Journal of molecular biomarkers & diagnosis最新文献

Insights of Rheumatoid Arthritis and Genetic Biomarkers 类风湿关节炎和遗传生物标志物的见解

Journal of molecular biomarkers & diagnosis Pub Date : 2021-01-01 DOI: 10.37421/2155-9929.2021.12.463

H. Kille

引用次数: 0

Editorial on Prostate Specific Antigen Test 前列腺特异性抗原检测社论

Journal of molecular biomarkers & diagnosis Pub Date : 2021-01-01 DOI: 10.37421/2155-9929.2021.12.477

A. SathvikRaj

引用次数: 0

Blood Transcriptome Biomarkers 血液转录组生物标志物

Journal of molecular biomarkers & diagnosis Pub Date : 2021-01-01 DOI: 10.37421/2155-9929.2021.12.491

A. SathvikRaj

引用次数: 0

Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea 儿童和成人阻塞性睡眠呼吸暂停患者血清miR-92a升高

Journal of molecular biomarkers & diagnosis Pub Date : 2020-07-27 DOI: 10.37421/JMBD.2020.11.426

Brendan Gongol, Fenqing Shang, M. He, Yingshuai Zhao, Weili Shi, Man-li Cheng, J. Shyy, Liuyi Wang, A. Malhotra, R. Bhattacharjee

{"title":"Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea","authors":"Brendan Gongol, Fenqing Shang, M. He, Yingshuai Zhao, Weili Shi, Man-li Cheng, J. Shyy, Liuyi Wang, A. Malhotra, R. Bhattacharjee","doi":"10.37421/JMBD.2020.11.426","DOIUrl":"https://doi.org/10.37421/JMBD.2020.11.426","url":null,"abstract":"Background: Obstructive Sleep Apnea (OSA) is a highly prevalent condition that is associated with several comorbidities including cardiovascular disease (CVD). Recent studies have revealed mixed results as to whether standard OSA therapy reverses CVD in adult patients. Thus, many advocate for earlier recognition of OSA induced CVD, as early as childhood, to prompt treatment antecedent to the onset of irreversible CVD. Here we investigated if the serum level of miR-92a, a known biomarker for CVD, can be used to identify patients with OSA in both children and adults. Methods: Consecutive snoring patients undergoing polysomnography were recruited for determination of circulating miR-92a, in addition to inflammatory and metabolic profiles. We assessed whether circulating miR-92a was associated with OSA severity. Results: Using two separate cohorts of adults (n=57) and children (n=13), we report a significant increase in the serum level of miR-92a in patients with severe OSA (p=0.021) and further demonstrate a significant correlation (Spearman rank correlation 0.308, p=0.010) with serum miR-92a levels and the apnea hypopnea index (AHI), a primary measure of OSA severity. Stepwise regression analysis revealed that serum miR-92a levels were independently associated with AHI (ß=0.332, p=0.003), age (ß=0.394, p=0.002) and LDL cholesterol levels (ß=0.368, p=0.004). Conclusion: Our study is the first to establish that miR-92a is a useful biomarker for OSA severity in both children and adults. Given the canonical role of miR-92a on endothelial dysfunction, miR-92a may be useful to identify early onset CVD in OSA patients or stratify patient CVD risk to identify those that may benefit from earlier OSA treatment.","PeriodicalId":89808,"journal":{"name":"Journal of molecular biomarkers & diagnosis","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43703653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea. 儿童和成人阻塞性睡眠呼吸暂停患者血清miR-92a升高

Journal of molecular biomarkers & diagnosis Pub Date : 2020-01-01 Epub Date: 2020-07-27

Brendan Gongol, Fenqing Shang, Ming He, Yingshuai Zhao, Weili Shi, Manli Cheng, John Yj Shyy, Liuyi Wang, Atul Malhotra, Rakesh Bhattacharjee

