ISRN ophthalmology最新文献

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Clinicopathological features of dacryolithiasis in Japanese patients: frequent association with infection in aged patients. 日本泪石症患者的临床病理特征:常与老年患者感染相关。
ISRN ophthalmology Pub Date : 2013-09-02 eCollection Date: 2013-01-01 DOI: 10.1155/2013/406153
Masabumi Kubo, Tomoki Sakuraba, Ryuichi Wada
{"title":"Clinicopathological features of dacryolithiasis in Japanese patients: frequent association with infection in aged patients.","authors":"Masabumi Kubo,&nbsp;Tomoki Sakuraba,&nbsp;Ryuichi Wada","doi":"10.1155/2013/406153","DOIUrl":"https://doi.org/10.1155/2013/406153","url":null,"abstract":"<p><p>Purpose. The purpose of this study is to elucidate the clinicopathological features of dacryolithiasis and prevalence of associated infection in Japanese patients. Materials and Methods. Out of 13,471 outclinic patients from 2006 to 2011, 268 patients were scheduled to be performed dacryocystorhinostomy (DCR) due to dacryocystitis with nasolacrimal duct obstruction. Actually 266 patients underwent dacryocystorhinostomy (DCR) and two patients were cured by only ophthalmic examination. Dacryoliths were found in 17 cases (6.3%). Among 17 cases of dacryolithiasis, three patients were male, and 14 were female. The age of the patients ranged from 32 to 82 (mean 67) years, and 13 cases (76%) were more than 65 years of age. Pathological examination disclosed the infectious agents in 9 cases (53%), and all patients with infection were more than 65 years of age. Special stains revealed colonies of fungus, suspicious of Aspergillus, in 6 cases and gram-positive rods, and suspicious of Actinomyces, in 3 cases. Conclusions. The current study showed the frequent association of infection with dacryolithiasis in aged Japanese patients. This should be taken into the consideration for the treatment of dacryolithiasis. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"406153"},"PeriodicalIF":0.0,"publicationDate":"2013-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/406153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32148447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Bevacizumab versus Ranibizumab on As-Needed Treatment Regimen for Neovascular Age-Related Macular Degeneration in Turkish Patients. 贝伐单抗与雷尼单抗在土耳其新生血管性年龄相关性黄斑变性患者的按需治疗方案
ISRN ophthalmology Pub Date : 2013-08-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/151027
Abdullah Ozkaya, Zeynep Alkin, Yalcin Karakucuk, Dilek Yasa, Ahmet Taylan Yazici, Ahmet Demirok
{"title":"Bevacizumab versus Ranibizumab on As-Needed Treatment Regimen for Neovascular Age-Related Macular Degeneration in Turkish Patients.","authors":"Abdullah Ozkaya,&nbsp;Zeynep Alkin,&nbsp;Yalcin Karakucuk,&nbsp;Dilek Yasa,&nbsp;Ahmet Taylan Yazici,&nbsp;Ahmet Demirok","doi":"10.1155/2013/151027","DOIUrl":"https://doi.org/10.1155/2013/151027","url":null,"abstract":"<p><p>Purpose. To compare the efficacy of intravitreal bevacizumab versus ranibizumab in the treatment of neovascular age-related macular degeneration (nAMD). Methods. Retrospective, comparative study. The newly diagnosed nAMD patients who were treated with intravitreal bevacizumab or ranibizumab on an as-needed treatment regimen were included in the study. Main outcome measures were the change in best corrected visual acuity (BCVA), and central retinal thickness (CRT). Secondary outcome measures were the number of injections, and complications. Results. A total of 154 patients were included in the study. Bevacizumab group consisted of 79 patients, and ranibizumab group consisted of 74 patients. Mean follow-up time was 18.9 months, and 18.3 months in the bevacizumab and ranibizumab groups, respectively. There was not a significant difference between the two groups regarding the change in BCVA and CRT at all time points (P > 0.05 for all). The mean number of injections at month 12 was 4.8 and 4.7 in bevacizumab and ranibizumab groups, respectively (P > 0.05). No serious complications were detected in any of the groups. Conclusion. Both of the bevacizumab and ranibizumab found to be effective in the treatment of nAMD in regards of functional and anatomical outcomes with similar number of treatments and similar side effects. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"151027"},"PeriodicalIF":0.0,"publicationDate":"2013-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/151027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32143861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Effect of 60 kHz and 150 kHz Femtosecond Lasers on Corneal Stromal Bed Surfaces: A Comparative Study. 60 kHz和150 kHz飞秒激光对角膜基质床表面影响的比较研究。
