Efficacy and safety of Banxia Xiexin Decoction in the treatment of gastric ulcer: a systematic review and meta-analysis of twenty-seven randomized controlled trials

Background: Banxia XieXin Decoction (BXD) is a traditional Chinese medicine decoction commonly used in the Chinese clinical treatment of gastric ulcer (GU). Although some people believe that it may have some advantages in this regard,There is no reliable evidence-based study demonstrating its effectiveness. This study aims to systematically evaluate the healing effect and security of BXD in the treatment of GU. Methods: PubMed, Cochrane Library, EMBASE, ScienceNet, China National Knowledge Infrastructure (CNKI), Wanfang database, Weipu database, and China biomedical literature service (CBM) database were systematically searched to obtain all randomized controlled trials (RCTs) evaluating the treatment GU of BXD published as of April 2022. Two researchers independently screened and extracted all research data, finally evaluated the bias risk of inclusion in the study using revman 5.4. Results: This meta-analysis included 27 randomized controlled trials and 1411 patients. The clinical effective rate, recurrence rate, HP eradication rate, adverse reaction rate, and visual analog score (VAS) of BXD combined treatment and standard treatment alone were compared. The results of the meta-analysis showed that BXD combined treatment improve the symptoms related to the gastric ulcers and reduce drug-related adverse reactions. Due to the low quality of the research included in this analysis, in-depth high-quality research is crucial for verifying these results.