{"title":"Bio301:一个基于web的EST注释管道，促进功能比较研究。","authors":"Yen-Chen Chen, Yun-Ching Chen, Wen-Dar Lin, Chung-Der Hsiao, Hung-Wen Chiu, Jan-Ming Ho","doi":"10.5402/2012/139842","DOIUrl":null,"url":null,"abstract":"<p><p>In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information. </p>","PeriodicalId":90877,"journal":{"name":"ISRN bioinformatics","volume":"2012 ","pages":"139842"},"PeriodicalIF":0.0000,"publicationDate":"2011-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407203/pdf/","citationCount":"4","resultStr":"{\"title\":\"Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies.\",\"authors\":\"Yen-Chen Chen, Yun-Ching Chen, Wen-Dar Lin, Chung-Der Hsiao, Hung-Wen Chiu, Jan-Ming Ho\",\"doi\":\"10.5402/2012/139842\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information. </p>\",\"PeriodicalId\":90877,\"journal\":{\"name\":\"ISRN bioinformatics\",\"volume\":\"2012 \",\"pages\":\"139842\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407203/pdf/\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ISRN bioinformatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5402/2012/139842\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ISRN bioinformatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5402/2012/139842","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies.
In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.
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