ISRN ophthalmology Pub Date : 2013-08-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/971451
Cristina Monterosso, Alessandro Galan, Elisabetta Böhm, Alfonso Zampini, Mohit Parekh, Luigi Caretti
{"title":"Effect of 60 kHz and 150 kHz Femtosecond Lasers on Corneal Stromal Bed Surfaces: A Comparative Study.","authors":"Cristina Monterosso,&nbsp;Alessandro Galan,&nbsp;Elisabetta Böhm,&nbsp;Alfonso Zampini,&nbsp;Mohit Parekh,&nbsp;Luigi Caretti","doi":"10.1155/2013/971451","DOIUrl":"https://doi.org/10.1155/2013/971451","url":null,"abstract":"<p><p>Purpose. To compare the effect of 60 kHz and 150 kHz femtosecond (FS) laser on the corneal stromal bed surfaces (SBS). Methods. Sixteen human donor corneal tissues unsuitable for transplantation were used. Anterior and posterior lamella was obtained using 60 kHz and 150 kHz FS laser. A standard depth of 400  μ m was set for anterior lamellar keratoplasty (ALK) and endothelial lamellar keratoplasty (ELK). The quality and smoothness of the SBS post-FS laser dissection were graded for statistics. Results. No intraoperative complications were found. The side cuts were straight, and the SBS appeared smoother in cuts obtained using 150 kHz. The average values of the SBS quality of the anterior lamellar cut were found to be 2.25 (±0.28) for 60 kHz and 3.125 (±0.25) for 150 kHz (P = 0.0039). Whereas, 2 (±0.4) for 60 kHz and 2.75 (±0.28) for 150 kHz (P = 0.0273) was the quality observed in endothelial cuts. No significant difference was found between anterior and posterior cuts performed using the same FS laser (60 kHz or 150 kHz) (P > 0.05). Conclusions. The 60 kHz and 150 kHz FS lasers are equally effective in performing lamellar dissection for ALK and ELK. 150 kHz FS laser allows a tighter spot and layer separation which creates a slightly smoother SBS. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"971451"},"PeriodicalIF":0.0,"publicationDate":"2013-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/971451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32144328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System. 渗出性黄斑变性的眼部危险因素:一种新型半自动分级系统。
ISRN ophthalmology Pub Date : 2013-07-30 eCollection Date: 2013-01-01 DOI: 10.1155/2013/464218
João Pedro Marques, Miguel Costa, Pedro Melo, Carlos Manta Oliveira, Isabel Pires, Maria Luz Cachulo, João Figueira, Rufino Silva
{"title":"Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System.","authors":"João Pedro Marques,&nbsp;Miguel Costa,&nbsp;Pedro Melo,&nbsp;Carlos Manta Oliveira,&nbsp;Isabel Pires,&nbsp;Maria Luz Cachulo,&nbsp;João Figueira,&nbsp;Rufino Silva","doi":"10.1155/2013/464218","DOIUrl":"https://doi.org/10.1155/2013/464218","url":null,"abstract":"<p><p>Purpose. To evaluate the contribution of the ocular risk factors in the conversion of the fellow eye of patients with unilateral exudative AMD, using a novel semiautomated grading system. Materials and Methods. Single-center, retrospective study including 89 consecutive patients with unilateral exudative AMD and ≥3 years of followup. Baseline color fundus photographs were graded using an innovative grading software, RetmarkerAMD (Critical Health SA). Results. The follow-up period was 60.9 ± 31.3 months. The occurrence of CNV was confirmed in 42 eyes (47.2%). The cumulative incidence of CNV was 23.6% at 2 years, 33.7% at 3 years, 39.3% at 5 years, and 47.2% at 10 years, with a mean annual incidence of 12.0% (95% CI = 0.088-0.162). The absolute number of drusen in the central 1000 and 3000  μ m (P < 0.05) and the absolute number of drusen ≥125 µm in the central 3000 and 6000 µm (P < 0.05) proved to be significant risk factors for CNV. Conclusion. The use of quantitative variables in the determination of the OR of developing CNV allowed the establishment of significant risk factors for neovascularization. The long follow-up period and the innovative methodology reinforce the value of our results. This trial is registered with ClinicalTrials.gov NCT00801541. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"464218"},"PeriodicalIF":0.0,"publicationDate":"2013-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/464218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32141108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
