Journal of gastroenterology and hepatology research最新文献

Research of the eradication of Helicobacter pylori to prevent gastric cancer 根除幽门螺杆菌预防胃癌的研究

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-065

Zhao-chun Chi

引用次数: 0

Study of the potential mechanism of acupuncture treatment for functional dyspepsia based on association rule mining and bioinformatics/network pharmacology approach 基于关联规则挖掘和生物信息学/网络药理学方法的针刺治疗功能性消化不良的潜在机制研究

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-071

Andong Zhao, L. Xiao, Hong-yue Niu, Lian Liu, Xiao-Yu Dai

{"title":"Study of the potential mechanism of acupuncture treatment for functional dyspepsia based on association rule mining and bioinformatics/network pharmacology approach","authors":"Andong Zhao, L. Xiao, Hong-yue Niu, Lian Liu, Xiao-Yu Dai","doi":"10.53388/ghr2023-03-071","DOIUrl":"https://doi.org/10.53388/ghr2023-03-071","url":null,"abstract":"Objective: To explore the main acupoint prescription and mechanism of acupuncture in treating Functional dyspepsia (FD) by analyzing the clinical randomized controlled trial literature on acupoints and targets of acupuncture in the treatment of FD combined with association rule mining and bioinformatics/network pharmacology methods. Methods: Search relevant clinical randomized controlled trial literature on acupoints and therapeutic targets of acupuncture in the treatment of FD from eight databases from their inception to June 18th, 2022. We obtained acupuncture selection points, meridian, and therapeutic targets and established acupoints database for acupuncture treatment of FD. FD-related targets were collected from GeneCards, DisGeNET, OMIM, and DrugBank databases. We obtained the potential targets of acupuncture on FD by taking the intersection of acupuncture for FD therapeutic targets and FD-related targets. We performed the protein-protein interaction network, Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Results: In this study, 26 Randomized Controlled Trials related to acupuncture treatment of FD were retrieved. We obtained 29 acupoints, 17 acupuncture for FD therapeutic targets, and 10 intersection targets. Tumor necrosis factor (TNF), Interleukin (IL)-1, and Neuropeptide Y (NPY) are key targets of acupuncture in the treatment of FD. Conclusion: ST36-CV12-PC6-LR3 is the main acupoint prescription for FD. Acupuncture may affect Neuroactive ligand-receptor interaction, Gastric acid secretion, and IL-17, TNF signaling pathways by regulating related key targets, and play a synergistic role in the treatment of FD by inhibiting gastric acid secretion, alleviating inflammatory response, regulating the brain-gut axis, improving mood and other aspects.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90227062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network meta-analysis of the compensatory effect of different Chinese herbal compounds combined with Entecavir in the treatment of hepatitis B cirrhosis 不同中药复方联合恩替卡韦治疗乙型肝炎肝硬化代偿作用的网络meta分析

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-069

Hui Zheng, Yang Zheng, Jianlong He, Can Xu, Wenqing He, Rui Xu, Jiahui Wang, Tiejian Zhao

引用次数: 0

A review on conventional and herbal drug approach to peptic ulcer 消化性溃疡的常规治疗与中药治疗综述

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-074

D. Kiran, A. Rohilla, Naresh Kalra

引用次数: 0

Classification of metabolic-associated fatty liver disease subtypes based on TCM clinical phenotype 基于中医临床表型的代谢性脂肪肝亚型分型研究

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-066

Chenxia Lu, Hui Zhu, Mingzhong Xiao, Xiaodong Li

引用次数: 0

Changing liver stiffness predict regression in advanced fibrosis patients with chronic hepatitis B, but not in moderate fibrosis patients 改变肝脏硬度可预测晚期纤维化合并慢性乙型肝炎患者的回归，但不能预测中度纤维化患者的回归

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-067

Zhengxin Li, Tingting Zhu, Zhimin Zhao, Li Shen, Gaofeng Chen, Hongtu Gu, Cheng-hai Liu

引用次数: 0

Mechanism of Zuojin Pill in the treatment of anxiety disorder and Major depressive disorder based on network pharmacology and molecular docking validation 左金丸治疗焦虑症、重性抑郁症的机制研究——基于网络药理学与分子对接验证

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/2023-03-068

P. Ge, Hongling Cheng, Wei-Fang Liu, Yan-Mei Cai, Qiao-yan Zhang, Shuang Dai, Bo Jia

引用次数: 0

Efficacy and safety of Banxia Xiexin Decoction in the treatment of gastric ulcer: a systematic review and meta-analysis of twenty-seven randomized controlled trials 半夏泻心汤治疗胃溃疡的疗效和安全性:27项随机对照试验的系统回顾和荟萃分析

