Case reports in clinical pathology最新文献

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A peculiar uncommon cutaneous neoplasia: Angiosarcoma of the head and neck of the elderly (Wilson Jones Angiosarcoma) 一种罕见的皮肤肿瘤:老年人头颈部血管肉瘤(威尔逊·琼斯血管肉瘤)
Case reports in clinical pathology Pub Date : 2019-07-19 DOI: 10.5430/CRCP.V6N1P9
A. D'Amuri, Federica Floccari, R. Filotico, M. Filotico
{"title":"A peculiar uncommon cutaneous neoplasia: Angiosarcoma of the head and neck of the elderly (Wilson Jones Angiosarcoma)","authors":"A. D'Amuri, Federica Floccari, R. Filotico, M. Filotico","doi":"10.5430/CRCP.V6N1P9","DOIUrl":"https://doi.org/10.5430/CRCP.V6N1P9","url":null,"abstract":"Cutaneous Angiosarcoma of the elderly's face is a rare and peculiar neoplasm with all its own clinical and morphological characteristics. The observation of a classic case in the clinical presentation and morphology has offered the opportunity to revisit this topic.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V6N1P9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48024101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophilic peritonitis in a patient with liver cirrhosis: A case report 肝硬化患者嗜酸性腹膜炎1例
Case reports in clinical pathology Pub Date : 2019-06-04 DOI: 10.5430/CRCP.V6N1P5
M-H Pang, F. Hua, Yixiao Zhi, E. Qin, Y. Tao, Rui Hua
{"title":"Eosinophilic peritonitis in a patient with liver cirrhosis: A case report","authors":"M-H Pang, F. Hua, Yixiao Zhi, E. Qin, Y. Tao, Rui Hua","doi":"10.5430/CRCP.V6N1P5","DOIUrl":"https://doi.org/10.5430/CRCP.V6N1P5","url":null,"abstract":"Eosinophilic gastroenteritis (EG) is a gastrointestinal disease characterized by abnormal infiltration of eosinophilic cells in the gastrointestinal tract, excluding known causes of eosinophilia. Eosinophilic peritonitis (EP) is rare and is considered by most scholars to be a systemic or local allergy to exogenous or endogenous allergens. It is a clinical manifestation of eosinophilic gastroenteritis involving the serosal layer. Hereby, we report a case of EP in a patient with liver cirrhosis. A 32-year-old man was admitted to our hospital for intermittent fatigue, abdominal distension and abdominal pain. On account of clinical feature and pathological results of peritoneal puncture biopsy, excluding other causes of peripheral eosinophilia, the diagnosis of EP with hepatic cirrhosis was established. The possibility of EP should be paid great attention to patients with cirrhosis with peritonitis. Gastrointestinal endoscope biopsy, laparoscopy or peritoneal puncture biopsy are conducive to the diagnosis and differential diagnosis. Therefore, once the disease is suspected, gastrointestinal endoscope biopsy should be performed actively, and multiple pathological samples should be taken to contribute to diagnosis and treatment. Laparoscopy or peritoneal puncture biopsy is of vital significance for definitive diagnosis. ","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V6N1P5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48454651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute transaminitis as an atypical presentation of Graft-versus-Host Disease following Hematopoietic Stem Cell Transplantation 急性转氨炎是造血干细胞移植后移植物抗宿主病的不典型表现
Case reports in clinical pathology Pub Date : 2019-03-25 DOI: 10.5430/CRCP.V6N1P1
R. Ramkissoon, A. Shetty, Adam C Doyle, O. Adeyi, K. Patel
{"title":"Acute transaminitis as an atypical presentation of Graft-versus-Host Disease following Hematopoietic Stem Cell Transplantation","authors":"R. Ramkissoon, A. Shetty, Adam C Doyle, O. Adeyi, K. Patel","doi":"10.5430/CRCP.V6N1P1","DOIUrl":"https://doi.org/10.5430/CRCP.V6N1P1","url":null,"abstract":"Graft versus Host Disease (GVHD) can present with mucocutaneous, gastrointestinal and hepatic manifestations, specifically a cholestatic transaminitis. Rarely, some cases can present with only a hepatocellular transaminitis. Our patient presented with an acute hepatitis on day +90 post-hematopoietic stem cell transplant, without other overt manifestations of GVHD. The initial work up was negative for a viral etiology or causative drug, and the patient’s transaminases continued to rise. On day +96, an erythematous rash appeared with biopsy indicating lymphocytic and eosinophilic infiltrates concerning for cutaneous GVHD. Subsequently, a liver biopsy was obtained, and showed marked ductopenia with cholestasis, consistent with hepatic GVHD. ","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V6N1P1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47996817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clear cell renal cell carcinoma with heterotopic bone formation: A case report and literature review 透明细胞肾细胞癌伴异位成骨1例并文献复习