The role of lumican in ocular disease. lumican在眼部疾病中的作用。
ISRN ophthalmology Pub Date : 2013-07-24 eCollection Date: 2013-01-01 DOI: 10.1155/2013/632302
Shahriar Amjadi, Kelly Mai, Peter McCluskey, Denis Wakefield
{"title":"The role of lumican in ocular disease.","authors":"Shahriar Amjadi,&nbsp;Kelly Mai,&nbsp;Peter McCluskey,&nbsp;Denis Wakefield","doi":"10.1155/2013/632302","DOIUrl":"https://doi.org/10.1155/2013/632302","url":null,"abstract":"<p><p>Lumican is keratan sulfate proteoglycan of the small leucine rich proteoglycan family. Through studies in animal models lumican has been found to be critical in maintaining corneal clarity. It maintains ordered collagen fibrils which are vital in keeping the cornea transparent. It may also be important in primary open angle glaucoma influencing aqueous outflow. Lumican deficiency in mice results in increased axial length with fibromodulin deficiency and thinner sclerae. There is evidence suggesting that this characteristic may be pertinent in humans and lumican gene polymorphisms could be related to high myopia. Lumican plays a fundamental role in inflammation and wound healing. It localises macrophages to the site of corneal injury and recruits neutrophils in lipopolysaccharide-induced keratitis in mice. It has also been shown to bind lipopolysaccharide which may be critical in inflammatory diseases such as uveitis. Lumican is also important in wound healing revealing decreased synthesis in scar tissue and mediating Fas-Fas ligand interactions. It is present in human placenta and amniotic membrane suggesting that it may ensure viable amniotic membrane grafts. Lumican may also be involved in the formation of posterior capsular opacification following cataract surgery. Research into the pivotal role of lumican in the pathogenesis of ocular disease has resulted in greater understanding of the key role which proteoglycans play in human disease. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"632302"},"PeriodicalIF":0.0,"publicationDate":"2013-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/632302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32143866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
New therapeutic targets for intraocular pressure lowering. 降低眼压的新治疗靶点。
ISRN ophthalmology Pub Date : 2013-07-16 eCollection Date: 2013-01-01 DOI: 10.1155/2013/261386
A Rocha-Sousa, J Rodrigues-Araújo, Petra Gouveia, João Barbosa-Breda, S Azevedo-Pinto, P Pereira-Silva, A Leite-Moreira
{"title":"New therapeutic targets for intraocular pressure lowering.","authors":"A Rocha-Sousa,&nbsp;J Rodrigues-Araújo,&nbsp;Petra Gouveia,&nbsp;João Barbosa-Breda,&nbsp;S Azevedo-Pinto,&nbsp;P Pereira-Silva,&nbsp;A Leite-Moreira","doi":"10.1155/2013/261386","DOIUrl":"https://doi.org/10.1155/2013/261386","url":null,"abstract":"<p><p>Primary open-angle glaucoma (POAG) is a leading cause of irreversible and preventable blindness and ocular hypertension is the strongest known risk factor. With current classes of drugs, management of the disease focuses on lowering intraocular pressure (IOP). Despite of their use to modify the course of the disease, none of the current medications for POAG is able to reduce the IOP by more than 25%-30%. Also, some glaucoma patients show disease progression despite of the therapeutics. This paper examines the new described physiological targets for reducing the IOP. The main cause of elevated IOP in POAG is thought to be an increased outflow resistance via the pressure-dependent trabecular outflow system, so there is a crescent interest in increasing trabecular meshwork outflow by extracellular matrix remodeling and/or by modulation of contractility/TM cytoskeleton disruption. Modulation of new agents that act mainly on trabecular meshwork outflow may be the future hypotensive treatment for glaucoma patients. There are also other agents in which modulation may decrease aqueous humour production or increase uveoscleral outflow by different mechanisms from those drugs available for glaucoma treatment. Recently, a role for the ghrelin-GHSR system in the pathophysiology modulation of the anterior segment, particularly regarding glaucoma, has been proposed. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"261386"},"PeriodicalIF":0.0,"publicationDate":"2013-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/261386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32143864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Comparison of octopus semi-automated kinetic perimetry and humphrey peripheral static perimetry in neuro-ophthalmic cases. 章鱼半自动化动态视野与汉弗莱周围静态视野在神经眼病例中的比较。
