Zhong liu za zhi最新文献_第2页

The Ca125 Concentration in Intraperitoneal Fluid as A Prognostic Factor in Ovarian Cancer Patients with Refractory Malignant Ascites: Nowara E et al. Ca125 in intraperitoneal fluid 卵巢癌难治性恶性腹水患者腹膜内Ca125浓度与预后的关系:Nowara等。腹腔液Ca125

Zhong liu za zhi Pub Date : 2016-12-18 DOI: 10.17554/j.issn.1819-6187.2016.04.97

E. Nowara, A. Badora-Rybicka, K. Świderska, J. Nieckula, M. Kubeczko, J. Huszno

{"title":"The Ca125 Concentration in Intraperitoneal Fluid as A Prognostic Factor in Ovarian Cancer Patients with Refractory Malignant Ascites: Nowara E et al. Ca125 in intraperitoneal fluid","authors":"E. Nowara, A. Badora-Rybicka, K. Świderska, J. Nieckula, M. Kubeczko, J. Huszno","doi":"10.17554/j.issn.1819-6187.2016.04.97","DOIUrl":"https://doi.org/10.17554/j.issn.1819-6187.2016.04.97","url":null,"abstract":"Aim: Chemotherapy refractory malignant ascites in ovarian cancer patients is still a serious problem which leads to significant deterioration in the quality of life by causing distressing symptoms such as pain, nausea, vomiting, anorexia, dyspnea. In this group of patients overall survival is short. Efficacy and tolerability of current available treatments is limited. The serum Ca125 concentration has been well documented as an useful marker for evaluating intravenous chemotherapy response in epithelial ovarian cancer patients. The main goal of this study was estimation of Ca125 concentration decline rate in the intraperitoneal fluid as a prognostic factor for intraperitoneal chemotherapy response and patients survival. Material and method: Patients included to this analysis attained intravenous chemorefractory malignant ascites in the ovarian cancer course. An intraperitoneal chemotherapy was cisplatin based. Ca125 concentration was measured twice in intraperitoneal fluid: before intraperitoneal chemotherapy infusion and 24 hours after. Results: Patients with Ca125 intraperitoneal concentration decrease more than 3 times lived longer than patients with lower Ca126 concentration reduction (78,5 vs 33,1 months), p=0.06. The results of this study have many limitations, mostly due to the group of pts being small. That is why the results should be taken into consideration with caution. Conclusions: Intraperitoneal fluid Ca125 concentration decrease rate after intraperitoneal chemotherapy seems to be prognostic factor for overall survival in ovarian cancer patients with refractory malignant ascites.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"474-477"},"PeriodicalIF":0.0,"publicationDate":"2016-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible Japanese Racial Predisposition for Particular Tumors In Edwards Syndrome 爱德华兹综合征中特定肿瘤的可能的日本种族倾向

Zhong liu za zhi Pub Date : 2016-12-18 DOI: 10.17554/J.ISSN.1819-6187.2016.04.99

M. Nishi

{"title":"Possible Japanese Racial Predisposition for Particular Tumors In Edwards Syndrome","authors":"M. Nishi","doi":"10.17554/J.ISSN.1819-6187.2016.04.99","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2016.04.99","url":null,"abstract":"It is known that a case with trisomy 18 (T18) develops hepatoblastoma (HB) or Wilms tumor (WT). But are there any differences among districts in the frequency of developing them? In this report, based on articles and abstracts, frequency of HB is compared between Japan andthe USA. Using key words of \"T18\", \"HB\", \"WT\", \"leukemia\", etc., articles and abstracts reporting cases with T18 and malignant neoplasms were gathered from the Pubmed as well as the Igaku Chuo Zassi (Japanese Central Journal of Medicine), which is a searching tool for medical articles written in Japanese and English. In Japan, a total of 21 cases with HB and only 1 case with WT were reported. In the USA, however, 5 cases with HB and 8 cases with WT in T18 cases were reported.　Long survival periods lead to increased chances to develop HB. Infant mortality of Japan is the lowest in the world, being less than half of that of the USA. Several authors reported survival rates of T18 cases in general. Survival rates of Japanese cases were longer than those in western countries. The general incidence of WT in Japan is about half of that in the USA. These facts might partially explain why HB cases are frequent and WT ones are less frequent in T18 cases in Japan. Considering the number of live births of the USA andthat of Japan, the frequency of HB cases in Japan is too high to be explained only by publication bias. There may besome racial differences that promote HB and suppress WT in Japanese T18 cases.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"456-460"},"PeriodicalIF":0.0,"publicationDate":"2016-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of P53 Codon 72 with Colon Cancer: the Role of Genetic Factors P53密码子72与结肠癌的关系:遗传因素的作用

