Nicolas Lorente, Karen Champenois, Jérôme Blanche, Marie Préau, Marie Suzan-Monti, Marion Mora, Lionel Fugon, Maria Patrizia Carrieri, Luis Sagaon-Teyssier, Jean-Marie Le Gall, Bruno Spire, Yazdan Yazdanpanah
{"title":"Investigating Recent Testing among MSM: Results from Community-Based HIV Rapid Testing Attendees in France.","authors":"Nicolas Lorente, Karen Champenois, Jérôme Blanche, Marie Préau, Marie Suzan-Monti, Marion Mora, Lionel Fugon, Maria Patrizia Carrieri, Luis Sagaon-Teyssier, Jean-Marie Le Gall, Bruno Spire, Yazdan Yazdanpanah","doi":"10.1155/2013/648791","DOIUrl":"https://doi.org/10.1155/2013/648791","url":null,"abstract":"<p><p>Background. We aimed to identify factors associated with recent HIV testing in MSM who attended two experimental community-based and nonmedicalized voluntary counselling and testing programmes (CB-VCT) targeting MSM in France. Methods. This analysis was based on data collected in 2009-2011 through a self-administered pretesting questionnaire. An index measuring the level of participants' sexual orientation disclosure was built: the higher the index, the greater the disclosure. Factors associated with recent HIV testing (last test ≤ 1 year) were identified using a multivariate logistic regression model adjusted for the CB-VCT programme of enrolment. Results. 716 MSM provided data on testing history. Overall, 49% were recently tested for HIV and 51% were not. Recently tested MSM had a higher homosexuality disclosure index (adjusted OR [95% confidence interval]: aOR = 1.2 [1.1-1.4]), reported more inconsistent condom use during anal sex with men (aOR = 1.6 [1.2-2.1]), and were less likely to have sex under the influence of club drugs (aOR = 0.6 [0.4-1.0]). Conclusion. New testing strategies should focus on those who live their homosexuality relatively secretly and those who use club drugs before sex. Governments should develop policies which encourage improved social acceptance of homosexuality as concealment of sexual orientation represents a major barrier to testing. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"648791"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33959098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Marchetti, Laura Comi, Teresa Bini, Marco Rovati, Francesca Bai, Barbara Cassani, Marina Ravizza, Marco Tarozzi, Alessandro Pandolfo, Serena Dalzero, Enrico Opocher, Solange Romagnoli, Antonio Carrassi, Silvano Bosari, Antonella d'Arminio Monforte
{"title":"HPV Infection in a Cohort of HIV-Positive Men and Women: Prevalence of Oncogenic Genotypes and Predictors of Mucosal Damage at Genital and Oral Sites.","authors":"Giulia Marchetti, Laura Comi, Teresa Bini, Marco Rovati, Francesca Bai, Barbara Cassani, Marina Ravizza, Marco Tarozzi, Alessandro Pandolfo, Serena Dalzero, Enrico Opocher, Solange Romagnoli, Antonio Carrassi, Silvano Bosari, Antonella d'Arminio Monforte","doi":"10.1155/2013/915169","DOIUrl":"https://doi.org/10.1155/2013/915169","url":null,"abstract":"<p><p>The aim of this study was to assess the prevalence of HPV infection and determinants of abnormal cytology in HIV-positive patients. In a cross-sectional study, patients of both sexes, asymptomatic for HPV, underwent anorectal (men)/cervical (women) and oral swabs. Cytology and HPV-PCR detection/genotyping (high- and low-risk genotypes, HR-LR/HPV) were performed. A total of 20% of the 277 enrolled patients showed oral HPV, with no atypical cytology; in men, anal HPV prevalence was 81% with 64% HR genotypes. In women, cervical HPV prevalence was 58% with 37% HR-HPV. The most frequent genotypes were HPV-16 and HPV-18; 37% of men and 20% of women harbored multiple genotypes. Also, 47% of men showed anal squamous intraepithelial lesions (SILs); 6% had high- and 35% low-grade SILs (HSILs/LSILs); 5% had atypical squamous cells of undetermined significance (ASC-US). HR-HPV was independently associated with anal-SIL in men (P = 0.039). Moreover, 37% of women showed cervical SIL: 14 ASC-US, 15 LSILs, 4 HSILs, and 1 in situ cancer. The presence of both LR and HR-HPV in women was independently associated with SIL (P = 0.003 and P = 0.0001). HR-HPV and atypical cytology were frequently identified in our cohort. HPV screening should be mandatory in HIV-infected subjects, and vaccine programs for HPV-negative patients should be implemented. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"915169"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/915169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33960018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Josephine Lusk, Ruby N N Uddin, Monica M Lahra, Frances L Garden, Ratan L Kundu, Pam Konecny
