发布求助
文献互助 智能选刊 最新文献

Bollettino chimico farmaceutico最新文献

筛选
英文 中文
Hyperhomocysteinemia is A risk marker for development of maternal pre-eclampsia. 高同型半胱氨酸血症是母体先兆子痫发展的危险标志。
Bollettino chimico farmaceutico Pub Date : 2004-09-01
Mahmoud R Fayed, Mamdouh Youssef, Mosad M Odah
{"title":"Hyperhomocysteinemia is A risk marker for development of maternal pre-eclampsia.","authors":"Mahmoud R Fayed,&nbsp;Mamdouh Youssef,&nbsp;Mosad M Odah","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The objective of the current study was to determine whether homocysteine elevations precede the development of pre-eclampsia, and to examine the relationship between the occurrence of pre-eclampsia and the degree of hyperhomocysteinemia, so as to find a new prognostic parameter for women with liable to develop pre-eclampsia. The study comprised 103 pregnant females chosen of those attending the Antenatal Care Unit at Benha University Hospital and accepted to donate blood samples at the 16th week of gestation. Women, who delivered at Benha University Hospital, were retrospectively allocated into two groups: Control group (Group C): comprised 64 (71.1%) parturient, who completed their full term pregnancy without the development of pre-eclampsia. Pre-eclampsia group (Group PEc): comprised 26 (28.9%) parturient who developed pre-eclampsia throughout their course of pregnancy but had completed their full term pregnancy. Through the present study, estimated fasting plasma tHcys levels were higher than the 90th percentile of the control group (> or = 5.1 ng/dl) in 6 (9.4%) women in group C and in 9 (34.6%) in group PEc. There was a significant (P<0.05) increase of fasting plasma tHcys levels in nullipara pre-eclamptic parturient as compared to multiparous control parturient. Also, a negative significant correlation was reported between parity and the fasting plasma tHcys level in pre-eclamptic parturient. The present results showed a significant increase of fasting plasma tHcys level in obese women with a positive significant correlation between fasting plasma tHcys level and BMI in PEc group. Thus, it can be concluded that hyperhomocysteinemia is an indirect risk factor for placental vasculopathy predating clinical pre-eclampsia, and can be used as a biomarker for identifying women at risk of complications and adverse pregnancy outcomes.</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 7","pages":"281-7"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25099047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluations of sulfa derivatives bearing heterocyclic moieties. 含杂环磺胺衍生物的合成及生物学评价。
Bollettino chimico farmaceutico Pub Date : 2004-07-01
Wafaa R Abdel-Monem
{"title":"Synthesis and biological evaluations of sulfa derivatives bearing heterocyclic moieties.","authors":"Wafaa R Abdel-Monem","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Some new sulfa derivatives bearing a heterocyclic moieties fural, pyrimidinone, thiazolidinone, benzimidazole and 1,2,4-triazinone and the related compounds 2-19 have been synthesized from treatment of sulfa drugs with thioisocyanate, acid chlorides, 3-chloro-1,2,4-triazines, aldehydes, esters and/or 2-methylbenzoxazole followed by ring closure reactions. Structures of the products have been deduced from their elemental analysis and spectral data. Significant antimicrobial activities were observed in vitro for some members of the series. Compounds 9b, 16 are highly active, while compounds 4b, 6d, 7,9a, 10 and 14 showing a moderate active towards gramme positive bacterium (b.subtilis). gramme negative bacterium (E. coli) and two fungi namely (A.nidulans & A.terreus).</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 6","pages":"239-47"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25099045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tetrazolo[1,5-a] quinoline derivatives as anti-inflammatory and antimicrobial agents [1]. 四唑[1,5-a]喹啉衍生物的抗炎和抗菌药物研究[1]。
Bollettino chimico farmaceutico Pub Date : 2004-07-01
Ola A El-Sayed, Turki M Al-Turki, Hessa M Al-Daffiri, Badr A Al-Bassam, Maher E Hussein
{"title":"Tetrazolo[1,5-a] quinoline derivatives as anti-inflammatory and antimicrobial agents [1].","authors":"Ola A El-Sayed,&nbsp;Turki M Al-Turki,&nbsp;Hessa M Al-Daffiri,&nbsp;Badr A Al-Bassam,&nbsp;Maher E Hussein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tetrazolo[1,5-a]quinoline derivatives bearing in the 4-position various thiazolidinone 3a-c, 5a-c and 7a-c, thiazinone 8a,b, thiazoline 9a-d and thiadiazoline 10a,b moieties have been synthesized and evaluated for anti-inflammatory activity and antimicrobial properties. The synthetic routes involved the reaction of tetrazolo[1,5-a]quinoline-4-carboxaldehyde 1 with amines and hydrazines to give the corresponding aniles 2a-c and hydrazones 4a-c respectively The latter compounds when treated with thioglycolic acid, furnished the corresponding thiazolidinone derivatives 3a-c and 5a-c. Moreover; thiosemicarbazone 6a-c derivatives were subsequently cyclized by various reagents giving rise the title compounds. Some of the products proved to possess potent anti-inflammatory and antimicrobial properties.</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 6","pages":"227-38"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25099042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrophotometric determination of captopril with DTNB reagent in pharmaceutical formulation. DTNB分光光度法测定制剂中卡托普利的含量。