Zhong liu za zhi Pub Date : 2016-12-18 DOI: 10.17554/J.ISSN.1819-6187.2016.04.96

C. Spina, F. Bottini, L. Coppeta, A. Neri, A. Magrini, E. Bottini

{"title":"Association of P53 Codon 72 with Colon Cancer: the Role of Genetic Factors","authors":"C. Spina, F. Bottini, L. Coppeta, A. Neri, A. Magrini, E. Bottini","doi":"10.17554/J.ISSN.1819-6187.2016.04.96","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2016.04.96","url":null,"abstract":"AIM: Studies on the association between p53 codon 72 and colon cancer have given contrasting results: in some populations a positive association has been found with *Pro variant, in other with *Arg variant and in other populations no association has been observed .We have studied the possible effect of genetic variability within four common polymorphisms on the association between p53 codon 72 and colon cancer. METHODS AND MATERIAL: 106 subjects with colon cancer and 476 controls from the White population of Rome were studied. p53 codon 72, ACP1, PTPN22, ADA2 and ADA6 polymorphisms were determined by DNA analysis. Statistical analyses were carried out by SPSS programs. RESULTS: The proportions of the joint genotypes of *Pro allele carriers with *B/*B genotype of ACP1, with carriers of *T allele of PTPN22, with the ADA1*1/*1 genotype and with carriers of ADA6*1 allele are higher in colon cancer than in controls. A statistically significant positive correlation is observed in colon cancer between the proportion of *Pro allele carriers and the number of the four genetic factors considered. Sex and cancer grade influence this correlation. CONCLUSIONS: Common genetic polymorphisms influence the strength of correlation between p53 codon 72 and colon cancer suggesting a possible explanation of the contrasting result observed between different populations. Moreover, the results support the multi-factorial origin of cancer.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"478-481"},"PeriodicalIF":0.0,"publicationDate":"2016-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of β-glucan supplementation on levels of IgM, IgA, IgG and its subclasses IgG1, IgG2, IgG3, and IgG4 in cancer patients 补充β-葡聚糖对肿瘤患者IgM、IgA、IgG及其亚类IgG1、IgG2、IgG3和IgG4水平的影响

Zhong liu za zhi Pub Date : 2016-12-18 DOI: 10.17554/J.ISSN.1819-6187.2016.04.98

R. Josef, Král Vlastimil, V. Vetvicka, Rajnohova Dobiasova Lucie

引用次数: 4

Clinical and Investigational Applications of Liquid Biopsy in Non-Small Cell Lung Cancer 液体活检在非小细胞肺癌中的临床和研究应用

Zhong liu za zhi Pub Date : 2016-11-24 DOI: 10.17554/J.ISSN.1819-6187.2016.04.95

D. Pérez-Callejo, M. Torrente, A. Romero, M. Provencio

引用次数: 1

Salivary Metabolomics and Oral Carcinogenesis 唾液代谢组学与口腔癌变

Zhong liu za zhi Pub Date : 2016-08-19 DOI: 10.17554/J.ISSN.1819-6187.2016.04.92

G. Sridharan, Sangeeta R. Patankar

{"title":"Salivary Metabolomics and Oral Carcinogenesis","authors":"G. Sridharan, Sangeeta R. Patankar","doi":"10.17554/J.ISSN.1819-6187.2016.04.92","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2016.04.92","url":null,"abstract":"Cancers of the oral cavity has received reasonable importance especially in developing countries due to its significant morbidity and mortality rates. Oral squamous cell carcinoma is the common type of cancer occurring either de novo or from pre-existing potentially malignant disorders like leukoplakia. Ever since the disease has been identified, efforts are made to understand its pathogenesis with an aim to identify methods for early diagnosis, evolve appropriate treatment strategies and improve prognosis. Though tobacco, alcohol and microbes are considered important risk factors for OSCC; these are usually accompanied by various genetic and epigenetic changes. Modern analytical technologies provide comprehensive methods for identification of these molecular changes which can serve as an important biomarker. Metabolomics forms a part of ‘omic’ group that also includes genomics, proteomics and transcriptomics which is associated with the identification and quantitation of small molecules involved in metabolic reactions. The identification of a wide range of metabolites in bodily fluids is considered as an important diagnostic tool for assessment of disease biomarkers. The role of saliva as an important diagnostic tool for biomarker analysis has been accepted as a safe alternative to blood owing to its easy and non-invasive nature of collection and its close proximity to the oral lesions. This review provides an overview of the use of salivary metabolomics in OSCC and presents the current literature findings and future implications.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"450-455"},"PeriodicalIF":0.0,"publicationDate":"2016-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic Value of Immunohistochemical Expressions of theStem Cell Biomarker "LGR5" and the Proliferation Biomarker"TPX2" in Colorectal Carcinoma 大肠癌干细胞生物标志物“LGR5”和增殖生物标志物“TPX2”免疫组化表达的预后价值

