Austin journal of clinical cardiology最新文献_第2页

Allograft Vasculopathy in Transplanted Hearts and the Role of FGF 23-Klotho Axis 同种异体移植心脏血管病变及FGF - 23-Klotho轴的作用

Austin journal of clinical cardiology Pub Date : 2022-03-19 DOI: 10.26420/austinjclincardiolog.2022.1088

Evlice M

{"title":"Allograft Vasculopathy in Transplanted Hearts and the Role of FGF 23-Klotho Axis","authors":"Evlice M","doi":"10.26420/austinjclincardiolog.2022.1088","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2022.1088","url":null,"abstract":"Background: There are increasing evidences in the role of the involvement of the fibroblast growth factor 23 (FGF 23) - clotho axis in the pathogenesis of endothelial disfunction and cardiovascular disease. This study intended to explore the role of FGF 23 - clotho axis in the development of allograft vasculopathy. Methods: A total of 38 biatrial heart transplant patients who were operated were included in the study (20 males, 11 females; mean age: 44 ± 7 years). CFR was measured in all patients and the patients were divided into two groups according to respective CFR values. CFR > 2 patients constituted CAV (-) group, CFR < 2 patients were enrolled into CAV (+) group. FGF 23 and clotho levels were analyzed and compared in both groups. Results: FGF 23 levels were significantly higher in CAV (+) group (264.0±114.4 vs. 183.5±56.0 p=0.04). There was a good but inverse correlation between CFR and FGF 23 levels in CAV (+) group (r= - 0.71 p=0.03). Clotho levels were significantly lower in patients who have CAV (2.76±1.6 vs. 4.77±0.87 p=0.01). There was a moderate correlation between CFR and clotho levels in CAV (+) group (r=0.62 p=0.04). There was an inverse correlation between clotho and FGF 23 levels in both CAV (+) and CAV (-) groups. Conclusion: In transplanted patients, there was a good but negative correlation between CFR and FGF 23 levels. Conversely, there was a good correlation between CFR and clotho levels. These results gave rise to the thought clotho-FGF 23 axis has a role in the development of CAV.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"400 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85490564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left Atrial Diameter as a Risk Factor for Atrial Fibrillation Recurrence after Surgical Ablation: A Systematic Review and Meta-analysis 左房内径是手术消融后房颤复发的危险因素:一项系统回顾和荟萃分析

Austin journal of clinical cardiology Pub Date : 2022-02-24 DOI: 10.26420/austinjclincardiolog.2022.1086

Ye Q, Gong Z, Zhao Y, L. K, Zhao C, L. Y, Zeng C, W. J

{"title":"Left Atrial Diameter as a Risk Factor for Atrial Fibrillation Recurrence after Surgical Ablation: A Systematic Review and Meta-analysis","authors":"Ye Q, Gong Z, Zhao Y, L. K, Zhao C, L. Y, Zeng C, W. J","doi":"10.26420/austinjclincardiolog.2022.1086","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2022.1086","url":null,"abstract":"Background: Surgical ablation (SA) is widely performed to eliminate atrial fibrillation (AF) and maintain atrial contraction. A larger left atrial diameter (LAD) has long been associated with the late recurrence of AF post-ablation. Objectives: We conducted a meta-analysis to assess the relationship between LAD and AF recurrence after SA and investigated the effect of LAD cut-off values on the probability of AF recurrence via subgroup analysis. Methods: The literature search was performed in the MEDLINE and Cochrane Central Register of Controlled Trials databases, from inception to July 2021. A random-effects model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). From 401 initial articles, 16 studies, comprising a total of 4,291 patients, were included in this review. Results: A meta-analysis of 10 studies (2,599 patients) demonstrated that the predicted probability of AF recurrence was 7% greater with each 1 mm increase in LAD (OR: 1.07; 95% CI: 1.04–1.09; P<0.01). Meanwhile, subgroup analysis revealed that the larger the cut-off value, the higher the risk of AF recurrence. The synthesis effect value (OR: 2.45; 95% CI: 1.77–3.39) was close to the OR when the LAD cut-off value was 55 mm (OR: 2.56; 95% CI: 1.22–5.38). Conclusions: In conclusion, a larger LAD is a significant risk factor for predicting AF recurrence after SA. More rigorously designed studies with larger sample sizes are needed to identify the best cut-off value of LAD when performing SA.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87208159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total Serum Protein as an Independent Predictor of Heart Failure with Preserved Ejection Fraction in Obese Pediatric Population 血清总蛋白作为肥胖儿童人群保留射血分数心力衰竭的独立预测因子

