The Immune Response Against Oryzatensin Increase VEGF and MMP-9 Experssion in HEP-G2 Cell Line

Abstract

ORZ (amino acid sequence: Gly-Tyr-Pro-Met-Tyr-Pro-LeuPro-Arg) is a digestion resistant peptide elicited from brown rice (molecular weight= 1093.3). The brown rice bio-active peptide illustrate various functions such as Polymorphonuclear cells stimulation, activation of C3a (one of the complement system components) receptor (C3aR) and the ileum contraction [1-2]. ORZ activates C3aR and imitates C3a function. The ORZ modification was firstly performed to produce a digestion resistant peptide with enhanced affinity to C3aR. Oral administration of modified ORZ, through the digestive system, induces a number of relatively important functions such as anti-amnesic, anorexigenic and antianalgesic ones [3,4].