B. Siddiqui, V. Anthony, K. Pathak, Shubhangi Singh, Rajeshwari Chandrakar, D. Jain
{"title":"Review on herbal drugs nanonization for the treatment of breast cancer","authors":"B. Siddiqui, V. Anthony, K. Pathak, Shubhangi Singh, Rajeshwari Chandrakar, D. Jain","doi":"10.55006/biolsciences.2022.2302","DOIUrl":"https://doi.org/10.55006/biolsciences.2022.2302","url":null,"abstract":"In the field of nanotechnology recent advances in phytomedicine are providing positive outcomes for the cancer treatment due to increasing knowledge of the molecular mechanisms underlying cancer progression. Naturally occurring chemical compounds from herbal plants are known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. With the application of nanotechnology of nanonization of herbal drugs, it will make the development of nanoherbal medicine possess high bioavaibility, extended half-life, increased immune evasion and targeted ability at the tumor site and good antitumor activity and eco-friendly which consequently will open the new era of herbal drug discovery. This review aims to highlight the potential of nanotechnology used with herbal plants, along with their pharmacologic action molecular or specific targets for the treatment of breast cancer.","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70991355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and Evaluation of Resveratrol Loaded Modified Oleic Acid Based Vesicles for the Treatment of UV-B Induced Precancerous Skin Lesions","authors":"Arun Singh Lalotra, Vishesh Singh","doi":"10.55006/biolsciences.2021.1104","DOIUrl":"https://doi.org/10.55006/biolsciences.2021.1104","url":null,"abstract":"","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70990577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The fate of carboxymethyl cellulose as a polymer of pharmaceutical importance","authors":"Arghya Paria, V. K. Rai","doi":"10.55006/biolsciences.2022.2204","DOIUrl":"https://doi.org/10.55006/biolsciences.2022.2204","url":null,"abstract":"Carboxymethyl cellulose (CMC) is one of the most widely used cellulose derivatives. This polymer is commonly used in several sectors, such as food, paper mills, textile, and pharmaceutical industries. CMC also has versatile applications in biomedical engineering, treatment of wastewater, energy production units, and many more. The main reason for selecting this polymer is its characteristic surface properties, mechanical/tensile strength, hydrophilicity, viscous properties, and majorly abundance source of raw materials. CMC production is a low-cost process that can be carried out quickly on a lab scale. Several research publications have been published on CMC, depending on the origins and application domains. This review provides general information on this material's properties, which justifies its applications in several medical and non-medical sectors.","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70990816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mishra, Disha Sharma, Km. Shanno, Sudhanshu Mishra
{"title":"Amyotrophic lateral sclerosis is a complicated challenge that needs distinct evaluation","authors":"M. Mishra, Disha Sharma, Km. Shanno, Sudhanshu Mishra","doi":"10.55006/biolsciences.2021.1109","DOIUrl":"https://doi.org/10.55006/biolsciences.2021.1109","url":null,"abstract":"","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70990748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atorvastatin with Lactobacillus rhamnosus supplementation Ameliorates Pathogenesis of High fat-High fructose diet induced non-alcoholic fatty liver disease in rats","authors":"A. Roy, Lahanya Guha","doi":"10.55006/biolsciences.2022.2206","DOIUrl":"https://doi.org/10.55006/biolsciences.2022.2206","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is a broad term that includes anything from simple adipose tissue deposition in the liver to more advanced steatosis with concomitant hepatitis, fibrosis, and cirrhosis. The incidence of NAFLD is predicted to rise because of the increased prevalence of related disorders such as obesity and type 2 diabetes mellitus (T2DM). All statins seem to be successful in decreasing patients' cholesterol levels with NAFLD, while there is greater experience with atorvastatin, the only statin that has been shown to reduce the risk of cardiovascular events in these individuals. Atorvastatin, like other statins, acts by blocking HMG-CoA reductase, an enzyme located in liver tissue that is important in the production of cholesterol in the body. But Atorvastatin's primary adverse impact is a loss of muscle and an accelerated breakdown of muscular tissue (rhabdomyolysis). Certain probiotic lactobacilli strains offer positive benefits, most likely via anti-inflammatory activities and intestinal barrier stability, which reduces liver diseases. The present study's goal is to see how Atorvastatin at a subtherapeutic dosage combined with a probiotic strain, Lactobacillus rhamnosus, affects male SD rats in the treatment of NAFLD.","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70991252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonia Tanwar, P. Dhakad, Garima Dhingra, Kartik Tanwar
