Journal of gastroenterology and hepatology research最新文献_第10页

Selective pathological and therapeutic potential of the cell cycle pathway in hepatitis B virus-related hepatocellular carcinoma 乙型肝炎病毒相关肝细胞癌细胞周期途径的选择性病理和治疗潜力

Journal of gastroenterology and hepatology research Pub Date : 2020-03-12 DOI: 10.12032/GHR2020-03-011

Chen Lu, M. Xiao, Xiaodong Li

引用次数: 0

Investigating the Key Pathogenesis of Malignant Transformation of Precancerous Changes in the Liver Based on the Theory “Liver Governs Growth” 基于“肝治生长”理论探讨肝脏癌前病变恶性转化的关键发病机制

Journal of gastroenterology and hepatology research Pub Date : 2020-03-12 DOI: 10.12032/GHR2020-03-009

Jingtao Li, Yonggang Liu, Hai-liang Wei, Shu-guang Yan, Qian Li, Di Ju, Ying-Gun Guo, Chang Zhanjie

引用次数: 0

Role of apoptosis in the pathogenesis of primary biliary cholangitis 细胞凋亡在原发性胆管炎发病机制中的作用

Journal of gastroenterology and hepatology research Pub Date : 2020-03-12 DOI: 10.12032/GHR2020-03-007

Bukun Zhu, Wei Zhang

引用次数: 0

Investigation on Hepatitis B Virus infection in a four-generation family in China 中国一个四代家庭乙型肝炎病毒感染调查

Journal of gastroenterology and hepatology research Pub Date : 2020-03-12 DOI: 10.12032/GHR2020-03-010

Fengxia Sun, Xiao-ling Li, M. Luo

引用次数: 0

Seroprevalence and Risk Factors of Helicobacter Pylori Infection Among Children in South-East Nigeria 尼日利亚东南部儿童幽门螺杆菌感染的血清流行率和危险因素

Journal of gastroenterology and hepatology research Pub Date : 2020-02-21 DOI: 10.17554/J.ISSN.2224-3992.2020.09.869

Daniyan Olapeju W, Ibe Chidozie B, Ezeonu Thecla C, Anyanwu Onyinye U, Ezeanosike Obumneme B, Omeje Kenneth N

{"title":"Seroprevalence and Risk Factors of Helicobacter Pylori Infection Among Children in South-East Nigeria","authors":"Daniyan Olapeju W, Ibe Chidozie B, Ezeonu Thecla C, Anyanwu Onyinye U, Ezeanosike Obumneme B, Omeje Kenneth N","doi":"10.17554/J.ISSN.2224-3992.2020.09.869","DOIUrl":"https://doi.org/10.17554/J.ISSN.2224-3992.2020.09.869","url":null,"abstract":"Background: Helicobacter pylori is a common cause of infection among humans. The organism is usually acquired in childhood but may persist into adulthood resulting in chronic gastritis, peptic ulcer disease and adenocarcinoma. Aim: To determine the seroprevalence and risk factors of H. pylori infection among children seen at the Paediatric Out-Patient Clinic of a tertiary teaching hospital in South- East, Nigeria. Methods: It was a cross-sectional study carried out among 248 children aged between 1 and 18 years seen at the Paediatric Outpatient Clinic at the tertiary hospital from August 2017 to October 2017. Information on socio-demographics, feeding practices, daycare attendance and vaccination were obtained and entered into a proforma. The serum obtained from the patient was tested for H. pylori antibodies. Results: The seroprevalence of H. pylori infection among the subjects was 36.3%. Statistically significant association was found between age of the subjects, parental education, social class, ingestion of uncooked/ raw food materials and H. pylori infection (p < 0.05). On logistic regression analysis, predictors of H. pylori infection were age 6-12 years (AOR = 2.42, 95% CI = 1.31-4.47, p = 0.005) and ingestion of uncooked/raw food materials (AOR= 2.38, 95% CI 1.14-8.33, p = 0.022). Conclusion: Risk factors associated with H. pylori infection include age, parental education, social class and ingestion of uncooked or raw food materials.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3066-3070"},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43469026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of Momordica Charantia on The Prevention of Changes in Serum and Hepatic Metabolism of Animals Fed A High Fat Diet 苦瓜对高脂饮食动物血清和肝代谢变化的预防作用

Journal of gastroenterology and hepatology research Pub Date : 2020-02-21 DOI: 10.17554/j.issn.2224-3992.2020.09.890

