ISBT science series最新文献

{"title":"Effectiveness of personal communication strategy in motivating replacement donors to become voluntary blood donors","authors":"Romesh Jain,&nbsp;Rakesh Kumar,&nbsp;Poonam Coshic,&nbsp;Hem Chandra Pandey,&nbsp;Shubhangi Jain","doi":"10.1111/voxs.12628","DOIUrl":"10.1111/voxs.12628","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and objectives</h3>\u0000 \u0000 <p>Blood donation is very crucial for continuous supply of blood in blood banks for the appropriate patient management. This study was conducted to obtain information from replacement blood donors regarding barriers for voluntary blood donation, and for this, we assessed the effectiveness of personal communication strategy to convert them into voluntary blood donors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>Prospective longitudinal interventional study with personal communication strategy as intervention, conducted on in-house replacement blood donors, who never donated voluntarily, and to convert them into future voluntary blood donors. Enrolled blood donors were randomized into the case and the control arms, and a questionnaire regarding barrier for voluntary blood donation was administered. Personal communication strategy was applied in the case arm, and no intervention was done in the control arm. Six months after the enrolment, donors were contacted telephonically and the history of repeat donation in the last 3 months was asked.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the selected 769 donors, 381 and 388 donors were randomized into the case and the control arms, respectively. Lack of awareness about voluntary blood donation, lack of time and convenience were the most common reasons for not donating blood voluntarily. In the post-motivational period, 23·35% and 3·35% of the blood donors in the case and the control arms, respectively, donated blood voluntarily.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study revealed the factors for not donating blood voluntarily. We believe that our results can be used to convert the existing replacement donors into voluntary donors by applying the personal communication strategy, and future study can be planned, combined with some other effective tools to bring the maximum desired results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 2","pages":"196-203"},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41822062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, observational study to compare effect of DTT treatment and heat inactivation on ABO isoagglutinin titers in O blood group donors","authors":"Prashant Pandey,&nbsp;Divya Setya,&nbsp;Shweta Ranjan,&nbsp;Mukesh Kumar Singh","doi":"10.1111/voxs.12629","DOIUrl":"10.1111/voxs.12629","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and aims</h3>\u0000 \u0000 <p>In order to determine actual concentration of clinically significant IgG antibodies, there is a need to inactivate IgM antibodies, which can be performed by DTT or heat. The aim of the present study was to compare the effect of DTT treatment and heat inactivation (HI) on ABO isoagglutinin titres performed by column agglutination technology (CAT) and conventional tube technique (CTT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors were included. Serum from each donor was treated with DTT, and heat and tests were performed by CTT and CAT before and after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 2005 donors were included. 401 (20%) samples had inter-observer variation by CTT, and 69 (3·4%) had inter-observer variation by CAT. Median anti-A and anti-B titre results were higher with CAT as compared to CTT. Median anti-A and anti-B IgG titre results showed a one- to twofold difference between CTT and CAT with higher titres reported by CAT. Median IgM titres decreased two- to threefold after DTT treatment, whereas onefold decrease was confirmed after HI. Concordance was found to be poor. However, correlation was found to be strong.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is overestimation of ABO IgG antibody titres and hence, estimation of ABO IgG titres after inactivation of IgM antibodies is strongly recommended. DTT treatment was found to be superior to HI in terms of efficiency in elimination of IgM activity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 4","pages":"258-268"},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42895680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality improvement interventions for Bedside Transfusion safety: An experience from a tertiary healthcare centre of Western India","authors":"Revathy Nair,&nbsp;Puneeth Babu Anne,&nbsp;Praveen Kumar Mishra,&nbsp;Akhil Dhanesh Goel,&nbsp;Bajpayee Archana","doi":"10.1111/voxs.12627","DOIUrl":"10.1111/voxs.12627","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Quality indicators in Transfusion Medicine are critically important aspects that can be measured and utilized to design interventions for continuous quality improvement. Interventions for improvement in bedside transfusion practices are required to check the adherence to standard protocol for safe transfusion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study design and methods</h3>\u0000 \u0000 <p>A prospective study was conducted with a structured checklist survey of 4 key elements, to collect data for baseline assessment phase I survey, subsequently phase II survey repeated after introduction of Transfusion Monitoring Form and Telephonic reminders from blood bank. Pre- and Post-intervention data collected, tabulated and analysed using Statistical Package for Social Sciences (SPSS version 23).