ISRN ophthalmology Pub Date : 2013-07-15 eCollection Date: 2013-01-01 DOI: 10.1155/2013/753202
Fiona J Rowe, Carmel Noonan, Melanie Manuel
{"title":"Comparison of octopus semi-automated kinetic perimetry and humphrey peripheral static perimetry in neuro-ophthalmic cases.","authors":"Fiona J Rowe,&nbsp;Carmel Noonan,&nbsp;Melanie Manuel","doi":"10.1155/2013/753202","DOIUrl":"https://doi.org/10.1155/2013/753202","url":null,"abstract":"<p><p>Aim. To compare semikinetic perimetry (SKP) on Octopus 900 perimetry to a peripheral static programme with Humphrey automated perimetry. Methods. Prospective cross-section study comparing Humphrey full field (FF) 120 two zone programme to a screening protocol for SKP on Octopus perimetry. Results were independently graded for presence/absence of field defect plus type and location of defect. Results. 64 patients (113 eyes) underwent dual perimetry assessment. Mean duration of assessment for SKP was 4.54 minutes ±0.18 and 6.17 ± 0.12 for FF120 (P = 0.0001). 80% of results were correctly matched for normal or abnormal visual fields using the I4e target versus FF120, and 73.5% were correctly matched using the I2e target versus FF120. When comparing Octopus results with combined I4e and I2e isopters to the FF120 result, a match for normal or abnormal fields was recorded in 87%. Conclusions. Humphrey perimetry test duration was generally longer than Octopus SKP. In the absence of kinetic perimetry, peripheral static suprathreshold programme options such as FF120 may be useful for detection of visual field defects. However, statokinetic dissociation may occur. Octopus SKP utilising both I4e and I2e targets provides detailed information of both the defect depth and size and may provide a more representative view of the actual visual field defect. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"753202"},"PeriodicalIF":0.0,"publicationDate":"2013-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/753202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32144323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Clinical outcomes of peripheral iridotomy in patients with the spectrum of chronic primary angle closure. 慢性原发性闭角谱患者外周血虹膜切开术的临床疗效。
ISRN ophthalmology Pub Date : 2013-06-26 eCollection Date: 2013-01-01 DOI: 10.1155/2013/828972
Ricardo J Cumba, Kundandeep S Nagi, Nicholas P Bell, Lauren S Blieden, Alice Z Chuang, Kimberly A Mankiewicz, Robert M Feldman
{"title":"Clinical outcomes of peripheral iridotomy in patients with the spectrum of chronic primary angle closure.","authors":"Ricardo J Cumba,&nbsp;Kundandeep S Nagi,&nbsp;Nicholas P Bell,&nbsp;Lauren S Blieden,&nbsp;Alice Z Chuang,&nbsp;Kimberly A Mankiewicz,&nbsp;Robert M Feldman","doi":"10.1155/2013/828972","DOIUrl":"https://doi.org/10.1155/2013/828972","url":null,"abstract":"<p><p>Purpose. To evaluate outcomes of peripheral iridotomy (PI) for initial management of primary angle closure suspects (PACS), chronic primary angle closure (CPAC), and chronic primary angle closure glaucoma (CPACG). Patients and Methods. Seventy-nine eyes with PACS, CPAC, or CPACG and better than 20/50 visual acuity that underwent PI as initial management were included. Eyes with previous acute angle closure attacks, laser trabeculoplasties, surgeries, or intraocular injections were excluded. Additional treatments, glaucomatous progression, intraocular pressure, visual acuity, and the number of medications were evaluated. Results. The mean followup was 57.1 ± 29.0 months (range 13.8-150.6 months). Sixty-eight eyes (86.1%) underwent additional medical, laser, or surgical treatment. Forty eyes (50.6%) underwent lens extraction due to reduced visual acuity. The mean 10× logMAR visual acuity score for all patients significantly declined from 0.94 ± 1.12 at baseline to 1.83 ± 3.49 (N = 79, P = 0.0261) at the last followup. Conclusions. Most patients who undergo PI for CPAC spectrum will require additional intervention for either IOP lowering or improvement of visual acuity. This suggests that a procedure that not only deepens the angle but also lowers IOP and improves visual acuity would be desirable as further intervention could be avoided. Evaluation of techniques that achieve all 3 goals is warranted. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"828972"},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/828972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32144325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Lens-Induced Glaucoma: The Need to Spread Awareness about Early Management of Cataract among Rural Population. 晶状体性青光眼:需要在农村人群中普及白内障早期治疗意识。
