Biomedical and Pharmacology Journal最新文献_第2页

Analysis of the Development of B-Cell Precursors in Day Three Incubated Chicken Embryos 鸡胚第3天b细胞前体发育分析

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2735

Maslichah Mafruchati, Wan Iryani Wan Ismail

{"title":"Analysis of the Development of B-Cell Precursors in Day Three Incubated Chicken Embryos","authors":"Maslichah Mafruchati, Wan Iryani Wan Ismail","doi":"10.13005/bpj/2735","DOIUrl":"https://doi.org/10.13005/bpj/2735","url":null,"abstract":"Background: In mammals, birds, and amphibians, the B lineage of lymphoid cells first arise during embryogenesis and are distinguished by their capacity to produce immunoglobulin. For the purpose of researching the development of the B-cell repertoire and the development of self-tolerance, these early B-cell precursors are of utmost importance. The genetic and/or microenvironmental variables that control the beginning of immunoglobulin synthesis in embryonic haemopoietic cells are, however, poorly understood. Purpose: The ontogeny of B-cell precursors in chicken embryos from day three of incubation was examined in this work. Research methods: The terms \"ontogeny, B-cell, precursors, chicken embryos, incubation\" were used in a thorough literature search in the PubMed, NCBI, and Google Scholar databases. After all articles were picked based on the inclusion and exclusion criteria, 38 papers that satisfied the criteria for inclusion were collected. Result: The study's findings show that clglarge basophilic hemopoietic stem cells and cIg+ small lymphoid B-cell precursors are two types of migrant cells that appear to enter the embryonic bursa of Fabricius. Hence, B lymphopoiesis does not only take place in the bursa of Fabricius in the avian embryo. Although the yolk sac and the hemopoietic tissues around the dorsal aorta are strong candidates, the identity of the extra-bursal location remains unknown. Conclusion: Hence, general haemopoietic organs may serve as the initial site of B lymphopoiesis in both birds and mammals. Only later in the course of avian development do the bursal follicles become accessible and take over.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Impact of Cybersecurity in High-risk Medical Devices And In-vitro Medical Devices All Over The World 全球高风险医疗器械及体外医疗器械网络安全影响综述

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2707

D. Nagasamy Venkatesh, Muthupranesh. K

引用次数: 0

A Review on Thrombolysis Enhancing Indian Edible Plants 促进印度食用植物溶栓的研究进展

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2709

Vartika Jain, Bhavika Kunwar, S. K. Verma

{"title":"A Review on Thrombolysis Enhancing Indian Edible Plants","authors":"Vartika Jain, Bhavika Kunwar, S. K. Verma","doi":"10.13005/bpj/2709","DOIUrl":"https://doi.org/10.13005/bpj/2709","url":null,"abstract":"Impaired thrombolysis is one of the causes of the development of cardiovascular diseases (CVD). The synthetic thrombolytic agents such as streptokinase, urokinase and antistreplase have their own side effects. Plants are always considered as safe and cost-effective therapeutic agents. Dietary therapeutics is an emerging branch for the prevention and treatment of several ailments. The present article compiles 43 edible plants which have shown in vitro thrombolytic potential and are also employed in the diets of several ethnic communities in India. Among these, Bauhinia purpurea and Baccaurea ramiflora are two plants having more than 70% in vitro clot lysis potential; Coccinia grandis, Curcuma longa, Cyperus rotundus, and Typha domingensis have 50-70% thrombolytic activity; and the rest of the plants have 11-49% thrombolytic activity. These 43 plants also include spices and condiments such as Turmeric, Black pepper, Indian Bayleaf, Coriander and Ginger, which affirms the traditional saying of using food as medicine. Besides, these edible plants also possess various phyto-constituents and health-beneficial pharmacological activities. If these plants could be incorporated into a routine diet, it might be possible to prevent or delay the onset of CVD. However, detailed studies are required to evaluate the pattern of CVD in ethnic communities consuming such plants, as well as systematic clinical trials are warranted to investigate the thrombolytic efficacy of these plants.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monkeypox Disease: An Updated Review 猴痘病:最新综述

