Journal of gastroenterology and hepatology research最新文献

{"title":"Hints for Therapeutic Interventions Through Exploring the Effects of Calorie Restriction on NAFLD by Mechanistic Approach","authors":"Nazanin Asghari Hanjani, M. Vafa","doi":"10.17554/J.ISSN.2224-3992.2018.07.780","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.780","url":null,"abstract":"BACKGROUND: The worldwide prevalence and severity of non-alcoholic fatty liver disease are increasing in parallel with the growing obesity epidemic. According to the US Practice Guidelines for the Diagnosis and Management of NAFLD, weight loss interventions based on hypocaloric diets – either alone or in conjugation with physical activity – can reduce hepatic steatosis. Hence, understanding the ways in which calorie restriction affects NAFLD can help in developing optimal treatments. METHOD: In this review study, the main focus was on possibly disturbed pathways in NAFLD, and how calorie restriction may attenuate them. For this purpose, both human and animal studies available through Pubmed were reviewed. RESULTS: Calorie restriction can upregulate energy-sensing pathways, including AMPK/SIRTUIN, and downregulate insulin-signaling pathway IGF1/PI3K/AKT. In NAFLD, AKT is over-activated through the PI3K-active mTOR and FOXO recruitment. Consequences include gluconeogenic and lipogenic enzyme alteration, insulin resistance, autophagy reduction, and liver cells apoptosis, all of which may be inverted through calorie restriction. Moreover, increased mitochondrial biogenesis, reduced inflammation, and increased fatty acid oxidation are mediated through AMPK, SIRTUIN, and PPARS, all of which are altered in NAFLD. CONCLUSION: This review outlines prominent pathways, the targeting of which may be promising for NAFLD treatment, according to evidence-based studies.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2649-2657"},"PeriodicalIF":0.0,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42730970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Colonic and Liver disease in Patients with group D Streptococcus Infection in Tertiary Hospital in Thailand","authors":"Piyanant Chonmaitree, Worawut Roongsangmanoon, D. Muntham, Piyanuch Piyasatit, Prasit Upapan","doi":"10.17554/J.ISSN.2224-3992.2018.07.783","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.783","url":null,"abstract":"Background: Group D Streptococcus (GDS) infection was most often associated with infective endocarditis and bacteremia. GDS formerly named as Streptococcus bovis. In addition to an association of GDS with colonic disease, evidence of a correlation with liver disease has been presented. This study aimed to evaluate the prevalence of colonic and liver disease in patients with GDS and to identify factors that increase risk of colonic and liver diseases in patients with GDS infection. Methods: A prospective study of all adult patients with GDS infection at Her Royal Highness Princess Maha Chakri Sirindhorn Medical Center between March 2016 and December 2017 and retrospective chart review between January 2012 and February 2016 were performed. Results: Sixty-two episodes of GDS infection in 45 patients were included in the study. Thirty-two patients (51.6%) were male and mean age was 64 ± 10.7 years. Two patients (3.2%) was diagnosed colorectal cancer and 49 patients (79%) had liver cirrhosis before GDS infection. Most of patients had bacteremia (93.5%). Subspecies were identified in 48.4% of patients, 25 patients (40.3%) were S. gallolyticus and 5 patients (8.1%) were S. pasteurianus. Forty-seven percent of patients had colonic evaluation and 19 patients (30.7%) had colonic disease. Prevalence of colonic disease and liver disease in GDS infection was 33.8% and 79%, respectively. Six patients with GDS infection had both colonic and liver disease. Overall median to mortality was 1.28 years (95%CI 0.68-1.86). Mortality rate was 48 person/100 person-year. Conclusion: Prevalence of colonic disease and liver disease was 33.8% and 79%, respectively. Patients with GDS infection should be evaluated for colonic and liver disease. Colonic and liver disease may simultaneous occurs in the patients with GDS infection.