Brazilian Journal of Microbiology最新文献

{"title":"Characterization of toxigenic genes of Bacillus cereus strains isolated from different spices sold in Algeria","authors":"Redhwane Madouri, Mohammed Ziane, Farouk Benaceur, Gizem Cufaoglu","doi":"10.1007/s42770-024-01514-8","DOIUrl":"https://doi.org/10.1007/s42770-024-01514-8","url":null,"abstract":"<p>Many cooked foods are prepared with spices and dried herbs; these can be contaminated by several types of microorganisms, including aerobic spore-forming bacteria. The <i>Bacillus cereus</i> group is very widespread in nature and is known among the common food contaminants. They are involved in food poisoning, causing two types of syndromes, diarrheal and emetic. The aims of the present work were to determine the prevalence of toxigenic <i>Bacillus cereus</i> spores in spices and herbs marketed in the Laghouat area and to identify their toxigenic genes via PCR. Among the 191 samples, 14.13% were determined to be <i>B. cereus</i>, with concentrations ranging from 2.52 to 5.82 log cfu/g, where the highest level of contamination was observed in allspice and ginger. Moreover, <i>entFM</i> (100%), <i>nhe</i> (88.23%) and <i>cytK</i> (70.58%) were the most frequently identified toxin genes, whereas <i>hbl</i> (23.52%) was less common, and no emetic toxin-encoding gene (<i>cesB</i>) was found in any of the samples. Considering the results of the present study, the <i>B. cereus</i> microbial load and toxin gene profiles of spices show that spices have potential for public health in Algeria. In this context, it is crucial to guarantee the microbiological safety of spices by respecting good hygiene practices, eliminating bacterial spores and toxin production via sterilization and using appropriate packaging for these products.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungi from Antarctic marine sediment: characterization and assessment for textile dye decolorization and detoxification","authors":"Thaís Tiemi Yoshinaga, Patrícia Giovanella, Gabriele Santana de Farias, Juliana Aparecida dos Santos, Elisa Pais Pellizzer, Lara Durães Sette","doi":"10.1007/s42770-024-01485-w","DOIUrl":"https://doi.org/10.1007/s42770-024-01485-w","url":null,"abstract":"<p>Cold-adapted microorganisms can produce enzymes with activity at low and mild temperatures, which can be applied to environmental biotechnology. This study aimed to characterize 20 Antarctic fungi to identify their genus (ITS rDNA marker) and growth temperatures and evaluate their ability to decolorize and detoxify the textile dye indigo carmine (IC). An individual screening was performed to assess the decolorization and detoxification of IC by the isolates, as well as in consortia with other fungi. The isolates were affiliated with seven ascomycete genera: <i>Aspergillus</i> (<i>n</i> = 4), <i>Cosmospora</i> (<i>n</i> = 2), <i>Leuconeurospora</i> (<i>n</i> = 2), <i>Penicillium</i> (<i>n</i> = 3), <i>Pseudogymnoascus</i> (<i>n</i> = 6), <i>Thelebolus</i> (<i>n</i> = 2), and <i>Trichoderma</i> (<i>n</i> = 1). The two isolates from the genus <i>Leuconeurospora</i> were characterized as psychrophilic, while the others were psychrotolerant. The <i>Penicillium</i> isolates were able to decolorize between 60 and 82% of IC. The isolates identified as <i>Pseudogymnoascus</i> showed the best detoxification capacity, with results varying from 49 to 74%. The consortium using only Antarctic ascomycetes (C1) showed 45% of decolorization, while the consortia with the addition of basidiomycetes (C1 + <i>Peniophora</i> and C1 + <i>Pholiota</i>) showed 40% and 50%, respectively. The consortia C1 with the addition of the basidiomycetes presented a lower toxicity after the treatments. In addition, a higher fungal biomass was produced in the presence of dye when compared with the experiment without the dye, which can be indicative of dye metabolization. The results highlight the potential of marine-derived Antarctic fungi in the process of textile dye degradation. The findings encourage further studies to elucidate the degradation and detoxification pathways of the dye IC by these fungal isolates.