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2712

Md. Mofazzal Hossain, Bidduth Kumar Sarkar, Arghya Prosun Sarkar, Maimuna Hasan, Mst. Sarmin Afroz

{"title":"Monkeypox Disease: An Updated Review","authors":"Md. Mofazzal Hossain, Bidduth Kumar Sarkar, Arghya Prosun Sarkar, Maimuna Hasan, Mst. Sarmin Afroz","doi":"10.13005/bpj/2712","DOIUrl":"https://doi.org/10.13005/bpj/2712","url":null,"abstract":"Monkeypox has recently garnered significant attention as a result of its rapid and simultaneous global dissemination. The objective of this study is to present a succinct overview of the existing literature, while also elucidating the development of the disease in respect to contemporary instances, possible therapeutic approaches, and strategies for preventing infection. To date, a total of 12,261 occurrences have been recorded over a wide range of 76 nations. Monkeypox is a zoonotic disease that has previously been limited to endemic areas in Western and Central Africa. However, there have been isolated outbreaks in other countries, including the United States, that have been linked to the importation of wild animals from Ghana and other affected areas. The current outbreak has seen a significant shift, with human-to-human transmission surpassing all other modes of transmission. This development has raised concerns regarding the potential extension of the outbreak within communities, particularly in cases that may have gone unreported. The observed results may be attributed to the increase in human-to-human transmission subsequent to the cessation of smallpox vaccination, which provided partial immunity against monkeypox. The occurrence of outbreaks beyond the African continent underscores the worldwide importance of the illness. The demographic that exhibits the highest vulnerability to infection is young males who engage in sexual activity with other males. While the existing understanding suggests that the clinical progression of the disease is very moderate, there remain several unresolved inquiries that necessitate additional investigation. These include the possibility of a genital reservoir of the virus in humans and the possibility of airborne transmission.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Obesity Diminishes Circulating Betatrophin Level in Middle-aged Male Subjects 中枢性肥胖降低中年男性受试者循环Betatrophin水平

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2764

Thiri Wai Linn, Chaw Su Hlaing, Ma Saung Oo, Zakaria AR, Khin Than Yee, Thin Thin Aung, Aniruddha Bhattacharjee, Minn Han, Mya Thanda Sein, Mya Mya Thwin

{"title":"Central Obesity Diminishes Circulating Betatrophin Level in Middle-aged Male Subjects","authors":"Thiri Wai Linn, Chaw Su Hlaing, Ma Saung Oo, Zakaria AR, Khin Than Yee, Thin Thin Aung, Aniruddha Bhattacharjee, Minn Han, Mya Thanda Sein, Mya Mya Thwin","doi":"10.13005/bpj/2764","DOIUrl":"https://doi.org/10.13005/bpj/2764","url":null,"abstract":"Central adiposity presents an important risk factor for advancing insulin insensitivity and type 2 diabetes mellitus. Betatrophin, a liver or adipocyte-derived hormone, was assumed to improve islet insulin secretion and compensate insulin resistance but its level during obesity is still conflicted. This study aimed to explore serum betatrophin level in centrally-obese middle-aged men with diabetic potentials compared with age-matched non-obese ones. Sixty-eight male subjects of 40-60 years of age, residing in North Okkalapa Township, Yangon, Myanmar, were recruited and classified into centrally-obese group (n=34) and non-obese group (n=34). Fasting blood samples were obtained to quantify plasma glucose by glucose oxidase method, and serum insulin and betatrophin levels by ELISA. Plasma glucose levels were comparable between the two groups, while insulin concentration of obese group was significantly greater than that of non-obese group. Therefore, HOMA-IR was markedly increased in obese subjects when compared to non-obese ones (4.87±0.28 vs 1.90±0.14, p<0.001) and so did HOMA-β (310.88±26.58 vs 149.00±11.83, p<0.001). Interestingly, betatrophin hormone level was significantly reduced in obese group than non-obese group (1.72±0.21 vs 2.72±0.26 ng/ml, p<0.01). Moreover, betatrophin had a strong negative correlation with glucose and insulin levels (p<0.05) as well as with the indicator of central adiposity, waist circumference (p<0.05), among the subjects. However, significant correlation between betatrophin and HOMA-IR and HOMA-β was not observed in both groups (p=0.14 and 0.20 respectively). Taken together, betatrophin hormone has been found to decrease in adult central obesity, which is noticeably associated with insulin resistance and compensatory beta-cell hyperfunction. Betatrophin, previously regarded as beta-cell mitogen, has been denied in this study, owing to lack of correlation with HOMA indexes of diabetes.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Metals, Fungi and Mycotoxins in Cat Meal Samples used in Saudi Arabia 沙特阿拉伯猫食样品中金属、真菌和真菌毒素的测定