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2665-2670"},"PeriodicalIF":0.0,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67620070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature treasure: Aloe vera and Bee-products","authors":"A. Kabbash, Mona El-Aasr, F. Mansour, M. Hasegawa, S. Ataka, A. Yagi","doi":"10.17554/J.ISSN.2224-3992.2018.07.790","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.790","url":null,"abstract":"Based on the standpoint of natural treasure: Aloe vera and bee-products, we presented the following information: (i) cardiovascular activity, (ii) usefulness to benign prostatic hyperplasia, chronic prostatitis, and menopausal syndromes, (iii) enhancement of muscle performance in athletes, (iv) others in vivo therapeutic effects, (v) side effects, and (vi) honey, (vii) response of chronic fatigue subjects to the ingestion of Aloe vera juice (AVJ) with or without bee-products (propolis and pollen), and case reports, (viii) future prospective, and (ix) summary. The efficacies of AVJ ingestion with bee-products supplement were demonstrated in questionnaire assessments: response of AVJ with bee products ingestion to chronic fatigue subjects. The results provided new possibilities for incorporation of bee-products with AVJ as quality of life-food stuffs. Futhermore, case reports of AVJ with bee-products to patients in metabolic syndrome and inflammation around the under-rectum in ulcerative colitis were demonstrated. Ingestion of Aloe vera juice with bee-products supplement could provide the noteworthy improvement.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2612-2631"},"PeriodicalIF":0.0,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42549717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diclofenac-Induced Post Infantile Giant Cell Hepatitis","authors":"S. Venkataraman, V. Mohan, J. Conyers, Rukma Govindu","doi":"10.17554/J.ISSN.2224-3992.2018.07.777","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.777","url":null,"abstract":"INTRODUCTION: Post-infantile Giant Cell Hepatitis (PIGCH) is a rare type of autoimmune hepatitis (AIH) characterized by an idiosyncratic response to liver injury from various causes in which liver cells respond to insult by rapid proliferation and without the appropriate cellular division, leading to the formation of the multi-nucleated giant cells. We encountered a case of Diclofenac induced PIGCH in a patient with untreated seropositive rheumatoid arthritis. To the best of our knowledge, this is first such case reported in the literature. CASE PRESENTATION: A 48-year-old Hispanic woman with type II diabetes and rheumatoid arthritis, not on DMARDs presented with acute onset jaundice and right upper quadrant pain. She was taking 50mg of Diclofenac, 2 pills daily for the past 3 months and unknown quantity of garlic tablets. Workup for hepatitis including infectious and toxic etiologies were ruled out. Serum IgG levels were elevated with increased globuin gap, and positive ANA titer of 640, anti-smooth muscle cell antibodies elevated at 41 units (moderate to strong positive > 30 units). Liver biopsy demonstrated submassive necrosis in the setting of post-infantile giant cell hepatitis. The differential diagnoses included idiopathic autoimmune hepatitis, viral or drug induced injury. Our diagnosis was drug induced autoimmune liver disease (DIALD), the etiology is likely due to Diclofenac given temporal relationship of drug intake and symptom onset, as well as a calculated Roussel Uclaf Causality Assessment Method (RUCAM) score of 6, signifying probable drug-induced liver disease. Patient was started on Prednisone and Azathioprine with complete resolution of clinical and laboratory findings within 5 months. DISCUSSION: The outcome of PIGCH is unpredictable, usually adopts a fulminant course leading to cirrhosis within months, however, a more benign course has also been described. PIGCH is triggered by three primary etiologies: drugs, infection, and autoimmune liver injury. This case highlights that giant cell hepatitis is a multifactorial condition that can be precipitated by drug use in the setting of autoimmune phenotype. Garlic and garlic extracts, through their antioxidant activities, have been reported to provide protection against free radical damage in the body. The innocuous course of PIGCH in our patient could possibly be due to concurrent consumption of garlic tablets. Further research is needed in this area.