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-073

Boran Gong, Zhehao Xu, Ying Wang, Zitong Feng, Zhao Li, Guodan Yu, Hui-fang Zhou, Yu-Hong Bian

{"title":"Efficacy and safety of Banxia Xiexin Decoction in the treatment of gastric ulcer: a systematic review and meta-analysis of twenty-seven randomized controlled trials","authors":"Boran Gong, Zhehao Xu, Ying Wang, Zitong Feng, Zhao Li, Guodan Yu, Hui-fang Zhou, Yu-Hong Bian","doi":"10.53388/ghr2023-03-073","DOIUrl":"https://doi.org/10.53388/ghr2023-03-073","url":null,"abstract":"Background: Banxia XieXin Decoction (BXD) is a traditional Chinese medicine decoction commonly used in the Chinese clinical treatment of gastric ulcer (GU). Although some people believe that it may have some advantages in this regard,There is no reliable evidence-based study demonstrating its effectiveness. This study aims to systematically evaluate the healing effect and security of BXD in the treatment of GU. Methods: PubMed, Cochrane Library, EMBASE, ScienceNet, China National Knowledge Infrastructure (CNKI), Wanfang database, Weipu database, and China biomedical literature service (CBM) database were systematically searched to obtain all randomized controlled trials (RCTs) evaluating the treatment GU of BXD published as of April 2022. Two researchers independently screened and extracted all research data, finally evaluated the bias risk of inclusion in the study using revman 5.4. Results: This meta-analysis included 27 randomized controlled trials and 1411 patients. The clinical effective rate, recurrence rate, HP eradication rate, adverse reaction rate, and visual analog score (VAS) of BXD combined treatment and standard treatment alone were compared. The results of the meta-analysis showed that BXD combined treatment improve the symptoms related to the gastric ulcers and reduce drug-related adverse reactions. Due to the low quality of the research included in this analysis, in-depth high-quality research is crucial for verifying these results.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83330837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Zangfu ointment and massage therapy on functional constipation: a protocol for a randomised controlled trial 脏腑软膏配合按摩治疗功能性便秘的疗效:一项随机对照试验方案

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-072

Xiao-na Zhang, Naiwei Zhang, Libao An, Bao-Tuan Zhao, Weifang Liu, Bo Jia, Hongling Cheng

{"title":"Effect of Zangfu ointment and massage therapy on functional constipation: a protocol for a randomised controlled trial","authors":"Xiao-na Zhang, Naiwei Zhang, Libao An, Bao-Tuan Zhao, Weifang Liu, Bo Jia, Hongling Cheng","doi":"10.53388/ghr2023-03-072","DOIUrl":"https://doi.org/10.53388/ghr2023-03-072","url":null,"abstract":"Introduction: Functional Constipation (FC) is a type of functional bowel disease that is in Clinically characterized by dysportia, decreased frequency of bowel movements, or incomplete bowel movements in the absence of irritable bowel syndrome syndrome, at least 6 months before diagnosis, and symptoms within the last 3 months. At present, commonly used drugs include enema and suppositories, laxatives, microecological preparations, gastrointestinal motility drugs and other treatments. However, the effect is limited. Traditional Chinese medicine (TCM) treatment of FC has advantages. Methods: In this randomized controlled study, 244 eligible patients were randomly assigned in a 1:1 ratio to a treatment group (Zangfu ointment and massage therapy + Lactulose Oral Liquid) and a control group (Lactulose Oral Liquid) for 14 days. Number of spontaneous defecation per week and First defecation time will be used as primary outcomes, and Traditional Chinese Medicine (TCM) syndrome scores and syndrome scores,PAC-QOL form will be used as secondary outcomes. Blood routine, liver function, and renal function will be used as safety outcomes. The primary and secondary outcomes will be performed at 0th, 7th, and 14th day, and the safety outcomes will be performed at 0th and 14th day. Ethics and dissemination: Ethical approval has been obtained from the Committee on Health Research Ethics of the Fangshan Hospital,","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"26 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77098493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment for non-alcoholic steatohepatitis with type 2 diabetes by traditional Chinese medicine: a case report and experience 中医药治疗非酒精性脂肪性肝炎合并2型糖尿病1例报告及体会

Journal of gastroenterology and hepatology research Pub Date : 2023-01-01 DOI: 10.53388/ghr2023-03-070

Jing Chang, Ling Liu, Qianfeng Wang, Xiang-Qing Cui

引用次数: 0