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2754

M. Amin Mir, Kim Andrews, Syed M Hasnain, Nidal Abu-Libdeh, Abid Iqbal, Shama Sehar, Adnan Younis

引用次数: 0

Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats 石榴皮提取物和左旋肉碱对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2762

Anwar M. M. Ezz, Omar N. ALheeti, Ahmed F. Hasan, Somaia Zaki, Ghada A. Tabl

{"title":"Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats","authors":"Anwar M. M. Ezz, Omar N. ALheeti, Ahmed F. Hasan, Somaia Zaki, Ghada A. Tabl","doi":"10.13005/bpj/2762","DOIUrl":"https://doi.org/10.13005/bpj/2762","url":null,"abstract":"Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with a few intricacies like hyperlipidemia. The current study aimed to study the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. A total of 70 male rats were divided into 7 groups (normal rats treated with the pomegranate peel extract and L-carnitine; rats given a high-fat diet to cause hyperlipidemia, this rats given low-dose intraperitoneal streptozotocin injections to cause type II diabetes; diabetic rats given PPE and L-carnitine orally every day for 12 weeks. Measurements of body mass, blood sugar, lipid profile and antioxidant enzyme activity were made.Results: The treatment group that received PPE + L-carnitine showed a significant decrease in weight, blood glucose, cholesterol, triglycerides and low-density lipoprotein were significantly reduced, while high-density lipoprotein levels were significantly increased. Superoxide dismutase levels were increased, catalase and Nuclear Factor Erythroid-derived 2 (Nfe2) in diabetic rats treated with PPE and L-carnitine, while Malondialdehyde levels decreased significantly. According to the results of the study, PPE and L-carnitine had significant anti-hyperglycemic, hypolipidemic, and antioxidant benefits after 12 weeks of treatment in streptozotocin-induced diabetic rats.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weakening of Virulence Factors and Biofilm in Salmonella Typhi by Medicinal Plants Extracts 药用植物提取物对伤寒沙门菌毒力因子和生物膜的削弱作用

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2740

Akhter Ahmed Ahmed, Pakhshan Abdulla Hassan, Abdulilah Saleh Ismaeil, Shahnaz Burhan Ali

{"title":"Weakening of Virulence Factors and Biofilm in Salmonella Typhi by Medicinal Plants Extracts","authors":"Akhter Ahmed Ahmed, Pakhshan Abdulla Hassan, Abdulilah Saleh Ismaeil, Shahnaz Burhan Ali","doi":"10.13005/bpj/2740","DOIUrl":"https://doi.org/10.13005/bpj/2740","url":null,"abstract":"Objective(s): Salmonella typhi, is a serious global health threat because it causes typhoid fever, a severe systemic infection. According to the World Health Organization, millions of cases of typhoid are recorded annually, and thousands of people die from it. To combat this pathogen, new medications are required. The current study aims to study the ability of medicinal plants (thyme and cinnamon) to modulate the properties of Salmonella typhi isolates instead of killing them. Materials and Methods: The plants were extracted with the help of solvents (ethanol and ethyl acetate) and to find out the minimum inhibitory concentration, the different concentrations were used. The biofilm and expression of genes (invA & fliC) of the bacterium were studied when exposed to sub-inhibitory concentrations of the plant extracts. Results: MIC values ranging between 20-25 mg/ml and 10-15 mg/ml for ethanol and ethyl acetate extracts of Thyme respectively. While the MIC values of cinnamon were 18-25 and 10-15 mg/ml for both ethanol and ethyl acetate extracts respectively. The examinations revealed a significant decrease in the composition of biofilms by isolates when treated with SICs from plant extracts. The transcription expression profile of invasion (invA) and flagellar (fliC) genes were downregulated when treated with the plant extracts. Conclusion: The findings indicate that both thyme and cinnamon extracts may have promising activity against the biofilm and virulence of S. typhi. Thus, they could be used as potential as an antibacterial drug.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico Study of Phenol Explorer Database as Potential Inhibitors of Quorum-Sensing Regulated Pathogenicity in Pseudomonas aeruginosa 苯酚探索者数据库作为群体感应调节铜绿假单胞菌致病性潜在抑制剂的计算机研究