Austin journal of clinical cardiology Pub Date : 2021-11-04 DOI: 10.26420/austinjclincardiolog.2021.1084

Poruban T, Banovcinova A, Vachalcova M, Sieradzka Ak, Jakubova M, S. I, Barkai Ll

{"title":"Total Serum Protein as an Independent Predictor of Heart Failure with Preserved Ejection Fraction in Obese Pediatric Population","authors":"Poruban T, Banovcinova A, Vachalcova M, Sieradzka Ak, Jakubova M, S. I, Barkai Ll","doi":"10.26420/austinjclincardiolog.2021.1084","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2021.1084","url":null,"abstract":"Objectives: We aimed to clarify the prognostic role of Total Serum Protein (TSP) in obese children with HFpEF and its using as an effective and noninvasive approach for screening of target population. Methods: In total, 587 patients who enrolled in our unique program aimed for children’s obesity treatment were referred. Among these patients, we identified and retrospectively studied 64 patients who met our criteria and compared them with 24 lean healthy subjects. Baseline examination, routine blood testing and transthoracic echocardiography were obtained. Results: We revealed that obese patients had higher TSP levels compared to them with normal weight. They also had worse echocardiographic results including a lower Left Ventricular Ejection Fraction (LVEF) and E/A ratio. Positive correlations between TSP and Pulmonary Artery Systolic Pressure (PASP), Left Atrial Volume Index (LAVI), and Interventricular Septal Systolic/Diastolic Dimension (IVSs, IVSd) and negative TSP correlations with LVEF and E/A ratio were found, too. Compared to the commonly used Albumin-to-Globulin Ratio (AGR), the TSP was a better metabolic predictor. There were more significant correlations in obese subgroup with HFpEF than to those without HFpEF. Conclusions: We first indicated that higher TSP levels are positively associated with obesity and HFpEF in children and could be used as a more easily available biomarker which provides a more-accurate HFpEF risk evaluation of obese pediatric population group than other objective indices, possibly allowing early implementation of appropriate intervention in daily practice and leads to better outcomes and early prevention in patients with higher HF risk.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90674921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Widow Marker, An EKG Sign We Should Not Miss 寡妇标记，一个我们不应该错过的心电图信号

Austin journal of clinical cardiology Pub Date : 2021-10-13 DOI: 10.26420/austincardiol.2021.1030

Sousa M, Piçarra B

引用次数: 0

Myocarditis in Patients with COVID-19 COVID-19患者的心肌炎

Austin journal of clinical cardiology Pub Date : 2021-10-07 DOI: 10.26420/austinjclincardiolog.2021.1083

P. M., De Stefano D

{"title":"Myocarditis in Patients with COVID-19","authors":"P. M., De Stefano D","doi":"10.26420/austinjclincardiolog.2021.1083","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2021.1083","url":null,"abstract":"SARS-CoV-2 is an enveloped RNA beta coronavirus, identified as the pathogen responsible for coronavirus disease 2019 (COVID-19). It primarily affects the respiratory system; however, cardiovascular complications have been found in 30% of hospitalized patients, associated with worse outcomes. The virus can invade human host cell by binding with high affinity the Angiotensin Converting Enzyme 2 (ACE 2) receptor, which is expressed especially in the lungs and heart, where the human immune response can lead to an inflammation of the myocardium itself. Patients with myocarditis commonly experience nonspecific signs and symptoms; laboratory tests often revealed elevated marker of myocardial necrosis and inflammation while electrocardiogram in most patients have demonstrated features similar to an acute coronary syndrome. Echocardiography is the first method of investigation to evaluate the left ventricular systolic function. In suspected case, Cardiac Magnetic Resonance Imaging (CMRI) is acknowledged as the non-invasive gold standard test for myocarditis, also useful in assessing prognosis. Endomyocardial biopsy (EMB), although considered a gold standard for the diagnostic confirmation of myocarditis, is an invasive procedure that cannot be performed in all patients. Current management is mainly supportive in association with glucocorticoids.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81043090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Myocardial Ischaemia Secondary to Anomalous Aortic Origin of the Left Main Coronary Artery 继发于左主干冠状动脉异常的心肌缺血

Austin journal of clinical cardiology Pub Date : 2021-10-05 DOI: 10.26420/austincardiol.2021.1029

Eng-Frost J, Choo Wk

引用次数: 0

Characterization of “Super-Responders” to Cryoballoon Ablation 低温球囊消融“超级应答者”的特征

Austin journal of clinical cardiology Pub Date : 2021-09-10 DOI: 10.26420/austinjclincardiolog.2021.1082

