Austin journal of clinical immunology最新文献

Biogenic Amines and Their Role in the Brain 生物胺及其在大脑中的作用

Austin journal of clinical immunology Pub Date : 2024-06-08 DOI: 10.26420/austinjclinimmunol.2023.1056

Maksimovich Nye, Bon Ei, Golushko As

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High Frequency of Monoclonal B-cell Lymphocytosis with a High Prevalence of Biclonal Cases in the Colombian Population 哥伦比亚人群中单克隆b细胞淋巴细胞增多症的高发与双克隆病例的高发

Austin journal of clinical immunology Pub Date : 2023-03-30 DOI: 10.26420/austinjclinimmunol.2023.1053

Celis Ma, Navarro Y, Serrano N, Calderón Dayro, M. D, Nieto Wg

{"title":"High Frequency of Monoclonal B-cell Lymphocytosis with a High Prevalence of Biclonal Cases in the Colombian Population","authors":"Celis Ma, Navarro Y, Serrano N, Calderón Dayro, M. D, Nieto Wg","doi":"10.26420/austinjclinimmunol.2023.1053","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2023.1053","url":null,"abstract":"The World Health Organization (WHO) defines monoclonal B-Cell Lymphocytosis (MBL) as the presence in Peripheral Blood (PB) of monoclonal populations of B-Lymphocytes (BL) of up to 5x109/L, with the phenotype of Chronic Lymphocytic Leukemia (CLL) typical, CLL atypical, or non-CLL, in the absence of B symptoms or clinical manifestations related to chronic B-Cell Lymphoproliferative Disorders (B-CLPD). It is classified as Low Count (LC) (<500 clonal BL/μL) and High Count (HC) (>500 clonal BL/μL) [1]. It has been described in up to 12% of the healthy adult population [1], a proportion that increases in relatives of patients with CLL/Small Lymphocytic Lymphoma (SLL) to around 15% [2]. It is usually a more frequent entity (28.5%) in people with Hepatitis C virus (HCV) [3] infection, and it tends to persist for a long time (90% of cases) with a progression rate of the MBL-HC to clinical manifest B-CLPD between 1-4% per year [1,2]. Currently, it continues to be an entity under study since its possible evolution to CLL or another B-CLPD is clearly unknown [4].","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"111 4 Pt 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89758596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Olfactory Bulbs of the Rat - Cyto- and Chemoarchitectonics 大鼠嗅球——细胞与化学建筑学

Austin journal of clinical immunology Pub Date : 2023-03-13 DOI: 10.26420/austinjclinimmunol.2023.1052

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PD-1/PD-L1 Immunotherapy: Combating Drug Resistance in Breast Cancer PD-1/PD-L1免疫治疗:对抗乳腺癌耐药

Austin journal of clinical immunology Pub Date : 2023-01-08 DOI: 10.26420/austinjclinimmunol.2023.1051

G. Antony, Sulfath Thottungal Parambil, Ajeesh Babu Littleflower, Lakshmi Subhadradevi

{"title":"PD-1/PD-L1 Immunotherapy: Combating Drug Resistance in Breast Cancer","authors":"G. Antony, Sulfath Thottungal Parambil, Ajeesh Babu Littleflower, Lakshmi Subhadradevi","doi":"10.26420/austinjclinimmunol.2023.1051","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2023.1051","url":null,"abstract":"In recent years, immune-checkpoint blocking therapy targeting the PD-1/PD-L1 axis has advanced tumor immunotherapy to a new level, with positive outcomes in a variety of malignant tumors. Tumors can avoid an antigen-specific T cell immune response by means of PD-1/PD-L1 signaling, which adversely controls T cell-mediated immune response. In clinical practice, it was shown that while some patients did have long-term success with immunotherapy, the majority eventually had resistance to drugs and recurrence. Hence, one of the main challenges that severely restricts the long-lasting benefits and widespread use of PD-1/PD-L1 blocking treatment is both primary and acquired resistance. Therefore, it is high time to understand the mechanisms of resistance for improving anti-PD-1/PD-L1 efficacy. In this review, we describe major signaling pathways that regulate PD-1/PD-L1 axis in cancers as well as the role of PD-1/PD-L1 in breast cancer development and progression. In addition, we further discuss the involvement of PD-1/PD-L1 axis in multi-drug resistance in cancers, which affected breast cancer and other solid tumor response rates and durability to treatment strategies.","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86917404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Anti-Rheumatoid Arthritis Effects of Dangshen Ejiao Pill Mediated through Nuclear Factor-κB Pathway 党参阿胶丸核因子-κB通路介导的抗类风湿关节炎作用

Austin journal of clinical immunology Pub Date : 2023-01-08 DOI: 10.26420/austinjclinimmunol.2023.1050

Liu T, Zhang L, L. J., H. K, Zhang D, X. M., L. Y.