{"title":"Pharyngeal Gonorrhoea in Women: An Important Reservoir for Increasing Neisseria gonorrhoea Prevalence in Urban Australian Heterosexuals?","authors":"M Josephine Lusk, Ruby N N Uddin, Monica M Lahra, Frances L Garden, Ratan L Kundu, Pam Konecny","doi":"10.1155/2013/967471","DOIUrl":"10.1155/2013/967471","url":null,"abstract":"<p><p>We aim to characterize sexual behavioral aspects of heterosexual Neisseria gonorrhoea (NG) acquisition in two Sexually Transmitted Diseases clinics in Sydney, Australia, in 2008-2012. Of 167 NG cases, 102 were heterosexually acquired with a trend of increasing NG prevalence in heterosexuals from 1.1% (95% CI 0.6-2.1) in 2008 to 3.0% (95% CI 2.0-4.0) in 2012 (P = 0.027). Of heterosexual male cases, unprotected fellatio was the likely sexual activity for NG acquisition in 21/69 (30.4%) and commercial sex work (CSW) contact the likely source in 28/69 (40.6%). NG prevalence overall in CSW (2.2%) was not significantly higher than in non-CSW (1.2%) (P = 0.15), but in 2012 there was a significant increase in NG prevalence in CSW (8.6%) compared to non-CSW (1.6%) (P < 0.001). Pharyngeal NG was found in 9/33 (27.3%) female cases. Decreased susceptibility to ceftriaxone (MIC ≥ 0.03 mg/L) occurred in 2.5% NG isolates, none heterosexually acquired. All were azithromycin susceptible. A significant trend of increasing prevalence of heterosexual gonorrhoea in an urban Australian STD clinic setting is reported. We advocate maintenance of NG screening in women, including pharyngeal screening in all women with partner change who report fellatio, as pharyngeal NG may be an important reservoir for heterosexual transmission. Outreach to CSW should be enhanced. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"967471"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33960021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christopher Darlow, Peter Tovey, Fiona Wallis, Clare Knowles, Ian Fairley, Charles Lacey, Fabiola Martin
{"title":"Remembering the Children: Implementation and Success of a Robust Method for Identifying and Testing Children of HIV Patients.","authors":"Christopher Darlow, Peter Tovey, Fiona Wallis, Clare Knowles, Ian Fairley, Charles Lacey, Fabiola Martin","doi":"10.1155/2013/828024","DOIUrl":"https://doi.org/10.1155/2013/828024","url":null,"abstract":"<p><p>Background. Children of HIV patients are a historically neglected demographic by HIV services. It has been recommended by CHIVA that HIV services have a robust method of detecting and testing untested children. We note that no such method is either in widespread use or in the literature. Method. In December 2011, a one-page proforma to identify HIV untested children and a clear multidisciplinary pathway to test them were implemented. Twelve months later the uptake of the proforma and pathway, the numbers of patients and children identified for testing, and their outcomes were audited. Results. The proforma was completed in 192/203 (94.6%) eligible patients. Twenty-five (21.5%) of 118 identified offspring had not been tested. Ten (8.5%) of these were <18 years old. All were reported to be clinically well. Ten children were referred for testing, seven were tested immediately, and three were tested within 18 months of identification. All children were tested HIV negative. Discussion. We have identified a method of identification that is easy and robust and provides a user-friendly safety net to empower healthcare providers to identify and test children at risk. We recommend the implementation of such strategies nationwide to prevent death due to undiagnosed HIV in children. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"828024"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/828024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33959101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Velia Ramírez-Amador, Gabriela Anaya-Saavedra, Brenda Crabtree-Ramírez, Lilly Esquivel-Pedraza, Marcela Saeb-Lima, Juan Sierra-Madero
