Bollettino chimico farmaceutico最新文献_第2页

Synthesis and antimicrobial properties of 3-sulfonyl-1,2,3,4-tetrahydropyrimido [4,5-d] pyrimidines. 3-磺酰基-1,2,3,4-四氢嘧啶[4,5-d]嘧啶的合成及抗菌性能

Bollettino chimico farmaceutico Pub Date : 2004-11-01

Jerzy Cieplik, Janusz Pluta, Olaf Gubrynowicz

引用次数: 0

Synthesis and anticonvulsant activity of some piperazine derivatives. 哌嗪类衍生物的合成及其抗惊厥活性。

Bollettino chimico farmaceutico Pub Date : 2004-11-01

H Marona, R Korona, E Szneler

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Bioequivalence study of sildenafil citrate tablets in healthy human volunteers. 枸橼酸西地那非片在健康人体的生物等效性研究。

Bollettino chimico farmaceutico Pub Date : 2004-11-01

U Mandal, Prashant Musmade, Mita Chakraborty, D Senthil Rajan, M Chakravarti, T K Pal, T K Chattaraj

{"title":"Bioequivalence study of sildenafil citrate tablets in healthy human volunteers.","authors":"U Mandal, Prashant Musmade, Mita Chakraborty, D Senthil Rajan, M Chakravarti, T K Pal, T K Chattaraj","doi":"","DOIUrl":"","url":null,"abstract":"Newly developed sildenafil citrate (SC), a selective inhibitor of cyclic guanosine monophosphate (c-GMP) specific phosphodiesterase type 5 (PDE 5) in the corpus cavernosum is used for the oral treatment of erectile dysfunction. A convenient, sensitive and simple method for the determination of sildenafil in human plasma is presented. The analytical technique was based on reversed-phase high-performance liquid chromatography coupled with UV detector set at 295 nm. Rofecoxib was used as internal standard (I.S). Liquid-liquid extraction using diethyl ether was performed to recover sildenafil and rofecoxib. The retention time of I.S and sildenafil were 5.5 minutes and 7.2 minutes respectively. The method was validated over a linear range of 10 to 1000 ng/ml from plasma. Separate stability study showed that sildenafil is stable under conditions of analysis. The extraction efficiency from plasma varied from 79.69% to 81.13 %. The minimum quantifiable concentration was set at 10 ng/ml. (%o CV<12.5%). The method was used for Bioequivalence Study of Two Brands of Sildenafil citrate 50 mg tablets in healthy human volunteers. All pharmacokinetic parameter were calculated along with statistical evaluation.","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 9","pages":"345-9"},"PeriodicalIF":0.0,"publicationDate":"2004-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25099569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and biological evaluation of novel naphthoquinone derivatives as potential anticancer and antimicrobial agents. 新型萘醌类抗癌和抗菌药物的合成及生物学评价。

Bollettino chimico farmaceutico Pub Date : 2004-10-01

Nargues S Habib, Mona A Mahran

引用次数: 0

Effect of 5-substituted benzylideneaminosalicylic acid on carrageenan-induced ulcerative colitis. 5-取代苄基氨基水杨酸对卡拉胶性溃疡性结肠炎的影响。

Bollettino chimico farmaceutico Pub Date : 2004-10-01

P Jaysekhar, S B Rao, G Santhakumari

引用次数: 0

Behavior of cinnamoyl-isothiocyanate towards carbon, nitrogen and oxygen reagents. 肉桂酰异硫氰酸酯对碳、氮、氧试剂的行为。

Bollettino chimico farmaceutico Pub Date : 2004-10-01

N H Ouf, S El-Bahaie, M G Assy, E El-Shaikh

引用次数: 0

Oral delivery system of insulin microspheres: effect on relative hypoglycemia of diabetic albino rats. 胰岛素微球口服给药系统对糖尿病白化大鼠相对低血糖的影响。

Bollettino chimico farmaceutico Pub Date : 2004-10-01

D Senthil Rajan, Uttam Kr Mandal, K Veeran Gowda, A Bose, M Ganesan, T K Pal

{"title":"Oral delivery system of insulin microspheres: effect on relative hypoglycemia of diabetic albino rats.","authors":"D Senthil Rajan, Uttam Kr Mandal, K Veeran Gowda, A Bose, M Ganesan, T K Pal","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the present work was to investigate the effectiveness of a dosage form approach for monitoring both the inactivation and the absorption process by targeting insulin delivery to the upper region of small intestine. The dosage form is based on the incorporation of insulin with protease inhibitor and absorption enhancer into polyacrylic polymer Eudragit L-100. Insulin microspheres were prepared by solvent evaporation technique. And also study the effect of these microspheres upon the relative hypoglycemia (RH) effect in white diabetic albino rats has been studied in comparison to that produced after subcutaneous injection of bovine insulin solution. The oral administration of formulation with aprotinin and bile salts gave significant (p< 0.01) hypoglycemia when compared with formulation with insulin alone and with insulin and bile salts. However, the duration, course and the intensity of effect were different for each formulation. It was interesting to observe that the co-administration of aprotinin and bile salts produce prolonged and significant reduction of blood glucose level. A reduction of 4.47-36.81% in plasma glucose levels and RH of about 11.7% relative to subcutaneous injection of soluble insulin solution can be achieved by encapsulation along with protease inhibitor and bile salts.","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 8","pages":"315-8"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25274629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of new triazolopyrimidines and substituted pyrimidines. 新三唑嘧啶及取代嘧啶的合成。

Bollettino chimico farmaceutico Pub Date : 2004-09-01

N H Ouf

引用次数: 0

The influence of some aminoalkanolic xanthone derivatives on central nervous and cardiovascular systems in rodents. 某些氨基醇类山酮衍生物对啮齿动物中枢神经和心血管系统的影响。

Bollettino chimico farmaceutico Pub Date : 2004-09-01

Tadeusz Librowski, Ryszard Czarnecki, Magdalena Jastrzebska-Wiesek, Wlodzimierz Opoka, Henryk Marona

引用次数: 0

Assessment of pharmacy patients' compliance in Bulgaria (2001--2002). 保加利亚药房患者依从性评估(2001- 2002)。

Bollettino chimico farmaceutico Pub Date : 2004-09-01

V Petkova, M Dimitrov

{"title":"Assessment of pharmacy patients' compliance in Bulgaria (2001--2002).","authors":"V Petkova, M Dimitrov","doi":"","DOIUrl":"","url":null,"abstract":"The goal of this issue is to assess the level of compliance, respectively of non-compliance among pharmacY patients between the years 2001 and 2002 in Sofia, Bulgaria. The authors study and emphasize on the factors that influence the non-compliance of the patients and also try to find different ways to increase the rate of compliance in Bulgaria. Two types of standard individual questionnaires are applied for assessment of the state of compliance and non-compliance among the pharmacy patients. The obtained results show that the main reasons, influencing the non-adherence of the patients are: the high average price of the drugs, the overload daily regimen, inattention, distrust to the treatment and others. The drug form appears to be one of the main factors that cause non-compliance, especially when the patients receive more than one drug in different drug forms few times a day and especially if elderly patients are addressed. Despite the presented comparatively high level of compliance among the patients (from 53% for 2001, to 82% for 2002), there are strategies to enhance compliance that have to be initiated. They incorporate communication tactics, patient's education, and proper dosage of the drugs and scheduling of the drug application. The results of the analysis of the received data show an increase in the level of compliance for the pharmacy patients in Bulgaria. For 2001 it was 53%, while for 2002 it has increased to 82%. This fact shows the influence of strategies for improvement of compliance.","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 7","pages":"263-6"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25100249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0