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2736

Arnica F Lal, Pushpraj S Gupta, Pramod Kumar Yadav

{"title":"In silico Study of Phenol Explorer Database as Potential Inhibitors of Quorum-Sensing Regulated Pathogenicity in Pseudomonas aeruginosa","authors":"Arnica F Lal, Pushpraj S Gupta, Pramod Kumar Yadav","doi":"10.13005/bpj/2736","DOIUrl":"https://doi.org/10.13005/bpj/2736","url":null,"abstract":"Immunocompromised patients get Pseudomonas aeruginosa infections. P. aeruginosa's harmful effect is linked to quorum sensing (QS), which causes bacterial biofilm. Targeting QS is a promising novel method to treat P. aeruginosa infections, which are antibiotic-resistant. The Las system has garnered great interest due to LasR, the expedited gene during QS that regulates other virulence-associated genes. We used high-throughput virtual screening (VS) of Phenol Explorer to uncover a new category of LasR inhibitors that might be used as antagonists. Molecular docking-based VS against LasR (PDB: 2UV0) resulted in six best-scored compounds: Chrysin, Galangin, Coumestrol, 3',4',7- Trihydroxyisoflavanone, Dihydrodaidzein, Dihydroformononetin with docking score of -11.0 kcal/mol and a suitable ADMET profile. Six compounds were chosen for their lack of carcinogenicity in mice and rats, low molecular weight of 270 Da, and moderate to total solubility. Our current work shows that these six chemicals could block P. aeruginosa quorum sensing. Molecular dynamics investigations of a prospective therapeutic candidate (Chrysin) using Gromacs version 2022.2 demonstrated system stability; nonetheless, the antibiofilm assay showed a positive reaction against our in silico finding, suggesting a disturbance in quorum sensing regulating pathogenicity, i.e., biofilm formation. This study is the first to describe chrysin as a disruptor of quorum sensing signaling by inhibiting biofilm formation.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality by Design Approach: Progress in Pharmaceutical method Development and Validation 设计质量:制药方法开发和验证的进展

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI: 10.13005/bpj/2745

Avinash V. Chavan, R. Gandhimathi

{"title":"Quality by Design Approach: Progress in Pharmaceutical method Development and Validation","authors":"Avinash V. Chavan, R. Gandhimathi","doi":"10.13005/bpj/2745","DOIUrl":"https://doi.org/10.13005/bpj/2745","url":null,"abstract":"Pharmaceutical analysis plays a significant role in pharmaceutical formulation quality assurance and control. Due to the pharmaceutical industries' rapid expansion and the production of pharmaceuticals all over the world, there is a greater need for novel analytical procedures in this sector. Establishing the identification, purity, physical properties, and potency of medications as well as the medication's bioavailability and stability is the goal of analytical method development. A few new drug applications were recently given regulatory flexibility by the Food and Drug Administration for an analytical method based on quality by design. With Quality by design, product design and development are performed methodically. Analytical methodologies have similar opportunities for implementing Quality by design as production procedures do. It consequently enhances formulation design, development efficiency, and capacity. The underpinnings of the QbD approach have been explored in this article due to their use in the creation and validation of analytical procedures. Additionally, a summary of experimental studies reporting the application of the QbD methodology to method development is included.","PeriodicalId":9054,"journal":{"name":"Biomedical and Pharmacology Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135032919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1