{"title":"Clinical Spectrum of Oral Secondary Syphilis in HIV-Infected Patients.","authors":"Velia Ramírez-Amador, Gabriela Anaya-Saavedra, Brenda Crabtree-Ramírez, Lilly Esquivel-Pedraza, Marcela Saeb-Lima, Juan Sierra-Madero","doi":"10.1155/2013/892427","DOIUrl":"https://doi.org/10.1155/2013/892427","url":null,"abstract":"<p><p>Background. Oral lesions may constitute the first clinical manifestation in secondary syphilis, but detailed descriptions in HIV-infected individuals are scarce. Objective. To describe the clinical characteristics of oral secondary syphilis in HIV-infected patients and its relevance in the early diagnosis of syphilis. Methods. Twenty HIV/AIDS adult subjects with oral secondary syphilis lesions presenting at two HIV/AIDS referral centers in Mexico City (2003-2011) are described. An oral examination was performed by specialists in oral pathology and medicine; when possible, a punch biopsy was done, and Warthin-Starry stain and immunohistochemistry were completed. Intraoral herpes virus infection and erythematous candidosis were ruled out by cytological analysis. Diagnosis of oral syphilis was confirmed with positive nontreponemal test (VDRL), and, if possible, fluorescent treponemal antibody test. Results. Twenty male patients (median age 31.5, 21-59 years) with oral secondary syphilis lesions were included. Oral lesions were the first clinical sign of syphilis in 16 (80%) cases. Mucous patch was the most common oral manifestation (17, 85.5%), followed by shallow ulcers (2, 10%) and macular lesions (1, 5%). Conclusions. Due to the recent rise in HIV-syphilis coinfection, dental and medical practitioners should consider secondary syphilis in the differential diagnosis of oral lesions, particularly in HIV-infected patients. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"892427"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/892427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33960017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Associated with Use of Latex Condom-Compatible Lubricants by Men Who Have Sex with Men in India: Implications for HIV Prevention.","authors":"Shreena Ramanathan, Venkatesan Chakrapani, Lakshmi Ramakrishnan, Prabuddhagopal Goswami, Diwakar Yadav, Bitra George, Shrabanti Sen, Harikumar Rachakulla, Thilakavathi Subramanian, Ramesh S Paranjape","doi":"10.1155/2013/161085","DOIUrl":"10.1155/2013/161085","url":null,"abstract":"<p><p>We examined the prevalence and type of rectal lubricants use and factors associated with exclusive use of latex-condom compatible lubricants (water-based lubricants) among men who have sex with men (MSM) using data from a large-scale cross-sectional survey conducted in 2009/10 in three Indian states. Using time-location cluster sampling, 3880 MSM were recruited from cruising sites. We used multiple logistic regression to assess the association between type of lubricants used and sociodemographic and programmatic indicators. Among those who reported using lubricants (64%) more than half (53%) exclusively used water-based lubricants, less than one-tenth used exclusively oil-based lubricants, and nearly 40% used both water-based and oil-based lubricants. Factors associated with exclusive use of water-based lubricants were exposure to HIV prevention interventions (AOR: 6.18, 95% CI 4.82 to 7.92) and kothi-identified MSM-feminine/anal-receptive (AOR: 2.56, 95% CI 2.12 to 3.10). Targeted HIV interventions among MSM need to promote and distribute latex condom-compatible lubricants for use during anal sex-irrespective of their presumed or stated sexual role in anal sex, and educate them not to use oil-based lubricants with condoms. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"161085"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34026356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesse B Fletcher, Joshua A Rusow, Hung Le, Raphael J Landovitz, Cathy J Reback
