017.05.00159

Meisam Barati, M. Yousefi, H. Mohammdi, M. Ebrahimi-Mameghani

引用次数: 0

Organism Cleansing and Human Life Prolongation 清洁生物体与延长人体寿命

MOJ immunology Pub Date : 2017-03-17 DOI: 10.15406/MOJI.2017.05.00157

B. Asanov

引用次数: 0

Future of Chimeric Antigen Receptors (Cars): Could it Drive Solutions Beyond Cancer? Examples in Autoimmune Diseases 嵌合抗原受体(Cars)的未来:它能推动癌症以外的解决方案吗?自身免疫性疾病的例子

MOJ immunology Pub Date : 2017-03-17 DOI: 10.15406/MOJI.2017.05.00158

Español Marta, M. Berta, Llobell Arturo, C. María, Boronat Anna

{"title":"Future of Chimeric Antigen Receptors (Cars): Could it Drive Solutions Beyond Cancer? Examples in Autoimmune Diseases","authors":"Español Marta, M. Berta, Llobell Arturo, C. María, Boronat Anna","doi":"10.15406/MOJI.2017.05.00158","DOIUrl":"https://doi.org/10.15406/MOJI.2017.05.00158","url":null,"abstract":"MOJ Immunol 2017, 5(3): 00158 vector). After collecting T-cells, usually from patient’s blood (leukoapheresis), they are ex-vivo modified by introducing CAR and by inducing its expression on the T-cell surface. After expanding these CAR+ T-cells, these cells are infused in the bloodstream of the patient to generate a specific immune response against tumour. CART cells become able to recognize cancerous cells through the specificity of a scFv (single-chain variable fragment) to detect an antigen on the surface of the tumour cells, and after that to kill them [2,3]. The affinity and the avidity of the interaction between a CAR and its ligand are higher than the interaction between T cell receptor (TCR) and its peptide-MHC ligand; however, a CAR (instead of TCRs) is unable to recognize intracellular molecules [4]. CAR consists of the combination of a scFv sequence, a transmembrane region and (usually at least two) domains activating for T-cells, such as signalling domains of CD3, CD28 and/or CD137 [5]. Although most of clinical trials are focused on refractory B cell lymphoprolipherative disorders, the CAR strategy is also being relied upon solid tumours. In any case the employment of CARs is not restricted to cancer therapy. A variety of CARs have been used to treat different pathologies such as viral or fungal infections [6] and autoimmune diseases, the main aspect reviewed in this article.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42712682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Anti-Cancer Therapy: Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) in Combination with Immunotherapy 抗癌治疗：非甾体抗炎药（NSAIDS）与免疫治疗相结合

MOJ immunology Pub Date : 2017-03-15 DOI: 10.15406/MOJI.2017.05.00156

Joseph F. Murphy

引用次数: 2

Research Proves the Brain Functions at Higher Levels When We Avoid "Hidden" Food Allergies & the Elimination Solution 研究证明，当我们避免“隐性”食物过敏时，大脑功能处于更高水平&消除方案

MOJ immunology Pub Date : 2017-03-10 DOI: 10.15406/MOJI.2017.05.00155

L. Hold

引用次数: 0

Can we Use a Genogram to Identify Potential Life Threatening Food Allergies in a Child 我们可以使用基因图谱来识别儿童潜在的危及生命的食物过敏吗