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Identification of Patient, Transfusion initiation within 30 min of issue, Vitals monitoring during transfusion and completion of transfusion within time limit are the four key elements of quality indicators were checked pre- and post-intervention. Mean composite score of quality indicators before intervention was 2·3 ± 1·3 and increased to 3·2 ± 1·3 (<i>P</i> value &lt; 0·001) after implementation of the Transfusion Monitoring form and Reminder calls from Blood Bank.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Manufacturing good quality blood components alone does not ensure good transfusion services. Active interventions by Transfusion specialist ensure good bedside transfusion practices. Introduction of blood transfusion monitoring form and Telephonic reminders from the blood centre brought in significant changes in the existing bedside transfusion practices and safer transfusion at our centre.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 4","pages":"341-345"},"PeriodicalIF":0.0,"publicationDate":"2021-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44963504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of donation return rate in young donors using machine-learning models","authors":"Marc Cloutier,&nbsp;Yves Grégoire,&nbsp;Karine Choucha,&nbsp;Anne-Marie Amja,&nbsp;Antoine Lewin","doi":"10.1111/voxs.12618","DOIUrl":"10.1111/voxs.12618","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and objectives</h3>\u0000 \u0000 <p>The identification of factors leading to high or low return rates among volunteer blood donors is increasingly important to maintain sufficient blood supply. A particular focus on young donors is an essential component of blood bank donor retention strategy. By means of large databases, our aim was to predict the donation frequency pattern of young donors using a random forest model, to potentially improve donor retention and increase donation frequency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>Random forests are an ensemble learning method for classification and regression designed to produce accurate predictions that do not overfit the data. They consist of a large number of independent decision trees that operate as an ensemble and classify data into groups in a sequential manner, using time-specific cut-offs to differentiate groups into branches. Since a large number of trees are grown, prediction of donation behaviour in young donors will be made with limited generalization errors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The final dataset analysed was composed of 81 986 donors aged 18–24 at the last donation. The model correctly predicts more than 91% of the donation frequencies, with an overall error rate of 8·16% and specific error rates of 4·6% and 12·3% for ‘unreturned donor’ and ‘returned donor’ groups, respectively. The best predictive variables used in the model appear to be the number of contacts used by the marketing department, the donors’ age, the number of adverse effects during donation, the donors’ status and the ethnicity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results provide relevant information for interpreting donor behaviour and could contribute to the improvement of initiatives by blood services to increase donation return rate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 1","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45971632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of nucleic acid amplification technology for blood screening in Hungary","authors":"Réka Siposné Sohajda,&nbsp;László Kokavecz,&nbsp;Klára Baróti-Tóth,&nbsp;Sándor Nagy,&nbsp;Melinda Paholcsek,&nbsp;Anikó Stágel","doi":"10.1111/voxs.12621","DOIUrl":"10.1111/voxs.12621","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background &amp; Aims</h3>\u0000 \u0000 <p>With this study, we intended to report our experiences about introducing nucleic acid testing for blood donation screening for human immunodeficiency virus, hepatitis B and C in Hungary. This study summarizes the experiences of nucleic acid amplification technology (NAT) screening of the first 16 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was conducted from 5 June 2018 to 30 September 2019 in two phases. During the first 7 months of the study, the NAT tests were performed in parallel with serology. The yields of the methods were compared. After the initial seven months, only seronegative samples were tested by NAT. NAT tests were performed in minipools of 96.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In this 16-month period, nearly 400 000 donations were screened by NAT. During the first phase, almost 150 000 samples were tested in parallel by serology and NAT screening. NAT screening during Phase I failed to identify 4 HCV- and 1 HBV-reactive donations. In the second phase, about 245 000 seronegative samples were screened, with only one HBV reactive yield.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Nucleic acid amplification technology testing proven to be an optimal diagnostic adjunct to serological screening, since it can help to identify early window period infections and occult hepatitis B infections. According to our experience however, the used pooling strategy represents a dilution rate of nucleic acid targets, which makes identifying these types of infections difficult. According to our cost–benefit analysis, reducing the pool size to 60 would result in a 60% sensitivity increase, at the expense of increasing the daily costs by 25%.