M. J, C. B., Jiménez-López J, C. J., Vallès E, Cladellas M

{"title":"Characterization of “Super-Responders” to Cryoballoon Ablation","authors":"M. J, C. B., Jiménez-López J, C. J., Vallès E, Cladellas M","doi":"10.26420/austinjclincardiolog.2021.1082","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2021.1082","url":null,"abstract":"Background: Pulmonary Veins Isolation (PVI) is the cornerstone in the treatment of atrial fibrillation. Recurrence rate is common in the long-term followup (FU); nevertheless, some patients maintain Sinus Rhythm (SR) for more than 5 years after the index ablation. The aim of this study is characterize this kind of patients so called “super-responders”. Methods: This is a retrospective single-center study including all patients summited for cryo-balloon ablation in our hospital from January 2011 to September 2020. We investigated clinical, electrocardiographic, echocardiographic variables and those linked to the ablation procedure. A univariate and multivariate logistic regression was performed. Results: During this period, 422 patients underwent PVI; however, 193 were excluded: 21 lost in the FU, 30 got radiofrequency ablation and 142 did not reach a minimum 5 years FU. Of the 229 finally included, 85 (group 1) did not have any recurrence during the follow-up, in front of 144 (group 2) with AF recurrences. In the multivariate analysis the p wave duration: OR: 0.92; 95% CI (0.89-0.94); p <0.001, BMI kg/m²: OR: 0.74; 95% CI (0.65-0.85); p <0.001, a temperature <-40°C in all the targeted veins: OR: 3.52; 95% CI (1.45-8.54); p=0.005 and SR on the ablation index day OR: 7.29; 95% CI (1.53-34.71); p=0.012, maintained statistical significance. Conclusions: In our series the p wave duration, BMI, the presence of SR the ablation index day and achieving a temperature <-40°C in all the targeted veins, resulted as protective factors to maintain SR in the long term follow-up. An adequate selection of patients probably could improve results and optimize resources.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87110740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Efficacy and Determining Various Factors Associated with the Effective Use of Vitamin-K Antagonist Therapy in the Indian Population 在印度人群中有效使用维生素k拮抗剂治疗的疗效评价和确定各种相关因素

Austin journal of clinical cardiology Pub Date : 2021-08-20 DOI: 10.26420/austinjclincardiolog.2021.1080

Darisi S, A. T, George J, Ramaiah B

{"title":"Evaluation of Efficacy and Determining Various Factors Associated with the Effective Use of Vitamin-K Antagonist Therapy in the Indian Population","authors":"Darisi S, A. T, George J, Ramaiah B","doi":"10.26420/austinjclincardiolog.2021.1080","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2021.1080","url":null,"abstract":"Aim: To assess the efficacy of Vitamin K antagonist to maintain stable INR in a tertiary care hospital. Methodology: All the patients who are on Vitamin K antagonists therapy for more than 6 months before the initiation of the study were included. Data, which include demographics, Personal history, medical history, medication history, Dietary habits, laboratory data (INR), and other relevant data, are collected. The laboratory results are further evaluated using the Rosendaal method and Time in Therapeutic Range, which was obtained which is evaluated, for assessing the use of medication, and other correlations were further made. Results and Discussion: The study showed a mean TTR of 25.638%, the mean TTR above and below the therapeutic range is 19.23% (±17.14), 55.11% (±29.64) respectively, this represents that the patients in the sample population are at higher risk of developing a new clot during the therapy with VKA, various chronic conditions such as Diabetes mellitus, the use of NSAIDs, PPI also showed a statistically significant difference on the patients TTR. Conclusion: Despite patients being therapeutically anticoagulated, based on the available data, many patients in the study population are at high risk of developing complications of anticoagulants and also the development of new clots even during the treatment, there are not many reports of TTR measurement in INDIAN population, The use of Vitamin K Antagonist comes with many limitations, many Newer Oral Anticoagulants (NOAC) can be used in patients as they are proven to be providing better control of TTR.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83401023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Day-Case Patent Foramen Ovale Closure Under Transthoracic Echocardiography and Fluoroscopic Guidance: A Safe and Cost-Effective Approach as Compared to Conventional Hospitalization 经胸超声心动图和透视指导下的卵圆孔未闭闭合:与传统住院治疗相比，一种安全、经济的方法

Austin journal of clinical cardiology Pub Date : 2021-08-20 DOI: 10.26420/austinjclincardiolog.2021.1081