Case reports in clinical pathology Pub Date : 2019-01-15 DOI: 10.5430/CRCP.V5N2P16
Estelle Oertling, Cacey Peters, R. Wood, J. Silberstein, Andrew B. Sholl, Nadja K. Falk
{"title":"Clear cell renal cell carcinoma with heterotopic bone formation: A case report and literature review","authors":"Estelle Oertling, Cacey Peters, R. Wood, J. Silberstein, Andrew B. Sholl, Nadja K. Falk","doi":"10.5430/CRCP.V5N2P16","DOIUrl":"https://doi.org/10.5430/CRCP.V5N2P16","url":null,"abstract":"The phenomenon of heterotopic bone formation (osseous metaplasia) is defined as an abnormal ossification of non-skeletal tissues and does represent a rare occurrence in the renal cell carcinoma setting. We describe a case of a 40-year old man with bilateral renal cell carcinomas of the histological clear cell subtype, with the right-sided renal cell carcinoma demonstrating heterotopic bone formation, as well as the presence of intratumoral adipose tissue. The etiology of bone formation in a renal cell carcinoma is unclear, but possible explanations include a response to tissue ischemia and the expression of Bone Morphogenetic Protein 2. The detection of these rare morphologic variations is of paramount importance, not to be mistaken as sarcomatoid transformation and renal sinus fat invasion, which would advance the pathologic tumor stage and aggressiveness of the disease. ","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V5N2P16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45924872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiolymphoid hyperplasia with eosinophilia: An uncommon presentation and novel treatment of a rare disease 血管淋巴样增生伴嗜酸性粒细胞增多:一种罕见疾病的罕见表现和新的治疗方法
Case reports in clinical pathology Pub Date : 2018-12-30 DOI: 10.5430/CRCP.V5N2P12
D. Surprenant, Amanda Goslawski, Karen C Kagha, D. Griffin, K. Mudaliar, K. Hutchens, D. Opel, R. Tung
{"title":"Angiolymphoid hyperplasia with eosinophilia: An uncommon presentation and novel treatment of a rare disease","authors":"D. Surprenant, Amanda Goslawski, Karen C Kagha, D. Griffin, K. Mudaliar, K. Hutchens, D. Opel, R. Tung","doi":"10.5430/CRCP.V5N2P12","DOIUrl":"https://doi.org/10.5430/CRCP.V5N2P12","url":null,"abstract":"Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vascular proliferation characterized by isolated or grouped red-brown papules or nodules, most often located on the head or neck. Treatment of ALHE is difficult, with high recurrence rates reported across a myriad of different interventions. We report an atypical clinical presentation of ALHE that was successfully treated with a novel dual-therapeutic approach consisting of surgical excision followed by treatment with the pulsed dye laser.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V5N2P12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41949500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
SDHB mutated paraganglioma imitating thyroid tumor: A case report and review of literature SDHB突变的模仿甲状腺肿瘤的副神经节瘤1例报告及文献复习
Case reports in clinical pathology Pub Date : 2018-08-28 DOI: 10.5430/CRCP.V5N2P5
Vygantė Maskoliūnaitė, G. Makunaite, A. Garnelytė, A. Abraitienė, V. Beisa
{"title":"SDHB mutated paraganglioma imitating thyroid tumor: A case report and review of literature","authors":"Vygantė Maskoliūnaitė, G. Makunaite, A. Garnelytė, A. Abraitienė, V. Beisa","doi":"10.5430/CRCP.V5N2P5","DOIUrl":"https://doi.org/10.5430/CRCP.V5N2P5","url":null,"abstract":"Paragangliomas of the head and neck are uncommon tumors arising from parasympathetic ganglia. Paragangliomas are mostly asymptomatic and may manifest as palpable mass of neck. The morphologic features are non-specific and comparable to the other neuroendocrine tumors. Most of hereditary cases are associated with alterations in genes of succinate