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 4","pages":"321-329"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46272612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective evaluation of preoperative anaemia management at a Melbourne metropolitan hospital: a framework for quality improvement","authors":"Benjamin J. Hargreaves,&nbsp;Amanda Baric","doi":"10.1111/voxs.12619","DOIUrl":"10.1111/voxs.12619","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is a strong evidence base supporting the implementation of patient blood management systems to treat preoperative anaemia and reduce perioperative transfusions, yet implementation of these systems remains limited. The patient blood management practices at Northern Health are currently under review. This study evaluates the prevalence of anaemia in the Northern Health surgical cohort and determines the current blood management practices of each surgical unit to create recommendations for a hospital-wide implementation strategy that can be used as a framework for quality improvement in similar metropolitan hospitals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Preadmission and perioperative data were collected for adults undergoing elective major surgery from orthopaedics, gynaecology, urology, colorectal and hepatobiliary units between April 2018 and March 2019. Data were analysed using the Shapiro–Wilk, the Kruskal–Wallis and Fisher’s exact tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 697 patient files were analysed. 14·2% of patients were anaemic at preadmission clinic with 37% of these attributable to iron deficiency. Anaemic patients had a higher rate of transfusion (<i>P</i> &lt; 0·05), length of stay (<i>P</i> &lt; 0·05) and complications (<i>P</i> &lt; 0·05) when compared to non-anaemic patients. The orthopaedic unit was the best performing in key areas of patient blood management. The orthopaedic unit successfully treated 44% of patients with anaemia, which was more than urology (33%; <i>P</i> &lt; 0·05), colorectal (25%; <i>P</i> &lt; 0·05) and hepatobiliary (0%; <i>P</i> &lt; 0·05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The orthopaedic unit has the most effective method for treating preoperative anaemia. We recommend that a hospital-wide patient blood management system be modelled from the current orthopaedic system and address specific barriers identified within each unit.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 4","pages":"330-340"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47360265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced disgust increases negative implicit attitudes towards blood donation","authors":"Philippe T. Gilchrist,&nbsp;Simone Schnall,&nbsp;Tudor Vrinceanu,&nbsp;Sebastien Nguyen,&nbsp;Blaine Ditto","doi":"10.1111/voxs.12620","DOIUrl":"10.1111/voxs.12620","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and objectives</h3>\u0000 \u0000 <p>The blood donation environment includes a variety of disgust-related stimuli that may influence attitudes among new and prospective donors. To explore the causal role of disgust in the context of attitudes towards blood donation, we experimentally induced feelings of disgust (vs. fear, moral elevation or control). We hypothesized that for people who are generally sensitive to their bodily sensations, disgust would lead to more negative implicit attitudes towards blood donation than other emotions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>A total of 123 participants completed a questionnaire package including private body consciousness, disgust, altruism and social desirability. Next, participants watched one of four videos with emotional content: a video segment depicting a filthy toilet (disgust), a man chasing a woman and child wielding an axe (fear), a man whose life was positively changed by a mentor (moral elevation) or a nature documentary (control). After the video, participants completed a Single-Target Implicit Association Test (ST-IAT) and questions regarding explicit attitudes towards blood donation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>As predicted, the disgust video resulted in lower implicit attitudes towards blood donation for participants high in private body consciousness. Disgust sensitivity predicted lower donation interest, but not implicit attitudes or explicit intention. There was no effect of emotion on explicit attitudes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Automatic processes should be considered in the development of interventions aimed at promoting prosocial and health behaviours. Management of disgust-related stimuli in donation centres and recruitment campaigns might improve attitudes towards blood donation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 2","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12620","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43869279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor deferral and return patterns – a South African perspective","authors":"Tanya Nadia Glatt,&nbsp;Ronel Swanevelder,&nbsp;Siemi Prithvi Raj,&nbsp;Josephine Mitchel,&nbsp;Karin van den Berg","doi":"10.1111/voxs.12622","DOIUrl":"10.1111/voxs.12622","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Donor eligibility assessment and subsequent return after deferral are key in maintaining an adequate and safe blood supply. Eligibility criteria should be reviewed regularly to ensure regional relevance and impact on donor deferral and return. Large-scale studies investigating donor deferral and return in Africa are currently lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study design and methods</h3>\u0000 \u0000 <p>Operationally collected blood donation data on whole blood donations at the South African