Biochemistry and analytical biochemistry : current research最新文献

{"title":"The Management of Tyrosinemia","authors":"P. Okpala, R. Okpala","doi":"10.35248/2161-1009.21.10.398","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.398","url":null,"abstract":"Tyrosinemia is a rare autosomal recessive genetic metabolic disorder, which occurs due to the error of metabolism that affects the body’s ability to breakdown tyrosine, an amino acid. Persons experience three types of tyrosinemia, which are tyrosinemia I, tyrosinemia II, and tyrosinemia III. In the United States, the incidence of tyrosinemia I am present in one in 100,000 live births. Individuals with tyrosinemia type I experience adverse signs and symptoms, including blood stools, vomiting, failure to thrive, fatigue, poor weight gain, diarrhea, and cabbage-like odor. The study offers detailed information on evidence-based treatment and prevention methods for tyrosinemia. The research's completion is based on empirical data and evidence from peer-reviewed articles with accurate and detailed information on tyrosinemia’s pharmacological and non-pharmacological treatment methods. The study includes an analysis of psychosocial support, genetic counseling, nutritional therapy, liver transplantation, patient education, and nitisinone therapy that medical practitioners use to manage tyrosinemia appropriately. Even though the literature review has detailed information, the articles fail to provide information about the side effects of nutritional, liver transplantation, and gene therapies. Scholars should conduct more research to reveal the side effects of pharmacological and non-pharmacological treatment methods. Overall, the study encourages interprofessional healthcare workers to apply evidence-based pharmacological and non-pharmacological treatment methods in managing tyrosinemia.","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69980827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deserted Ant Colony Dwelling Places of Formica polyctena and Soil Heterogeneity in a Mild Deciduous Timberland: Morphology and Natural Matter Piece","authors":"Susanne J Kuhel","doi":"10.35248/2161-1009.21.10.394","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.394","url":null,"abstract":"","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computing the Reflexes Regulating Blood Pressure and it's Components in Response to Various Pathological and Physiological Factors in Healthy Adolescents.","authors":"S. Herlekar","doi":"10.35248/2161-1009.21.10.401","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.401","url":null,"abstract":"An observational study was directed on healthy youth in the age group of 18-22yrs to assess the influences of various physiological and pathophysiological components on individual element of blood pressure. Cardiovascular reflexes were re-gauged to explain probable mechanism for observations made. The results from 120 normotensive subjects helped us revalidate following hypothesis on blood pressure regulatory mechanisms; gender difference showed lower BP elements in females probably due to estrogens protective role on both cardia and vasculature through nitric oxide induction and more. Significant negative correlation of age was seen with RPP hypothesising early and reduced cardiac oxygen extraction. BMI correlated positively with BP proposing changes within circulating blood volume, cardiac output and large vessels. No correlation was seen between handedness and BP element. The extended biopsychosocial model and active baroreceptor reflex have been used to explain influences of acute perceived stress on BP unlike baroreceptor resetting seen during acute physical stress. Rumination, cardiovascular refashioning, reflex adaptation and resetting may be probable explanations for the BP changes seen with chronic perceived stress.","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Diabetic Effect of Methanolic Extract of Aristolochia ringensLeaf","authors":"R. Tijani, Lawal So, Oyekan Jo, Koleoso Ok, S. S. Onasanya, Fasasi Aa","doi":"10.35248/2161-1009.21.10.397","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.397","url":null,"abstract":"The aim and objective of this study is to investigate the hypoglycemic, hepatoprotective, hypolipidemic and antioxidant potentials of the methanolic extract of Aristolochia ringens leaf (MLAR) in STZ-induced diabetic wistar rats. The airdried and powdered leaf of the plant (Aristolochia ringens) was extracted by cold maceration and concentrated. In vitro analysis was carried out by screening the extract for phytochemical constituents and antioxidant activities using different models. In vivo analysis was also carried out by randomly dividing forty eight (48) male wistar rats (140-170 g) into eight groups of six (6) rats each. Group 1 served as control; group 2 received STZ (60 mg/kg wt i.p); groups 3 to 8 served as the treatment group. The animals were sacrificed without anesthesia after 30 days and their blood were collected for biochemical investigation. The in vitro results showed that MLAR possesses good antioxidant potential when compared with the standard and it is also known to contain a number of phytochemicals. Also, the administration of STZ caused significant (p<0.05) elevation of the serum level of glucose, ALT AST, GGT, ALP, total cholesterol, LDL, TRIGS, MDA, NO and MPO activity by 100%, 47%, 38%, 32%, 51%, 29%, 34%, 41%, 51%, 29%, 54% and 59% respectively and significant reduction in HDL, Catalase, GPx, GSH, SOD, GST and plasma insulin by 34%, 34%, 61%, 46%, 66%, 55% and 52% respectively, but supplementation with MLAR brought all these parameters close to normal. In conclusion, Aristolochia ringens may be used as a prophylactic and an alternative medicine in the treatment of diabetes mellitus as it was established in this study that it possesses antioxidant, antiinflammatory, hypolipidemic and hypoglycemic effects which may be due to the presence of phytochemicals in it.","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Animal Models for Preclinical Evaluation of Symmetrical Diiodinated Squaraine Dye","authors":"Touharoki Saki","doi":"10.35248/2161-1009.21.10.E175","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.E175","url":null,"abstract":"","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Cellulases and its Applications: A Review","authors":"N. R. Chavda, K. Panchal, Roshan