Journal of aging science最新文献

{"title":"The Importance of New Findings of Research on Consciousness for the Treatment of Depression in Elderly","authors":"A. Różyk-Myrta, A. Brodziak, M. Muc-Wierzgoń","doi":"10.35248/2329-8847.9.S4.001","DOIUrl":"https://doi.org/10.35248/2329-8847.9.S4.001","url":null,"abstract":"The recent resumption of the discussion of Stuart Hameroff's and Roger Penrose's theory, which assume that theperception of qualia is realized by a quantum physics information processing in microtubules and coincidingpublication, at the same time of recent progress of the so called conscious electromagnetic information field (cemi)theory prompted the authors to the trial to integrate these theories with the earlier explanations of consciousness. Inorder to present the intuitive model of interacting components of consciousness, the authors provide short reviews ofthe 'Orch OR' and ‘cemi’ theories. This enables them to distinguish three distinct, cooperating processes underlyingthe phenomenon of consciousness, namely (a) perception, including the feeling of qualia, (b) the realization ofmental imagery and (c) the feeling of subjectivity, identity manifested by the ability to self-awareness. The ability tounderstand the essence of the self-awareness is important for health care professionals, because consciousnessdisorders are a frequent medical symptom in emergencies, anesthesia and depressive syndromes in elderly. Theauthors emphasize the usefulness of transcranial magnetic stimulation, as a method of intervention in brain'sendogenous electromagnetic field, or more precisely in its element caused by the 'default mode network'. Theyemphasize also that effectiveness of the use of mindfulness methods in the treatment of depressive syndromes alsoresults from reducing the activity of \"Default Mode Network”.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"24 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70005292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of a Novel Clinical Triad (Chandrans TRIAD) for Early Diagnosis of Autoimmune Encephalitis (AIE) in Patients with Progressive Cognitive Decline","authors":"T. Issac","doi":"10.35248/2329-8847.9.S4.002","DOIUrl":"https://doi.org/10.35248/2329-8847.9.S4.002","url":null,"abstract":"Autoimmune Encephalitis (AIE) often presents with cognitive and behavioural symptoms often mimickingprogressive degenerative dementias. Early identification of these potentially reversible conditions can improve patientoutcomes, reduce caregiver burden and promote cost effectiveness. The clinical trial of symptoms namely panicattacks, catatonia and day time sleepiness is often associated with anti N-methyl D-aspartate (NMDA) receptormediated encephalitis and the former two symptoms along with seizures is suggestive of anti-Voltage Gated PotassiumChannel (VGKC) receptor mediated encephalitis. This triad serves as a pragmatic tool to easily identify AIE and alsohelps to distinguish between the two conditions.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70005344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Note On Aging Reasons","authors":"M. Subramanyam","doi":"10.35248/2329-8847.21.9.E232","DOIUrl":"https://doi.org/10.35248/2329-8847.21.9.E232","url":null,"abstract":"","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70005433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin Converting Enzyme 2 (ACE2) Expression in the Aged Brain and Visual System.","authors":"James M Hill,&nbsp;Christian Clement,&nbsp;L Arceneaux,&nbsp;Walter J Lukiw","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multiple lines of evidence currently indicate that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains entry into human host cells <i>via</i> a high-affinity interaction with the angiotensin-converting enzyme 2 (ACE2) transmembrane receptor. Research has further shown the widespread expression of the ACE2 receptor on the surface of many different immune, non-immune and neural host cell types, and that SARS-CoV-2 has the remarkable capability to attack many different types of human-host cells simultaneously. One principal neuroanatomical region for high ACE2 expression patterns occurs in the brainstem, an area of the brain containing regulatory centers for respiration, and this may in part explain the predisposition of many COVID-19 patients to respiratory distress. Early studies also indicated extensive ACE2 expression in the whole eye and the brain's visual circuitry in aged humans. In this study we analyzed ACE2 receptor expression at the mRNA and protein level in multiple cell types involved in human vision, including cell types of the external eye and several deep brain regions known to be involved in the processing of visual signals. Here we provide evidence: (<b>i</b>) that many different optical and neural cell types of the