Austin journal of clinical immunology最新文献_第2页

B2 Microglobulin and Bence Jones Proteinuria Guide the Diagnosis of Idiopathic AA Amyloidosis: A Journal to Diagnosis B2微球蛋白和本·琼斯蛋白尿指导特发性AA淀粉样变性的诊断:诊断杂志

Austin journal of clinical immunology Pub Date : 2021-11-06 DOI: 10.26420/austinjclinimmunol.2021.1044

A. M., B. A., H. Q, A. D.

{"title":"B2 Microglobulin and Bence Jones Proteinuria Guide the Diagnosis of Idiopathic AA Amyloidosis: A Journal to Diagnosis","authors":"A. M., B. A., H. Q, A. D.","doi":"10.26420/austinjclinimmunol.2021.1044","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2021.1044","url":null,"abstract":"Amyloidosis is a disease caused by the extracellular deposition of pathological insoluble fibrillary protein in multiple tissues and may result in severe organ dysfunction. There are two major forms of amyloidosis: AL amyloid and AA amyloidosis, which complicates any chronic inflammatory condition, including rheumatologic, chronic infections, and certain neoplasms. In small but increasing numbers, the chronic inflammatory state underlying AA amyloidosis remains obscure, despite extensive investigations, which are known as idiopathic. In the current case, the first extensive evaluation to determine the inflammatory disease was negative. The patient had B2 microglobulin elevation and Bence jones proteinuria, which are non-specific findings, but are not conclusive, for malignancies. The diagnosis of Idiopathic AA amyloidosis was guided by understanding the pathophysiology of B2 microglobulin and Bence jones proteinuria along with excluding all other etiologies. Unfortunately, the development of restrictive cardiomyopathy and ESRD within 3 months indicates a rapid progression and poor prognosis in this patient. Clinicians may not be familiar that B2 microglobulin and Bence jones proteinuria are also found in amyloidosis, which may delay the diagnosis. Inflammatory process and kidney injury due to AA amyloidosis caused previous markers positivity in our patient. It is plausible that delays in diagnosis may be multi-faceted and heavily influenced by the average age of the patient, the complexity and the rareness of the disease. Also, non-disease-specific symptoms may reduce the likelihood of a prompt diagnosis. Therefore, establishing the diagnosis is difficult, and early diagnosis requires high clinical suspicion.","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82495924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oligoclonal IgGs against DNA, Histones, and Myelin Basic Protein in the Cerebrospinal Fluid of Patients with Multiple Sclerosis 多发性硬化症患者脑脊液中抗DNA、组蛋白和髓鞘碱性蛋白的寡克隆igg

Austin journal of clinical immunology Pub Date : 2021-08-16 DOI: 10.26420/austinjclinimmunol.2021.1043

Kostrikina Ia, Granieri E, Nevinsky Ga

{"title":"Oligoclonal IgGs against DNA, Histones, and Myelin Basic Protein in the Cerebrospinal Fluid of Patients with Multiple Sclerosis","authors":"Kostrikina Ia, Granieri E, Nevinsky Ga","doi":"10.26420/austinjclinimmunol.2021.1043","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2021.1043","url":null,"abstract":"Multiple Sclerosis (MS) is known as a chronic demyelinating pathology of the central nervous system. The most accepted MS pathogenesis theory assigns the main role to demyelination of myelin-proteolipid shells due to inflammationrelated with autoimmune reactions. One of the features of MS patients is the enhanced synthesis of oligoclonal IgGs in the bone marrow Cerebrospinal Fluid (CSF). By antigen-specific immunoblotting after isoelectrofocusing of IgGs, oligoclonal IgGs in CSF of MS patients were revealed only against the components of Epstein-Barr virus and Chlamydia. However, there was still unknown to which human auto-antigens in MS patients oligoclonal IgGs may be produced. Here it was first shown that in the CSF of a narrow percentage of MS patients, oligoclonal IgGs are produced against their own antigens: DNA (24% patients), histones (20%), and myelin basic protein (12%). At the same time, the CSF of MS patients contains a very large amount of auto-IgGs-abzymes that hydrolyze DNA, histones, and myelin basic protein, which during isofocusing, are distributed throughout the gel from pH 3 to 10. It is concluded that these multiple IgGs-abzymes, which are dangerous to humans since stimulate development of MS, in the main are non-oligoclonal antibodies.","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84130003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnant with COVID-19 and Rubella: Impact in the Maternal and Newborn Health COVID-19和风疹孕妇:对孕产妇和新生儿健康的影响

Austin journal of clinical immunology Pub Date : 2021-06-09 DOI: 10.26420/austinjclinimmunol.2021.1042

Dias Vc, Silva Vl, Diniz Cg, A. B. Ferreira-Machado, Bastos Vqa, Bastos Rv, Bastos Lqa, Bastos An

引用次数: 0

NKG2D Ligands in Cancer Immunotherapy: Target or Not? NKG2D配体在癌症免疫治疗中的作用:是靶还是非靶?

Austin journal of clinical immunology Pub Date : 2014-01-06

Jennifer Wu

引用次数: 0

Natural Killercell Deficiency (NKD) 自然杀伤细胞缺乏症

Austin journal of clinical immunology Pub Date : 1900-01-01 DOI: 10.26420/austinimmunol.2021.1019

Hussain M, Tipu Hn, A. D, A. M, Sheikh S, Ijaz Y

引用次数: 0