{"title":"High-risk Sexual Behavior is Associated with Post-Exposure Prophylaxis Non-adherence among Men who have Sex with Men Enrolled in a Combination Prevention Intervention.","authors":"Jesse B Fletcher, Joshua A Rusow, Hung Le, Raphael J Landovitz, Cathy J Reback","doi":"10.1155/2013/210403","DOIUrl":"https://doi.org/10.1155/2013/210403","url":null,"abstract":"<p><p>Methamphetamine use among men who have sex with men (MSM) is associated with increased HIV prevalence, due to increased engagement in high-risk sexual behavior. Fifty-three HIV-negative, methamphetamine-using MSM were enrolled in a biobehavioral combination prevention intervention in Los Angeles, CA, to assess the feasibility of administering postexposure prophylaxis (PEP) in combination with contingency management (CM) to prevent HIV seroconversion. The study combined a CM behavioral intervention targeting reductions in methamphetamine use with a PEP biomedical intervention for HIV prevention. Those who reported recent exposure to HIV were initiated on tenofovir/emtricitabine- (Truvada)-based PEP (<i>n</i>=35). This secondary analysis sought to determine whether recent and/or lifetime sexual risk taking was associated with PEP adherence. Regression analyses controlling for participant sociodemographics demonstrated that, at baseline, increased number of lifetime sexually transmitted diseases (STDs; Coef.=-0.07; 95% CI=(-0.12) - (-0.01)) and recent episodes of unprotected anal intercourse (UAI; Coef.=-0.01; 95% CI= (-.01) - (-0.002)) were each associated with reductions in medication adherence. Given these associations between baseline sexual risk and PEP adherence, providers working with high-risk MSM may look to target reductions in sexual risk taking; this will reduce direct risk of HIV infection and may work to optimize medication adherence in the case of PEP initiation. Clinicaltrials.gov identifier: NCT00856323.</p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"210403"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/210403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32117613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aaron F Bochner, Purnima Madhivanan, Bhavana Niranjankumar, Kavitha Ravi, Anjali Arun, Karl Krupp, Jeffrey D Klausner
{"title":"The Epidemiology of Herpes Simplex Virus Type-2 Infection among Pregnant Women in Rural Mysore Taluk, India.","authors":"Aaron F Bochner, Purnima Madhivanan, Bhavana Niranjankumar, Kavitha Ravi, Anjali Arun, Karl Krupp, Jeffrey D Klausner","doi":"10.1155/2013/750415","DOIUrl":"https://doi.org/10.1155/2013/750415","url":null,"abstract":"<p><p>Objectives. To assess the prevalence and determinants of herpes simplex virus type 2 (HSV-2) infections among pregnant women attending mobile antenatal health clinic in rural villages in Mysore Taluk, India. Methods. Between January and September 2009, 487 women from 52 villages participated in this study. Each participant consented to provide a blood sample for HSV-2 and HIV testing and underwent an interviewer-administered questionnaire. Results. HSV-2 prevalence was 6.7% (95% confidence interval (CI) 4.4-9.0), and one woman tested positive for HIV. The median age of women was 20 years and 99% of women reported having a single lifetime sex partner. Women whose sex partner traveled away from home had 2.68 (CI: 1.13-6.34) times the odds of being HSV-2 seropositive compared to women whose sex partner did not travel. Having experienced genital lesions was also associated with HSV-2 infection (P value = 0.08). Conclusion. The 6.7% HSV-2 prevalence was similar to results obtained in studies among pregnant women in other parts of India. It appeared that most women in this study contracted HSV-2 from their spouses and few regularly used condoms. This finding highlights the need for public health policies to increase awareness and education about prevention methods among women and men living in rural India. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"750415"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/750415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33959100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huy Ha, Michael W Ross, Jan M H Risser, Huong T M Nguyen