Zhong liu za zhi Pub Date : 2016-06-29 DOI: 10.17554/J.ISSN.1819-6187.2016.04.93

O. Harb, Abdelmonem Awad Hegazy, L. Gertallah, R. Haggag, S. Shorbagy

{"title":"Prognostic Value of Immunohistochemical Expressions of the\u0000Stem Cell Biomarker \"LGR5\" and the Proliferation Biomarker\u0000\"TPX2\" in Colorectal Carcinoma","authors":"O. Harb, Abdelmonem Awad Hegazy, L. Gertallah, R. Haggag, S. Shorbagy","doi":"10.17554/J.ISSN.1819-6187.2016.04.93","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2016.04.93","url":null,"abstract":"Aim: Colorectal carcinoma (CRC) is the commonest and most deathly malignant gastrointestinal tumors. Carcinogenic process starts in a group of cancer cells, called cancer stem cells (CSCs) having the ability to start and maintain tumor growth and invasion. In order to detect and remove colon CSCs, a selective biomarker \"LGR5 (leucine-rich-repeat-containing G-protein-coupled receptor 5)\" might be required. At the same time, an abnormal expression of TPX2 (targeting protein for xenopus kinesin-like protein 2) has been found to be related to the development and progression of tumors. We aimed to evaluate the immunohistochemical expressions of LGR5 and TPX2 in CRC in a trial to clarify their relations to proliferation and metastasis of CRC, and hence its prognosis. Methods: Immunohistochemical staining of both LGR5 and TPX2 was assessed in sections from sixty paraffin blocks of CRC . The relationships between their levels of expressions with the clinicopathological parameters and patient outcome were statistically analyzed. Results: The immunoexpression of LGR5 in CRC was significantly positively correlated with location of the tumor, grade, stage, local recurrence, lymph node and distant metastasis (p <0.001). The expression of TPX2 in CRC was also found to be significantly correlated with the previous parameters (p <0.001). High LGR5 and TPX2 immunohistochemical expressions were strongly correlated with worse 3-year overall survival (OS), local recurrence free survival (LRFS) and distant metastases free survival (DMFS) (P <0.001). Conclusion: High immunohistochemical expressions of both LGR5 and TPX2 and the positive correlation between both of them represent signs of poor prognosis of CRC.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"448-456"},"PeriodicalIF":0.0,"publicationDate":"2016-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Primitive Neuroectodermal Tumour (Pnet) of Kidney with Review of Literature 肾脏原始神经外胚层肿瘤1例并附文献复习

Zhong liu za zhi Pub Date : 2016-06-29 DOI: 10.17554/J.ISSN.1819-6187.2016.04.91

Narendra Kumar, D. Das, V. Simha, V. Bharani, U. Mete

引用次数: 0

PKC-Inhibitors Induce Apoptosis by Inhibiting Hsp70-Mediated Protection of Anti-Apoptotic Bcl2 Proteins in Dalton’s Lymphoma Cells pkc抑制剂通过抑制hsp70介导的抗凋亡Bcl2蛋白的保护诱导道尔顿淋巴瘤细胞凋亡