MOJ immunology Pub Date : 2017-03-10 DOI: 10.15406/moji.2017.05.00154

L. Hold

引用次数: 0

Weaning in Italy between Myths and Reality 在神话与现实之间的意大利断奶

MOJ immunology Pub Date : 2017-03-06 DOI: 10.15406/moji.2017.05.00153

G. Rumi

{"title":"Weaning in Italy between Myths and Reality","authors":"G. Rumi","doi":"10.15406/moji.2017.05.00153","DOIUrl":"https://doi.org/10.15406/moji.2017.05.00153","url":null,"abstract":"Elegant works such as the paper of Pastor-Vargas and colleagues have shown that some of the most allergenic proteinsincluding also the Pru p3-come into contact with the immune system of the infant well before six months [3]. As well as other proteins that are introduced prematurely, these are at the same time very dangerous. For example, concerning the PR10, we have introduced carrots in the vegetable broth used during the first months of weaning. The carrot PR-10 are less labile to digestion and heat, and this kind of protein would seem to be, together with those contained in soy and celery, the most indicted for systemic reactions. Why do we not reflect more deeply on the most common scenarios in order to raise awareness in different population. We should think about the most common allergens for every population and speculate how to introduce them in the infants weaning. How come that alongside the traditional food there are not integrated amounts of protein subsidiaries, belonging to genres of families as the PR-10 or the calcium binding protein that could improve the outcome of tolerance for different allergens [4]? Why the scientific community does not invest more in such a delicate and complex area of interest? Shall we investigate what are the proteins and not the food to be introduced before the child consumption? Which kind of protein is better to introduce in maternal consumption during pregnancy and breastfeeding period? As an allergist and as a father I hereby submit these questions to the attention of the scientific community.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42505716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjuvant Effect of Royal Jelly on HIV-1 Multi-Epitope Vaccine Candidate: Induction of Th1 Cytokine Pattern 蜂王浆对HIV-1多表位候选疫苗的佐剂作用：Th1细胞因子模式的诱导

MOJ immunology Pub Date : 2017-02-17 DOI: 10.15406/MOJI.2017.05.00152

M. Mahdavi, Mahboobeh Cheragh, K. Bagheri, Mohammad Mehdi Adibzadeh, A. Tajik, HamedMemariani, Mohammad Ali Savoji, Seyed Mohammad Mahdi Ghahari, D. Shahbazzadeh

{"title":"Adjuvant Effect of Royal Jelly on HIV-1 Multi-Epitope Vaccine Candidate: Induction of Th1 Cytokine Pattern","authors":"M. Mahdavi, Mahboobeh Cheragh, K. Bagheri, Mohammad Mehdi Adibzadeh, A. Tajik, HamedMemariani, Mohammad Ali Savoji, Seyed Mohammad Mahdi Ghahari, D. Shahbazzadeh","doi":"10.15406/MOJI.2017.05.00152","DOIUrl":"https://doi.org/10.15406/MOJI.2017.05.00152","url":null,"abstract":"Studies show that, royal jelly as a naturally substance could improves immune responses. So, here, royal jelly as adjuvant was used in mixture with a recombinant multi-epitope HIV-1 vaccine model and cellular and humoral immune pattern was analyzed. Mice were immunized three times with recombinant HIV-1 vaccine that formulated in Royal jelly or mixture of Royal jelly/alum with two week interval. Then lymphocyte proliferation assessed with BrdU and IL-4, IFN-γ cytokines, total IgG antibodies and IgG1, IgG2a, IgG2b and IgM isotypes were assessed with ELISA. Results show Royal jellyas adjuvant increased lymphocyteproliferationand IFN-γ cytokine secretion versus control groups (P<0.05).Also, Royal jelly has increased total antibody and isotypes of antibody such as IgM, IgG1, IgG2a, and IgG2b (P<0.05).Overally, Royal jelly at dose of 10 µg could increase cellular and humoral immune responses alone and shows synergistic effect with alum adjuvant in the improvement of immunologic parameters. It is believed that bioactive molecules in Royal jelly could act as immunopotentiator as a part of mixture adjuvant and promote Th1 immune platform.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42077843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Update on Breast Cancer Biomarkers 癌症生物标志物研究进展

MOJ immunology Pub Date : 2017-02-16 DOI: 10.15406/MOJI.2017.05.00150

Braira Wahid, Khansa Wahid, Sohaib Bin Wahid

引用次数: 2

Genetic Ancestry and Health 遗传祖先与健康

MOJ immunology Pub Date : 2017-02-16 DOI: 10.15406/moji.2017.05.00151

H. A. Edinur, Geoffrey Keith Chamber

引用次数: 4