human visual system provide receptors essential for SARS-CoV-2 invasion; (<b>ii</b>) of the remarkable ubiquity of ACE2 presence in cells of the eye and anatomical regions of the brain involved in visual signal processing; (<b>iii</b>) that ACE2 receptor expression in different ocular cell types and visual processing centers of the brain provide multiple compartments for SARS-CoV-2 infiltration; and (<b>iv)</b> of a gradient of increasing ACE2 expression from the anterior surface of the eye to the visual signal processing areas of the occipital lobe and the primary visual neocortex. A gradient of ACE2 expression from the eye surface to the occipital lobe may provide the SARS-CoV-2 virus a novel pathway from the outer eye into deeper anatomical regions of the brain involved in vision. These findings may explain, in part, the many recently reported neuro-ophthalmic manifestations of SARS-CoV-2 infection in COVID-19 affected patients.</p>","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"Vol 9 Suppl 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39721277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging and the Science","authors":"A. Rajput","doi":"10.35248/2329-8847.21.9.253","DOIUrl":"https://doi.org/10.35248/2329-8847.21.9.253","url":null,"abstract":"Human body evolves continuously from infancy to old age. Life expectancy has been increasing for several decades. Consequently, we now have the largest proportion of the elderly in the population, than at any time before. As in all age categories, some diseases are more common in the elderly. Additionally, normal age related changes may resemble some well-known treatable diseases. Most of the current medical knowledge is based on studies of young/middle aged individuals, some of which is not applicable to the elderly. The response to certain drugs is different in the elderly than in the younger persons. Distinguishing between “normal” aging and disease is therefore important. This article provides an example of Parkinson’s disease in the elderly. As the number of the elderly in the population is increasing there is greater need to provide proper health service for the population. The Father of modern treatment of Parkinson’s disease, Professor Hornykiewicz was making major discoveries at age 90. Age based retirement is being phased out at many institutions. That would help use the valuable skills which the older individuals have acquired in life. Research in the elderly is needed to provide the best services for this growing segment of population.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"9 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70004857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Isometric Endurance of Abdominal and Back Extensor Muscles in Manual and Sedentary Males in the Age Group of 20-40 Years","authors":"A. Suresh, Dimple Kashyap, T. Behera, D. EbenezerWilsonRajKumar","doi":"10.35248/2329-8847.21.9.254","DOIUrl":"https://doi.org/10.35248/2329-8847.21.9.254","url":null,"abstract":"Background: Stabilization of trunk flexors and extensors are essential for normal lumbo-pelvic function. These muscles, known as “core muscles”, have a basic role in balance and coordination in sitting. The core is the lumbopelvic- hip complex which includes lumbar spine, pelvis, hips, and their respective musculature. Pattern of core activity changes in sitting and dysfunction of core muscles increased the risk of damage of the upper and lower extremities segments. Powerful core muscles support stabilizes the vertebra and pelvis, prevents balance disorder and decreases the rate of LBP which is one of the most prevalent occupational disorders. Endurance of trunk muscles depends on the life style and working condition of individuals. Imbalance in the trunk muscle endurance secondarily leads to back pain, which disables the person and reduces the functional capacity of individuals. Objective: The aim of this study is to evaluate the difference in isometric endurance between abdominal and back extensor muscle in manual and sedentary workers and guide them about the importance of endurance training in preventing the back pain in the future. Materials and methods: This study includes 40 simple randomly sampled normal male subjects according to the inclusion and exclusion criteria in the age group of 20-40 years, recruited on voluntary basis and allotted to Group A (N=20, Manual workers) and Group B (N=20, Sedentary workers). Modified Kraus weber’s test for abdominal muscles and Modified Sorensen’s test for back extensor muscles were performed by both Group A and Group B in two successive trials for each test with a rest break of 3-5 minutes in between the trials and the best of trials in seconds is recorded with a stop watch and the data is analyzed using SPSS statistics software version 19. Results: The isometric