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel broad host-range promoter sequences functional in diverse Pseudomonadota by a promoter-trap approach","authors":"Diego M. Roldán, Vanesa Amarelle","doi":"10.1007/s42770-024-01512-w","DOIUrl":"https://doi.org/10.1007/s42770-024-01512-w","url":null,"abstract":"<p>Finding novel promoter sequences is a cornerstone of synthetic biology. To contribute to the expanding catalog of biological parts, we employed a promoter-trap approach to identify novel sequences within an Antarctic microbial community that act as broad host-range promoters functional in diverse <i>Pseudomonadota</i>. Using <i>Pseudomonas putida</i> KT2440 as host, we generated a library comprising approximately 2,000 clones resulting in the identification of thirteen functional promoter sequences, thereby expanding the genetic toolkit available for this chassis. Some of the discovered promoter sequences prove to be broad host-range as they drove gene expression not only in <i>P. putida</i> KT2440 but also in <i>Escherichia coli</i> DH5α, <i>Cupriavidus taiwanensis</i> R1^T, <i>Paraburkholderia phymatum</i> STM 815^T, <i>Ensifer meliloti</i> 1021, and an indigenous Antarctic bacterium, <i>Pseudomonas</i> sp. UYIF39. Our findings enrich the existing catalog of biological parts, offering a repertoire of broad host-range promoter sequences that exhibit functionality across diverse members of the phylum <i>Pseudomonadota</i>, proving Antarctic microbial community as a valuable resource for prospecting new biological parts for synthetic biology.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CoronaVac-vaccinated kidney transplant recipients with hybrid immunity have strong neutralizing responses against Omicron and Mu variants of SARS-CoV-2","authors":"Yazmin R. Arias-Murillo, María A. Salinas-N, Camilo Montero, Fernando Giron, Marcela Mercado","doi":"10.1007/s42770-024-01507-7","DOIUrl":"https://doi.org/10.1007/s42770-024-01507-7","url":null,"abstract":"<p>Neutralizing antibody (nAb) responses against SARS-CoV-2 variants after inactivated virus vaccine (CoronaVac) in kidney transplant recipients (KTRs) with or without SARS-CoV-2 infection history remains unclear. We aimed to evaluate the neutralizing antibody responses against emerging SARS-CoV-2 variants after two doses of CoronaVac in these patients. 22.2% of participants had hybrid immunity. Anti-spike IgG antibodies were evidenced in 44% of the patients. nAbs against B.1.111, Mu, and Omicron were detected in 28.5%, 17.9%, and 21.4% of naïve KTRs, respectively. Furthermore, nearly 100% of KTRs with hybrid immunity had nAbs against the variants evaluated. Thus, a significant proportion of infection-naïve KTRs had no detectable nAb titers against Mu and Omicron variants after two doses of the CoronaVac vaccine. However, the nAb titers were significantly higher in patients with hybrid immunity, and it was no association between the immunosuppressive regimen and the seropositivity rate of anti-SARS-CoV-2 neutralizing antibodies. Therefore, hybrid KTRs are protected against COVID-19 by emerging variants able to escape from vaccine-elicited nAbs such as Mu and Omicron.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine secretion by in vitro cultures of lung epithelial cells, differentiated macrophages and differentiated dendritic cells incubated with pneumococci and pneumococcal extracellular vesicles","authors":"Adriano Palharini de Araújo, Tasson da Costa Rodrigues, Maria Leonor Sarno de Oliveira, Eliane Namie Miyaji","doi":"10.1007/s42770-024-01511-x","DOIUrl":"https://doi.org/10.1007/s42770-024-01511-x","url":null,"abstract":"<p><i>Streptococcus pneumoniae</i> is an important human pathogen that can colonize the respiratory tract of healthy individuals. The respiratory tract mucosa is thus the first barrier for this pathogen. In this study, we have tested three models of the respiratory epithelium with immune cells: (i) monolayer of A549 human lung epithelial cells, (ii) A549 + macrophages differentiated from the human monocytic THP-1 cell line (dMφ) and (iii) A549 + dMφ + dendritic cells differentiated from THP-1 (dDC) using a two-chamber system. Pneumococcal strains Rx1 (non-encapsulated) and BHN418 (serotype 6B) were incubated with the cells and secretion of IL-6, IL-8, IL-1β, TNF-α and IL-10 was evaluated. Overall, the models using co-cultures of A549 + dMφ and A549 + dMφ + dDC elicited higher levels of pro-inflammatory cytokines and the non-encapsulated strain elicited an earlier cytokine response. BHN418 <i>pspA</i> (pneumococcal surface protein A) and <i>pspC</i> (pneumococcal surface protein C) knockouts elicited similar cytokine secretion in the co-culture models, whereas BHN18 p<i>ly</i> (pneumolysin) knockout induced much lower levels. The results are in accordance with the activation of the inflammasome by Ply. Finally, we evaluated pneumococcal extracellular vesicles (pEVs) in the co-culture models and observed secretion of pro-inflammatory cytokines in the absence of cytotoxicity. Since pEVs are being studied as vaccine candidate against pneumococcal infections, the co-cultures of A549 + dMφ and A549 + dMφ + dDC are simple models that could be used to evaluate pEV vaccine batches.