Metallomics最新文献_第7页

Mercury and selenium distribution in human brain tissue using synchrotron micro-X-ray fluorescence. 利用同步加速器显微 X 射线荧光分析人脑组织中汞和硒的分布。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae018

Alexis N Webb, Olga Antipova, Serena Shughoury, Jose M Farfel, David A Bennett, Yansheng Du, Wei Zheng, Linda H Nie

{"title":"Mercury and selenium distribution in human brain tissue using synchrotron micro-X-ray fluorescence.","authors":"Alexis N Webb, Olga Antipova, Serena Shughoury, Jose M Farfel, David A Bennett, Yansheng Du, Wei Zheng, Linda H Nie","doi":"10.1093/mtomcs/mfae018","DOIUrl":"10.1093/mtomcs/mfae018","url":null,"abstract":"Mercury is a well-recognized environmental contaminant and neurotoxin, having been associated with a number of deleterious neurological conditions including neurodegenerative diseases, such as Alzheimer's disease. To investigate how mercury and other metals behave in the brain, we used synchrotron micro-X-ray fluorescence to map the distribution pattern and quantify concentrations of metals in human brain. Brain tissue was provided by the Rush Alzheimer's Disease Center and samples originated from individuals diagnosed with Alzheimer's disease and without cognitive impairment. Data were collected at the 2-ID-E beamline at the Advanced Photon Source at Argonne National Laboratory with an incident beam energy of 13 keV. Course scans were performed at low resolution to determine gross tissue features, after which smaller regions were selected to image at higher resolution. The findings revealed (1) the existence of mercury particles in the brain samples of two subjects; (2) co-localization and linear correlation of mercury and selenium in all particles; (3) co-localization of these particles with zinc structures; and (4) association with sulfur in some of these particles. These results suggest that selenium and sulfur may play protective roles against mercury in the brain, potentially binding with the metal to reduce the induced toxicity, although at different affinities. Our findings call for further studies to investigate the relationship between mercury, selenium, and sulfur, as well as the potential implications in Alzheimer's disease and related dementias.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":"16 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro. 甘氨酰-L-组氨酰-L-赖氨酸（GHK）可在体外防止铜和锌诱导的蛋白质聚集和中枢神经系统细胞死亡。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae019

Jin-Hong Min, Heela Sarlus, Robert A Harris

{"title":"Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitro.","authors":"Jin-Hong Min, Heela Sarlus, Robert A Harris","doi":"10.1093/mtomcs/mfae019","DOIUrl":"10.1093/mtomcs/mfae019","url":null,"abstract":"Common features of neurodegenerative diseases are oxidative and inflammatory imbalances as well as the misfolding of proteins. An excess of free metal ions can be pathological and contribute to cell death, but only copper and zinc strongly promote protein aggregation. Herein we demonstrate that the endogenous copper-binding tripeptide glycyl-l-histidyl-l-lysine (GHK) has the ability to bind to and reduce copper redox activity and to prevent copper- and zinc-induced cell death in vitro. In addition, GHK prevents copper- and zinc-induced bovine serum albumin aggregation and reverses aggregation through resolubilizing the protein. We further demonstrate the enhanced toxicity of copper during inflammation and the ability of GHK to attenuate this toxicity. Finally, we investigated the effects of copper on enhancing paraquat toxicity and report a protective effect of GHK. We therefore conclude that GHK has potential as a cytoprotective compound with regard to copper and zinc toxicity, with positive effects on protein solubility and aggregation that warrant further investigation in the treatment of neurodegenerative diseases.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quest for a stable Cu-ligand complex with a high catalytic activity to produce reactive oxygen species. 探索具有高催化活性的稳定铜配体复合物，以产生 ROS。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae020

Merwan Bouraguba, Adeline M Schmitt, Venkata Suseela Yelisetty, Bertrand Vileno, Frédéric Melin, Elise Glattard, Christophe Orvain, Vincent Lebrun, Laurent Raibaut, Marianne Ilbert, Burkhard Bechinger, Petra Hellwig, Christian Gaiddon, Angélique Sour, Peter Faller