{"title":"Serum miR-92a is Elevated in Children and Adults with Obstructive Sleep Apnea.","authors":"Brendan Gongol, Fenqing Shang, Ming He, Yingshuai Zhao, Weili Shi, Manli Cheng, John Yj Shyy, Liuyi Wang, Atul Malhotra, Rakesh Bhattacharjee","doi":"","DOIUrl":"","url":null,"abstract":"Background: Obstructive Sleep Apnea (OSA) is a highly prevalent condition that is associated with several comorbidities including cardiovascular disease (CVD). Recent studies have revealed mixed results as to whether standard OSA therapy reverses CVD in adult patients. Thus, many advocate for earlier recognition of OSA induced CVD, as early as childhood, to prompt treatment antecedent to the onset of irreversible CVD. Here we investigated if the serum level of miR-92a, a known biomarker for CVD, can be used to identify patients with OSA in both children and adults.Methods: Consecutive snoring patients undergoing polysomnography were recruited for determination of circulating miR-92a, in addition to inflammatory and metabolic profiles. We assessed whether circulating miR-92a was associated with OSA severity.Results: Using two separate cohorts of adults (n=57) and children (n=13), we report a significant increase in the serum level of miR-92a in patients with severe OSA (p=0.021) and further demonstrate a significant correlation (Spearman rank correlation 0.308, p=0.010) with serum miR-92a levels and the apnea hypopnea index (AHI), a primary measure of OSA severity. Stepwise regression analysis revealed that serum miR-92a levels were independently associated with AHI (ß=0.332, p=0.003), age (ß=0.394, p=0.002) and LDL cholesterol levels (ß=0.368, p=0.004).Conclusion: Our study is the first to establish that miR-92a is a useful biomarker for OSA severity in both children and adults. Given the canonical role of miR-92a on endothelial dysfunction, miR-92a may be useful to identify early onset CVD in OSA patients or stratify patient CVD risk to identify those that may benefit from earlier OSA treatment.","PeriodicalId":89808,"journal":{"name":"Journal of molecular biomarkers & diagnosis","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38803648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the expression of Notch1 and related proteins in lung carcinoma cells Notch1及相关蛋白在肺癌细胞中的表达

Journal of molecular biomarkers & diagnosis Pub Date : 2019-11-26 DOI: 10.4172/2155-9929.1000408

W. Hassan, Takaaki Ito

引用次数: 0

The Role of 16s Ribosomal RNA in Diagnosing Spontaneous Bacterial Peritonitis 16s核糖体RNA在自发性细菌性腹膜炎诊断中的作用

Journal of molecular biomarkers & diagnosis Pub Date : 2019-01-01 DOI: 10.4172/2155-9929.1000411

S. Abed, Mohamed Egezy, T. Sheta, M. Zaki

引用次数: 0

HNSCC and Immunotherapy: The Beginning of a Long Story HNSCC和免疫治疗:一个漫长故事的开始

Journal of molecular biomarkers & diagnosis Pub Date : 2019-01-01 DOI: 10.4172/2155-9929.1000412

Thibault Gauduchon, T. Reverdy, A. Karabajakian, L. Collet, Max Gau, E. Neidhardt, J. Fayette

引用次数: 0

Prognostic Role of RANK and RANKL Expression in Recurrent Giant Cell Tumor of Bone: A Retrospective Study RANK和RANKL表达在复发性骨巨细胞瘤预后中的作用:回顾性研究

Journal of molecular biomarkers & diagnosis Pub Date : 2018-06-21 DOI: 10.4172/21559929.1000394

