ISRN bioinformatics最新文献_第3页

A Systolic Array-Based FPGA Parallel Architecture for the BLAST Algorithm. 基于收缩阵列的BLAST算法FPGA并行架构。

ISRN bioinformatics Pub Date : 2012-09-04 eCollection Date: 2012-01-01 DOI: 10.5402/2012/195658

Xinyu Guo, Hong Wang, Vijay Devabhaktuni

引用次数: 21

Enhancing de novo transcriptome assembly by incorporating multiple overlap sizes. 通过合并多个重叠大小增强从头转录组组装。

ISRN bioinformatics Pub Date : 2012-04-23 eCollection Date: 2012-01-01 DOI: 10.5402/2012/816402

Chien-Chih Chen, Wen-Dar Lin, Yu-Jung Chang, Chuen-Liang Chen, Jan-Ming Ho

引用次数: 3

Nonlinear dependence in the discovery of differentially expressed genes. 发现差异表达基因的非线性依赖。

ISRN bioinformatics Pub Date : 2012-04-12 eCollection Date: 2012-01-01 DOI: 10.5402/2012/564715

J R Deller, Hayder Radha, J Justin McCormick, Huiyan Wang

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引用次数: 2

Chemical Entity Recognition and Resolution to ChEBI. ChEBI的化学实体识别与解析。

ISRN bioinformatics Pub Date : 2012-02-15 eCollection Date: 2012-01-01 DOI: 10.5402/2012/619427

Tiago Grego, Catia Pesquita, Hugo P Bastos, Francisco M Couto

引用次数: 28

Signal Peptidase Complex Subunit 1 and Hydroxyacyl-CoA Dehydrogenase Beta Subunit Are Suitable Reference Genes in Human Lungs. 信号肽酶复合体亚基1和羟酰基辅酶a脱氢酶β亚基是人体肺部合适的内参基因。

ISRN bioinformatics Pub Date : 2011-12-28 eCollection Date: 2012-01-01 DOI: 10.5402/2012/790452

Issac H K Too, Maurice H T Ling

{"title":"Signal Peptidase Complex Subunit 1 and Hydroxyacyl-CoA Dehydrogenase Beta Subunit Are Suitable Reference Genes in Human Lungs.","authors":"Issac H K Too, Maurice H T Ling","doi":"10.5402/2012/790452","DOIUrl":"https://doi.org/10.5402/2012/790452","url":null,"abstract":"Lung cancer is a common cancer, and expression profiling can provide an accurate indication to advance the medical intervention. However, this requires the availability of stably expressed genes as reference. Recent studies had shown that genes that are stably expressed in a tissue may not be stably expressed in other tissues suggesting the need to identify stably expressed genes in each tissue for use as reference genes. DNA microarray analysis has been used to identify those reference genes with low fluctuation. Fourteen datasets with different lung conditions were employed in our study. Coefficient of variance, followed by NormFinder, was used to identify stably expressed genes. Our results showed that classical reference genes such as GAPDH and HPRT1 were highly variable; thus, they are unsuitable as reference genes. Signal peptidase complex subunit 1 (SPCS1) and hydroxyacyl-CoA dehydrogenase beta subunit (HADHB), which are involved in fundamental biochemical processes, demonstrated high expression stability suggesting their suitability in human lung cell profiling. ","PeriodicalId":90877,"journal":{"name":"ISRN bioinformatics","volume":"2012 ","pages":"790452"},"PeriodicalIF":0.0,"publicationDate":"2011-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33173866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Construction of a drug safety assurance information system based on clinical genotyping. 基于临床基因分型的药品安全保障信息系统构建。

ISRN bioinformatics Pub Date : 2011-11-29 eCollection Date: 2012-01-01 DOI: 10.5402/2012/982737

John A Springer, Nicholas V Iannotti, Jon E Sprague, Michael D Kane

引用次数: 1

Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies. Bio301:一个基于web的EST注释管道，促进功能比较研究。

ISRN bioinformatics Pub Date : 2011-09-27 eCollection Date: 2012-01-01 DOI: 10.5402/2012/139842

Yen-Chen Chen, Yun-Ching Chen, Wen-Dar Lin, Chung-Der Hsiao, Hung-Wen Chiu, Jan-Ming Ho

引用次数: 4