Zhong liu za zhi最新文献

{"title":"A Spontaneously Regressing Botryomycoma of the Tongue in A Young Boy With Down Syndrome","authors":"D. Satgé, N. Bourdon, C. Mircher","doi":"10.17554/j.issn.1819-6187.2019.07.116","DOIUrl":"https://doi.org/10.17554/j.issn.1819-6187.2019.07.116","url":null,"abstract":"A 4 1/2 –year-old boy with Down syndrome (DS) presented a tongue botryomycoma which recurred after complete surgical resection; then spontaneously regressed. Beside Riga-Fede disease reported in DS it is a first observation of a tongue botryomycoma in this genetic condition.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48679598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic Autologous Cancer Cells Immunization Inhibits Triple Negative Breast Tumors’ Growth and Metastasis in 4T1 Tumor-Bearing BALB/c Mice","authors":"Amirhosein Kefayat, Ensiyeh Moghadas, Parvin Goli, A. Rezaei, N. Esmaeil","doi":"10.17554/J.ISSN.1819-6187.2019.07.115","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2019.07.115","url":null,"abstract":"Triple negative breast cancer (TNBC), a type of breast cancer, is still incurable and 4T1 tumor is an equal experimental model of TNBC which is highly metastatic and invasive. In the present study, we assessed the prophylactic cancer vaccine effects on survival and metastasis in 4T1 tumor bearing mice. Female BALB/c mice were divided in three groups and subcutaneously (s.c) injected with PBS incomplete Freund’s adjuvant (IFA) and a mix of the homogenized 4T1 cancer cells emulsified with IFA, respectively. Also, in the third group, the last immunization was contained just the homogenized cancer cells. Tumor induction was performed with 4T1 cells injection at the 4th mammary fat pad of each mouse. Tumor diameter and the number of macroscopic metastatic nodules on the lungs’ surface were investigated two weeks after the last immunization. We found that the immunization of mice with homogenized 4T1 cancer cells and IFA significantly inhibited 4T1 tumors’ growth. Also, metastatic colonies in the lungs significantly decreased in mice which immunized with 4T1 cancer cells and IFA. Overall, the effective induction of immune response by the vaccine used in our study seems to have prevented cancer cells migration and metastasis to other organs. However, precise immunological studies are required to determine the mechanism of such a vaccine.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48796547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for adjuvant therapy in Gall Bladder and Bile duct carcinomas","authors":"Aman Sharma, V. Raina, B. Mohanti","doi":"10.17554/j.issn.1819-6187.2018.06.109","DOIUrl":"https://doi.org/10.17554/j.issn.1819-6187.2018.06.109","url":null,"abstract":"Biliary tract cancers are rare cancers that arise from epithelial lining of gallbladder and bile ducts. Gallbladder cancer (GBC) is the most common cancer of the biliary tract and accounts for two thirds of the cases, whereas bile duct cancer accounts for the remaining one-third. Although anatomically these malignancies are related and have similar metastatic patterns, each has a distinct clinical presentation, molecular pathology, and prognosis. Radical surgery offers the only chance of cure, given their proximity to the complex anatomy of porta hepatis, only one third of cases at presentation are resectable, after radical resection relapse is often very frequent. Pattern of recurrence is typically local, although first relapse at a distant site is not uncommon. With high rates of relapse, strategy aimed at optimizing local control with postoperative radiation alone or in combination with chemotherapy or optimizing systemic recurrence with chemotherapy have potential to improve treatment outcomes. Evidence for use of adjuvant therapy for these rare tumors is fragmentary and has not been evaluated in prospective randomised controlled trials. On basis of uncontrolled institutional series and registry analyses adjuvant approach is favoured and used in up to 70% of centres worldwide.  However there is lack of consensus regarding optimal use of post operative therapy, in the present article we review and present pertinent data for use of adjuvant radiotherapy, chemo-radiotherapy and chemotherapy for intrahepatic, extrahepatic cholangiocarcinomas and carcinoma of the gall bladder and propose guidelines for use of adjuvant therapy based upon retrospective data.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"6 1","pages":"526-535"},"PeriodicalIF":0.0,"publicationDate":"2018-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47624816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptosis and Carcinogenesis: An Update","authors":"K. Mokbel, K. Mokbel","doi":"10.17554/j.issn.1819-6187.2018.06.106","DOIUrl":"https://doi.org/10.17554/j.issn.1819-6187.2018.06.106","url":null,"abstract":"A conserved, intact and tightly regulated apoptotic pathway is necessary for embryonic organogenesis, maintenance of tissue homeostasis and tumour suppression in healthy organisms. This pathway is also activated in response to hypoxia, oncogenic overexpression or DNA damage and serves to eliminate cells that have experienced lethal doses of genotoxic stress. Several studies suggest that resistance to apoptosis, also known as programmed cell death, results in the survival of mutant cells which can induce tumourigenesis. Therefore, inhibition of apoptosis is considered a requirement for tumourigenesis and thus an acquired resistance to apoptosis has become a “hallmark” for cancer. The intrinsic, or mitochondrial, pathway of apoptosis is mainly controlled by the interactions between mitochondrial and cytosolic pro- and anti-apoptotic proteins of the Bcl-2 family. Thus, resistance to apoptosis can be acquired by mutations in pro- or anti-apoptotic genes of Bcl-2 family members or in the tumour suppressor gene p53 which is the DNA damage sensor in the intrinsic apoptotic signalling circuitry. Moreover, multiple epigenetic studies have illustrated the role DNA methylation plays in the aberrant apoptosis in many human cancers, and thus in the survival of tumours. Novel therapeutics that target the intrinsic pathway of apoptosis have also been the subject of considerable investigation.