Journal of electroanalytical chemistry and interfacial electrochemistry最新文献

{"title":"Aggregation-Induced Electrochemiluminescence-active Ruthenium(Ⅱ) Complex for Selective Detection of Dopamine","authors":"Ziqi Wang, Yafang Gao, Zhangjin He, Liping Lu","doi":"10.1016/j.jelechem.2023.117783","DOIUrl":"https://doi.org/10.1016/j.jelechem.2023.117783","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45970477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding real news, believing in fake news? Investigating pathways from information overload to misbelief.","authors":"Edson C Tandoc, Hye Kyung Kim","doi":"10.1177/14648849221090744","DOIUrl":"10.1177/14648849221090744","url":null,"abstract":"<p><p>This study sought to examine the potential role of news avoidance in belief in COVID-19 misinformation. Using two-wave panel survey data in Singapore, we found that information overload is associated with news fatigue as well as with difficulty in analyzing information. News fatigue and analysis paralysis also subsequently led to news avoidance, which increased belief in COVID-19 misinformation. However, this link is present only among those who are frequently exposed to misinformation about COVID-19.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"50 1","pages":"1174-1192"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77956770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Algorithms for the Discovery of Homogeneous Catalysts.","authors":"Simone Gallarati, Puck Van Gerwen, Alexandre A Schoepfer, Ruben Laplaza, Clemence Corminboeuf","doi":"10.2533/chimia.2023.39","DOIUrl":"10.2533/chimia.2023.39","url":null,"abstract":"<p><p>In this account, we discuss the use of genetic algorithms in the inverse design process of homogeneous catalysts for chemical transformations. We describe the main components of evolutionary experiments, specifically the nature of the fitness function to optimize, the library of molecular fragments from which potential catalysts are assembled, and the settings of the genetic algorithm itself. While not exhaustive, this review summarizes the key challenges and characteristics of our own (i.e., NaviCatGA) and other GAs for the discovery of new catalysts.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"182 1","pages":"39-47"},"PeriodicalIF":1.2,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75426969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural studies of bacteriorhodopsin in BC era.","authors":"Mikio Kataoka","doi":"10.2142/biophysico.bppb-v20.s006","DOIUrl":"10.2142/biophysico.bppb-v20.s006","url":null,"abstract":"<p><p>It marked half a century since the discovery of bacteriorhodopsin two years ago. On this occasion, I have revisited historically important diffraction studies of this membrane protein, based on my recollections. X-ray diffraction and electron diffraction, and electron microscopy, described the low-resolution structure of bacteriorhodopsin within the purple membrane. Neutron diffraction was effective to assign the helical regions in the primary structure with 7 rods revealed by low-resolution structure as well as to describe the retinal position. Substantial conformational changes upon light illumination were clarified by the structures of various photointermediates. Early trials of time-resolved studies were also introduced. Models for the mechanism of light-driven proton pump based on the low-resolution structural studies are also described. Significantly, they are not far from the today's understanding. I believe that the spirit of the early research scientists in this field and the essence of their studies, which constitute the foundations of the field, still actively fertilizes current membrane protein research.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"437 1","pages":"e201006"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10865857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77509416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-Associated Sacroiliitis following an Uncomplicated Pregnancy.","authors":"Maryam Ahmadi, Farid Abiri, Somaieh Ahmadiani, Ensiyeh Jenabi","doi":"10.1155/2022/3596672","DOIUrl":"10.1155/2022/3596672","url":null,"abstract":"<p><p>Pregnancy-associated sacroiliitis is infrequent during the peripartum period. Although pregnancy-associated pyogenic sacroiliitis rarely occurs, it is associated with significant morbidity and mortality. A timely diagnosis of the disease is challenging due to its nonspecific clinical symptoms. We reviewed a case that experienced an acute illness during pregnancy. The illness was manifested by localized pain in the hips or buttocks, sacroiliac joint tenderness, and debilitating hip pain during ambulation. Magnetic resonance imaging revealed little joint involvement, and the patient was treated with antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and glucocorticoids. The patient responded well to the therapy with marked improvement in her ambulation. Septic sacroiliitis should be considered in peripartum patients presenting with increased inflammatory markers and severe localized pain. Medical management is usually curative and without an adverse effect on pregnancy. Although we could not perform a biopsy to verify the cause of the disease, the patient's excellent response to the treatment confirmed our diagnosis.