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2676-2680"},"PeriodicalIF":0.0,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49492535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Hepatic Progenitor Cell Expansion in Liver Fibrosis of Elderly Cadavers","authors":"K. Mak, S. Chiu","doi":"10.17554/J.ISSN.2224-3992.2018.07.776","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.776","url":null,"abstract":"AIMS: Expansion of human hepatic progenitor cells (HPCs) is a key feature of liver fibrosis associated with a variety of chronic liver diseases. We studied HPC expansion and its relationship to canals of Hering (CoH) and ductular reaction (DR) in liver fibrosis progression of aged cadavers. METHODS: Thirty-five cadavers (83.8 ± 10.8 years) with minimal fibrosis, septal fibrosis, bridging fibrosis and incomplete cirrhosis were studied. Cytokertin 7 immunoperoxidase staining was used to highlight HPCs, CoH and DR. RESULTS: HPC counts in the periportal HPC compartment and in the mid-lobule and centrilobule were 2.3-2.7 times and 2.8-4.5 times higher in advanced fibrosis stages (septal fibrosis, bridging fibrosis and incomplete cirrhosis) compared to minimal fibrosis, respectively. Periportal CoH numbers and DR grades were 2.0-2.6 times and 2.6-2.7 times higher in advanced fibrosis than in minimal fibrosis, respectively. Both CoH numbers and DR grades significantly correlated with periportal HPC counts. There was also a significant correlation between CoH numbers and DR grades. Portal inflammation, but not lobular inflammation, was significant in bridging fibrosis. Steatosis was not an obvious feature associated with the HPC expansion. CONCLUSION: Increased periportal and lobular HPC counts reflect an expansion of HPCs with increased periportal to lobular HPC migration. The expansion likely represents a regenerative response to chronic liver injury in the elderly. Our findings also point to an intricate linkage between the HPCs, CoH and DR in hepatic fibrogenesis. Cadaveric livers provide a source of specimens for evaluating the role of HPCs in fibrosis progression of the aged liver.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2632-2643"},"PeriodicalIF":0.0,"publicationDate":"2018-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48560060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Blood Pressure Status and Colorectal Polyps in a Taiwanese Population","authors":"N. Shin, Hung-Yu Chen, Yi-Ching Yang, F. Lu, Hsin-En Huang, Jin‐Shang Wu, Chih-Jen Chang","doi":"10.17554/J.ISSN.2224-3992.2018.07.766","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.766","url":null,"abstract":"Aim : Colorectal cancer is the third most common cancer worldwide, especially in more developed countries. Colorectal adenomas can progress to malignant carcinoma based on the pathogenesis of adenoma-carcinoma sequence. This study was conducted to investigate the association with colorectal polyps of blood pressure status after excluding the confounding effect of anti-hypertensive agents. MATERIALS AND METHODS : A total of 8,700 eligible subjects with age ≥ 18 years were enrolled from the Health Examination Center of National Cheng Kung University Hospital (NCKUH) between June 2001 and August 2009. We categorized colonoscopic findings into four subgroups: polyp-free, non-neoplastic polyps, non-advanced adenomatous polyps, and advanced adenomatous polyps. Subjects were divided into normal blood pressure, prehypertension and hypertension. RESULTS : The subjects were divided into polyp-free (n = 6,773), non-neoplastic polyps (n = 806), non-advanced adenomatous polyps (n = 876), and advanced adenomatous polyps (n = 245). With adjustments for other variables, hypertension was positively related to non-advanced adenomatous polyps (OR: 1.40, 95% CI: 1.14–1.73) and advanced adenomatous polyps (OR: 1.93, 95% CI: 1.37–2.72). Prehypertension was associated with a higher risk of non-neoplastic polyps (OR: 1.20, 95% CI: 1.01–1.43) and non-advanced adenomatous polyps (OR: 1.42, 95% CI: 1.21–1.68), but not associated with advanced adenomatous polyps. CONCLUSION : Hypertension was positively related to an increased risk of non-advanced and advanced adenomatous polyps, but not non-neoplastic polyps. In contrast, prehypertension was associated with a less advanced stage of colon polyps, including non-neoplastic polyps and non-advanced adenomatous polyps, but not associated with advanced adenomatous polyps.