ISRN ophthalmology Pub Date : 2013-06-25 eCollection Date: 2013-01-01 DOI: 10.1155/2013/581727
Raghunandan Kothari, Sandeep Tathe, Pratik Gogri, Akshay Bhandari
{"title":"Lens-Induced Glaucoma: The Need to Spread Awareness about Early Management of Cataract among Rural Population.","authors":"Raghunandan Kothari,&nbsp;Sandeep Tathe,&nbsp;Pratik Gogri,&nbsp;Akshay Bhandari","doi":"10.1155/2013/581727","DOIUrl":"https://doi.org/10.1155/2013/581727","url":null,"abstract":"<p><p>Purpose. To determine the clinical profile of lens-induced glaucoma (LIG), reasons for late presentation, and outcome of current management. Methods. Retrospective analysis of 50 eyes with LIG over a 6-year period between 2005 and 2011 at a tertiary care centre in rural India. Visual acuity and intraocular pressure (IOP) were assessed preoperatively and postoperatively along with postoperative complications. Results. Fifty (2.4%) of 12,004 senile cataracts operated at Pravara Rural Hospital, Loni, presented with LIG. There were 39 (78%) phacomorphic cases and 11 (22%) phacolytic glaucoma. Following cataract surgery, 21 of 50 operated eyes (42%) had visual acuity 6/60 or worse. Conclusion. The results highlight the importance of early diagnosis and treatment of visually disabling cataract. There is a need to educate both the patient and the cataract surgeon about the dangers of lens-induced glaucoma and of about poor outcome if treatment is delayed. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"581727"},"PeriodicalIF":0.0,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/581727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32141109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Association of reticular pseudodrusen and early onset drusen. 网状假性早衰与早发性早衰的关系。
ISRN ophthalmology Pub Date : 2013-05-16 eCollection Date: 2013-01-01 DOI: 10.1155/2013/273085
Flore De Bats, Benjamin Wolff, Martine Mauget-Faÿsse, Isabelle Meunier, Philippe Denis, Laurent Kodjikian
{"title":"Association of reticular pseudodrusen and early onset drusen.","authors":"Flore De Bats,&nbsp;Benjamin Wolff,&nbsp;Martine Mauget-Faÿsse,&nbsp;Isabelle Meunier,&nbsp;Philippe Denis,&nbsp;Laurent Kodjikian","doi":"10.1155/2013/273085","DOIUrl":"https://doi.org/10.1155/2013/273085","url":null,"abstract":"<p><p>Purpose. To report an association between reticular pseudodrusen, located above the retinal pigment epithelium (RPE), and Early Onset Drusen (EOD) as described using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods. Eight patients (16 eyes) with EOD were examined. EOD were classified into three entities called Large Colloid Drusen (LCD), Malattia Leventinese (ML), and Cuticular Drusen (CD). Best-corrected visual acuity, fundus examination, color fundus photographs, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and SD-OCT were performed in all study patients. Results. Four patients had LCD, 2 had ML, and 2 had CD. Reticular pseudodrusen were observed with SD-OCT in all study patients; all these patients had hyperreflective lesions above and below the RPE. Conclusion. Early Onset Drusen appear to be associated with reticular pseudodrusen. SD-OCT is helpful in distinguishing the location of the deposits that are above and below the RPE in EOD. Further studies are needed to understand the role of reticular pseudodrusen in the pathophysiology of EOD. </p>","PeriodicalId":90193,"journal":{"name":"ISRN ophthalmology","volume":"2013 ","pages":"273085"},"PeriodicalIF":0.0,"publicationDate":"2013-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/273085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32148443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
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