Zhong liu za zhi Pub Date : 2016-06-29 DOI: 10.17554/J.ISSN.1819-6187.2016.04.85

Sanjay Kumar, M. Tomar, A. Acharya

{"title":"PKC-Inhibitors Induce Apoptosis by Inhibiting Hsp70-Mediated Protection of Anti-Apoptotic Bcl2 Proteins in Dalton’s Lymphoma Cells","authors":"Sanjay Kumar, M. Tomar, A. Acharya","doi":"10.17554/J.ISSN.1819-6187.2016.04.85","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2016.04.85","url":null,"abstract":"BACKGROUND : Proteins of BCl2 family regulate mitochondria-dependent apoptotic pathway, whose down regulation induced apoptosis for which the basis is poorly understood. Therefore, aims of the present investigation were to study the effect of PKC inhibitors (chelerythrine and staurosporine) on the expression of BCl2 proteins in Dalton’s Lymphoma (DL) cells. Further, to identify whether exogenous application of tumor derived hsp70 protects DL cells from PKC-inhibitor-mediated apoptosis. METHODS : To investigate this, cells were harvested from tumor bearing mice after 18 days of post transplantation and cultured for 48hrs in RPMI-1640 supplemented with 10% FBS and 5µg/mL pen/strep in 5% CO2 at 37℃. Cells were then treated with PKC inhibitors (CHE-10µM/STS-1µM) in the presence of HS+, cHS+ and tumor derived hsp70, immunocytochemistry, western blots, RT-PCR, caspase assay, and flowcytomery were carried out. RESULTS : Our results showed that PKC inhibitors (CHE/STS) treatment resulted in depressed expression of BCl2 and Bcl-xL proteins in hsp70-mediated protection while Bax and Bcl-xL were found to be upregulated significantly. Altered expression of BCl2 proteins induced activation of caspase-3 and apoptosis ultimately. CONCLUSION : PKC inhibitors (CHE/STS) treatment may contribute to develop effective therapeutic regimen against Dalton’s lymphoma.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"435-444"},"PeriodicalIF":0.0,"publicationDate":"2016-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pleomorphic Adenoma Versus Warthin Tumor of the Parotid Gland: Diagnostic Value of CT Perfusion Imaging and Its Pathologic Explanation 腮腺多形性腺瘤与疣状瘤:CT灌注成像的诊断价值及其病理解释

Zhong liu za zhi Pub Date : 2016-04-24 DOI: 10.17554/J.ISSN.1819-6187.2016.04.74

Zhifeng Xu, Fangning Rong, Tian Yu, Ying-Yu Chen, Q. Gao, Tian Zhou, A. Pan

{"title":"Pleomorphic Adenoma Versus Warthin Tumor of the Parotid Gland: Diagnostic Value of CT Perfusion Imaging and Its Pathologic Explanation","authors":"Zhifeng Xu, Fangning Rong, Tian Yu, Ying-Yu Chen, Q. Gao, Tian Zhou, A. Pan","doi":"10.17554/J.ISSN.1819-6187.2016.04.74","DOIUrl":"https://doi.org/10.17554/J.ISSN.1819-6187.2016.04.74","url":null,"abstract":"AIM: To investigate the value of CT perfusion (CTP) imaging in the differentiation of pleomorphic adenoma and warthin tumor deriving singly from the parotid gland, and to explain its pathological basis. Methods: CTP was successfully performed in 29 patients with parotid tumors whose diagnoses were confirmed by surgery or biopsy. Data were postprocessed by using the Philips EBW workstation and analyzed using a dynamic analysis module. Postprocessing-generated a tissue time-density curve (TDC) and maps showed blood flow (BF), blood volume (BV), time-to-peak (TTP) and peak enhancement index (PEI). Independent-sample test and receiver operating characteristic (ROC) curves were used to analyze the difference and diagnostic efficacies of all perfusion data between the tumors. HE dyeing pathological section of all tumors was obtained after operation. Results: Perfusion maps of all tumors were successfully obtained. TDC of pleomorphic adenomas mainly showed a gradually ascension, and warthin tumours showed a fast ascent followed by a fast descent. The BF, BV, PEI and TTP values were statistically signiﬁcant different between the pleomorphic adenomas and warthin tumors (p < 0. 01). ROC demonstrated that BF, BV and PEI, except for TTP, had actual significant differences between these two tumor types. Warthin tumors contains rich capillary network, and with a high cellularity-stromal grade. With regard to pleomorphic adenomas, it had less angiogenesis, but abundant muciform and chondroid tissue. Conclusions: CTP could provide TDC and perfusion data, which is feasible to differentiate pleomorphic adenomas from Warthin tumors, and could reflect tumors histopathological feature.","PeriodicalId":90400,"journal":{"name":"Zhong liu za zhi","volume":"4 1","pages":"419-425"},"PeriodicalIF":0.0,"publicationDate":"2016-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67616144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3