abdominal muscles endurance is more in manual workers than the sedentary workers, at a significance level of p<0.005.The isometric endurance of back extensor muscles is more than isometric abdominal muscles in both the groups, at a significance level of p<0.005.The isometric back extensor muscles endurance is more in manual workers than in sedentary workers, at a significance level of p<0.005. Conclusion: The isometric abdominal muscles endurance is less in both the groups as compared to isometric back extensor muscles endurance. So, abdominal muscles should be concentrated during endurance training. The objective of any fitness regime, maintenance of good health and posture and treatment of back pain is identifying dangerous causes that require immediate attention and attempt to prevent chronic low back pain problems. The modified Sorensen’s and Kraus Weber’s test can be used to asses and train the trunk muscles endurance as they are simple, easy, reliable and replace the costly and time consuming machine methods for evaluating and training endurance.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70004885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illustration of Older People","authors":"M. Subramanyam","doi":"10.35248/2329-8847.21.9.255","DOIUrl":"https://doi.org/10.35248/2329-8847.21.9.255","url":null,"abstract":"","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70004902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Impact on Aging and Life Span","authors":"M. Subramanyam","doi":"10.35248/2329-8847.21.9.259","DOIUrl":"https://doi.org/10.35248/2329-8847.21.9.259","url":null,"abstract":"","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70005037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who is Responsible for Aging: Life Style or Genetics or Both?","authors":"PD Gupta","doi":"10.35248/2329-8847.21.9.247","DOIUrl":"https://doi.org/10.35248/2329-8847.21.9.247","url":null,"abstract":"Aging is the total outcome of interactions among genetic, environmental and lifestyle factors at a given time. Survivalevents such as, well-beyond average life expectancy, delayed onset of age-related diseases (before 80 years of age)and/or preservation of good health/function is very common presently may be due to improvement in health andnutritional conditions. Researchers at Yale University hooked the organs to a system that pumped in a bloodsubstitute. Similarly researchers have revived the disembodied brains of pigs four hours after the animals wereslaughtered pointing towards rejuvenation of life, Modern data analysis and in particular, AI approaches could betransformative toward identifying strategies for preservation of good health with advancing age.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"9 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70005244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Diabetes Comorbidity in Populations with Movement Disorders Related to Parkinson's Disease","authors":"F. Zarola","doi":"10.35248/2329-8847.9.S4.004","DOIUrl":"https://doi.org/10.35248/2329-8847.9.S4.004","url":null,"abstract":"Background and aim of the work: Some studies during the time have shown a high comorbidity of diabetes in parkinson's disease and related disorders. This imprerssion was also detected in our clinical experience. Therefore it was decided to carry out a study about the incidence of diabetes in affected populations using the raw data collected in clinical practice. The purpose of the analysis was to establish a possible action of diabetes as a risk factor for extrapyramidal diseases. Methods: We studied a group of 88 subjects with Parkinson’s Disease (PD) of which 18 with diabetes (20.45%, about 1 in 4), a group with Essential Tremor (ET) consisting of 68 subjects of which 17 affected by diabetes (25%) and a group with Vascular Parkinsonism (VP) consisting of 21 subjects of which 5 with diabetes (23.8%). Results: The ratios showed a relatively homogeneous distribution in the three sub-populations of the given diabetic disease. The results indicated that the statistic comparison between the various groups examined did not give any statistical significance. Similarly, the comparison between the individual groups with the pathologies examined (PD, VP and ET) and the recruited control population was not significant as regards the incidence of diabetes as comorbidity. Conclusion: The scarce relevance in the differences between patients with diabetes and without does not exclude tout court a possible influence of the dysmetabolic disorder on extrapyramidal diseases as it is necessary to take into account biochemical factors that are difficult to measure with clinical studies.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"1 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70006073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}