The open circulation & vascular journal最新文献_第2页

Angiogenesis in Diabetes. Unraveling the Angiogenic Paradox 糖尿病中的血管生成。解开血管生成悖论

The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010003

R. Soares

{"title":"Angiogenesis in Diabetes. Unraveling the Angiogenic Paradox","authors":"R. Soares","doi":"10.2174/1874382601003010003","DOIUrl":"https://doi.org/10.2174/1874382601003010003","url":null,"abstract":"Angiogenesis can be regarded as a double-edged sword given its useful actions in repairing tissues, and secondly due to its effects in enhancing tissue damage. Angiogenesis is actually involved in the pathogenesis of disorders in which the inflammatory component is a major contributor for disease progression, such as diabetes. It is now stated that angiogenesis together with vasculogenesis partake to neovascular development. A peculiar characteristic of diabetes is the co-existence of vascular impairment and excessive angiogenesis in distinct organs. But despite this knowledge, many questions remain unanswered. Due to the importance of these systems in diabetes-associated complications, a better understanding of the molecular and cellular processes may open new mechanism-based therapeutic options. Accordingly, the available treatment strategies for diabetes management are not completely efficient, as highlighted by the elevated mortality and morbidity rates associated with this condition. Diabetic nephropathy, which may evolve to end-stage renal failure, and diabetic retinopathy that may progress to blindness are important causes of morbidity. Additionally, chronic nonhealing skin ulceration greatly impairs the quality of life of diabetic patients, resulting often in limb amputation. Cardiovascular events, in turn, are responsible for a significant number of deaths in diabetes. This review aims at highlighting the state-of-the-art in diabetic vascular complications, and comprehends the characterization of neovascular system alterations. The elucidation of the diabetic-associated angiogenic paradox is fundamental for prospecting novel therapeutic interventions.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":"39 1","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Endothelial Progenitor Cells and the Diabetic Paradox Current Knowledge and Therapeutic Perspectives 内皮祖细胞与糖尿病悖论，目前的知识和治疗前景

The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010010

C. Costa

{"title":"Endothelial Progenitor Cells and the Diabetic Paradox Current Knowledge and Therapeutic Perspectives","authors":"C. Costa","doi":"10.2174/1874382601003010010","DOIUrl":"https://doi.org/10.2174/1874382601003010010","url":null,"abstract":"The discovery of postnatal vasculogenesis and of the important roles played by bone marrow-derived Endothelial Progenitor Cells was a landmark in vascular biology that forever has changed the concept of neovascularization. Diabetes associated vascular complications involve distinct modifications in neovascular formation, which is reduced in cardiovascular disease and increased in diabetic retinopathy, defining the diabetic paradox. The vasculogenic process seems to play a central dual role in these alterations: by one side dysfunctional EPCs impair endothelial regeneration in peripheral vasculopathy and on the other hand alterations in EPCs are involved in increased retinal vessel growth in diabetic retinopathy. Although still under investigation, these divergent features seem related to a differential response of progenitor cells to ischemic-induced depletion/induction of angiogenic factors. Due to the importance of vasculogenesis, therapeutic interventions targeting EPCs in diabetic vascular complications arose as a potential tool. However, scarce information has been disclosed regarding the safety and harmful side effects of these therapies. Future research is mandatory in order to further elucidate the complex mechanisms governing the diabetic- vasculogenic paradigm, bringing also novel insights into the potential therapeutic usefulness of EPCs.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":"3 1","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diabetic Retinopathy: Understanding Pathologic Angiogenesis and Exploring its Treatment Options 糖尿病视网膜病变:了解病理性血管生成和探索其治疗方案

The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010030

Manuel Falcão, F. Falcão-Reis, A. Rocha-Sousa

{"title":"Diabetic Retinopathy: Understanding Pathologic Angiogenesis and Exploring its Treatment Options","authors":"Manuel Falcão, F. Falcão-Reis, A. Rocha-Sousa","doi":"10.2174/1874382601003010030","DOIUrl":"https://doi.org/10.2174/1874382601003010030","url":null,"abstract":"Diabetic retinopathy is the major cause of blindness at working age. The pathogenesis behind visual loss is re- lated with retinal angiogenesis and increased retinal vascular permeability. These changes seem to be the result of chronic hyperglycemia and hypoxia. Several mechanisms have been proposed to cause the retinal and vasculature cellular dam- age. They include the formation of advanced end glycation products, aldose reductase activity and reactive oxygen spe- cies. Ultimately, they lead to the expression of VEGF-A. This growth factor seems to play the pivotal role in the devel- opment of the complications associated with the disease including break down of the inner blood retinal barrier, macular edema and vasoproliferation. Other mechanisms like inflammation, protein kinase C activity and erythropoietin have been strongly associated with the pathogenesis. Laser therapy is still the standard of care for diabetic retinopathy and prevents severe vision loss in 95% of patients if timely treatment is performed. The better understanding of the disease has led to the production of new management op- tions that may become important adjuvants for the disease. They include intravitreal anti-VEGF therapy, intravitreal ster- oid therapy and systemic protein kinase C inhibitors. Vitrectomy is an important option for advanced cases of the disease such as tractional retinal detachment or non-absorbing vitreous hemorrhages.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":"3 1","pages":"30-42"},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Investigation of the Leg Lymphatic Function in Patients with Leg Acute Venous Thrombosis and in Patients with Leg Post-Thrombotic Syndrome~!2009-11-26~!2009-12-30~!2010-07-07~! 下肢急性静脉血栓及血栓后综合征患者下肢淋巴功能的研究2009-11-26 2009-12-30 2010-07-07

