Journal of clinical & experimental pathology最新文献

{"title":"THE EFFECT OF SHORT-TERM INHALATIONS WITH CONCENTRATED OXYGEN ON TOLERANCE DURING VARIOUS TYPES OF PHYSICAL ACTIVITY IN YOUNG HEALTHY PEOPLE","authors":"E. Shorikov, D. Shorikova, O. Mandrik, G. Shumko, P. Shorikov","doi":"10.24061/1727-4338.XIX.2.72.2020.11","DOIUrl":"https://doi.org/10.24061/1727-4338.XIX.2.72.2020.11","url":null,"abstract":". The article presents the results of a study concerning the effect of short-term inhalations with concentrated oxygen on tolerance during various types of physical activity in young healthy people. Material and methods. The study involved 30 healthy volunteers mean age 23.6±3.78 years. The complex of general clinical investigations included functional tests of Ruffier, Stange, Genche was used. Results of investigation. It was found that running speed per 100 m after inhalation of highly concentrated oxygen increased 14.6%, which is significantly better than in control group 1 (p<0.05). The 500 m running speed increased 10.6% (p<0.05) after the course of oxygen inhalation, as well as an increase in anaerobic reserve and maximum aerobic capacity (p 1 <0.05). The result of the parameter of limitation of the number of flexions and extensions of the hands in supine support in-group 1 was lower (18.6%) than the result of group 2 (p<0.05). As a whole, after the short-term inhalation of highly concentrated oxygen, the indicator under study increased 38.5% over the initial data. Conclusions. Short-term inhalations with concentrated oxygen increase tolerance at different types of physical activity in young healthy people.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82878342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THYROID HOMEOSTASIS CHANGES AS THE CAUSE OF A RECURRENCE OF BENIGN FOCAL THYROID GLAND PATHOLOGY","authors":"N. Tkachuk","doi":"10.24061/1727-4338.XIX.2.72.2020.10","DOIUrl":"https://doi.org/10.24061/1727-4338.XIX.2.72.2020.10","url":null,"abstract":"The aim of the study is to establish the characteristics of thyroid homeostasis disorders in patients with benign focal thyroid gland pathology (FTGP) with recurrence of the disease and non-recurring of the disease. Ninety-six patients examined as follows: the first group was formed by 30 patients with postoperative relapse of the nodular (multi-node) euthyroid goiter. The second group included 30 patients with a nodular (multi-node) euthyroid goiter, in which, according to the ultrasonic data, the rapid growth of the nodes was recorded. The third group included 36 patients with a nodular (multi-knot) goiter in which the slow growth of thyroid nodules was diagnosed with ultrasound. Twenty women without thyroid pathology formed a comparison group. Results. research, we have established that in patients with benign focal pathology of the thyroid gland there is a disturbance of peripheral conversion of thyroid hormones, a decrease of the of fT 3 , an increase in the of fT 4 , the serrated coefficient of fT 3 / fT 4 and the total thyroid index. We also the compensatory of the hypothalamic-pituitary system, the growth of the TSH, the ratio of TSH / fT 3 , TSH / fT 4 ; the of the credits Roperoxidase and Antithy-thyroglobulin autoantibodies, the risk of the of thyroid tissue we the high in thyroid volume is associated with the activation of the hypothalamus-gland pituitary system, disruption of peripheral conversion of thyroid hormones, increase of titer antibodies, and thyroid gland damage. Conclusions. Thus, indicators reflecting the function of the hypothalamus-pituitary axis, the activity of peripheral conversion of thyroid hormones, the antithyroid antibody titer, and the blood serum thyroid globulin can be used as a marker for relapsing nodulation in thyroid gland tissue.