Research and reports in endocrine disorders最新文献

Association between the biochemical profiles in blood and bone mineral density in Chinese Han population: findings from a cross-sectional study 中国汉族人群血液生化特征与骨密度之间的关系:一项横断面研究的结果

Research and reports in endocrine disorders Pub Date : 2016-11-03 DOI: 10.2147/RRED.S99437

Hongxia Chen, Libing Wu, Z. Meng

引用次数: 0

Prader–Willi syndrome: clinical problems in transition from pediatric to adult care 普拉德-威利综合征:从儿科到成人护理过渡的临床问题

Research and reports in endocrine disorders Pub Date : 2016-07-18 DOI: 10.2147/RRED.S56401

A. Crinò, D. Fintini, S. Bocchini, C. Carducci, G. Grugni

引用次数: 8

Shared decision making and patient choice for growth hormone therapy: current perspectives 共同决策和患者选择生长激素治疗:目前的观点

Research and reports in endocrine disorders Pub Date : 2016-06-09 DOI: 10.2147/RRED.S79144

B. George, V. Ayyar

引用次数: 1

Prediction of diabetic foot ulcer healing in type 2 diabetic subjects using routine clinical and laboratory parameters 应用常规临床和实验室参数预测2型糖尿病患者糖尿病足溃疡愈合

Research and reports in endocrine disorders Pub Date : 2016-03-22 DOI: 10.2147/RRED.S98506

A. Algoblan, Ibrahim M Alrasheedi, Osman H Basheir, K. Haider

引用次数: 14

Pathophysiology and therapeutic options in osteogenesis imperfecta: an update 成骨不全症的病理生理学和治疗选择:最新进展

Research and reports in endocrine disorders Pub Date : 2016-03-01 DOI: 10.2147/RRED.S96578

J. Shapiro, E. Brizola, T. Félix

引用次数: 9

Profile of alglucosidase alfa in the treatment of Pompe disease: safety, efficacy, and patient acceptability alfa糖苷酶治疗庞贝病的概况:安全性、有效性和患者可接受性

Research and reports in endocrine disorders Pub Date : 2016-01-08 DOI: 10.2147/RRED.S72834

I. Schneider, S. Zierz

引用次数: 6

Type 1 diabetes: addressing the transition from pediatric to adult-oriented health care. 1 型糖尿病：解决从以儿童为导向的医疗保健向以成人为导向的医疗保健过渡的问题。

Research and reports in endocrine disorders Pub Date : 2016-01-01 Epub Date: 2016-04-13 DOI: 10.2147/RRED.S56609

Maureen Monaghan, Katherine Baumann

{"title":"Type 1 diabetes: addressing the transition from pediatric to adult-oriented health care.","authors":"Maureen Monaghan, Katherine Baumann","doi":"10.2147/RRED.S56609","DOIUrl":"10.2147/RRED.S56609","url":null,"abstract":"<p><p>Adolescents and young adults with type 1 diabetes are at risk for poor health outcomes, including poor glycemic control, acute and chronic complications, and emergency department admissions. During this developmental period, adolescent and young adult patients also experience significant changes in living situation, education, and/or health care delivery, including transferring from pediatric to adult health care. In recent years, professional and advocacy organizations have proposed expert guidelines to improve the process of preparation for and transition to adult-oriented health care. However, challenges remain and evidence-based practices for preparing youth for adult health care are still emerging. Qualitative research suggests that adolescent and young adult patients rely on health care providers to guide them through the transition process and appreciate a gradual approach to preparing for adult-oriented health care, keeping parents in supportive roles into young adulthood. Patients also benefit from specific referrals and contact information for adult care providers. Promising models of transition care include provision of transition navigators, attendance at a young adult bridge clinic, or joint visits with pediatric and adult care providers. However, much of this research is in its early stages, and more rigorous trials need to be conducted to evaluate health outcomes during transition into adult health care. The purpose of this review is to provide an overview of the transition process, patient and health care provider perceptions of transition care, and emerging evidence of successful models of care for engagement in adult-oriented health care. Recommendations and resources for health care providers are also presented.</p>","PeriodicalId":90317,"journal":{"name":"Research and reports in endocrine disorders","volume":"6 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68477579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystic fibrosis-related diabetes: links, challenges, and future directions 囊性纤维化相关糖尿病:联系、挑战和未来方向

Research and reports in endocrine disorders Pub Date : 2015-11-05 DOI: 10.2147/RRED.S68278

S. Sheikh, A. Kelly

引用次数: 2

Hsp90 as a therapeutic target in endocrinology: current evidence Hsp90作为内分泌学的治疗靶点:目前的证据