The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010067

A. Cariati

{"title":"Investigation of the Leg Lymphatic Function in Patients with Leg Acute Venous Thrombosis and in Patients with Leg Post-Thrombotic Syndrome~!2009-11-26~!2009-12-30~!2010-07-07~!","authors":"A. Cariati","doi":"10.2174/1874382601003010067","DOIUrl":"https://doi.org/10.2174/1874382601003010067","url":null,"abstract":"Lymphatic and venous systems work together to drain interstitial fluid and blood respectively. Data on lym- phatic function in chronic venous insufficiency and in chronic venous ulcerations are discordant. Modification of lymphatic function in acute venous thrombosis have been never described. The aim of this study is to report the modifications of the function of the lymphatic system in acute venous thrombosis, chronic venous ulceration and post-thrombotic syndrome. Material and Methods: Patients were studied with qualitative and semi-quantitative lymphoscintigraphy. The transport in- dex (TI 60) have been calculated for each patients. Data obtained in group a (13 patients with acute venous thrombosis) (TI 60 = 398); group b (12 limbs of 6 controls) (TI 60 = 203); group c (10 limbs with chronic venous ulcerations) (TI 60 = 114); group d (6 limbs with post-thrombotic syndrome in absence of ulcerations) (TI 60 = 148) were compared with Krus- call-Wallis statistic and Mann-Whitney test. Results: The TI 60 is different in the four groups. Differences are significant between: group a (TI 60 = 398) and group b (TI 60 = 203); group b (TI 60 = 203) and group c (TI 60 = 114); group b (TI 60 = 203) and group d (TI 60 = 148). Discussion: The compensatory function of lymphatic system in acute venous thrombosis is definitively demonstrated. The lymphatic drainage of the limb affected by chronic venous ulceration is reduced. After the healing of the ulceration the lymphatic flow of the limbs affected by post-thrombotic syndrome improves but it remains under the levels of normal subjects.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages. 在晚期动脉粥样硬化病变和氧化LDL处理的人单核细胞源性巨噬细胞中增加Wnt5a mRNA表达。

The open circulation & vascular journal Pub Date : 2012-01-01 DOI: 10.2174/1877382601205010001

Pooja M Bhatt, Christopher J Lewis, Denise L House, Chad M Keller, Leonard D Kohn, Mitchell J Silver, Kelly D McCall, Douglas J Goetz, Ramiro Malgor

{"title":"Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages.","authors":"Pooja M Bhatt, Christopher J Lewis, Denise L House, Chad M Keller, Leonard D Kohn, Mitchell J Silver, Kelly D McCall, Douglas J Goetz, Ramiro Malgor","doi":"10.2174/1877382601205010001","DOIUrl":"https://doi.org/10.2174/1877382601205010001","url":null,"abstract":"Objective: Wnt5a is a secreted glycoprotein highly present in atherosclerotic lesions. Uptake of oxidized-low density lipoprotein (ox-LDL) by monocytes/macrophages plays a critical role in atherosclerosis. The objective of this study was to determine if Wnt5a mRNA expression correlates with the severity of atherosclerotic lesions, and if, ox-LDL can induce Wnt5a mRNA in macrophages.Methods: Wnt5a mRNA in tissue sections from carotid arteries of patients undergoing endarterectomy was quantified via RT-PCR and correlated with plaque severity. Human monocyte-derived macrophages and differentiated THP-1 cells, a human monocytic cell line, were treated with ox-LDL or native-LDL. Subsequently, Wnt5a transcripts were quantified by RT-PCR.Results: Regions of the arteries with more severe plaques had detectable and significant levels of Wnt5a mRNA, while regions of the arteries containing less vulnerable plaques had low or non-detectable Wnt5a. Ox-LDL, but not native-LDL, induced Wnt5a mRNA in both human monocyte-derived macrophages and differentiated THP-1 cells.Conclusion: Our results demonstrate that the expression of Wnt5a correlates with the severity of atherosclerotic lesions, and that ox-LDL induces Wnt5a mRNA expression in human macrophages. These findings are consistent with the hypothesis that Wnt5a plays a critical role in atherosclerosis progression and that a source of Wnt5a is ox-LDL stimulated macrophages.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":"5 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/85/9b/nihms626059.PMC4270053.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32925941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Angiogenesis In Vitro Utilizing Murine Vascular Explants in Miniaturized 3-Dimensional Collagen Gels. 利用小鼠血管外植体在微型三维胶原凝胶中的体外血管生成。

The open circulation & vascular journal Pub Date : 2011-05-09 DOI: 10.2174/1877382601104010012

May J Reed, Mamatha Damodarasamy, Robert B Vernon

引用次数: 4

Evidence for a Role of Cyclic AMP and Endothelium in Rat Aortic Relaxation Induced by R-PIA 环AMP和内皮在R-PIA诱导的大鼠主动脉舒张中的作用证据

The open circulation & vascular journal Pub Date : 2011-03-03 DOI: 10.2174/1877382601104010006

G. Allende, S. Acevedo

引用次数: 3