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"370 1","pages":"3596672"},"PeriodicalIF":0.8,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75089644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells.","authors":"Sarah Trouvilliez, Julien Cicero, Romain Lévêque, Léo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Völkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jérôme de Ruyck, Véronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon","doi":"10.1186/s13046-022-02314-4","DOIUrl":"10.1186/s13046-022-02314-4","url":null,"abstract":"<p><strong>Background: </strong>CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF) induction. Our study aimed to understand how CD44 and TrkA interact and the consequences of inhibiting this interaction regarding the pro-tumoral effect of NGF in breast cancer.</p><p><strong>Methods: </strong>After determining which CD44 isoforms (variants) are involved in forming the TrkA/CD44 complex using proximity ligation assays, we investigated the molecular determinants of this interaction. By molecular modeling, we isolated the amino acids involved and confirmed their involvement using mutations. A CD44v3 mimetic peptide was then synthesized to block the TrkA/CD44v3 interaction. The effects of this peptide on the growth, migration and invasion of xenografted triple-negative breast cancer cells were assessed. Finally, we investigated the correlations between the expression of the TrkA/CD44v3 complex in tumors and histo-pronostic parameters.</p><p><strong>Results: </strong>We demonstrated that isoform v3 (CD44v3), but not v6, binds to TrkA in response to NGF stimulation. The final 10 amino acids of exon v3 and the TrkA H112 residue are necessary for the association of CD44v3 with TrkA. Functionally, the CD44v3 mimetic peptide impairs not only NGF-induced RhoA activation, clonogenicity, and migration/invasion of breast cancer cells in vitro but also tumor growth and metastasis in a xenograft mouse model. We also detected TrkA/CD44v3 only in cancerous cells, not in normal adjacent tissues.</p><p><strong>Conclusion: </strong>Collectively, our results suggest that blocking the CD44v3/TrkA interaction can be a new therapeutic option for triple-negative breast cancers.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"59 1","pages":"110"},"PeriodicalIF":11.4,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77978361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Faster, Novel Technique to Detect COVID-19 Neutralizing Antibodies.","authors":"Wei-Huai Chiu, Wei-Yi Kong, Yu-Jang Su, Jyun-Wei Wen, Ciao-Ming Tsai, Chitsung Hong, Pang-Yen Chen, Cheng-Hao Ko","doi":"10.12659/MSM.935812","DOIUrl":"10.12659/MSM.935812","url":null,"abstract":"<p><p>BACKGROUND The COVID-19 pandemic has spread globally in a short period of time. It is known that antibody (nAb) level can effectively predict vaccine efficacy, which leads to the exploration of vaccine trials for efficacy assessment. Thus, the current study aimed to develop a platform to quantify nAb levels faster, at lower cost, and with better efficiency. MATERIAL AND METHODS A total of 69 sera samples were collected for the research, 28 of which were from unvaccinated participants. The other 27 samples and the remaining 14 samples were from the participants who had received the first and second dose, respectively, of AZ vaccine 1 month before. With cPass assays (Genscript cPass nAb ELISA assay) used as a criterion standard and lateral flow immunoassay kit (Healgen Scientific - LFIA test kit) coupled with a spectrometer (LFIA+S) for checking each specimen, we aimed to detect the presence of neutralizing antibodies in sera and to confirm the relationship between the inhibition rate from cPass assays and the nAb index from the LFIA+S. RESULTS Data analysis of the research were taken from the certified ELISA and LFIA+S, which indicated a high consistency (Pearson's r =0.864; ICC=0.90138) between the 2 methods. CONCLUSIONS The dataset demonstrated that LFIA+S was affordable, had a strong correlation with results of the cPass nAbs detection kit, and has potential clinical applications, with an exclusive feature that allows non-experts to use it with ease. It is believed that the proposed platform can be promoted in the near future.