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2592-2597"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45459628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening by Chromo Endoscopy for Colorectal Cancer and Dysplasia in Ulcerative Colitis: An Algerian Prospective Cohort","authors":"H. Saoula, A. Boutaleb, Z. Amir, S. Berkane, A. Balamane, T. Boucekkine, M. Nakmouche","doi":"10.17554/J.ISSN.2224-3992.2018.07.767","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.767","url":null,"abstract":"Patients with longstanding extensive ulcerative colitis have an increased risk of colorectal cancer. Aims : To determine the incidence of dysplasia and colorectal cancer, in patients with longstanding ulcerative colitis. To evaluate prospectively, the proportion of dysplastic lesions detected by chromoendoscopy from targeted biopsies of macroscopically visible abnormalities, as opposed to random biopsies of colonic mucosa. Patients and methods : In this prospective study, consecutive patients with clinically inactive, longstanding UC (more than 8 years) were recruited from 4 centers; colonoscopy with chromoendoscopy using 0.1% methylene blue was performed for each patient. Four mucosal biopsy specimens were taken every 10 cm between the cecum and the rectum, with additional biopsies or removal of any mucosal abnormality. All the endoscopies were performed by a single specialist in gastroenterology. All the biopsies have been reviewed by a pathologist experienced in gastroenterology. Results: Two hundred and twenty four chromoendoscopies were performed in 106 patients. We diagnosed 49 neoplastic lesions in 31 patients; there were six adenocarcinomas, eight high grade dysplasia, 24 low grade dysplasia, and 11 lesions indefinite for dysplasia. We took 8035 random biopsies and found seven dysplastic lesions in six patients: one high grade dysplasia, two low grade dysplasia and four lesions indefinite for dysplasia. Random biopsies alone diagnosed dysplasia in two patients (1.8%), and had clinical impact only in one patient (0.9%). Conclusion : In our cohort, we experienced a high diagnostic yield of chromoendoscopy in the detection of neoplasia in high risk IBD patients. Random biopsies don’t have clinical impact and should be abandoned.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2598-2603"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44836442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Amebiasis among Histologically confirmed colitis patients","authors":"R. Salama, M. Emara, I. Amer, Shimma Elsharawy","doi":"10.17554/J.ISSN.2224-3992.2018.07.772","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.772","url":null,"abstract":"ABSTRACT Background and study aim: Amebiasis is a prevalent infection worldwide and associated with colitis that may mimic different types of colitis. The aim of this study is to determine the prevalence of amebiasis among patients with endoscopically and histologically confirmed colitis among Egyptian patients. Patients and Methods: This study was conducted in the period from June 2017 to March 2018. Patients in the final analysis were divided into 2 groups according to their histopathologic features: Group I: Inflammatory bowel disease (IBD) patients comprised 60, 49 patients diagnosed as ulcerative colitis (UC) and 11 patients diagnosed as Crohn’s disease (CD). Group II: Non-specific colitis. Comprised a total of 100 patients. Results The prevalence of Entamoeba histolytica cysts and trophozoits among the study patients was 9.37% (15/160). They were 11 patients with IBD (6.87%) cases and 4 patients with non- specific colitis (2.5%). Patients with non- specific colitis are younger in age, had less blood levels of CRP and lower prevalence rates of amebiasis when compared with IBD patients. When patients with IBD were compared as ulcerative colitis and Crohn's disease it seem that the younger age CD did not show different prevalence rates of amebiasis when compared with UC (P value 1). Conclusions: The prevalence of amebiasis in histologically confirmed colitis is 9.37% (15/160). They were 11 patients with IBD (6.87%) cases and 4 patients with non- specific colitis (2.5%). Regarding IBD the prevalence of amebiasis was 11 patients/out of 60 (18.3%) and prevalence was higher in ulcerative colitis when compared with Crohn’s disease with figure of 9 patients (15%) and 2 patients (3.3%) respectively. Further studies are needed to clarify the impact of amebiais on the course of IBD and non-specific colitis.