{"title":"Quest for a stable Cu-ligand complex with a high catalytic activity to produce reactive oxygen species.","authors":"Merwan Bouraguba, Adeline M Schmitt, Venkata Suseela Yelisetty, Bertrand Vileno, Frédéric Melin, Elise Glattard, Christophe Orvain, Vincent Lebrun, Laurent Raibaut, Marianne Ilbert, Burkhard Bechinger, Petra Hellwig, Christian Gaiddon, Angélique Sour, Peter Faller","doi":"10.1093/mtomcs/mfae020","DOIUrl":"10.1093/mtomcs/mfae020","url":null,"abstract":"Metal ion-catalyzed overproduction of reactive oxygen species (ROS) is believed to contribute significantly to oxidative stress and be involved in several biological processes, from immune defense to development of diseases. Among the essential metal ions, copper is one of the most efficient catalysts in ROS production in the presence of O2 and a physiological reducing agent such as ascorbate. To control this chemistry, Cu ions are tightly coordinated to biomolecules. Free or loosely bound Cu ions are generally avoided to prevent their toxicity. In the present report, we aim to find stable Cu-ligand complexes (Cu-L) that can efficiently catalyze the production of ROS in the presence of ascorbate under aerobic conditions. Thermodynamic stability would be needed to avoid dissociation in the biological environment, and high ROS catalysis is of interest for applications as antimicrobial or anticancer agents. A series of Cu complexes with the well-known tripodal and tetradentate ligands containing a central amine linked to three pyridyl-alkyl arms of different lengths were investigated. Two of them with mixed arm length showed a higher catalytic activity in the oxidation of ascorbate and subsequent ROS production than Cu salts in buffer, which is an unprecedented result. Despite these high catalytic activities, no increased antimicrobial activity toward Escherichia coli or cytotoxicity against eukaryotic AGS cells in culture related to Cu-L-based ROS production could be observed. The potential reasons for discrepancy between in vitro and in cell data are discussed.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of aging on copper isotopic composition in the murine brain. 衰老对鼠脑中铜同位素组成的影响

IF 2.9 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae008

Esther Lahoud, Frédéric Moynier, Tu-Han Luu, Brandon Mahan, Marie Le Borgne

{"title":"Impact of aging on copper isotopic composition in the murine brain.","authors":"Esther Lahoud, Frédéric Moynier, Tu-Han Luu, Brandon Mahan, Marie Le Borgne","doi":"10.1093/mtomcs/mfae008","DOIUrl":"10.1093/mtomcs/mfae008","url":null,"abstract":"Aging is the main risk factor for Alzheimer's disease (AD). AD is linked to alterations in metal homeostasis and changes in stable metal isotopic composition can occur, possibly allowing the latter to serve as relevant biomarkers for potential AD diagnosis. Copper stable isotopes are used to investigate changes in Cu homeostasis associated with various diseases. Prior work has shown that in AD mouse models, the accumulation of 63Cu in the brain is associated with the disease's progression. However, our understanding of how the normal aging process influences the brain's isotopic composition of copper remains limited. In order to determine the utility and predictive power of Cu isotopes in AD diagnostics, we aim-in this study-to develop a baseline trajectory of Cu isotopic composition in the normally aging mouse brain. We determined the copper concentration and isotopic composition in brains of 30 healthy mice (WT) ranging in age from 6 to 12 mo, and further incorporate prior data obtained for 3-mo-old healthy mice; this range approximately equates to 20-50 yr in human equivalency. A significant 65Cu enrichment has been observed in the 12-mo-old mice compared to the youngest group, concomitant with an increase in Cu concentration with age. Meanwhile, literature data for brains of AD mice display an enrichment in 63Cu isotope compared to WT. It is acutely important that this baseline enrichment in 65Cu is fully constrained and normalized against if any coherent diagnostic observations regarding 63Cu enrichment as a biomarker for AD are to be developed.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-exposure to lead and high-fat diet aggravates systemic inflammation in mice by altering gut microbiota and the LPS/TLR4 pathway. 通过改变肠道微生物群和 LPS/TLR4 通路，共同暴露于铅和高脂饮食会加重小鼠的全身炎症。

IF 2.9 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae022

Nana Wang, Changhao Li, Xue Gao, Yuan Huo, Yuting Li, Fangru Cheng, Fei Jiang, Zengli Zhang