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76889747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE CHARACTERISTICS OF THE HEMOMICROCIRCULATORY BED OF THE SCIATIC NERVE TRUNK IN RATS WITH SINGLE ADMINISTRATION OF CRYOPRESERVED PLACENTA AND IN ACUTE ASEPTIC INFLAMMATION","authors":"R. V. Svyridyuk, K. Shepitko, O. A. Polyvyana, I. V. Klypachenko","doi":"10.24061/1727-4338.XIX.2.72.2020.6","DOIUrl":"https://doi.org/10.24061/1727-4338.XIX.2.72.2020.6","url":null,"abstract":"Objective. To study the response of the sciatic nerve trunk’s hemomicrocirculatory bed to a single administration of cryopreserved placenta and intraperitoneal administration of λ -carrageenan. Material and methods. An experimental study was performed on the sciatic nerve trunk of 100 sexually-mature rats. Histological research methods were used. It was established that when transplanting a cryopreserved placenta, all parts of the hemomicrocirculatory bed (HMCB) respond. Thus, the resistive part of the sciatic nerve trunk HMCB during cryopreserved placenta transplantation was characterized by a gradual increase in the mean diameters with the maximum value on the 5th-7th days and their complete recovery on the 10th day of the study. In the simulation of acute aseptic peritonitis there is a sharp decrease in diameters on the 2nd-3rd days, followed by their increase on the 5th-14th days and recovery on the 30th day. Results. In transplantation of cryopreserved placenta, the exchange link of the HMCB reacted significantly by increasing the mean diameter of the capillaries on the 5th day. In the simulation of acute aseptic peritonitis, the mean diameter of the capillaries increased on the 1st day and did not return to the control group limits on the 30th day of the study. Capacitive link responded to transplantation of cryopreserved placenta by an increase in diameter with the maximum value on the 5th day and recovery on the 10th day of the study (p <0.05). When simulating acute aseptic peritonitis, there is also an increase in diameters with the maximum value on the 7th day. On the 30th day of the study, the index value did not reach the limits of the control group. Conclusions. A single administration of cryopreserved placenta fragment causes short-term changes in the hemomicrocirculatory bed with the maximum values on the 5th-7th days of the study, in contrast to a single injection of 5 mg of λ-carrageenan (Sigma -USA), which leads to reactive inflammation and lasts for over 30 days.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91237856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATHOGENESIS OF THE MORPHOFUNCTIONAL STATE DISORDERS OF THE LIVER IN DIABETES MELLITUS TYPE 1","authors":"O. Tkachuk, S. Tkachuk, M. Povar, S. Boshtan, V. D. Sorokhan","doi":"10.24061/1727-4338.XIX.2.72.2020.14","DOIUrl":"https://doi.org/10.24061/1727-4338.XIX.2.72.2020.14","url":null,"abstract":"Вступ Діабетичні гепатопатії є поширеною патологією гепатобіліарної системи при цукровому діабеті (ЦД) [1, 2]. Вони проявляються низкою аномалій печінки, як-от глікогеноз, неалкогольна жирова хвороба печінки (НАЖХП), фіброз, цироз печінки, гепатоцелюлярні карциноми [3, 4]. Окрім того, надмірне накопичення жиру в печінці може сприяти розвитку і прогресуванню інсулінорезистентності та призвести до тяжких порушень метаболізму [5]. Тривалий час гепатопатії асоціювалися винятково з ЦД 2 типу, однак протягом останнього десятиліття отримано достатньо наукових підтверджень порушення морфофункціонального стану печінки у хворих на ЦД типу 1 (ЦД 1).","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"399 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80642756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF DEXAMETHASONE PROLONGED USE, HIGH LEVEL OF NACL IN WATER AND L-CARNITINE ON THE ACTIVITY OF SUPEROXIDE DISMUTASE AND CATALASE IN RAT MYOCARDIUM","authors":"Yu. A. Sveredyuk","doi":"10.24061/1727-4338.xix.1.71.2020.12","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.1.71.2020.12","url":null,"abstract":". The objective of the work was to study the activity of superoxide dismutase and catalase in the myocardium of male and female animals with prolonged use of dexamethasone, high NaCl content in water and the possibility of using L-carnitine as a protective agent. Material and methods. The experiment was performed on 96 mature white non-linear rats (age 5-6 months, weight 0.17-0.23 kg). Long-term glucocorticosteroid therapy was modeled by per os dexamethasone intake. Half of the animals received drinking water with a high NaCl content. Correction was carried out by per os L-carnitine intake. Long-term use of dexamethasone has led to a decrease of the catalase and superoxide dismutase activity. Increased NaCl content in water exerted a slight negative effect in conjunction with glucocorticoids, more in males. Results. During prolonged use of dexamethasone L-carnitine completely resumed the activity of superoxide dismutase in female and male animals. In female rat catalase activity was restored in all groups of animals. In male rat with a high salt content (4%) in water, the catalase activity could not fully recover.