Godart F, Baudelet J B, Chatillon-Domanski O, Polge A S, Houeijeh A

{"title":"Day-Case Patent Foramen Ovale Closure Under Transthoracic Echocardiography and Fluoroscopic Guidance: A Safe and Cost-Effective Approach as Compared to Conventional Hospitalization","authors":"Godart F, Baudelet J B, Chatillon-Domanski O, Polge A S, Houeijeh A","doi":"10.26420/austinjclincardiolog.2021.1081","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2021.1081","url":null,"abstract":"Background: Transcatheter Patent Foramen Ovale (PFO) is recommended as a therapy in secondary prevention of cryptogenic stroke. The aim of this study was to report one-year French single-center experience in PFO closure under sole Transthoracic Echocardiography (TTE) and fluoroscopy guidance performed as a day-case procedure versus a 3-day hospitalization. Methods: In 2018, all consecutive patients undergoing PFO closure for stroke were retrospectively included: 108 patients as a day-case procedure (group 1) versus 20 patients performed under a 3-day hospitalization (group 2). A comparison was performed between Occlutech and Amplatzer PFO devices and the impact on hospitalization costs was studied. Results: Occluders included Occlutech (n=81), Amplatzer (n=43), Lifetech (n=2) and PFM (n=2) PFO devices. Implantation succeeded in all. In-group 1, hospital discharge was delayed in only 3 cases. At one-month, 5 patients had Atrial Fibrillation (AF) and 91 patients (84%) had no residual shunt. In-group 2, hospital discharge was delayed in 4 patients. At one month, 1 patient had AF and no shunt was observed in 80%. In the comparative study, no significant statistical difference could be observed between Amplatzer and Occlutech devices. The one-day strategy leaded to a positive balance of 1825 euros per procedure in 2018, with a difference of 3785 euros with group 2. Conclusion: Our experience suggests that day-case PFO closure under fluoroscopy and TTE guidance is safe and effective in the majority of patients leading to a cost reduction and no increased risk of embolization.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73105782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Combined Same Session Aerobic and Resistance Training on Physical Performance in Coronary Artery Disease Patients: Protocol Comparison 同一次有氧和阻力训练对冠心病患者体能的影响:方案比较

Austin journal of clinical cardiology Pub Date : 2021-06-19 DOI: 10.26420/austinjclincardiolog.2021.1077

P. Clavario, C. Bárbara, A. Porcile, C. Russo, T. Zappulla, E apurroa, T Cornero, C FerrariAggradi, T. Mäkikallio, Arto Hautala

{"title":"The Effects of Combined Same Session Aerobic and Resistance Training on Physical Performance in Coronary Artery Disease Patients: Protocol Comparison","authors":"P. Clavario, C. Bárbara, A. Porcile, C. Russo, T. Zappulla, E apurroa, T Cornero, C FerrariAggradi, T. Mäkikallio, Arto Hautala","doi":"10.26420/austinjclincardiolog.2021.1077","DOIUrl":"https://doi.org/10.26420/austinjclincardiolog.2021.1077","url":null,"abstract":"Aerobic training is included to cardiac rehabilitation programs together with resistance training. The effects of combined aerobic and resistance training performed in a same session with different protocols on peak aerobic capacity (VO2peak) and maximal dynamic strength (1RM: one repetition maximum) are not well known. We compared the effectiveness of two different combined aerobic and resistance training programs for 12 weeks performed three times in a week in stable Coronary Artery Disease (CAD) patients (n=30) who had previously performed aerobic training only. The patients were randomized to High Volume- Low Intensity Group (HLG) or Low Volume-High Intensity Group (LHG). Both groups performed laboratory controlled aerobic exercise first (60min, 80% of lactate threshold) followed by six major muscle group resistance exercises (HLG: 30-35% of 1RM, 3 sets, 12 repetitions) or (LHG: 60-70% of 1RM, 3 sets, 6 repetitions). VO2peak remained at the baseline level for whole study group (23 ± 6 vs. 24 ± 7 ml·kg-1·min-1, p=0.380) and the responses did not differ between the HLG and LHG (p=0.891). Muscle strength increased when analyzed as one group for both upper (Push Up; 24 ± 8 vs. 30 ± 7 kg, p <0.0001) and lower body (Leg Extension; 20 ± 6 vs. 27 ± 6 kg, p <0.0001) with no difference between subgroups (p=0.240 and p=0.504, respectively). As conclusion, combined aerobic and resistance training in the same training session for 12 weeks improved maximal strength independently of the intensity of resistance training. These results highlight the importance of regular resistance training, even at moderate intensity, for CAD patients in terms of physical performance and independent living.","PeriodicalId":90445,"journal":{"name":"Austin journal of clinical cardiology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85000783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0