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2604-2608"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48069633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descriptive analysis of Infective Colitis in a large hospital cohort: Features in IBD and non-IBD patients","authors":"S. Mumtaz, S. Kelly, S. Everett","doi":"10.17554/J.ISSN.2224-3992.2018.07.775","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.775","url":null,"abstract":"Background: Clinical features associated with infective colitis and flare up of Inflammatory Bowel Disease (IBD) are very similar and presents a challenge to gastroenterologists to distinguish the two. This is especially difficult in patients with established IBD disease in whom the incidence of bacterial infections is comparable to the general population. Methods: This was a retrospective analytical cohort study conducted at Leeds Teaching Hospitals (LTHT), UK. Subjects included were those with diarrhoeal symptoms, referred by the emergency department or primary care physicians to the Gastroenterology unit of LTHT, over an eight-year period between 2004-2012, with a positive stool culture for Campylobacter, Salmonella, Shigella or E.Coli O157. Results: We analysed 102 consecutive cases. Median duration of symptoms was 4 days (IQR 2 – 7). The most common reported symptom was abdominal pain 91 patients (91%), followed by rectal bleeding 53 patients (52%) and vomiting 44 patients (43%). Blood tests revealed that 98% patients had a substantially elevated C-reactive protein (CRP) concentration [median 95 mg/L (IQR 44-143)]. Thirteen patients had pre-existing IBD, who when compared to non-IBD patients, showed no difference in clinical presentation. In the IBD group, however, median platelet count was significantly higher [282 (IQR 225-415) vs 237 (IQR 194-281) p=0.03) and haemoglobin concentration lower [12.1 (IQR 11-14) v 14.3 (IQR 13-15) p=0.01). Conclusions: In patients where infective diarrhoea is suspected a short duration of symptoms, abdominal pain and elevated CRP concentration are pointers that can support the diagnosis, whereas low Haemoglobin and high Platelet count favours a background of IBD.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2587-2591"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49238920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Celiac Disease in Patients with Inflammatory Bowel Disease in Northeastern Brazil","authors":"B. Carvalho, V. Martinelli, C. Constant, E. Siqueira","doi":"10.17554/J.ISSN.2224-3992.2018.07.774","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2018.07.774","url":null,"abstract":"AIM: Evaluate the prevalence of celiac disease in patients diagnosed with inflammatory bowel disease followed at the General Hospital - UFPE. Celiac disease represents an autoimmune enteropathy related to gluten intolerance, causing chronic inflammation, especially of the small intestine. The typical clinical presentation is marked by disabsorptive diarrhea, abdominal distension and malnutrition. Atypical forms, however, have been increasingly documented, demonstrating that the occurrence of the disease, previously considered rare, may reach 1% of the population in some series. Some recent case reports and more recent cross-sectional studies have suggested higher prevalence of celiac disease in patients with inflammatory bowel disease. MATERIALS AND METHODS: As screening test, anti-endomysial IgA antibodies were measured by indirect immunofluorescence in 83 patients with confirmed diagnosis of Crohn’s disease or idiopathic ulcerative colitis, in order to select those who would be referred for duodenal biopsy. RESULTS: No test was positive for anti-endomysial antibodies. CONCLUSION: Despite the small number of patients evaluated, it can be suggested that there is no higher prevalence of celiac disease in patients with inflammatory bowel disease.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"7 1","pages":"2609-2611"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43586460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}