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It’s a Fact: The Pandemic is Still Going On 这是事实:大流行仍在继续

Austin journal of clinical immunology Pub Date : 2022-09-30 DOI: 10.26420/austinjclinimmunol.2022.1049

Cavani M, Riofrío W

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Relationship Between Annual Airbornepollen Levels (1974–2014) and the Occurrence of Idiopathic Dilated Cardiomyopathy, Myasthenia Gravis, Polymyositis/ Dermatomyositis, and Vasculitis Syndrome Based on the National Registry Database of Specific Intractable Disease in Japan: A Retrospective Study 基于日本特殊顽固性疾病国家登记数据库的年度空气花粉水平(1974-2014)与特发性扩张型心肌病、重症肌无力、多发性肌炎/皮肌炎和血管炎综合征发生的关系:一项回顾性研究

Austin journal of clinical immunology Pub Date : 2022-06-30 DOI: 10.26420/austinjclinimmunol.2022.1048

A. Awaya, Y. Kuroiwa

{"title":"Relationship Between Annual Airbornepollen Levels (1974–2014) and the Occurrence of Idiopathic Dilated Cardiomyopathy, Myasthenia Gravis, Polymyositis/ Dermatomyositis, and Vasculitis Syndrome Based on the National Registry Database of Specific Intractable Disease in Japan: A Retrospective Study","authors":"A. Awaya, Y. Kuroiwa","doi":"10.26420/austinjclinimmunol.2022.1048","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2022.1048","url":null,"abstract":"Background: In Japan, pollen counts increased between 1977 and 1987, including three peaks (1978-1980, 1982, 1984-1986) coinciding with Kawasaki disease (KD) outbreaks. KD and related diseases may be related to pollen exposure (PE). Methods and Results: To elucidate the effects of PE on outbreaks of intractable muscular diseases and vasculitis syndromes, we evaluated the annual occurrence of disorders in relation to pollen counts using data from a national database. Specifically, we evaluated the occurrence of idiopathic dilated cardiomyopathy (IDCM), myasthenia gravis (MG), polymyositis/dermatomyositis (PM/DM), Takayasu arteritis (TAK), granulomatosis with polyangiitis (GPA), and periarteritis nodosa (PAN). While we did not observe increased disease rates during the first pollen count peak (1978-1980), increased rates of all evaluated diseases were observed during the 1982 and 1984-86 peaks. Furthermore, simultaneous outbreaks coincided with 10pollen count peaks between 1988 and 2013. We observed significant correlations between the annual number of newly registered patients (nRPs) with IDCM, MG, PM/DM, and PAN and annual pollen levels (PL). Significant correlations were also observed between nRPs and the annual PL measured with a lag of 2 years for IDCM and GPA, 1–4 years for PAN, and 6 years for MG, PM/DM, TAK, GPA, and PAN. Conclusion: Data suggest that the cumulative effects of PE within 6 years prior to diagnosis might possibly trigger onset of muscular specific intractable diseases.","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79288550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Review of Water Problems in the Era of COVID-19 新冠肺炎时代的水问题综述

Austin journal of clinical immunology Pub Date : 2022-06-14 DOI: 10.26420/austinjclinimmunol.2022.1047

María del Rosario Molina González, Celia Yaneth Quiroz Campas, Gilberto Bermudez Ruíz, F. Morales, C. Lirios

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M1- and M2-Polarized Macrophages Modified Inflammatory Environment and Affects Malignant Behaviors of Cancer Stem-like Cells (CSCs) Derived from Human Melanoma Cells A375 M1和m2极化巨噬细胞改变炎症环境并影响来源于人黑色素瘤细胞A375的癌干细胞(CSCs)的恶性行为

Austin journal of clinical immunology Pub Date : 2022-03-02 DOI: 10.26420/austinjclinimmunol.2022.1045