Nannaphat Atsawaphidsawat, Piti Ungarreevittaya, C. Sumananont

{"title":"Prognostic Role of RANK and RANKL Expression in Recurrent Giant Cell Tumor of Bone: A Retrospective Study","authors":"Nannaphat Atsawaphidsawat, Piti Ungarreevittaya, C. Sumananont","doi":"10.4172/21559929.1000394","DOIUrl":"https://doi.org/10.4172/21559929.1000394","url":null,"abstract":"Objective: Giant cell tumor of bone (GCTB) is a benign locally aggressive primary bone tumor with a tendency for recurrence which is one of the major problems in this disease. Recent data demonstrated the important role of the receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) pathway in the pathogenesis. However, the roles of RANK and RANKL in predicting recurrence have never been proposed. Therefore, we aim to investigate the prognostic value of RANK and RANKL expression in predicting recurrence of GCTB which may change the treatment paradigm of the disease. Method: 53 cases of GCTB were enrolled in the study. Data on patient demographics and clinical characteristics were reviewed. Immunohistochemistry was used to detect the expression of RANK and RANKL. Recurrence-free survival (RFS) analysis was performed by Kaplan–Meier method and the difference between survival curves were sought using the log-rank test. Cox’s proportional hazards model and binary logistic regression analyses were used to define the risk of recurrence. Result: Of 53 cases, there were 8 patients (15.1%) had recurrent disease. The univariate analysis revealed that age (log rank 10.749, p=0.005), RANKL overexpression (log rank 5.187, p=0.023), RANK overexpression (log rank 4.055, p=0.044 for RANK) and co-overexpression of RANK/RANKL (log rank 7.541, p<0.006) were associated with recurrence of GCTB. Cox’s proportional hazards model emerged that the only significant prognostic parameter capable of defining the risk for recurrence was co-overexpression of RANK and RANKL (Hazard ratio 2.910; 95%CI 1.099-7.708; p= 0.032). Binary logistic regression multivariate analysis followed by ROC analysis confirmed that cooverexpression of RANK/RANKL represented a significant biological model to predict local recurrence (area under the curve=0.731±0.098; 95% CI 0.539–0.922, p=0.039). Conclusion: RANK and RANKL co-overexpression increases the risk of recurrence of GCTB and could be a prognostic marker for recurrent disease.","PeriodicalId":89808,"journal":{"name":"Journal of molecular biomarkers & diagnosis","volume":"9 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45391779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Interleukin-6 (IL-6) Associate with Aortic Dimensions in Genetic Aortic Conditions 遗传性主动脉疾病中循环白细胞介素-6 (IL-6)与主动脉尺寸的关系

Journal of molecular biomarkers & diagnosis Pub Date : 2018-02-10 DOI: 10.4172/2155-9929.1000379

G. Investigators, Daishi Fujita, L. Preiss, K. Aizawa, K. Eagle, Toru Suzuki

{"title":"Circulating Interleukin-6 (IL-6) Associate with Aortic Dimensions in Genetic Aortic Conditions","authors":"G. Investigators, Daishi Fujita, L. Preiss, K. Aizawa, K. Eagle, Toru Suzuki","doi":"10.4172/2155-9929.1000379","DOIUrl":"https://doi.org/10.4172/2155-9929.1000379","url":null,"abstract":"Background: Biomarkers that reflect progression of dilatation of the aorta in patients with aortic conditions are needed as surrogate tools to assist in monitoring the condition in a non-invasive manner in combination with imaging procedures but are yet to be established. This study aimed to establish clinically useful biomarkers for aortic conditions in patients enrolled in the Genetically-Triggered Thoracic Aortic Conditions (GenTAC) registry. Methods: Plasma samples of 159 patients enrolled in the GenTAC registry were assessed for circulating biomarkers (interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP1), tissue inhibitor of metalloproteinase-2 (TIMP-2) and transforming growth factor-β1 (TGF β1)] by enzyme-linked immunosorbent assay. Primary diagnosis and aortic image data were compared with the measured values. Results: IL-6 showed significant positive correlations with aortic dimensions at each segment of the aorta, the correlation becoming stronger as it shifts to distal (ascending aorta R=0.26 p=0.004, proximal arch R=0.35 p<0.0001, transverse arch R=0.30 p=0.0005, mid-descending thoracic aorta R=0.40 p<0.0001, thoracoabdominal aorta R=0.38 p<0.0001, suprarenal abdominal aorta R=0.42 p<0.0001, and infrarenal aorta R=0.43 p<0.0001). TIMP-1 also showed a significant correlation albeit weaker, also exhibiting stronger correlation towards the distal end. Conclusion: Circulating IL-6 and TIMP-1 were associated with aortic dimensions in the aortopathies as registered in the GenTAC cohort. Our results provide support that IL-6 and TIMP-1 are associated with aortic aneurysm formation in patients with genetically-triggered thoracic aortic conditions.","PeriodicalId":89808,"journal":{"name":"Journal of molecular biomarkers & diagnosis","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47417580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0