F. N. Franco, Marcos Augusto Nascimento Porto

{"title":"Effect of Momordica Charantia on The Prevention of Changes in Serum and Hepatic Metabolism of Animals Fed A High Fat Diet","authors":"F. N. Franco, Marcos Augusto Nascimento Porto","doi":"10.17554/j.issn.2224-3992.2020.09.890","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.890","url":null,"abstract":"Excess lipids stored in adipose tissue can lead to changes in metabolism. It is known that the treatment with Momordica charantia (MC) is able to stimulate lipolysis, decrease insulin resistance, triacylglycerol concentration and body weight. Thus, the aim of this study was to investigate the effect of MC tea administration to prevent biochemical changes in the metabolism of mice fed high fat diet. For this, swiss mice were fed with a control diet (C) or a high fat diet for 4 and 8 weeks (HF). They also received water or MC tea during treatment (CP, HFP). Body weight, food and water intake were evaluated daily. After treatment, the HF and HFP animals were submitted to the Glucose Tolerance Test. All groups were euthanized and blood was collected for analysis of biochemical parameters. The epididymal, retroperitoneal and liver tissues were weighed. hepatic tissue were also used to quantification of lipids. The results were analyzed using Student's T test (p<0.05) and expressed as mean ± SE. A progressive decrease in the accumulation of lipids in adipose tissues and in the liver, as well as in the serum levels of TAG and VLDL was observed between the HFP8 vs HFP4 groups The carbohydrate metabolism presented very expressive changes in a short time of treatment (HFP4). The data suggest that MC appears to be effective in preventing changes in metabolism, probably by preventing the increase of lipid deposits, decreasing the inflammatory process and leading to an improvement in insulin sensitivity.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":"9 1","pages":"3082-3087"},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45028225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Reports: Beneficial Roles of Aloe vera Juice-successive Ingestion to Children with Steroid-Sensitive Nephrotic Syndrome 病例报告:连续摄入芦荟汁对患有类固醇敏感性肾病综合征的儿童有益

Journal of gastroenterology and hepatology research Pub Date : 2020-02-21 DOI: 10.17554/j.issn.2224-3992.2020.09.893

K. Koizumi, M. Hasegawa, Akira Mukaitani, A. Yagi

引用次数: 2

Impact of Insulin Resistance on Therapeutic Response to Oral Treatment of Chronic Hepatitis C Virus Infection 胰岛素抵抗对慢性丙型肝炎病毒感染口服治疗疗效的影响

Journal of gastroenterology and hepatology research Pub Date : 2020-02-21 DOI: 10.17554/j.issn.2224-3992.2020.09.888

M. Hassan, Soha Saoud Abd El Monem, A. Hasanain, Rasha Hosny Sayed, Amal Aziz

{"title":"Impact of Insulin Resistance on Therapeutic Response to Oral Treatment of Chronic Hepatitis C Virus Infection","authors":"M. Hassan, Soha Saoud Abd El Monem, A. Hasanain, Rasha Hosny Sayed, Amal Aziz","doi":"10.17554/j.issn.2224-3992.2020.09.888","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.888","url":null,"abstract":"Background& aim: HCV infection is one of the major health problems in our country. Prevalence of DM is higher among patients with chronic HCV infection. Insulin resistance (IR) is common in such and its impact on sustained virological response (SVR) is not well studied. This work was designed to assess impact of IR on SVR. Patients & methods: Between July 2016 and June 2017; 200 patients with chronic HCV infection were enrolled in a prospective study. Exclusion criteria included decompensated cirrhosis, hepatocellular carcinoma or extrahepatic malignancy, co-infection with HBV or HIV infection. HOMA and IR were assessed at baseline of therapy and 3-months post-therapy. Patients received sofosbuvir and daclatasvir for 3 months (chronic hepatitis) and for 6 months in (liver cirrhosis). Results: Mean age of patients was 49.89 ± 9.01 years, 111 (55.5%) patients were male and 180 (90%) achieved SVR. Baseline IR had insignificant difference between responders and non-responders (93% v. 90%; P = 0.45), while baseline HOMA was significantly higher in non-responders (10.11 ± 3.03 vs. 8.48 ± 2.98; P = 0.01). Also, post-therapy IR had insignificant difference between both groups (73.3% vs. 85%; P = 0.05), while post-therapy HOMA was significantly higher in non-responders (7.12 ± 2.31 vs. 5.06 ± 1.34; P = 0.01). Predictors of non-responders were age (> 40 years), low serum albumin and post-therapy IR. Conclusion: Baseline IR had no impact on SVR but it showed significant improvement in presence of SVR.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46511743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and Risk Factors for Diabetes, Hypertension and Hyperlipidemia after Liver Transplantation 肝移植术后糖尿病、高血压、高脂血症的发病率及危险因素分析

Journal of gastroenterology and hepatology research Pub Date : 2020-02-21 DOI: 10.17554/j.issn.2224-3992.2020.09.884