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method for evaluation of Streptomyces growth and metabolism in the presence of glyphosate-based herbicide","authors":"Luísa Machado Ramos, Renata Medina-Silva, Leandro Vieira Astarita, Eliane Romanato Santarém","doi":"10.1007/s42770-024-01488-7","DOIUrl":"https://doi.org/10.1007/s42770-024-01488-7","url":null,"abstract":"<p>The use of pesticides, such as glyphosate, has increased due to population growth and the rising demand for food. Plant growth-promoting rhizobacteria (PGPR), such as <i>Streptomyces</i>, offer a more ecologically friendly alternative to the excessive use of pesticides. However, these bacteria undergo a complex life cycle involving the formation of hyphae, mycelia, and spores, which makes standardizing laboratory cultures challenging. In this context, we tested three methods for cultivating a <i>Streptomyces</i> isolate (CLV322) in the presence of the stressor agent glyphosate, denoted as M1, M2, and M3. These methods involved the simultaneous addition of the herbicide 24–48 h after the start of cultivation. We evaluated the growth and cell viability of CLV322 using the 2,3,5-triphenyl tetrazolium chloride (TTC) assay under glyphosate-based herbicide stress (Roundup^® Original DI) at concentrations ranging from 0.002 to 7.2 mg mL^− 1. We also assessed the ability of CLV322 to maintain PGPR characteristics in the presence of the herbicide by quantifying indolic compounds, siderophores, and phenazines. The cultivation method significantly influenced the production of metabolites by CLV322, with M3 yielding more consistent results across the evaluated parameters. Our findings suggest that germinating <i>Streptomyces</i> spores for 48 h before introducing glyphosate (M3) enables the analysis of bacterial tolerance to herbicide stress. This methodology may also apply to evaluate other abiotic stresses on <i>Streptomyces</i> strains.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-metal tolerant Porostereum umbrinoalutaceum isolated from Pleurotus ostreatus fruit body showing root colonization, growth promotion of chilli (Capsicum annuum L.) plant and antagonism against fungal pathogens","authors":"Rituparna Sarkar, Bejoysekhar Datta","doi":"10.1007/s42770-024-01513-9","DOIUrl":"https://doi.org/10.1007/s42770-024-01513-9","url":null,"abstract":"<p>Mushroom associated microbes could be utilized to improve crop productivity providing nutrients, plant growth promoting substances, production of hydrolytic enzymes and protecting plant from biotic and abiotic stress. An endophyte designated as KUFC101 was isolated from fruit body of <i>Pleurotus ostreatus</i> and identified as <i>Porostereum umbrinoalutaceum</i> based on nuclear-rRNA gene sequence analysis. Growth in different culture media, metal tolerance, biochemical characterization and effect on chilli plant growth promotion were studied. The isolate showed best growth in Malt extract medium and least growth in synthetic media. It could tolerate toxic metals (Mg, Ca, Fe, Cu, Mn, Zn and Cd each at 100 ppm concentration). It produced amylase, cellulase, chitinase, pectinase, catecholate type of siderophore and indole acetic acid, and inhibited growth of <i>Alternaria solani</i> and <i>Penicillium citrinum</i>. It could colonize in the rhizosphere of chilli plant and influence growth of chilli plant by improving biomass and metabolite content. <i>Porostereum umbrinoalutaceum</i> KUFC101 could be utilized in formulation of biofertiliser under sustainable agricultural system.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insect cell production of chimeric virus-like particles based on human immunodeficiency virus GAG proteins and yellow fever virus envelope protein","authors":"Fabricio da Silva Morgado, Roberta Cahú, Daniela Carrilho de Jesus, Lorena Carvalho de Souza Chaves, Bergmann Morais Ribeiro","doi":"10.1007/s42770-024-01509-5","DOIUrl":"https://doi.org/10.1007/s42770-024-01509-5","url":null,"abstract":"<p>The yellow fever virus (YFV) is a single stranded RNA virus belonging to the genus <i>Orthoflavivirus</i> that is capable of zoonotic transmissions that infect nonhuman and human primates. It is endemic in Brazil with recurrent epidemics of the disease, and it is transmitted through mosquitoes. The detection and immunization against YFV and other flaviviruses are fundamental for the management of the impacts of the disease in human environments. In an ongoing effort to develop new approaches for diagnostics and immunizations, we expressed VLPs displaying the yellow fever virus envelope protein (YFE) using recombinant baculovirus in insect cells. By co-expressing HIV-1 Pr55^Gag protein (GAG) together with YFE we were able to generate chimeric VLPs containing a GAG core together with an envelope containing the YFE protein. The YFE and the chimeric GAG-YFE VLPs have potential as vaccine candidates and as reagents for serological assays in the detection of these viruses in human sera.