Bollettino chimico farmaceutico Pub Date : 2004-07-01
S J Hosseinimehr, P Ebrahimi, N Hassani, P Mirzabeigi, M Amini
{"title":"Spectrophotometric determination of captopril with DTNB reagent in pharmaceutical formulation.","authors":"S J Hosseinimehr,&nbsp;P Ebrahimi,&nbsp;N Hassani,&nbsp;P Mirzabeigi,&nbsp;M Amini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simple and sensitive spectrophotometeric method has been developed for the determination of captopril in its dosage form. The method is based on the reaction of the drug with DTNB reagent in pH 8 to produce a yellow coloured species measurable at 412 nm. The absorbance-concentration plot is linear over the range 1-10 x 10(-5) M with correlation coefficient of 0.997. The molar absorptivity and minimum delectability were 13553 and 3.2 x 10(-7) respectively. The proposed method was applied successfully for determination of captopril in its tablets form. The mean quantity and recovery were found to be 25.01+/-2% and 100.04+/-2% (each tablet contain 25 mg captopril). Quantification of the same tablets was determined by a standard method such as HPLC. The mean quantity of each tablet was found to be 25.07+/-1.22% by using HPLC method. It was not statistically, significant difference between Ellman's and HPLC method. This proposed method can be successfully applied to the determination of captopril in water and its dosage form and can use instead HPLC.</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 6","pages":"249-51"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25099046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination and correlation of the reversed-phase thin-layer chromatographic parameter (Rm) of a series of 3-(4-substituted-1-piperazinyl)-1-substituted-1-phenyl propanol derivatives with their LD50 values. 一系列3-(4-取代-1-哌嗪基)-1-取代-1-苯基丙醇衍生物反相薄层色谱参数Rm与其LD50值的测定及相关性
Bollettino chimico farmaceutico Pub Date : 2004-07-01
Osadebe, O Patience
{"title":"Determination and correlation of the reversed-phase thin-layer chromatographic parameter (Rm) of a series of 3-(4-substituted-1-piperazinyl)-1-substituted-1-phenyl propanol derivatives with their LD50 values.","authors":"Osadebe,&nbsp;O Patience","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experimental Rm values of four series of 3-(4-substituted-1- piperazinyl)-1-substituted-1-phenyl propanol derivatives, previously prepared for quantitative structure-activity relationship studies, were determined using reversed-phased thin-layer chromatography. The Rm values were determined for various concentrations of acetone in water (50, 60, 70, 80 and 90%), and the obtained correlation lines of Rm against proportion of acetone were extrapolated to 100% water The extrapolated Rm values of two of the four series of the 3-(4-benzyl-1-piperazinyl)-1-phenyl propanol derivatives were correlated with LD50 values obtained from 24-hour acute toxicity studies in albino mice. The extrapolated Rm values correlated parabolically with the LD50s.</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 6","pages":"253-60"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25099049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five technologies to lead the biotek. 引领biotek的五大技术。
Bollettino chimico farmaceutico Pub Date : 2004-06-01
G C Lubner
{"title":"Five technologies to lead the biotek.","authors":"G C Lubner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 5","pages":"194"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24677193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and properties of N-methyl and N-phenyl derivatives of 1,4-dioxo-1,2,3,4-tetrahydropyrido[3,4-d]pyridazines. 1,4-二氧基-1,2,3,4-四氢吡啶[3,4-d]吡嗪n -甲基和n -苯基衍生物的合成及性质
Bollettino chimico farmaceutico Pub Date : 2004-06-01
H Sladowska, M Sokolowska, A Sabiniarz, B Filipek, J Sapa