{"title":"A review on salient pharmacological features and chemical constituents of bitter melon","authors":"Sonia Tanwar, P. Dhakad, Garima Dhingra, Kartik Tanwar","doi":"10.55006/biolsciences.2022.2207","DOIUrl":"https://doi.org/10.55006/biolsciences.2022.2207","url":null,"abstract":"Since prehistoric times, plants have been used as medicine and foodstuff across the world. The Cucurbitaceae family includes the Bitter Melon, Momordica charantia. The bitter melon plant is a vine with green leaves and yellow blooms, and the cucumber-like fruit is rectangular and green. It has been used as food and medicine for millennia in the Amazon, Asia, South America, India, East Africa, and the Caribbean. The name \"Momordica\" derives from the Latin word mordica, which means \"to bite,\" and refers to the notched margins of the leaf that appear to have been bitten. The plant, also known as \"bitter melon\" or \"bitter gourd,\" lives truly the case to its common name by being exceedingly bitter throughout, including the fruit. This review seeks to offer information on the distribution and cultivation of bitter gourd and also explain the chemical constituents and their biological or pharmacological activity of herbal drugs of Momordica charantia Linn. (Cucurbitaceae). Our first goal was to understand more about the different pharmacological activity of the plant and the mode of action through which the activity is responsible. This review gives a thorough knowledge of traditional use of Momordica charantia with its detailed botanical description. Momordica charantia includes a large number of chemically distinct compounds, needing intensive screening processes to determine the pharmacological effects of its phytoconstituents at the molecular level. Furthermore, the paper highlights the medicinal potential of its bioactive components as well as their use in value-added food items. It has the power to fight against numerous lifestyle-related ailments, such as cancer recurrence, diabetes mellitus, abdominal pain, kidney (stone), fever, and scabies, due to the presence of bioactive chemicals.","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70991289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Rahman, Mohd Rabi Bazaz, Tulasi Pasam, M. Kumar, Manoj P. Dandekar
{"title":"Importance of biological clock epigenetics in the manifestation of polycystic ovary syndrome","authors":"Z. Rahman, Mohd Rabi Bazaz, Tulasi Pasam, M. Kumar, Manoj P. Dandekar","doi":"10.55006/biolsciences.2021.1107","DOIUrl":"https://doi.org/10.55006/biolsciences.2021.1107","url":null,"abstract":"","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70990642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"P53 an oncogene or tumor suppressor gene: A confusion","authors":"J. A. Malik","doi":"10.55006/biolsciences.2021.1108","DOIUrl":"https://doi.org/10.55006/biolsciences.2021.1108","url":null,"abstract":"","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70990683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Green synthesis of metallic nanoparticles: Advancements and future perspectives","authors":"Smriti Ojha","doi":"10.55006/biolsciences.2022.2305","DOIUrl":"https://doi.org/10.55006/biolsciences.2022.2305","url":null,"abstract":"As an alternative to chemical and physical approaches, green synthesis of metal nanoparticles is a developing area in the field of bio-nanotechnology and offers economic and environmental benefits. In the field of health and hygiene, engineered metal nanoparticles have increased their popularity due to their effectiveness in penetrating living systems. Metal nanoparticles can be efficiently biosynthesized using a range of microbes and plant extracts. Green synthesis of these nanoparticles and their use in diverse technologies have a bright future due to the shifting perspectives of the international community on sustainable development, environmental improvement, and the reduction of dangerous man-made waste. The focus of the current review was primarily on various methods employed for the green synthesis of metal nanoparticles, which is a more environment-friendly technique for creating metallic nanocarriers and altering their surfaces, use these metal nanoparticles, including metal sulfides, zinc oxide, copper, gold, platinum, and palladium, as well as nano metal-organic frameworks, in drug delivery systems.","PeriodicalId":90302,"journal":{"name":"Progress in nuclear energy. Series 6 Biological sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70991094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}