Chen Z, Pu Y, Zhou K, L. R, Cen Y, C. J

{"title":"M1- and M2-Polarized Macrophages Modified Inflammatory Environment and Affects Malignant Behaviors of Cancer Stem-like Cells (CSCs) Derived from Human Melanoma Cells A375","authors":"Chen Z, Pu Y, Zhou K, L. R, Cen Y, C. J","doi":"10.26420/austinjclinimmunol.2022.1045","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2022.1045","url":null,"abstract":"Tumors contain a sub-population of cells characterized by self-renewal and expanding capacities which were known as cancer stem-like cells (CSCs). Sphere formation in conditioned serum-free medium supplemented with epidermal growth factor and basic fibroblast growth factor is a well-accepted manner for enriching CSCs from several kinds of tumor cells, including melanoma cells A375. The effects of polarized macrophages on malignant behaviors of melanoma cells were well studied, however, little was known about the effects of inflammatory environment modified by polarized macrophages on melanoma CSCs. In this study, tied to figure out these effects, we firstly stimulated the polarization of M1- and M2-state macrophages and confirmed the successful stimulation via detecting hallmarkers. Then the successful enrichment of A375 CSCs was confirmed by performing self-renewal capacity. Via detecting the malignant behaviors, it is observed that inflammatory environment modified by M1-polarized macrophages inhibited proliferation, blocked cell cycle phases at G1/G0, decreased invasive, tumor formatting abilities and induced cisplatin-sensitivity by promoting apoptosis. Contrarily, M2-conditioned medium desensitized A375 CSCs to cisplatin without affecting other malignant behaviors including proliferation, cell cycle, invasion and tumor formation. Meanwhile, M2- conditioned medium protected stemness of CSCs under oxidative stress. How the modified inflammatory microenvironment affects CSCs was performed by adding macrophage-specific cytokines and the results indicate that M1-polarized and M2-polarized macrophages partially affected CSCs via increased secretion of cytokines, including IL-1β, TNF-α and TGF-β. Taken together, we provide evidence that different macrophage polarization affected malignant behaviors of A375 CSCs partially via secretion of cytokines.","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86703666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Propofol Protects Cardiac Myocytes from H2O2-induced Cell Injury via Regulating ROS Accumulation and Mitochondrial Function from Oxidative Stress via Regulating ROS and Mitochondria 异丙酚通过调节ROS积累和线粒体功能来保护心肌细胞免受h2o2诱导的细胞损伤

Austin journal of clinical immunology Pub Date : 2022-03-02 DOI: 10.26420/austinjclinimmunol.2022.1046

Hou Z, G. L., Zhang Q

{"title":"Propofol Protects Cardiac Myocytes from H2O2-induced Cell Injury via Regulating ROS Accumulation and Mitochondrial Function from Oxidative Stress via Regulating ROS and Mitochondria","authors":"Hou Z, G. L., Zhang Q","doi":"10.26420/austinjclinimmunol.2022.1046","DOIUrl":"https://doi.org/10.26420/austinjclinimmunol.2022.1046","url":null,"abstract":"Oxidative stress is one of the main mechanisms of myocardial ischaemia-reperfusion (I/R)-induced injury, which is one of the main cause of cardiomyocyte death and precipitates life-threatening heart failure. Propofol (2,6-diisopropylphenyl, PR) plays critical roles, including in I/R-induced oxidative stress; however, its protective effects on I/R-induced oxidative stress are still largely unknown. Considering that oxidative stress strongly affects mitochondrial function, we hypothesized that propofol may regulate I/R-induced H9C2 injury by modifying mitochondrial function. In a H2O2-induced cell model, propofol treatment reversed the H2O2-induced blockade of the cell cycle at the G1 phase and promotion of apoptosis. Two-hour pretreatment promoted proliferation and inhibited apoptosis, indicating that propofol pretreatment may, decrease H2O2-induced ROS accumulation. Propofol decreased oxidative stress-induced haem oxygenase-1 (HO-1) expression, and ROS scavenging mediated by treatment with NAC also decreased HO-1 expression. Propofol decreased ROS accumulation after H2O2 treatment, which was similar to the effects of the ROS scavenger NAC. Further results also showed that propofol enhanced the maintenance of mitochondrial function. However, without affecting the mitochondrial DNA content, propofol decreased mitochondrial ATP production and transcriptional activity, indicating that propofol may temporarily block mitochondrial function to prevent oxidative stress. These results suggest that propofol protects cardiomyocytes by regulating mitochondrial function.","PeriodicalId":90446,"journal":{"name":"Austin journal of clinical immunology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90707639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0