{"title":"糖尿病、胃饥饿素和相关肽:从病理生理学到血管病变","authors":"A. Rocha-Sousa","doi":"10.2174/1874382601003010017","DOIUrl":null,"url":null,"abstract":"Ghrelin and obestatin are two different peptides originated from the same gene isolated in the stomach. Numer- ous actions have been described where these two peptides are implicated in metabolism, appetite regulation, glucose lev- els regulation, and a wide range of systemic effects. In this article, we summarize (1) the cellular receptors implicated in ghrelin and obestatin effects; (2) the role of ghrelin and obestatin in metabolism and appetite regulation; (3) their role in the glucose homeostasis regulation and its implication in diabetes patho-physiology; (5) the effects of ghrelin and obes- tatin in regulation of normal angiogenesis and (6) their possible role in the regulation of diabetes-induced pathologic angi- ogenesis.","PeriodicalId":90364,"journal":{"name":"The open circulation & vascular journal","volume":"9 33 1","pages":"17-29"},"PeriodicalIF":0.0000,"publicationDate":"2012-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Diabetes, Ghrelin And Related Peptides: From Pathophysiology To Vasculopathy\",\"authors\":\"A. Rocha-Sousa\",\"doi\":\"10.2174/1874382601003010017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ghrelin and obestatin are two different peptides originated from the same gene isolated in the stomach. Numer- ous actions have been described where these two peptides are implicated in metabolism, appetite regulation, glucose lev- els regulation, and a wide range of systemic effects. In this article, we summarize (1) the cellular receptors implicated in ghrelin and obestatin effects; (2) the role of ghrelin and obestatin in metabolism and appetite regulation; (3) their role in the glucose homeostasis regulation and its implication in diabetes patho-physiology; (5) the effects of ghrelin and obes- tatin in regulation of normal angiogenesis and (6) their possible role in the regulation of diabetes-induced pathologic angi- ogenesis.\",\"PeriodicalId\":90364,\"journal\":{\"name\":\"The open circulation & vascular journal\",\"volume\":\"9 33 1\",\"pages\":\"17-29\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The open circulation & vascular journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874382601003010017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open circulation & vascular journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874382601003010017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Diabetes, Ghrelin And Related Peptides: From Pathophysiology To Vasculopathy
Ghrelin and obestatin are two different peptides originated from the same gene isolated in the stomach. Numer- ous actions have been described where these two peptides are implicated in metabolism, appetite regulation, glucose lev- els regulation, and a wide range of systemic effects. In this article, we summarize (1) the cellular receptors implicated in ghrelin and obestatin effects; (2) the role of ghrelin and obestatin in metabolism and appetite regulation; (3) their role in the glucose homeostasis regulation and its implication in diabetes patho-physiology; (5) the effects of ghrelin and obes- tatin in regulation of normal angiogenesis and (6) their possible role in the regulation of diabetes-induced pathologic angi- ogenesis.