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73242623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF INCORRECTED RISK FACTORS ON CLINICALNEUROPSCHOLOGICAL, HAEMODYNAMIC CHANGES AND LIFE QUALITY IN PATIENTS IN THE RESTORATIVE PERIOD OF STROKE","authors":"Yu. І. Gudar’yan","doi":"10.24061/1727-4338.xix.1.71.2020.10","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.1.71.2020.10","url":null,"abstract":"Purpose. An increase of rehabilitation efficiency of patients with consequences of hemispheric brain infarction including cognitive and emotional violations at the expense of determination of influence of the basic incorrected risk factors: arterial hypertension, dyslipidemia, activity of the blood coagulation system, hyperglycaemia on its results and life quality by the improvement of the rehabilitation measures policy.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80193219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FUNCTIONAL STATE CHANGES OF THE VEGETATIVE NERVOUS SYSTEM IN PATIENTS WITH ACALCULOUS CHOLECYSTITIS DEPENDING ON THE TYPE OF SOMATOFORM VEGETATIVE DYSFUNCTION AND ESSENTIAL HYPERTENSION","authors":"A. Antoniv, Z. Y. Kotsyubiychuk, E. G. Makhrova","doi":"10.24061/1727-4338.xix.1.71.2020.1","DOIUrl":"https://doi.org/10.24061/1727-4338.xix.1.71.2020.1","url":null,"abstract":"Objective: to establish the features of the functional state changes of the autonomicnervous system in patients with chronic noncalculous cholecystitis, depending on the typeof concomitant somatoform autonomic dysfunction and hypertension stage II.Material and methods. 138 patients were examined: 98 of them with chronic acalculouscholecystitis in the exacerbation phase and concomitant somatoform autonomicdysfunction, 40 patients with chronic noncalculous cholecystitis in the phase ofexacerbation with accompanying essential hypertension stage II and 30 practicallyhealthy persons who made up the control group. To characterize the state of theautonomic nervous system we used A.M. Vein vegetative symptoms scale, Ashner-Danyini,Danielopulu (orthoclinostatic) tests.Results. Indices’ analysis of the carried out investigation of the general vegetativesymptoms have shown that the skin color changes during excitement, physical activity inpatients with somatoform autonomic dysfunction according to hypertensive type, cardiacneurosis and hypertension had a negative tendency, that is, the skin was pale, whatreflects an increase of the sympathetic nervous system tone and forms a decrease fromthe state of eutonia in scores by 1.7 times, 1.6 times and 2.0 times respectively (p<0.05).Pulse rate veritably increased (51.6%, 41.9% and 54.8% (p<0.05)) in patients of the 1st,3rd and 4th groups, in patients of the 2nd group it veritably decreased (29.0% (p <0.05))when conducting orthostatic test. During clino-orthostatic test, the pulse rate changed inthe diametrically opposite direction: in patients of the 1st, 3rd and 4th groups it sloweddown (21.9%, 28.1% and 31.3%, respectively (p< 0.05)), in patients of the 2nd groupit probably accelerated (21.9% (p <0.05)). During Ashner’s test in patients of the 1stand 3rd groups the pulse rate paradoxically tended to accelerate (20.0% and 26.7% (p<0.05)); in patients of the 4th group it veritably increased 30.0% (p <0.05), in patients ofthe 2nd group it veritably decreased (52.8%, p <0.05).Conclusions. Thus, an increase in the tone of the sympathetic part of the autonomicnervous system with frequent sympathoadrenal crises is observed in patients withchronic acalculous cholecystitis and concomitant somatoform vegetative dysfunction byhypertension type and cardiac neurosis as well as hypertension type II, and vagotonia witha predominance of the vago-insular crises is peculiar for the patients with concomitantsomatoform vegetative dysfunction according to hypotonic type.","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"640 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74728875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STATISTICAL