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"6 1","pages":"520-525"},"PeriodicalIF":0.0,"publicationDate":"2018-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43880345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tow Rare Cases of Carotid Body Tumour with Review of Literature in Baghdad Radiation Oncology Center, Medical City, Baghdad, Iraq","authors":"A. Al‐shewered, Khudair J. Al-Rawaq, Manwar Al-Naqqash, Ashraf Fs Al-Awadi","doi":"10.17554/J.ISSN.1819-6187.2018.06.110","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2018.06.110","url":null,"abstract":"Background: The carotid body tumors are relatively rare tumor but constitute majority of head and neck paragangliomas about 70%.  The purpose of this review article is to simplify understanding the basic and clinical aspects of this challenging tumour, which is the first time study in Iraq. Case presentation: Tow Iraqi people male and female presented with neck lump to Baghdad Radiation Oncology center. Radiotherapy performed for them as 50 Gy/ 25 fractions to treated conditions. Conclusion: Throughout more than four decades working in this field, we faced 2 cases of CBTs, so it is very rare tumour. It is a challenging tumour management. Surgery is treatment of choice while radiotherapy is standard treatment for recurrent cases.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"6 1","pages":"516-519"},"PeriodicalIF":0.0,"publicationDate":"2018-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48825261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Genetic Characteristics of Colorectal Cancer in Patients 90 Years and Older Differ from the Findings in Younger Patients","authors":"P. Zauber, R. Kapoor, S. Marotta, M. Sabbath‐Solitare","doi":"10.17554/J.ISSN.1819-6187.2018.06.108","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2018.06.108","url":null,"abstract":"Aim: Only limited information is available on the molecular characteristics of colorectal cancers diagnosed in patients 90 years and older. There are indirect suggestions that in cancers from very elderly patients, molecular genetic changes may be either more, or less prevalent; thus, raising the question as to the similarity in genetic changes found in colorectal cancers between very elderly and younger patients. We examined several molecular changes associated with colorectal cancers in 41 very elderly patients, and compared the results to the findings of a younger cohort, between ages 55 and 79 years. Methods: We evaluated MSI, loss of heterozygosity for APC and DCC genes, KRAS and BRAF gene mutations, and DNA methylation in colon cancer tissue samples using standard PCR techniques. Results: our data indicate that colorectal cancers from very elderly patients are more frequently right-sided and more likely to demonstrate microsatellite instability. If the cancers contain a KRAS mutation, it is less likely to be in the second codon position. Finally, KRAS 61 may be more frequent in the very elderly. Conclusions: Overall, the colorectal cancers from our very elderly patients, 90 years and older, have at least as many, if not more, molecular genetic changes than the cancers from younger.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"6 1","pages":"510-515"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49622178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of hypopharyngeal and oropharyngeal cancers in Japan","authors":"M. Nishi","doi":"10.17554/J.ISSN.1819-6187.2018.06.107","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2018.06.107","url":null,"abstract":"BACKGROUND: Both hypopharyngeal cancer and oropharyngeal cancer are rare malignancies. However, it is reported that the incidences of these cancers have increased in Japan. It is known that smoking and drinking are risk factors for both cancers. Recently, human papillomavirus (HPV) is regarded as a risk factor for oropharyngeal cancer. In this article the changes in the mortality rates of these cancers are described from the viewpoint of descriptive epidemiology. METHODS: The numbers of deaths due to the 2 cancers from 1979 to 2016 were obtained from the vital statistics of Japan. The numbers of persons in each of the years were obtained from the census and vital statistics of Japan. RESULTS: For males, the ratio of the numbers of deaths from hypopharyngeal cancer/oropharyngeal cancer has been almost constant, at about 2. The crude mortality rate of hypopharyngeal cancer for males has been increasing. The rate in 2016 was about 9 times that in 1979. The male/female ratio has been increasing as well, which is due to the large increase for males and the small increase for females. The crude mortality rate of oropharyngeal cancer for males has been increasing. The rate in 2016 was more than 10 times that in 1979. In the group 50-59 years of age, the crude mortality rate of hypopharyngeal cancer for males has been almost constant. However, in the groups aged 70 years and older, it has been rapidly increasing.  The changes in the crude mortality rates of oropharyngeal cancer were similar to those of hypopharyngeal cancer. In the group aged 50-59 years, the crude mortality rate remained stable. However, in the groups 70 years of age and older, it has been rapidly increasing. The age-adjusted mortality rate of hypopharyngeal cancer for males has been increasing, and there has been no clear sign of a decrease. The age-adjusted mortality rate of oropharyngeal cancer for males has been increasing as well, and there has been no sign of a decrease. While the smoking rate has been decreasing since 1966, the number of cigarettes per smoker per day was increasing during the period from 1960 to 2000. The percentage of heavy drinkers among the population remained almost stable. CONCLUSIONS: For males, since the age-adjusted mortality rates of the 2 cancers have been increasing, it is certain that their incidences have been increasing. Their incidences may largely increase in older age groups. The contribution of the number of cigarettes per smoker to the pathogenesis of these 2 cancers may be larger than that of the smoking rate. The influence of HPV on oropharyngeal cancer was not apparent in the data for mortality rates.