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Flow Resistance of Vessels with an Enlarged Total Cross-Sectional Area in the Midsection 中截面总横截面积增大时血管的流动阻力
The open circulation & vascular journal Pub Date : 2013-12-27 DOI: 10.2174/1877382601306010009
Yanchun Hu, Shenju Song, Yanxia Hu
{"title":"Flow Resistance of Vessels with an Enlarged Total Cross-Sectional Area in the Midsection","authors":"Yanchun Hu, Shenju Song, Yanxia Hu","doi":"10.2174/1877382601306010009","DOIUrl":"https://doi.org/10.2174/1877382601306010009","url":null,"abstract":"To understand the hemodynamics of the microcirculation, we compared the resistance of vessels that either had an enlarged cross-sectional area in the midsection (denoted vessel 1) or had a uniform diameter (denoted vessel 2). The length of the two vessels and the pressure difference between the ends were equal. The two vessels were filled with water, and the volume of water flowing through the two vessels per second was measured. The volume of water flowing through vessel 1 was 4.05 ml/sec, and the volume of water flowing through vessel 2 was 4.37 ml/sec. Vessel 1 had a higher resis- tance, and water drained more slowly than from vessel 2. These results demonstrate that vessels with a greater cross- sectional area in the midsection have a lower flow than vessels with a constant cross-section, even though resistance in the midsection is lower when the cross-sectional area is greater.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68153481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Role of Collagen in the Aorta's Structure 胶原蛋白在主动脉结构中的作用
The open circulation & vascular journal Pub Date : 2013-02-01 DOI: 10.2174/1877382601306010001
P. Berillis
{"title":"The Role of Collagen in the Aorta's Structure","authors":"P. Berillis","doi":"10.2174/1877382601306010001","DOIUrl":"https://doi.org/10.2174/1877382601306010001","url":null,"abstract":"Aorta is the largest artery in the body. Anatomically, it is traditionally divided into the ascending, the aortic arch, the descending, the thoracic and the abdominal aorta. Collagen is one of the most important components of the aortic wall. Its concentration and its total amount play a significant role in the aortas' function and mechanical properties, such as tensile strength and stiffness. The two main types of collagen found in the aorta are types I and III and they account for 80-90% of the total collagen. Age, sex hormones, aneurysms and hypertension are factors that can alter collagen and its subtypes in the aorta wall. As the aorta is a crucial artery and collagen is one of its most important components, collagen study is a helpful way to deal with aorta's abnormalities.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68153455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
Stent-Assisted Coiling of a Ruptured Renal Artery Aneurysm: an Unusual Cause of Low Back Pain 支架辅助的肾动脉瘤破裂的卷绕:腰痛的一个不寻常的原因
The open circulation & vascular journal Pub Date : 2012-05-15 DOI: 10.2174/1877382601205010008
Jorge A Brenes, A. Irfanullah
{"title":"Stent-Assisted Coiling of a Ruptured Renal Artery Aneurysm: an Unusual Cause of Low Back Pain","authors":"Jorge A Brenes, A. Irfanullah","doi":"10.2174/1877382601205010008","DOIUrl":"https://doi.org/10.2174/1877382601205010008","url":null,"abstract":"Renal artery aneurysms are rare, but their reported incidence has increased as a result of the widespread use of imaging techniques. Most aneurysms are asymptomatic and discovered incidentally; however, they can present with refractory hypertension, pain and hematuria. We report the case of a 42 year old normotensive woman who presented with acute lower back pain with unremarkable lumbar x rays, in the setting of acute anemia with hypotension, leading to a high suspicion for internal bleeding. CT scan of the abdomen and pelvis revealed the presence of a ruptured 1.8 cm right renal artery aneurysm. Successful exclusion of the aneurysm was accomplished by stent-assisted coiling. Follow up imaging at one and six month intervals revealed patency of the stent and no deleterious effects on renal function.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68153009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory and Angiogenic Abnormalities in Diabetic Wound Healing: Role of Neuropeptides and Therapeutic Perspectives 糖尿病伤口愈合中的炎症和血管生成异常:神经肽的作用和治疗前景
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010043
A. Tellechea, E. Leal, A. Veves, E. Carvalho