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional conditions affecting of selenium nanoparticles synthesized by Fusarium oxysporum (CCASU-2023-F9), and their biological activities against mycotoxin-producing fungi isolated from animal feed.","authors":"Mohamed M Gharieb, Esraa M Hassan, Azza Mahmoud Soliman","doi":"10.1007/s42770-024-01494-9","DOIUrl":"https://doi.org/10.1007/s42770-024-01494-9","url":null,"abstract":"<p><p>One of the most promising biologically based nanomanufacturing processes is the production of selenium nanoparticles (SeNPs) by fungi. The use of these biosynthesized nanoparticles in agricultural practices has emerged as a new approach for controlling pathogen growth and mycotoxin production. In the present study, different chemical and physical parameters were investigated for the growth of Fusarium oxysporum (CCASU-2023-F9) to increase selenite reduction and obtain the highest yield of selenium nanoparticles (SeNPs). Fusarium oxysporum (CCASU-2023-F9) exhibited tolerance to up to 1 mM sodium selenite (Na₂SeO₃), accompanied by red coloration of the medium, which suggested the reduction of selenite and the formation of selenium nanoparticles (SeNPs). Reduced selenite was quantified using inductively coupled plasma‒mass spectrometry (ICP-MS), and the results revealed that Fusarium oxysporum (CCASU-2023-F9) is able to transform 45.5% and 50.9% of selenite into elemental selenium by using fructose and urea as the best carbon and nitrogen sources, respectively. An incubation temperature of 30 °C was the best physical condition at which 67.4% of the selenite was transformed into elemental selenium. The results also indicated that pH 7 was the optimum pH, as it displayed 27.2% selenite reduction with a net dry weight of 6.8 mg/mL. Increasing the concentration of sulfate resulted in a significant increase in selenite reduction, as it reached a maximum value of 75.3% at 0.15% g/ml sulfate. The maximum reduction in sodium selenite content was 85.2% at a C/N ratio of 2:1. The biosynthesized SeNPs exhibited antifungal activity against several fungi, such as Aspergillus flavus, Aspergillus niger, and Fusarium oxysporum, that were isolated from animal and poultry feed. Elevated SeNP concentrations (10500 ppm) significantly inhibited fungal growth. SeNPs at a concentration of 5000 ppm inhibited aflatoxin production (B1, B2, G1, and G2) by A. flavus, in addition to inhibiting mycotoxin production (T2 toxin, fumonisin B1, zearaleone, fusarin C, and moniliformin) by F. oxysporum. In conclusion, the results revealed favorable nutritional conditions for the maximum production of SeNPs by Fusarium oxysporum (CCASU-2023-F9) and indicated the marked inhibitory effect of SeNPs on mycotoxins that contaminate animal feed, causing serious consequences for animal health, and that lead to improving the quality of commercially produced animal feed. The obtained results can serve as a basis for commercial applicability.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical characterization and biological activity of Curvularia Lunata, an endophytic fungus isolated from lemongrass (Cymbopogon citratus).","authors":"Mehak Kaur, Rahul C Mishra, Vaibhavi Lahane, Anita Kumari, Akhilesh K Yadav, Monika Garg, Colin J Barrow, Mayurika Goel","doi":"10.1007/s42770-024-01503-x","DOIUrl":"https://doi.org/10.1007/s42770-024-01503-x","url":null,"abstract":"<p><p>Exploration of medicinal plants for bioactive-producing endophytic fungi is a relatively unmapped source of pharmaceutically important compounds. In this study, the endophytic fungus Curvularia lunata AREF029 isolated from the medicinal plant Cymbopogon citratus (known as lemongrass) was assessed for its biological activity. The methanolic extract of AREF029 had minimum inhibition concentration (MIC) ranging from 38 to 174 µg/ml against phytopathogenic fungi Alteranria solani, Fusarium oxysporum and Rhizoctonia solani. Furthermore, the AREF029 methanolic extract displayed a broad-spectrum MIC of 25 µg/ml in the case of Staphylococcus aureus, Salmonella typhimurium and MRSA (methicillin-resistant S. aureus). In vitro cytotoxicity analysis with murine macrophage cell line RAW 264.7 determined 56% nitric oxide inhibition activity at 200 µg/ml concentration of the extract and more than 99% cell viability. Gas chromatography-mass spectrometry (GC-MS) and Liquid chromatography-high resolution mass spectrometry (LC-HRMS) analyses showed the presence of methoxy-5-methyl-4-oxo-2,5-hexadienoic acid (penicillic acid), phthalic acid, bis (7-methyloctyl) ester, 8-hydroxyquinoline, tetroquinone, curvulamine, Curvuleremophilane B/D, Chromonilinc acid A/C and other putative bioactive compounds in the extract. The current investigation supports the significance of the endophytic fungus C. lunata as a source of potent antibacterial, antifungal and anti-inflammatory compounds.</p>","PeriodicalId":9090,"journal":{"name":"Brazilian Journal of Microbiology","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}