{"title":"Co-exposure to lead and high-fat diet aggravates systemic inflammation in mice by altering gut microbiota and the LPS/TLR4 pathway.","authors":"Nana Wang, Changhao Li, Xue Gao, Yuan Huo, Yuting Li, Fangru Cheng, Fei Jiang, Zengli Zhang","doi":"10.1093/mtomcs/mfae022","DOIUrl":"10.1093/mtomcs/mfae022","url":null,"abstract":"This study reports the toxicity of Pb exposure on systemic inflammation in high-fat-diet (HFD) mice and the potential mechanisms. Results indicated that Pb exacerbated intestinal barrier damage and increased serum levels of lipopolysaccharide (LPS) and diamine oxidase in HFD mice. Elevated LPS activates the colonic and ileal LPS-TLR4 inflammatory signaling pathway and further induces hepatic and adipose inflammatory expression. The 16S rRNA gene sequencing results showed that Pb promoted the abundance of potentially harmful and LPS-producing bacteria such as Coriobacteriaceae_UCG-002, Alloprevotella, and Oscillibacter in the intestines of HFD mice, and their abundance was positively correlated with LPS levels. Additionally, Pb inhibited the abundance of the beneficial bacteria Akkermansia, resulting in lower levels of the metabolite short-chain fatty acids (SCFAs). Meanwhile, Pb inhibited adenosine 5'-monophosphate-activated protein kinase signaling-mediated lipid metabolism pathways, promoting hepatic lipid accumulation. The above results suggest that Pb exacerbates systemic inflammation and lipid disorders in HFD mice by altering the gut microbiota, intestinal barrier, and the mediation of metabolites LPS and SCFAs. Our study provides potential novel mechanisms of human health related to Pb-induced metabolic damage and offers new evidence for a comprehensive assessment of Pb risk.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron-sulfur protein odyssey: exploring their cluster functional versatility and challenging identification. 铁硫蛋白奥德赛：探索其集群功能多样性和具有挑战性的鉴定。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae025

Cindy Vallières, Orane Benoit, Olivier Guittet, Meng-Er Huang, Michel Lepoivre, Marie-Pierre Golinelli-Cohen, Laurence Vernis

{"title":"Iron-sulfur protein odyssey: exploring their cluster functional versatility and challenging identification.","authors":"Cindy Vallières, Orane Benoit, Olivier Guittet, Meng-Er Huang, Michel Lepoivre, Marie-Pierre Golinelli-Cohen, Laurence Vernis","doi":"10.1093/mtomcs/mfae025","DOIUrl":"10.1093/mtomcs/mfae025","url":null,"abstract":"Iron-sulfur (Fe-S) clusters are an essential and ubiquitous class of protein-bound prosthetic centers that are involved in a broad range of biological processes (e.g. respiration, photosynthesis, DNA replication and repair and gene regulation) performing a wide range of functions including electron transfer, enzyme catalysis, and sensing. In a general manner, Fe-S clusters can gain or lose electrons through redox reactions, and are highly sensitive to oxidation, notably by small molecules such as oxygen and nitric oxide. The [2Fe-2S] and [4Fe-4S] clusters, the most common Fe-S cofactors, are typically coordinated by four amino acid side chains from the protein, usually cysteine thiolates, but other residues (e.g. histidine, aspartic acid) can also be found. While diversity in cluster coordination ensures the functional variety of the Fe-S clusters, the lack of conserved motifs makes new Fe-S protein identification challenging especially when the Fe-S cluster is also shared between two proteins as observed in several dimeric transcriptional regulators and in the mitoribosome. Thanks to the recent development of in cellulo, in vitro, and in silico approaches, new Fe-S proteins are still regularly identified, highlighting the functional diversity of this class of proteins. In this review, we will present three main functions of the Fe-S clusters and explain the difficulties encountered to identify Fe-S proteins and methods that have been employed to overcome these issues.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-binding proteins and exonic splicing enhancers and silencers. 铜结合蛋白与外显子剪接增强子和沉默子。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae023

Dara Bakhtiar, Igor Vorechovsky

{"title":"Copper-binding proteins and exonic splicing enhancers and silencers.","authors":"Dara Bakhtiar, Igor Vorechovsky","doi":"10.1093/mtomcs/mfae023","DOIUrl":"10.1093/mtomcs/mfae023","url":null,"abstract":"Eukaryotic DNA codes not only for proteins but contains a wealth of information required for accurate splicing of messenger RNA precursors and inclusion of constitutively or alternatively spliced exons in mature transcripts. This \"auxiliary\" splicing code has been characterized as exonic splicing enhancers and silencers (ESE and ESS). The exact interplay between protein and splicing codes is, however, poorly understood. Here, we show that exons encoding copper-coordinating amino acids in human cuproproteins lack ESEs and/or have an excess of ESSs, yet RNA sequencing and expressed sequence tags data show that they are more efficiently included in mature transcripts by the splicing machinery than average exons. Their largely constitutive inclusion in messenger RNA is facilitated by stronger splice sites, including polypyrimidine tracts, consistent with an important role of the surrounding intron architecture in ensuring high expression of metal-binding residues during evolution. ESE/ESS profiles of codons and entire exons that code for copper-coordinating residues were very similar to those encoding residues that coordinate zinc but markedly different from those that coordinate calcium. Together, these results reveal how the traditional and auxiliary splicing motifs responded to constraints of metal coordination in proteins.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the role of zinc ions on struvite nucleation and growth in the context of infection urinary stones. 了解锌离子在感染性泌尿系结石中对结石成核和生长的作用。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-05-02 DOI: 10.1093/mtomcs/mfae017