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"369 1","pages":"e935812"},"PeriodicalIF":0.0,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75144236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of Homozygous Mutants of Migratory Locust using CRISPR/Cas9 Technology.","authors":"Qiang Yan, Yingying He, Yang Yue, Luyao Jie, Tingmei Wen, Yumiao Zhao, Min Zhang, Tingting Zhang","doi":"10.3791/63629","DOIUrl":"10.3791/63629","url":null,"abstract":"<p><p>The migratory locust, Locusta migratoria, is not only one of the worldwide plague locusts that caused huge economic losses to human beings but also an important research model for insect metamorphosis. The CRISPR/Cas9 system can accurately locate at a specific DNA locus and cleave within the target site, efficiently introducing double-strand breaks to induce target gene knockout or integrate new gene fragments into the specific locus. CRISPR/Cas9-mediated genome editing is a powerful tool for addressing questions encountered in locust research as well as a promising technology for locust control. This study provides a systematic protocol for CRISPR/Cas9-mediated gene knockout with the complex of Cas9 protein and single guide RNAs (sgRNAs) in migratory locusts. The selection of target sites and design of sgRNA are described in detail, followed by in vitro synthesis and verification of the sgRNAs. Subsequent procedures include egg raft collection and tanned-egg separation to achieve successful microinjection with low mortality rate, egg culture, preliminary estimation of the mutation rate, locust breeding as well as detection, preservation, and passage of the mutants to ensure population stability of the edited locusts. This method can be used as a reference for CRISPR/Cas9 based gene editing applications in migratory locusts as well as in other insects.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"300 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75025746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using voltammetry augmented with physics-based modeling and Bayesian hypothesis testing to identify analytes in electrolyte solutions","authors":"Alexis Fenton, Jr., F. Brushett","doi":"10.33774/chemrxiv-2021-nfp3b-v3","DOIUrl":"https://doi.org/10.33774/chemrxiv-2021-nfp3b-v3","url":null,"abstract":"Voltammetry is a foundational electrochemical technique that can qualitatively and quantitatively probe electroactive species in solutions and as such has been used in numerous fields of study. Recently, automation has been introduced to extend the capabilities of voltammetric analysis through approaches such as Bayesian parameter estimation and compound identification. However, opportunities exist to enable more versatile methods across a wider range of solution compositions and experimental conditions. Here, we present a protocol that uses experimental voltammetry, physics-driven models, binary hypothesis testing, and Bayesian inference to enable robust labeling of analytes in multicomponent solutions across multiple techniques. We first describe the development of this protocol, and we subsequently validate the methodology in a case study involving five N-functionalized phenothiazine derivatives. In this analysis, the protocol correctly labeled solutions each containing 10H-phenothiazine and 10-methylphenothiazine from both cyclic voltammograms and cyclic square wave voltammograms, demonstrating the ability to identify redox-active constituents of a multicomponent solution. Finally, we identify areas of further improvement—such as achieving greater detection accuracy—and future applications to potentially enhance in situ or operando diagnostic workflows.","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47670888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electropolymerization of molecularly imprinted polypyrrole film on multiwalled carbon nanotube surface for highly selective and stable determination of carcinogenic amaranth","authors":"Yiyong Wu, Guangli Li, Yaling Tian, Jinxia Feng, Jingyun Xiao, Jun Liu, Xia Liu, Quanguo He","doi":"10.1016/j.jelechem.2021.115494","DOIUrl":"https://doi.org/10.1016/j.jelechem.2021.115494","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jelechem.2021.115494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45457399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}