dehydrogenase (SDH). SDHA and SDHB immunohistochemistry is considered as reliable screening method to detect tumors with genetical alterations. Of note, SDHB mutated paragangliomas have the highest risk of local recurrence, distant metastasis and the development of other tumor phenotypes, which are associated with mutation. Therefore, active surveillance of patients and early surgical treatment are essential. In contrast, SDHB mutated head and neck paragangliomas was considered as completely benign tumors, although, the latest literature describes more controversial cases, which may increase awareness. Here, we present a rare case of 21 years old female with asymptomatic neck paraganglioma, which was unexpectedly diagnosed after pathological and immunohistochemical testing of removed thyroid gland and showed unusual immunohistochemical variation for SDH mutation.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V5N2P5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45691321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cellular schwannoma of the breast: A case report and review of literature 乳腺细胞神经鞘瘤1例报告及文献复习
Case reports in clinical pathology Pub Date : 2018-07-09 DOI: 10.5430/CRCP.V5N2P1
Yan Zhang, Hongyi Gao, An-qin Zhang, Jiang-yu Zhang, Kun-he Wu, Yi Wang
{"title":"Cellular schwannoma of the breast: A case report and review of literature","authors":"Yan Zhang, Hongyi Gao, An-qin Zhang, Jiang-yu Zhang, Kun-he Wu, Yi Wang","doi":"10.5430/CRCP.V5N2P1","DOIUrl":"https://doi.org/10.5430/CRCP.V5N2P1","url":null,"abstract":"Schwannoma of breast is a relatively uncommon disease characterized by painless and slow growing. We report a case of a 28-year-old female who present a mass of the right breast. Ultrasonography revealed a well-circumscribed and inhomogeneous hypoechoic mass under the skin of the breast. Then a biopsy and immunohistochemical analysis were performed. The results were suggestive for cellular schwannoma of breast. The tumour was removed successfully and the patient has been followed-up for six months with no evidence of recurrence. Cellular schwannoma is a rare benign neoplasm without metastasis. Distinction cellular schwannoma from other malignant tumours is very important. It is necessary to combine strict criteria on histological, immunohistochemical analysis, biological behavior, image examination and clinical features for the final diagnosis.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V5N2P1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42884887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hemosiderotic fibrolipomatous tumor: A poorly known entity 含铁血黄素纤维脂肪瘤:一个鲜为人知的实体
Case reports in clinical pathology Pub Date : 2018-06-28 DOI: 10.5430/crcp.v5n1p23
S. Chaieb, M. Njima, N. B. Abdeljelil, A. Bellalah, S. Chouchane, A. Zakhama, A. Moussa
{"title":"Hemosiderotic fibrolipomatous tumor: A poorly known entity","authors":"S. Chaieb, M. Njima, N. B. Abdeljelil, A. Bellalah, S. Chouchane, A. Zakhama, A. Moussa","doi":"10.5430/crcp.v5n1p23","DOIUrl":"https://doi.org/10.5430/crcp.v5n1p23","url":null,"abstract":"Hemosiderotic fibrohistiocytic lipomatous tumor (HFLT) is a rare and supposedly benign fibrolipomatous entity. Clinical and imaging features are not specific. So, histologic, immunohistochemical and molecular analyses are required for diagnosis. The clinic and pathologic aspects of this lesion are diversely reported. Moreover, its reactive or neoplastic origin is still under debate. This lesion should be treated by complete excision. It is mandatory to be aware of its tendency to harbor higher-grade lesions with aggressive outcome. We report a case of HFLT affecting the dorsum of the third right finger in a 52-year-old women, in order to describe histologic patterns of this tumor and to discuss the current literature regarding the etiopathogeny and the cytogenetic features of this rare entity.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/crcp.v5n1p23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42281368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report of acquired hemophagocytic lymphohistiocytosis associated with progression of monoclonal gammopathy of unknown significance (MGUS) 获得性噬血细胞性淋巴组织细胞增多症伴不明意义单克隆γ病进展1例报告