Jolanta Prywer, Agnieszka Torzewska, Ewa Mielniczek-Brzóska

{"title":"Understanding the role of zinc ions on struvite nucleation and growth in the context of infection urinary stones.","authors":"Jolanta Prywer, Agnieszka Torzewska, Ewa Mielniczek-Brzóska","doi":"10.1093/mtomcs/mfae017","DOIUrl":"10.1093/mtomcs/mfae017","url":null,"abstract":"Taking into account that in recent decades there has been an increase in the incidence of urinary stones, especially in highly developed countries, from a wide range of potentially harmful substances commonly available in such countries, we chose zinc for the research presented in this article, which is classified by some sources as a heavy metal. In this article, we present the results of research on the influence of Zn2+ ion on the nucleation and growth of struvite crystals-the main component of infection urinary stones. The tests were carried out in an artificial urine environment with and without the presence of Proteus mirabilis bacteria. In the latter case, the activity of bacterial urease was simulated chemically, by systematic addition of an aqueous ammonia solution. The obtained results indicate that Zn2+ ions compete with Mg2+ ions, which leads to the gradual replacement of Mg2+ ions in the struvite crystal lattice with Zn2+ ions to some extent. This means co-precipitation of Mg-struvite (MgNH4PO4·6H2O) and Znx-struvite (Mg1-xZnxNH4PO4·6H2O). Speciation analysis of chemical complexes showed that Znx-struvite precipitates at slightly lower pH values than Mg-struvite. This means that Zn2+ ions shift the nucleation point of crystalline solids towards a lower pH. Additionally, the conducted research shows that Zn2+ ions, in the range of tested concentrations, do not have a toxic effect on bacteria; on the contrary, it has a positive effect on cellular metabolism, enabling bacteria to develop better. It means that Zn2+ ions in artificial urine, in vitro, slightly increase the risk of developing infection urinary stones.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The decline in cellular iron is crucial for differentiation in keratinocytes. 细胞铁的减少对角质形成细胞的分化至关重要。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-04-05 DOI: 10.1093/mtomcs/mfae014

Junya Abe, Yuichi Aono, Yohei Hirai

{"title":"The decline in cellular iron is crucial for differentiation in keratinocytes.","authors":"Junya Abe, Yuichi Aono, Yohei Hirai","doi":"10.1093/mtomcs/mfae014","DOIUrl":"10.1093/mtomcs/mfae014","url":null,"abstract":"Iron is a vital metal for most biological functions in tissues, and its concentration is exquisitely regulated at the cellular level. During the process of differentiation, keratinocytes in the epidermis undergo a noticeable reduction in iron content. Conversely, psoriatic lesions, characterized by disruptions in epidermal differentiation, frequently reveal an excessive accumulation of iron within keratinocytes that have undergone differentiation. In this study, we clarified the significance of attenuated cellular iron content in the intricate course of epidermal differentiation. We illustrated this phenomenon through the utilization of hinokitiol, an iron chelator derived from the heartwood of Taiwanese hinoki, which forcibly delivers iron into cells independent of the intrinsic iron-regulation systems. While primary cultured keratinocytes readily succumbed to necrotic cell death by this iron chelator, mild administration of the hinokitiol-iron complex modestly disrupts the process of differentiation in these cells. Notably, keratinocyte model cells HaCaT and anaplastic skin rudiments exhibit remarkable resilience against the cytotoxic impact of hinokitiol, and the potent artificial influx of iron explains a suppressive effect selectively on epidermal differentiation. Moreover, the augmentation of iron content induced by the overexpression of divalent metal transporter 1 culminates in the inhibition of differentiation in HaCaT cells. Consequently, the diminution in cellular iron content emerges as an important determinant influencing the trajectory of keratinocyte differentiation.","PeriodicalId":89,"journal":{"name":"Metallomics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction of: Nitrogen sources enhance siderophore-mediated competition for iron between potato common scab and late blight causative agents. 撤回：氮源可增强嗜苷酸盐介导的马铃薯普通疮痂病和晚疫病病原菌之间的铁竞争。

IF 3.4 3区生物学

Metallomics Pub Date : 2024-04-05 DOI: 10.1093/mtomcs/mfae021

引用次数: 0