{"title":"Synthesis and properties of N-methyl and N-phenyl derivatives of 1,4-dioxo-1,2,3,4-tetrahydropyrido[3,4-d]pyridazines.","authors":"H Sladowska,&nbsp;M Sokolowska,&nbsp;A Sabiniarz,&nbsp;B Filipek,&nbsp;J Sapa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>2-Methoxy- and 2-ethoxy-6-methyl-3,4-pyridinedicarboximides (XI, XII) reacted with N-methylhydrazine giving 2- and 3-methyl derivatives of the appropriate 1,4-dioxo-1,2,3,4-tetrahydropyrido[3,4-d]pyridazines (XV, XIII and XVI, XIV). In both cases 3-methyl isomer (XIII, XIV) was formed in higher yield than 2-methyl derivative (XV, XVI). Reaction of the imide XII with N-phenylhydrazine gave the salts of the suitable N-phenyldihydropyrido[3,4d]pyridazines with NH2-NHC6H5 (XXI and XXII) which transformed into N-phenylaminoimide (XXIII) during the boiling in 80% CH3COOH. Imide XXIII isomerized to the appropriate 2-phenyl and 3-phenylpyrido[3,4-d]pyridazines (XXIV - main reaction product and XXV) under the influence of heating in ethanolic solution of C2H5ONa. Some of N-phenylpiperazinylhydroxyalkyl(alkyl) derivatives of compound XXIV (XXVII, XXVIII) were pharmacologically active.</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 5","pages":"211-8"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24677195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopharmaceutical and pharmacodynamic studies on topically applied diclofenac gel available in Indian market. 印度市场上外用双氯芬酸凝胶的生物制药和药效学研究。
Bollettino chimico farmaceutico Pub Date : 2004-06-01
K Bhaskar, S Ramachandran, S K Sridhar, A T Rajarajan, A Ramkumar, K Sanathkumar, G Srinivasa Rao, J Anbu, M D Dhanaraju, M Saravanan
{"title":"Biopharmaceutical and pharmacodynamic studies on topically applied diclofenac gel available in Indian market.","authors":"K Bhaskar,&nbsp;S Ramachandran,&nbsp;S K Sridhar,&nbsp;A T Rajarajan,&nbsp;A Ramkumar,&nbsp;K Sanathkumar,&nbsp;G Srinivasa Rao,&nbsp;J Anbu,&nbsp;M D Dhanaraju,&nbsp;M Saravanan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present investigation, an attempt was made to study and compare, analgesic and anti-inflammatory activity produced by four marketed topical diclofenac formulations in order to justify their usefulness in the treatment of pain and inflammation. By using a diffusion cell, in vitro percutaneous permeation studies were carried out to correlate in vivo activity. The in vivo analgesic activity study was performed by tail flick method on Wistar albino rats. The anti-inflammatory activity was performed on rats by carrageenan induced inflammation. It was evident from the study that three among tested three gels; diclofenac permeated effectively through the skin and was able to elicit analgesic and anti-inflammatory responses. The study also indicated the presence of therapeutic inequivalence among the marketed topical formulation and the need of bio equivalency and therapeutic equivalency testing of marketed topical applications meant for therapeutic use.</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 5","pages":"208-10"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24677194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of quality control parameters and interchangeability of multisourced metformin HCl tablets marketed in Nigeria. 尼日利亚销售的多来源盐酸二甲双胍片的质量控制参数和互换性评价。
Bollettino chimico farmaceutico Pub Date : 2004-05-01
P O Osadebe, I C Akabogu
{"title":"Assessment of quality control parameters and interchangeability of multisourced metformin HCl tablets marketed in Nigeria.","authors":"P O Osadebe,&nbsp;I C Akabogu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A quality control assessment of five brands of metformin hydrochloride tablets marketed in Nigeria [Glucophage (R) (Merck, Quetta), Metformin BDC (Bangkok labs, Bangkok), Metformin (Medopharm, India), Glucophage (R) (Ilsan), Glucophage (Lipha)] was carried out in order to determine the brands that are interchangeable or switchable. The disintegration time, dissolution rate and absolute drug content were determined in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes. The weight uniformity and hardness tests were also performed according to the official methods. A variation of the concept of dissolution efficiency (DE), known as predicted availability equivalent (PAE), was used to predict the likely in vivo bioavailability. Our results showed that all the five brands passed the uniformity of weight and disintegration tests. Dissolution efficiency was found to be higher in SGF than in SIF. In SGF, all the brands were bioequivalent. In SIF, all the brands, except Medopharm, were also bioequivalent. The study showed that four brands of metformin hydrochloride (Merck, BDC, Lipha and Ilsan) marketed in Nigeria are of acceptable standards and hence BDC, Lipha and Ilsan brands of glucophage are interchangeable with the innovator drug, glucophage R (Merck).</p>","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 4","pages":"170-3"},"PeriodicalIF":0.0,"publicationDate":"2004-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24616628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metrological analysis of calibration]. [计量分析校准]。
Bollettino chimico farmaceutico Pub Date : 2004-05-01
{"title":"[Metrological analysis of calibration].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9085,"journal":{"name":"Bollettino chimico farmaceutico","volume":"143 4","pages":"150-1"},"PeriodicalIF":0.0,"publicationDate":"2004-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24617748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信