ANALYSIS OF RELATIVE QUANTITIES IN MEDICINE","authors":"M. A. Ivanchuk, I. Malyk, T. Knignitska, T. Lukashiv","doi":"10.24061/1727-4338.xviii.4.70.2019.18","DOIUrl":"https://doi.org/10.24061/1727-4338.xviii.4.70.2019.18","url":null,"abstract":"","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75353075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ПОЛІМОРФІЗМ 5G4 ГЕНА ІНГІБІТОРУ АКТИВАТОРА ПЛАЗМІНОГЕНА 1 (PAI-1) У ХВОРИХ НА ГОСТРІ УСКЛАДНЕННЯ ВИРАЗКОВОЇ ХВОРОБИ","authors":"I. Dutka, I. Panchuk, R. A. Volkov, F. V. Grynchuk, A. Ushakov","doi":"10.24061/1727-4338.xviii.4.70.2019.4","DOIUrl":"https://doi.org/10.24061/1727-4338.xviii.4.70.2019.4","url":null,"abstract":"Objective of the study. To carry out a comparative analysis of the frequency of PAI-1 gene G43A polymorphism in citizens of Chernivtsi region who suffer from various forms of ulcer disease, and to study the possible relationship between different types of genotype and the development of complications. Material and methods. 60 patients with ulcer disease were examined: 42 (70%) men, 18 (30%) women. 37 (61.67%) patients had a duodenal ulcer, the rest ones (38.33%) had a gastric ulcer. Uncomplicated ulcer disease was diagnosed in 12 (20%) patients. 5 (8.33%) patients were found to have an ulcer perforation. In 43 (71.67%) patients there was an ulcer complicated by acute bleeding. In 29 (67.44%) patients the bleeding was stopped. In 14 (32.56%) patients there was a relapse of bleeding. PAI genotyping by G43A mutation was performed by using polymerase chain reaction (PCR). PCR amplification of the corresponding RAI gene fragment was performed by using a specific pair of primers 5’-CCA ACA GAG GAC TCT TGG TC-3’ and 5’- CAC AGA GAG AGT CTG GCC ACG-3’. PCR was performed by using a CFX96 amplifier (Bio-Rad, USA). PCR results were carried out by electrophoresis in 2% agarose gel using a tris-borate buffer. For DNA fragments visualization the gel was stained with ethidium bromide and photographed using ultraviolet light on the GelDoc 2000 installation (BioRad, USA). To determine the length of the obtained fragments, their electrophoretic mobility was compared with the mobility of the DNA marker Gene Ruler DNA Leader Mix (Thermoscientific). The statistical dependence between the values was tested by determining the Fisher criterion, χ2-criterion by Pearson, in particular, the correspondence of the genotype distribution to the Hardy-Weinberg equilibrium. Results. 94.12% patients without acute bleeding and 91.67% patients without acute complications were found to have GG genotype. One female patient (8.33%) without any acute complications was found to have homozygous AA genotype by the mutant allele. No patient with an ulcer perforation was a carrier of allele A. None of the patients without bleeding had a heterozygous GA genotype. GA genotype was found in 25.58% of patients with an acute ulcerative bleeding, which is statistically significantly higher than in patients without any bleeding. Allele A was more common among patients with recurrent bleeding than in ones without it. Conclusions. 1. Among patients with ulcer disease without acute complications of Chernivtsi region 91.67% of whom have homozygous GG genotype by polymorphism G43A РАІ-1 gene, and 8.33% – AA genotype; no heterozygous genotype GA was found in any case. 2. All examined patients with a perforated ulcer had the GG genotype. 3. Patients with acute ulcerative bleeding, 27.91% of whom are carriers of mutant allele A (among them 25.58% have heterozygous GA genotype, and 2.33% – homozygous AA genotype), which is statistically significantly higher than in patients with ulcer disease without any bl","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72906908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF MORPHOLOGICAL TRANSFORMATIONS OF THE HAND BONES IN ONTOGENESIS OF THE HUMAN BEING","authors":"O. Marchuk, V. Marchuk, Yulia Marchuk, D. Andriychuk, V. Kulachek, Y. Kulachek","doi":"10.24061/1727-4338.xviii.4.70.2019.8","DOIUrl":"https://doi.org/10.24061/1727-4338.xviii.4.70.2019.8","url":null,"abstract":"","PeriodicalId":89801,"journal":{"name":"Journal of clinical & experimental pathology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74477682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}