THYROID HOMEOSTASIS CHANGES AS THE CAUSE OF A RECURRENCE OF BENIGN FOCAL THYROID GLAND PATHOLOGY

Abstract

The aim of the study is to establish the characteristics of thyroid homeostasis disorders in patients with benign focal thyroid gland pathology (FTGP) with recurrence of the disease and non-recurring of the disease. Ninety-six patients examined as follows: the first group was formed by 30 patients with postoperative relapse of the nodular (multi-node) euthyroid goiter. The second group included 30 patients with a nodular (multi-node) euthyroid goiter, in which, according to the ultrasonic data, the rapid growth of the nodes was recorded. The third group included 36 patients with a nodular (multi-knot) goiter in which the slow growth of thyroid nodules was diagnosed with ultrasound. Twenty women without thyroid pathology formed a comparison group. Results. research, we have established that in patients with benign focal pathology of the thyroid gland there is a disturbance of peripheral conversion of thyroid hormones, a decrease of the of fT 3 , an increase in the of fT 4 , the serrated coefficient of fT 3 / fT 4 and the total thyroid index. We also the compensatory of the hypothalamic-pituitary system, the growth of the TSH, the ratio of TSH / fT 3 , TSH / fT 4 ; the of the credits Roperoxidase and Antithy-thyroglobulin autoantibodies, the risk of the of thyroid tissue we the high in thyroid volume is associated with the activation of the hypothalamus-gland pituitary system, disruption of peripheral conversion of thyroid hormones, increase of titer antibodies, and thyroid gland damage. Conclusions. Thus, indicators reflecting the function of the hypothalamus-pituitary axis, the activity of peripheral conversion of thyroid hormones, the antithyroid antibody titer, and the blood serum thyroid globulin can be used as a marker for relapsing nodulation in thyroid gland tissue.