M. Hashim, Maha Alsabaawy, S. Afify, Gaser El-Azab, N. Omar

{"title":"Incidence and Risk Factors for Diabetes, Hypertension and Hyperlipidemia after Liver Transplantation","authors":"M. Hashim, Maha Alsabaawy, S. Afify, Gaser El-Azab, N. Omar","doi":"10.17554/j.issn.2224-3992.2020.09.884","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.884","url":null,"abstract":"Introduction and aim: Post-liver transplant recipients present a vast array of metabolic disturbances in the post-transplant period which impact on their morbidity and mortality. Post-transplant diabetes and hypertension were associated with increased risks of graft failure, infection, cardiovascular disease, and death. Therefore, predicting and preventing post-transplant metabolic complications would be a compelling objective for improving care of post-transplant recipients. The aim of this study was to identify the incidence and risk factors of metabolic complications after liver transplantation. Methods: Incidence and risk factors for new onset arterial hypertension, diabetes mellitus and hyperlipidemia were assessed progressively in 100 post- liver transplant recipients at least one year after transplantation (91% male; mean age 52 ± 7.7 y). Risk factors were assessed using logistic regression analysis according to demographic, clinical and laboratory variables. Results: The incidence of hypertension was 38.6%; diabetes, 39.7% and hyperlipidemia, 19% at one year post-liver transplantation (LTX). Independent risk factors for new onset of hypertension were family history of hypertension (OR: 4.85; 95% CI: 3.04-7.74), and cyclosporine use (OR: 6.33; 95%CI: 2.36-16.96). Risk factor for new onset of diabetes were HCV infection (OR: 2.54; 95%CI: 0.84-7.72) and cyclosporine use (12.63; 95%CI: 3.06-52.09). The incidence of hyperlipidemia after LTX was related to the use of cyclosporine (OR: 1.56; 95%CI: 1.04-1.98), or tacrolimus (OR: 1.34; 95%CI: 1.02-1.67). Conclusion: LTX was associated with significantly increased rates of hypertension, diabetes and hyperlipidemia. Furthermore, the incidences of these disorders were related to immunosuppressive therapy.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42082163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Predictors of Emergency Visits Within 14 Days of Outpatient Endoscopy at A Safety-Net Hospital: A Case-Control Study 安全网医院门诊内镜检查后14天内急诊就诊的预测因素：一项病例对照研究

Journal of gastroenterology and hepatology research Pub Date : 2020-02-21 DOI: 10.17554/j.issn.2224-3992.2020.09.883

Abdul Kouanda, Adam Tabbaa, J. Sewell, D. Selvig, L. Day

{"title":"Predictors of Emergency Visits Within 14 Days of Outpatient Endoscopy at A Safety-Net Hospital: A Case-Control Study","authors":"Abdul Kouanda, Adam Tabbaa, J. Sewell, D. Selvig, L. Day","doi":"10.17554/j.issn.2224-3992.2020.09.883","DOIUrl":"https://doi.org/10.17554/j.issn.2224-3992.2020.09.883","url":null,"abstract":"AIMS: Gastrointestinal endoscopic procedures are commonly performed outpatient procedures associated with adverse events that may lead to emergency department visits. Establishing risk factor for post-endoscopy emergency department visits may guide quality improvement efforts. MATERIALS AND METHODS: Matched case control study of patients over the age of 18 presenting to the emergency department of a safety-net hospital within two weeks of any outpatient endoscopic procedure between July 1, 2013 and December 31, 2014. Controls were matched to cases by age, sex, procedure type, date, and day of week procedure was performed. Univariable and multivariable analysis were performed to identify predictors of emergency visits after endoscopy. REULTS: We identified 143 cases from a total of 6,601 outpatient procedures during the study period. 64 (44.8%) of the visits were attributed to the procedure yielding a visit rate of 0.97%. Compared to controls, cases were more likely to have MediCal (Medicaid) insurance (75.7% vs 59.2%, p = 0.003), prior ED visits (2.5 vs 0.5, p < 0.001), multiple primary care visits (4.9 vs 3.3, p < 0.001), trainee involvement (62.9% vs 44.4%, p = 0.002), and speak English (67.1% vs 54.9%, p = 0.04). On multivariable analysis of cases with visits attributable to the procedure, antiplatelet/anticoagulant use (OR 2.81, CI 1.07-7.34, p = 0.04), MediCal insurance (OR 2.55, CI 1.02-6.40, p = 0.05), multiple ED visits per year (OR 3.31, CI 2.22-4.94, p < 0.001), number of endoscopic interventions (OR 1.22, CI 1.06-1.40, p = 0.006), and trainee involvement (OR 2.55, CI 1.09-5.97, p = 0.03) were all risk factors for post-procedure visits. CONCLUSION: In a safety-net system, medically complex patients, greater number of endoscopic interventions, and lower socioeconomic status may influence emergency department utilization after endoscopy. This information may inform future quality improvement efforts.","PeriodicalId":90217,"journal":{"name":"Journal of gastroenterology and hepatology research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42302612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0