Research and reports in endocrine disorders Pub Date : 2015-10-23 DOI: 10.2147/RRED.S68546

T. Ratajczak, B. Ward, J. Walsh, C. Cluning

{"title":"Hsp90 as a therapeutic target in endocrinology: current evidence","authors":"T. Ratajczak, B. Ward, J. Walsh, C. Cluning","doi":"10.2147/RRED.S68546","DOIUrl":"https://doi.org/10.2147/RRED.S68546","url":null,"abstract":"The ability of heat shock protein 90 (Hsp90) to modulate many growth and signal- ing pathways simultaneously makes it an attractive target in the field of cancer therapeutics and provided the initial impetus for significant efforts over the past decade to identify Hsp90 inhibitors, several of which are now showing promise in the clinic for cancer treatment. The four known human Hsp90 members are compartmentalized: Hsp90α and β in the cytoplasm, GRP94 in the endoplasmic reticulum, and TRAP1 in the mitochondrial matrix. While these isoforms share a similar N-terminal domain adenosine triphosphate-binding pocket, structural variations allow unique interactions for inhibitors targeting this binding site, providing an avenue for the development of paralog-selective drugs with different biological effects applicable therapeuti- cally to a wide range of diseases. At the same time, the conformational flexibility of the Hsp90 molecular chaperone has unveiled multiple small-molecule target sites within all subdomains of the protein, greatly expanding opportunities for viable drug development. This review summa- rizes the function, expression, and clinical significance of the Hsp90 isoforms and elaborates on the inhibitors and modulators that impact Hsp90 chaperone activity. Finally, the review focuses on the therapeutic utility of a range of Hsp90-modulating agents in the treatment of specific diseases associated with the endocrine system.","PeriodicalId":90317,"journal":{"name":"Research and reports in endocrine disorders","volume":"5 1","pages":"141-155"},"PeriodicalIF":0.0,"publicationDate":"2015-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRED.S68546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68477519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Prevalence of 25-hydroxyvitamin D deficiency in healthy personnel from an academic institution of an urban area in Costa Rica 哥斯达黎加城市地区某学术机构健康人员25-羟基维生素D缺乏症患病率

Research and reports in endocrine disorders Pub Date : 2015-10-12 DOI: 10.2147/RRED.S90435

Tatiana Gamboa-Gamboa, Gabriel Abarca-Soto, José G. Jiménez-Montero

{"title":"Prevalence of 25-hydroxyvitamin D deficiency in healthy personnel from an academic institution of an urban area in Costa Rica","authors":"Tatiana Gamboa-Gamboa, Gabriel Abarca-Soto, José G. Jiménez-Montero","doi":"10.2147/RRED.S90435","DOIUrl":"https://doi.org/10.2147/RRED.S90435","url":null,"abstract":"Objective: The aim of this study was to determine 25-hydroxyvitamin D concentrations in healthy employees of the Universidad de Ciencias Médicas, Costa Rica. Methods: Levels of 25-hydroxyvitamin D, calcium, phosphorus, intact parathyroid hormone (iPTH), and creatinine were measured in 80 people. Solar ultraviolet radiation exposure and 25- hydroxyvitamin D intake were estimated using a previously designed questionnaire. Participants were 52 women aged (mean ± standard deviation) 35.8 ± 10.0 years old, body mass index of 27.1 ± 5.9 kg/m 2 , and 26 men aged 36.4 ± 10.8 years old, body mass index of 27.5 ± 5.0 kg/m 2 . Results: All participants were normocalcemic, eight females were postmenopausal, three were hypertensive; none had renal, gastrointestinal, or thyroid disease. The level of 25-hydroxyvitamin D was 23.9 ± 7.0 ng/dL and iPTH 40.1 ± 17.5 pg/dL. A level of 25-hydroxyvitamin D $ 30 ng/dL was seen in 17% of the population. The eight participants with iPTH higher than 67 ng/dL, had 25-hydroxyvitamin D of 18.9 ± 4.8 ng/dL. Two participants who received 25-hydroxyvitamin D and calcium supplements were excluded. Conclusion: The 25-hydroxyvitamin D insufficiency and deficiency found in healthy employees from an academic center in Costa Rica may be due to working long hours in-doors and solar ultraviolet radiation exposure. It is unknown whether secondary hyperparathyroidism seen in nearly 10% of this population, may have long-term effects on bone health.","PeriodicalId":90317,"journal":{"name":"Research and reports in endocrine disorders","volume":"5 1","pages":"135-140"},"PeriodicalIF":0.0,"publicationDate":"2015-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRED.S90435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68478301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0