Case reports in clinical pathology Pub Date : 2018-06-21 DOI: 10.5430/CRCP.V5N1P19
Li Liu, L. Contis, O. Palmer
{"title":"Case report of acquired hemophagocytic lymphohistiocytosis associated with progression of monoclonal gammopathy of unknown significance (MGUS)","authors":"Li Liu, L. Contis, O. Palmer","doi":"10.5430/CRCP.V5N1P19","DOIUrl":"https://doi.org/10.5430/CRCP.V5N1P19","url":null,"abstract":"Background: Acquired hemophagocytic lymphohistiocytosis (HLH) is an aggressive hyperinflammatory syndrome. Without prompt diagnosis and proper treatment, it can be life-threatening. HLH is commonly present in the setting of other autoimmune disorders, infection, organ transplantation, and malignancy.  However, to our knowledge, HLH associated with monoclonal gammopathy of undetermined significance (MGUS) has not been reported.Case presentation: A 67-year-old woman with an extensive history of MGUS and renal transplant presented with progressive fatigue, weight loss, intermittent fevers, splenomegaly, and pancytopenia. Serum protein electrophoresis with immunofixation identified a new monoclonal protein IgG lambda and a rapidly increasing pre-existing free kappa light chain. A bone marrow biopsy revealed focal clusters of kappa restricted plasma cells which comprised less than 10% of marrow cellularity. Skeletal survey was negative for osteolytic lesions. She was also free of any end-organ damage.  Histological examination showed a prominent increase in histiocytes and macrophages, many of which show erythrophagocytosis and lymphophagocytosis. Together with her clinical presentation along with a hyperferritinemia, a diagnosis of HLH was confirmed utilizing the criteria of the Histiocyte Society. The patient underwent a splenectomy. Prompt treatment with etoposide and high dose dexamethasone eventually stabilized the patient and resulted in a full recovery, which coincided with the disappearance of the serum monoclonal IgG lambda.Conclusions: This report reveals a novel association of HLH with the progression of MGUS. Familiarity with this syndrome and its association with other conditions is indicated to ensure prompt diagnosis and appropriate patient treatment.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V5N1P19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46473346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urachal mucinous neoplasms--to be or not to be: Two cases and a review of current diagnostic criteria (WHO 2016) 脐尿管粘液性肿瘤——是或不是:两例病例和当前诊断标准的回顾(世界卫生组织2016)
Case reports in clinical pathology Pub Date : 2018-05-28 DOI: 10.5430/CRCP.V5N1P12
J. Cuadra, L. Pérez, I. García, M. Álvarez, Bernardo Herrera, I. Hierro, L. Vicioso
{"title":"Urachal mucinous neoplasms--to be or not to be: Two cases and a review of current diagnostic criteria (WHO 2016)","authors":"J. Cuadra, L. Pérez, I. García, M. Álvarez, Bernardo Herrera, I. Hierro, L. Vicioso","doi":"10.5430/CRCP.V5N1P12","DOIUrl":"https://doi.org/10.5430/CRCP.V5N1P12","url":null,"abstract":"The urachus is an embryological remnant that extends from the bladder to the umbilicus. Urachal neoplasms represent less than 1% of malignant bladder tumors. The new 2016 edition of disease classifications from the WHO has updated the classification of epithelial neoplasms of urachal origin, distinguishing between glandular and non-glandular neoplasms and between cystic and non-cystic adenocarcinomas. In this article, we present two cases with similar clinical presentations but differing histology. We address their morphological, immunohistochemical, and molecular characterization; review the classification and diagnostic criteria of glandular urachal neoplasms included in the most recent literature with the aim of clarifying their differential diagnosis as well as their prognostic implication; and, ultimately, better understand these infrequent biological entities.","PeriodicalId":90463,"journal":{"name":"Case reports in clinical pathology","volume":"5 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2018-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5430/CRCP.V5N1P12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46855697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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