{"title":"Inflammatory and Angiogenic Abnormalities in Diabetic Wound Healing: Role of Neuropeptides and Therapeutic Perspectives","authors":"A. Tellechea, E. Leal, A. Veves, E. Carvalho","doi":"10.2174/1874382601003010043","DOIUrl":"https://doi.org/10.2174/1874382601003010043","url":null,"abstract":"Diabetic foot ulceration (DFU) is one of the most costly and debilitating complications of diabetes and is the leading cause of non-traumatic amputations, affecting 15% of the diabetic population. Impaired wound healing in diabetic patients without large-vessel disease has been attributed to microvascular dysfunction, neuropathy, and abnormal cellular and inflammatory responses. These abnormalities have been examined mainly in animal models although a few studies have been undertaken in diabetic patients. This review provides an overview of the inflammatory and vascular abnormali- ties in DFU and emphasises the role of angiogenic growth factors, endothelial progenitor cells (EPCs), and neuropeptides as mediators of wound healing and potential therapeutic agents for these chronic, non-healing ulcers.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 43
Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination 以压疮消除为重点的伤口愈合技术
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010072
D. Kuffler
{"title":"Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination","authors":"D. Kuffler","doi":"10.2174/1874382601003010072","DOIUrl":"https://doi.org/10.2174/1874382601003010072","url":null,"abstract":"Pressure ulcers, also called decubitus ulcers, are a common challenge of humanity. They are wounds initiated by pressure on the skin that blocks circulation causing the skin and underlying tissues to die. Without care, pressure ulcers continue to grow in diameter and depth and are exceptionally difficult to heal. They have probably always existed, and are present on Egyptian mummies. Pressure ulcers are a serious health issue, very painful, a significant physiological challenge, can shorten the life of a patient, are an emotional and financial burden to the patient, those who deal with them, and in the United States alone annually costs in excess over $10 billion dollars for care and prolonged hospitalization. Pressure ulcers can develop with as little as two hours of pressure, and because even a brief lapse in avoidance of pressure leads to ulcers, they are frequently impossible to prevent, even for the most conscientious patient with an extensive support group and unlimited financial resources. Therefore, enormous effort is required to find effective and reliable techniques for preventing the initiation of ulcers and eliminating them once they develop. This review looks at the various approaches presently used and in development for the treatment of pressure ulcers, evaluates which may be best in eliminating ulcers, and discusses combinations of techniques that may be most effective in eliminating pressure ulcers.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
The Role of Oxidative Stress in Modulation of the Relaxant Responses of Saphenous Vein and Internal Mammary Artery 氧化应激在调节隐静脉和乳腺内动脉松弛反应中的作用
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010059
A. Muir
{"title":"The Role of Oxidative Stress in Modulation of the Relaxant Responses of Saphenous Vein and Internal Mammary Artery","authors":"A. Muir","doi":"10.2174/1874382601003010059","DOIUrl":"https://doi.org/10.2174/1874382601003010059","url":null,"abstract":"Altered endothelial activity is enumerated amongst the leading causes of graft dysfunction following coronary artery bypass surgery and may account for differences in patency between arterial and venous grafts. This study investigates whether differences exist between basal endothelial functions of saphenous vein (SV) and internal mammary arteries (IMA) and explores the putative involvements of reactive oxygen species in this phenomenon. Basal relaxations were greater in IMA than SV. Specific inhibitor of nitric oxide synthase (L-NAME) attenuated dilatory responses while a superoxide anion scavenger (Tiron) displayed a positive effect in both vessel types. MnTBAP, a superoxide dismutase mimetic, improved relaxation in the SV only whereas specific inhibitors of pro-oxidant enzyme NADPH oxidase and cGMP pathway reduced that of the IMA. Rotenone, allopurinol and indomethacin diminished relaxations in the IMA but accentuated SV dilatation. In conclusion, the greater intrinsic antioxidant capacity may explain why IMA make better conduits than SV.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Diabetes, Ghrelin And Related Peptides: From Pathophysiology To Vasculopathy 糖尿病、胃饥饿素和相关肽:从病理生理学到血管病变
