Anti-Diabetic Effects of Pomegranate Peel Extract and L-Carnitine on Streptozotocin Induced Diabetes In Rats

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2762

Anwar M. M. Ezz, Omar N. ALheeti, Ahmed F. Hasan, Somaia Zaki, Ghada A. Tabl

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Abstract

Type 2 diabetes mellitus is a far reaching ongoing metabolic problem portrayed by hyperglycemia and related with a few intricacies like hyperlipidemia. The current study aimed to study the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. A total of 70 male rats were divided into 7 groups (normal rats treated with the pomegranate peel extract and L-carnitine; rats given a high-fat diet to cause hyperlipidemia, this rats given low-dose intraperitoneal streptozotocin injections to cause type II diabetes; diabetic rats given PPE and L-carnitine orally every day for 12 weeks. Measurements of body mass, blood sugar, lipid profile and antioxidant enzyme activity were made.Results: The treatment group that received PPE + L-carnitine showed a significant decrease in weight, blood glucose, cholesterol, triglycerides and low-density lipoprotein were significantly reduced, while high-density lipoprotein levels were significantly increased. Superoxide dismutase levels were increased, catalase and Nuclear Factor Erythroid-derived 2 (Nfe2) in diabetic rats treated with PPE and L-carnitine, while Malondialdehyde levels decreased significantly. According to the results of the study, PPE and L-carnitine had significant anti-hyperglycemic, hypolipidemic, and antioxidant benefits after 12 weeks of treatment in streptozotocin-induced diabetic rats.

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石榴皮提取物和左旋肉碱对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用

2型糖尿病是一种影响深远的持续代谢问题，由高血糖引起，并与高脂血症等并发症有关。本研究旨在研究石榴皮提取物和左旋肉碱对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用。将70只雄性大鼠分为7组(正常大鼠给予石榴皮提取物和左旋肉碱;高脂饮食引起高脂血症的大鼠，腹腔注射低剂量链脲佐菌素引起II型糖尿病的大鼠;糖尿病大鼠每天口服PPE和左旋肉碱，连续12周。测量了体重、血糖、血脂和抗氧化酶活性。结果:PPE +左旋肉碱治疗组患者体重明显下降，血糖、胆固醇、甘油三酯、低密度脂蛋白明显降低，高密度脂蛋白水平明显升高。PPE和左旋肉碱使糖尿病大鼠超氧化物歧化酶、过氧化氢酶和核因子红系衍生2 (Nfe2)水平升高，丙二醛水平显著降低。根据研究结果，PPE和左旋肉碱在链脲佐菌素诱导的糖尿病大鼠治疗12周后具有显著的降糖、降血脂和抗氧化作用。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.