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"6 1","pages":"504-509"},"PeriodicalIF":0.0,"publicationDate":"2018-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43032852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main title- Controversial odontogenic hamartomas- review on their pathogenesis and histopathology","authors":"A. Banerjee, Tiwari V Tanu, M. Divakaran, K. Singroha, Menon K Amrita, Wakhloo Tulika, Singh Sakshi","doi":"10.17554/J.ISSN.1819-6187.2017.05.104","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2017.05.104","url":null,"abstract":"Odontogenic tumour represents as growth and swellings of varied origin. The features of hamartomatous odontogenic entities are distinct and also exhibit different biological behavior. The pathobiology of these lesions is sometimes understated. There always lays a big controversy depicting the hamartoma like behavior. Hamartomas are frequently encountered in major organs like liver, lung, pancreas etc  but the occurrence in oral cavity is rare. The lesions enlisted in this review may not be true hamartomas but depicts strong correlation as hamartomas or neoplasm in hamartoma.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"5 1","pages":"492-497"},"PeriodicalIF":0.0,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44700954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colonic stenting in the management of acute left-sided malignant colonic obstruction is oncologically safe?","authors":"D. Belinda, Catena Fausto","doi":"10.17554/J.ISSN.1819-6187.2017.05.101","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2017.05.101","url":null,"abstract":"The management of patients presenting with acute large bowel obstructioncaused by left sided colorectal cancer is still debated.Colonic stenting (CS) seems to be a good therapeutical option toemergency surgery: it is able to convert an urgent situation in anelective one. Lately conflicting results were published about thistechnique used as bridge to surgery in comparison with the emergencysurgery in terms of oncologic safety and recurrence rate.Actually self expandable metallic stents (SEMS) are not “allowed”to treat potentially curable patients. Data reported in literatureshow that colonic stenting improves primary anastomosis ratewith a low stoma creation in comparison with emergency surgery,enhancing patients’ quality of life, without differences in terms ofmortality and morbidity rate. According to available data, at oneyear follow up time, the recurrence rate is higher in patients treatedwith stent, with no statistical difference in terms of disease freesurvival and overall survival.Endoscopist’s experience, type of colic obstruction (partial or total),type of stent, insertion technique and timing of surgery arefundamental to reach CS technical and clinical success.Oncologic (un)-safety of colonic stenting has to be still investigatedand confirmed by medium and long term follow up of largeprospective studies and randomized controlled trials comparingSEMS and ES.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"5 1","pages":"482-487"},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of High-Grade Serous Tubal Intraepithelial Carcinoma Diagnosed with Adenocarcinoma by Ascitic Fluid Cytology","authors":"Ryosuke Takeshita, T. Shoji, Rika Mukaida, Tamotsu Sato, S. Sasou, H. Itamochi, T. Sugiyama","doi":"10.17554/J.ISSN.1819-6187.2017.05.103","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2017.05.103","url":null,"abstract":"Fallopian tube cancer is a very rare disease that is difficult to detect in its early stages. To our knowledge, we encountered the first case of serous tubal intraepithelial carcinoma (STIC) diagnosed with adenocarcinoma by ascitic fluid cytology. The patient was a 51-year-old woman who visited our department because of a leiomyoma detected during a uterine cancer screening. Transvaginal ultrasound found multiple leiomyomas and an endometrial cyst of the left ovary. The patients’ cancer antigen 125 level was elevated and the leiomyomas showed a tendency to grow. Therefore, surgical treatment was considered to be appropriate. Preoperative imaging showed no evidence of malignancy. We performed abdominal hysterectomy and bilateral salpingo-oophorectomy. The patient had stage IV endometriosis according to the revised American Society of Reproductive Medicine classification, and no macroscopic abnormalities were found in either fallopian tube. Postoperative histopathological findings led to the diagnosis of STIC in the right fallopian tube; cytological examination of the ascitic fluid also confirmed the presence of adenocarcinoma. We performed a staging laparotomy and found no evidence of metastasis to the lymph nodes or the greater omentum; the staging classification was determined to be IC3. After surgery, six cycles of paclitaxel + carboplatin therapy were administered. The patient has since been relapse-free for 15 months to date. Much attention has been directed to the fallopian tubes as the origin of malignant epithelial ovarian tumors, and STIC is now considered to be the origin of high-grade serous ovarian cancer. To avoid overlooking early-stage fallopian tube cancer, surgery for benign disease should also be accompanied by a detailed histopathological examination of the fallopian tubes.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"5 1","pages":"488-491"},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47549135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}