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010017
A. Rocha-Sousa
{"title":"Diabetes, Ghrelin And Related Peptides: From Pathophysiology To Vasculopathy","authors":"A. Rocha-Sousa","doi":"10.2174/1874382601003010017","DOIUrl":"https://doi.org/10.2174/1874382601003010017","url":null,"abstract":"Ghrelin and obestatin are two different peptides originated from the same gene isolated in the stomach. Numer- ous actions have been described where these two peptides are implicated in metabolism, appetite regulation, glucose lev- els regulation, and a wide range of systemic effects. In this article, we summarize (1) the cellular receptors implicated in ghrelin and obestatin effects; (2) the role of ghrelin and obestatin in metabolism and appetite regulation; (3) their role in the glucose homeostasis regulation and its implication in diabetes patho-physiology; (5) the effects of ghrelin and obes- tatin in regulation of normal angiogenesis and (6) their possible role in the regulation of diabetes-induced pathologic angi- ogenesis.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Vascular Responses to Shear Stress: The Involvement of Mechanosensors in Endothelial Cells~!2009-12-23~!2010-04-27~!2010-08-06~! 血管对剪切应力的反应:内皮细胞中机械传感器的参与
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010085
C. Ngai, X. Yao
{"title":"Vascular Responses to Shear Stress: The Involvement of Mechanosensors in Endothelial Cells~!2009-12-23~!2010-04-27~!2010-08-06~!","authors":"C. Ngai, X. Yao","doi":"10.2174/1874382601003010085","DOIUrl":"https://doi.org/10.2174/1874382601003010085","url":null,"abstract":"Shear stress, the frictional drag on the endothelium from blood flow, is a major determinant of vascular physi- ology and pathology. Due to the pulsatile nature of blood flow, blood vessels are subjected to significant variations in me- chanical forces. Endothelial cells situated at the interface between blood and the vessel wall play a crucial role in detecting and responding to the mechanical forces generated by shear stress. Multiple sensing mechanisms are used by endothelial cells to detect changes in mechanical forces, leading to the activation of signaling networks. This review attempts to bring together recent findings on the mechanosensors present in the endothelial cells, and the regulation of endothelium-derived vasoactive autacoid production by shear stress.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Mistaken Identity of Popliteal Artery Pseudoaneurysm for Deep Vein Thrombosis: a Case Report~!2009-05-04~!2009-08-31~!2010-04-07~! 误认腘动脉假性动脉瘤为深静脉血栓1例
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010056
T. G. Rashid, Z. Andreou, M. Metcalfe, A. Marcus, K. Lotzof, R. Bird
{"title":"Mistaken Identity of Popliteal Artery Pseudoaneurysm for Deep Vein Thrombosis: a Case Report~!2009-05-04~!2009-08-31~!2010-04-07~!","authors":"T. G. Rashid, Z. Andreou, M. Metcalfe, A. Marcus, K. Lotzof, R. Bird","doi":"10.2174/1874382601003010056","DOIUrl":"https://doi.org/10.2174/1874382601003010056","url":null,"abstract":"Popliteal artery aneurysms are often incorrectly diagnosed and subsequently mismanaged with resultant preventable complications. We present a case of a swollen lower extremity clinically resembling a deep vein thrombosis (DVT), following tibial fracture fixation. It was treated as a DVT on the basis of ultrasound imaging at a different hospital. Subsequent imaging showed a popliteal artery pseudoaneurysm for which the patient required 'acute' surgical intervention. DVTs and popliteal artery aneurysms and pseudoaneurysms may coexist. We stress the importance of searching for them in patients with suspected DVT, despite an ultrasound scan (USS) which is negative or positive for thrombosis.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Editorial - Vascular Complications in Diabetes 社论-糖尿病的血管并发症
The open circulation & vascular journal Pub Date : 2012-03-15 DOI: 10.2174/1874382601003010001
R. Soares
{"title":"Editorial - Vascular Complications in Diabetes","authors":"R. Soares","doi":"10.2174/1874382601003010001","DOIUrl":"https://doi.org/10.2174/1874382601003010001","url":null,"abstract":"","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68069714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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