Blood vessels最新文献_第5页

Hypernoradrenergic innervation and vascular smooth muscle hyperplastic change. 高去甲肾上腺素能神经支配与血管平滑肌增生性改变。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158858

R J Head

引用次数: 47

Spatial and temporal resolution of serotonin-induced changes in intracellular calcium in a cultured arterial smooth muscle cell line. 5 -羟色胺诱导的动脉平滑肌细胞系细胞内钙变化的时空分辨率。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158870

W F Goldman

{"title":"Spatial and temporal resolution of serotonin-induced changes in intracellular calcium in a cultured arterial smooth muscle cell line.","authors":"W F Goldman","doi":"10.1159/000158870","DOIUrl":"https://doi.org/10.1159/000158870","url":null,"abstract":"Ca2+ transients (1-2 microM) evoked by serotonin (5-HT) in cultured A7r5 cells were studied using fura-2 and digital imaging microscopy. Fura-2 was introduced into cells either by incubation with its acetoxymethyl ester analogue fura-2/AM or by transient ATP-induced permeabilization of the sarcolemma such that the free fura-2 entered the cell directly. The distribution of cytoplasmic Ca2+ in unstimulated cells loaded by the former method was heterogeneous, reflecting, in part, separate pools of Ca2+ in the cytosol and sarcoplasmic reticulum (SR). In contrast, the distribution of Ca2+ was uniform in cells loaded with fura-2 by transient permeabilization; this reflected the restriction of fura-2 to the cytosol. Average Ca2+ in these cells was substantially lower than that in fura-2/AM-loaded cells, because SR Ca2+ influences the fura-2 signal from fura-2/AM-loaded cells, but not from cells loaded with free fura-2. The differences in the Ca2+ distribution measured by the two loading methods were also evident during the course of 5-HT-evoked Ca2+ transients. Spatial and temporal resolution of the rising phase of 5-HT-evoked Ca2+ transients in fura-2/AM-loaded cells revealed that the onset of the Ca2+ transients was first manifested as small regions of elevated Ca2+ that subsequently expanded until peak apparent intracellular Ca2+ levels were present in virtually all of the nonnuclear regions of the cells. The rate of rise of Ca2+ varied in different cell regions with the nucleus responding the slowest.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13159383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Release of vasoactive peptides from autonomic and sensory nerves. 自主神经和感觉神经血管活性肽的释放。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158840

J M Lundberg, A Franco-Cereceda, J S Lacroix, J Pernow

引用次数: 29

Postischemic cerebral blood flow and neuroeffector mechanisms. 脑缺血后血流和神经效应机制。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158842

R Macfarlane, M A Moskowitz, E Tasdemiroglu, E P Wei, H A Kontos

{"title":"Postischemic cerebral blood flow and neuroeffector mechanisms.","authors":"R Macfarlane, M A Moskowitz, E Tasdemiroglu, E P Wei, H A Kontos","doi":"10.1159/000158842","DOIUrl":"https://doi.org/10.1159/000158842","url":null,"abstract":"The influence of neuroeffector mechanisms in the regulation of postischemic cerebral blood flow was investigated by microsphere determination in 8 cats after chronic unilateral vascular deafferentation by trigeminal ganglionectomy. The animals were subjected to 90 min of reperfusion following 10 min of global ischemia induced by 4-vessel occlusion and systemic hypotension. Cortical hyperemia 30 min after reperfusion was attenuated by up to 48% in cortical gray matter ipsilateral to the side of trigeminal ganglionectomy (p less than 0.01). Axon reflex mechanisms involving the release of neuropeptides from peripheral sensory nerve fibers, such as substance P (SP), calcitonin gene-related peptide (CGRP) and neurokinin A (NKA), mediate this response. SP and NKA cause vasodilation by endothelium-dependent mechanisms (endothelium-dependent relaxing factor), whereas CGRP relaxes vascular smooth muscle by direct receptor interactions. Studies were therefore undertaken to determine the extent to which endothelium-dependent mechanisms mediate the hyperemia following global cerebral ischemia. In 7 intact cats, the postischemic response of pial arterioles to the topical application of acetylcholine (ACh; 10(-7) M), an endothelial-dependent vasodilator, was measured using a closed cranial window technique. Although ACh increased pial arteriolar caliber by 17% under resting conditions, the same dose elicited a vasoconstrictor response (87% of pre-ACh diameter 30 min after reperfusion) for the first 60 min of reperfusion after 10 min of ischemia. ACh-induced vasodilation was restored by 75 min (105%), but was less than control even at 120 min (109 vs. 117%; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13159386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Contractile and morphologic properties of a saphenous vein after 12 years as an aortocoronary bypass graft. 冠状动脉旁路移植术12年后隐静脉的收缩和形态学特征。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158880

S. Steen, R. Willén, T. Sjöberg, B. Carlén

引用次数: 5

L-arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. l -精氨酸在体外不能恢复动脉粥样硬化兔主动脉内皮功能障碍。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158881

A Mügge, D G Harrison

引用次数: 55

Effect of age on rabbit aortic responses to relaxant endothelium-dependent and endothelium-independent agents. 年龄对兔主动脉对舒张性内皮依赖性和非内皮依赖性药物反应的影响。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158882

A Chinellato, L Pandolfo, E Ragazzi, M R Zambonin, G Froldi, M De Biasi, L Caparrotta, G Fassina

{"title":"Effect of age on rabbit aortic responses to relaxant endothelium-dependent and endothelium-independent agents.","authors":"A Chinellato, L Pandolfo, E Ragazzi, M R Zambonin, G Froldi, M De Biasi, L Caparrotta, G Fassina","doi":"10.1159/000158882","DOIUrl":"https://doi.org/10.1159/000158882","url":null,"abstract":"The aim of this study was to evaluate the effects of aging on endothelium-dependent and endothelium-independent relaxation of rabbit thoracic aorta from New Zealand white rabbits aged 4-6 and 7-12 months. The contractile response to noradrenaline (NA) decreased with increasing age, but NA [EC50] did not vary significantly. Acetylcholine (Ach)-induced relaxation of aortic rings precontracted with NA [EC50] did not change significantly with increasing age. The relaxation induced by ATP of aortic rings, precontracted with NA [EC50], was significantly greater in young than in adult rabbits. This difference between young and adult animals became more evident in aortic rings deprived of endothelium: in adult animals, the ATP-induced relaxation of aortic rings with endothelium was significantly greater than in the rings without endothelium. The endothelium-independent relaxation by sodium nitrite (NaNO2) at lower concentrations was significantly greater in young than in adult rabbit aortic rings precontracted with NA [EC50]. Concluding, the age-induced changes in vascular response in male New Zealand white rabbits are related to an impaired mechanism at smooth muscle level.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158882","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13071550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Development of collaterals in the cerebral circulation. 经络在脑循环中的发展。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158860

P Coyle, D D Heistad

引用次数: 94

Is there a role for the vascular renin-angiotensin system in the determination of vascular structure? 血管肾素-血管紧张素系统在决定血管结构中是否有作用?

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158866

M J Mulvany

引用次数: 5

Role of the local renin-angiotensin system in the autoregulation of the cerebral circulation. 局部肾素-血管紧张素系统在脑循环自动调节中的作用。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158867

O B Paulson, G Waldemar

引用次数: 36