{"title":"Measurement of Stigma in Men Who Have Sex with Men in Hanoi, Vietnam: Assessment of a Homosexuality-Related Stigma Scale.","authors":"Huy Ha, Michael W Ross, Jan M H Risser, Huong T M Nguyen","doi":"10.1155/2013/174506","DOIUrl":"https://doi.org/10.1155/2013/174506","url":null,"abstract":"<p><p>Objective. To develop and assess a homosexuality-related stigma scale among men who have sex with men (MSM) in Hanoi, Vietnam. Methods. We conducted a cross-sectional study using respondent-driven sampling in Hanoi, Vietnam, in 2011. We used a cross-validation approach. Factor analysis was performed, and interitem correlation matrices were constructed to identify the latent factor structures, examine the goodness of fit, and assess convergent and discriminant validity of the determined scales. Internal consistency checks were performed in split samples and whole sample, and separately for each determined factor. Results. The findings were consistent in split samples. Three homosexuality-related stigma factors were identified: enacted homosexual stigma, perceived homosexual stigma, and internalized homosexual stigma. The fit indices of the confirmatory factor analysis in both split samples supported the hypothesized three-factor structures (in subsamples A and B: χ (2)/degrees of freedom ratio = 1.77 and 1.59, nonnormed fit index = 0.92 and 0.94, comparative fit index = 0.93 and 0.95, and the root mean square of approximation = 0.06 and 0.05, resp.). The interitem correlation supported the convergent and discriminant validity of the scales. The reliability of the three scales indicated good consistency (Cronbach's alpha: 0.79-0.84) across split samples and for the whole data. Conclusion. Our scales have good psychometric properties for measuring homosexuality-related stigma. These comprehensive and practical tools are crucial not only to assess stigma against MSM and its consequence, but also to guide the development of interventions targeting MSM, as well as to evaluate the efficacy of existing stigma reduction efforts in Vietnam and other countries with similar settings. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"174506"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/174506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34026357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sumathi Muralidhar, Richa Talwar, Deepa Anil Kumar, Joginder Kumar, Manju Bala, Nilofar Khan, V Ramesh
{"title":"Genital Ulcer Disease: How Worrisome Is It Today? A Status Report from New Delhi, India.","authors":"Sumathi Muralidhar, Richa Talwar, Deepa Anil Kumar, Joginder Kumar, Manju Bala, Nilofar Khan, V Ramesh","doi":"10.1155/2013/203636","DOIUrl":"10.1155/2013/203636","url":null,"abstract":"<p><p>Background and Objectives. Genital ulcer diseases represent a diagnostic dilemma, especially in India, where few STI clinics have access to reliable laboratory facility. The changing STI trends require that a correct diagnosis be made in order to institute appropriate treatment and formulate control policies. The objective of this study was to determine recent trends in aetiology of genital ulcers, by using accurate diagnostic tools. Methods. Specimens from 90 ulcer patients were processed for dark field microscopy, stained smears, culture for H. ducreyi, and real-time PCR. Blood samples were collected for serological tests. Results. Prevalence of GUD was 7.45 with mean age at initial sexual experience as 19.2 years. Use of condom with regular and nonregular partners was 19.5% and 42.1%, respectively. Sexual orientation was heterosexual (92.2%) or homosexual (2.2%). There were 8 cases positive for HIV (8.9%). Herpes simplex virus ulcers were the commonest, followed by syphilis and chancroid. There were no cases of donovanosis and LGV. Conclusions. A valuable contribution of this study was in validating clinical and syndromic diagnoses of genital ulcers with an accurate aetiological diagnosis. Such reliable data will aid treatment and better define control measures of common agents and help eliminate diseases amenable to elimination, like donovanosis. </p>","PeriodicalId":90237,"journal":{"name":"Journal of sexually transmitted diseases","volume":"2013 ","pages":"203636"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34026359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}