Chaudhary, P. Patel","doi":"10.35248/2161-1009.21.10.400","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.400","url":null,"abstract":"The most abundant biomass on earth is cellulose. Lignocellulosic biomass is the alternative of fossil fuels and can be used in the production of Biofuels. Degradation of this cellulolytic biomass requires cellulases produced by microorganisms including Bacteria, Fungi and actinomycetes. A wide variety of microorganisms are available in nature that can be isolated from different environment. Endoglucanases obtained from bacteria are able to degrade the s-1, 4-glucan linkages present in amorphous cellulose whereas exoglycanases help in cleaving the remaining chain of Oligosaccharide. Bacterial Cellulases are reported to have higher growth rate and versatility in genetic composition which makes them advantageous. These enzymes have several applications in industries worldwide which include Fermentation, Textile, Paper and pulp Agriculture and Food. This review summarizes the various applications of bacterial cellulases with future challenges.","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Plant Growth Promoting Rhizobacteria (PGPR) on Salt Stress Tolerance of Barnyard Millet (Echinochloa frumentacea)","authors":"R. Singh, Yashwant Singh Tariyal, J. S. Chauhan","doi":"10.35248/2161-1009.21.10.403","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.403","url":null,"abstract":"Salinity stress is a crucial environmental stress adversely affecting crop production by plummeting crop growth. The impacts of rhizobacteria to alleviate salinity stress on germination and growth of barnyard millet were assessed using different concentration of NaCl. It is a well acknowledged strategy to improve plant salt tolerance through inoculation with beneficial microorganisms. The results indicated that the PGPR significantly improved germination percent, root and shoot length and fresh and dry weight of seedling and leaf chlorophyll under salt stress in comparison to non-stressed and plants without inoculants. The results of present study showed that PGPR could be helpful to alleviate the salinity stress at the time of seed germination and growth. It can be concluded that PGPRs are the cost effective and economical tool for salinity tolerance and growth promotion in crop plants.","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino Acid Manufacturing, Purification, and Research Microalgae Proteins: Their Make-Up","authors":"Susanne J Kuhel","doi":"10.35248/2161-1009.21.10.395","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.395","url":null,"abstract":"The absolute protein content in the biomass of microalgae relies upon the sort of microalgae and can reach 70% of the dry weight [1,2]. The cell dividers of microalgae are frequently obliterated to guarantee admittance to proteins, amino acids, and different segments. It has been accounted for that some microalgae contain dissolvable proteins in their cytoplasm [3,4]. Also, microalgae with chloroplasts contain solvent protein, focal pyrenoid, and phytobiliproteins, albeit some microalgae, for example, Arthrospira platensis, all things being equal, have thylakoid sacs encompassing the fringe cytoplasm related with phycobilisomes. The quantity of studies on strategies for handling microalgae and utilizing them as a wellspring of protein has quickly expanded lately proposed another strategy for protein extraction from Arthrospira platensis dependent on the consolidated impact of three boundaries: pressing factor, temperature, and ultrasound. When utilizing the created strategy, the creators figured out how to expand the protein yield by 229% as contrasted and the traditional technique for ultrasonic openness. It was accepted that the joined impact of pressing factor, temperature, and ultrasound was better at annihilating cells and strengthening the cycle of mass exchange as contrasted and utilizing just ultrasound. Acoustic cavitation influenced Arthrospira platensis fibers through different instruments like discontinuity, sonoporation, and obliteration. These marvels added to the more proficient extraction of proteins from Arthrospira platensis. Numerous strategies for concentrating and disconnecting proteins from microalgae are hard proportional up. The three-stage division technique has drawn in light of a legitimate concern for some scientists because of its quick, straightforward, and adaptable use for concentrating, separating, and deactivating proteins from unrefined examples considered the impact of different boundaries on the three-stage partition strategy to improve the cycle of protein separation from Chlorella pyrenoidosa. Protein extraction from microalgae Chlorella vulgaris by the technique for three-stage division with sonication was introduced in their work. Because of utilizing the extra ultrasonic treatment, the creators figured out how to acquire an expanded protein yield in a more limited timeframe. It is accepted that ultrasonic threestage partition is a more productive technique for extricating biomolecules from microalgae proposed a strategy for microwave three-stage division of proteins of microalga Chlorella vulgaris, which was an improved adaptation of the conventional threestage detachment technique. The creators enhanced the conditions for applying the strategy as follows: grouping of ammonium sulfate (30% w/w), suspension to dissolvable proportion (1:1), microwave radiation time (120 s), obligation cycle (80%), microwave radiation power (100 W), and the convergence of biomass of microalgae (0.5% w/w). The created techniq","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cell Junctions Changed by Viral Infection","authors":"Susanne J Kuhel","doi":"10.35248/2161-1009.21.10.399","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.399","url":null,"abstract":"","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69980935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Serum Biochemistry, Metabolomics and Microbiome Parameters","authors":"Touharoki Saki","doi":"10.35248/2161-1009.21.10.E173","DOIUrl":"https://doi.org/10.35248/2161-1009.21.10.E173","url":null,"abstract":"","PeriodicalId":89896,"journal":{"name":"Biochemistry and analytical biochemistry : current research","volume":"10 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69981571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}