National Blood Service during the five years from January 2015 to December 2019 were extracted and analysed. Separate multivariable logistic regression models for factors associated with donor deferral and donor return were developed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 5 068 638 donor presentations, 869 840 (17·2%) resulted in deferral of which out of range haemoglobin was most common (45·9%). New (aOR 3·99; 95% CI 3·97–4·01), female (aOR 2·51; 95% CI 2·50–2·53) and Black African (aOR 1·90; 95% CI 1·89–1·91) donors had greater odds of being deferred compared to Repeat, male and White donors, respectively. Of the donors deferred during 2015–2018, 328 306 (47·2%) returned within 12 months. Odds of returning increased with increasing age. Lower odds of return were noted among female (aOR 0·82; 95% CI 0·81–0·83) and Black African (aOR 0·75; 95% CI 0·74–0·76) donors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We confirmed high proportions of deferral among SANBS donors with almost half returning within 12 month. Donor deferral and return patterns differed significantly by donor characteristics, the latter also by deferral indication. Further understanding the interaction between haemoglobin deferral and changing donor demographics may assist in refining eligibility criteria and recruitment efforts.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 2","pages":"178-187"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41787334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of convalescent plasma for managing severe COVID-19 infection in 2-month-old infant","authors":"Umesh Shukla,&nbsp;Bhanu Bhakhri,&nbsp;Satyam Arora,&nbsp;Mukul Jain,&nbsp;Vikas Jain,&nbsp;Seema Dua,&nbsp;Dharmendra Kumar Singh,&nbsp;Devendra Kumar Gupta","doi":"10.1111/voxs.12616","DOIUrl":"10.1111/voxs.12616","url":null,"abstract":"<p>A 58-day-old female infant reported with complaints of fever, difficult breathing, loose stool, vomiting and refusal to feed for 4 days. Laboratory work showed anaemia, leucocytosis with elevated neutrophils and thrombocytopenia along with high C-reactive protein and D-dimer with bilateral patchy infiltrate on X-ray and positivity for COVID-19. Her blood culture was also positive for Gram-negative bacilli (acinetobacter lwoffii). Along with antibiotics, she was given 50 ml convalescent plasma. She was off oxygen within 2 days and showed improvement in lung lesions, and RT-PCR was negative by day 7 and discharged by day 10 of transfusion.</p>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 1","pages":"102-105"},"PeriodicalIF":0.0,"publicationDate":"2021-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43255654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rh disease prevention: the European Perspective","authors":"Cécile Toly-Ndour,&nbsp;Stéphanie Huguet-Jacquot,&nbsp;Agnès Mailloux,&nbsp;Hélène Delaby,&nbsp;Giorgia Canellini,&nbsp;Martin L. Olsson,&nbsp;Agneta Wikman,&nbsp;Joke M. Koelewijn,&nbsp;Jean-Marc Minon,&nbsp;Tobias J. Legler,&nbsp;Frederik B. Clausen,&nbsp;Mark Lambert,&nbsp;Helen Ryan,&nbsp;Irena Bricl,&nbsp;Sys Hasslund,&nbsp;Agnieszka Orzinska,&nbsp;Katarzyna Guz,&nbsp;Malgorzata Uhrynowska,&nbsp;Antonella Matteocci,&nbsp;Nuria Nogues,&nbsp;Eduardo Muniz-Diaz,&nbsp;Susanna Sainio,&nbsp;Masja De Haas,&nbsp;C. Ellen Van der Schoot","doi":"10.1111/voxs.12617","DOIUrl":"10.1111/voxs.12617","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>In Europe, postnatal and subsequently antenatal administration of anti-RH1 (D) immunoglobulins (Ig) has reduced the number of maternal anti-RH1 immunizations and the incidence of haemolytic disease of the foetus and newborn since the 1960s. Non-invasive foetal <i>RHD</i> genotyping now enables antenatal prophylaxis to be targeted only to women carrying <i>RHD</i>-positive foetus. We aimed at describing how Rh disease prevention is currently managed in different European countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We prepared an online survey on guidelines and biological tests performed for Rh disease prevention. The link was sent to 15 expert laboratories among Europe, selected by their publications in the field.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Experts from thirteen countries responded. Guidelines on anti-RH1 prophylaxis are similar regarding the major aspects of RH disease prevention, including indication and timing of anti-RH1 Ig administration, as well as indication of foetal <i>RHD</i> genotyping. Different anti-RH1 Ig preparations are used, and the dosing may differ depending on gestational age. Other controversial issues include (1) timing for foetal <i>RHD</i> genotyping, (2) indication of tests performed to quantitate feto-maternal haemorrhage prior to anti-RH1 Ig administration, (3) if there is a remaining indication for newborn RH1 phenotyping. Procedures for monitoring the prophylaxis efficiency and evaluating the national prevention programme also differ among countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite some differences among countries, the Rh disease prevention policies are very efficient in Europe, but HDFN cases due to maternal anti-RH1 immunization have not completely disappeared. It therefore remains important to share best practices for continuous improvement in reducing anti-RH1 alloimmunization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":89948,"journal":{"name":"ISBT science series","volume":"16 1","pages":"106-118"},"PeriodicalIF":0.0,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/voxs.12617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44691852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}