M. Mahmoudi, Saeed Akbari-Zardkhaneh, A. A. B. Zadeh, Bagher Ghobari-Bonab, M. Shokoohi-yekta, Hadi Moradi, H. Pouretemad
{"title":"An Autism Screening Expert System: Reliability, Validity and Factorial Structure","authors":"M. Mahmoudi, Saeed Akbari-Zardkhaneh, A. A. B. Zadeh, Bagher Ghobari-Bonab, M. Shokoohi-yekta, Hadi Moradi, H. Pouretemad","doi":"10.4172/2165-7890.1000230","DOIUrl":"https://doi.org/10.4172/2165-7890.1000230","url":null,"abstract":"Purpose: The main aim of the current study was to develop an expert system for screening autism spectrum disorders. The statistical properties of the system were further examined. Methods: To design an expert system, having a reliable and valid knowledge base (KL) is very important. To provide the knowledge base, items linked to autism diagnoses were collected from the literature and then reviewed by a group of psychologists and psychometrists experts. The questionnaire was completed by parents of children with autism (85), parents of normal children (65) and parents of children with Down syndrome (20). Next, some psychometric and machine learning methods were implemented to select the items having more power to discriminate children with autism from normal children and children with Down syndrome and evaluate its reliability and validity features. Results: Findings yielded good reliability (0.96) and criterion validity (0.86) for the system. The accuracy was about 0.93 and .92, using Random Forest (RF) and Support Vector Machines (SVM)), respectively. In addition, specificity and sensitivity of the system using SVM is 84.1 and 98.5%, respectively, while RF is 73.4 specificity and 99.3% sensitivity. Conclusion: This system can be considered as a reliable and valid system for screening ASDs. Citation: Mahmoudi M, Akbari-Zardkhaneh S, Zadeh AAB, Ghobari-Bonab B, Shokoohi-Yekta M, et al. (2018) An Autism Screening Expert System: Reliability, Validity and Factorial Structure. Autism Open Access 8: 230. doi:10.4172/2165-7890.1000230","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78162417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution and Preliminary Testing of a Hyperoxic Therapy for Autism Spectrum Disorders","authors":"Peterson Re, Allen Mw","doi":"10.4172/2165-7890.1000233","DOIUrl":"https://doi.org/10.4172/2165-7890.1000233","url":null,"abstract":"The diagnosis of autism spectrum disorders (ASD) comprises a range of developmental disabilities, the established prevalence of which has been increasing globally. Despite decades of research, however, ASD is still not well understood and a generally accepted intervention or group of interventions which consistently and comprehensively address the spectrum of needs has not yet been identified or developed. Thus, in seeking a solution to their children's conditions, some parents have felt compelled to try complementary and alternative medical treatments.One such intervention that has attracted some advocates is off-label hyperbaric oxygen therapy. In examining the data for this application, we were struck by the wide range of oxygen partial pressures reported to have benefit and the fact that many could be easily provided at normobaric pressure. As we knew of no reason for the use of increased pressure in treating ASD with hyperoxic therapy, we determined to find out if benefits could be obtained from such treatments at normal atmospheric pressure.A pilot study with five cases involving preteens and teenagers with autism was conducted using a normobaric form of hyperoxic treatment we have called Microbaric® Oxygen Therapy (MBO2). All five cases benefitted, three remarkably so. Improvements were across the full range of symptoms of autism, and no regression was reported on cessation of treatment or during follow up for as long as six years. Thus, it appears that the outcomes of MBO2 for autism are permanent. As a consequence of this pilot study, it would seem imperative to conduct controlled research to confirm our findings. Should similar outcomes be obtained, then MBO2 would offer a new, cost-effective, and time efficient way forward as a stand-alone therapy or as an adjunct to other therapies in the treatment of autism.","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"147 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86650467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design interventions for Sensory comfort of Autistic children","authors":"Arathy Gopal, Jayaprakash Raghavan","doi":"10.4172/2165-7890.1000227","DOIUrl":"https://doi.org/10.4172/2165-7890.1000227","url":null,"abstract":"The aim of the study was to arrive at design interventions for sensory comfort of Autistic children. The scope of study included vast and systematic review of literature and few observation studies supplemented with survey of caregivers. A matrix with detailed design guidelines was the study outcome. It was concluded that designing for sensorily comfortable spaces could make the child more manageable and formulated guidelines could aid the design process. But the risk of child insisting on the same setting with prolonged exposure cannot be neglected. Future potential research areas involving design interventions for possibly enhancing neural connectivity in brain regions involved in sensory perception and integration, is also discussed.","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"21 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78877985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Treatment for Improvement of Sensory-Motor, Function and Emotional Behavior of a Child with Autism Spectrum Disorder: A History Case Report","authors":"Y. Harel, O. Atun-Einy, M. Lotan","doi":"10.4172/2165-7890.1000220","DOIUrl":"https://doi.org/10.4172/2165-7890.1000220","url":null,"abstract":"Background: Tailored interventions. One potential novel intervention is orthotic under-garments (OUG Autism spectrum disorder (ASD) is a prevalent neuro-developmental disorder frequently presenting sensory-motor impairments. The complexity and diversity of ASD typically calls for individualized). Aim: To explore the feasibility and effect of OUG as a supplementary therapeutic modality on motor, sensory capabilities and behavior of a child with ASD. Participant: A five years and eight months old child with ASD that presents hypotonia, poor postural control and coordination, a significant motor delay, severe sensory modulation problems, and unusual behaviors. Procedure: Motor, sensory and behavioral evaluations were performed pre (Pre-I) and after (Post-I) a four months intervention: Peabody Developmental Motor Scales-2 (PDMS-2), The Short Sensory Profile (SSP), therapists’ reports and parental interviews served as a behavior and emotion evaluation. Results: Motor function has improved (PDMS-2 percentile <1 Pre-I vs. Post-I 3). Sensory function has improved (Total SSP score 136 Pre-I vs. Post-I 102). Therapeutic and parental reports indicated a decrease of atypical behaviors, improvement in self-confidence and better social participation. Conclusion: According to the current case report, the OUG was found to be useful in improving sensory-motor functions and emotional behaviors of a child with ASD. Our findings provide a possible support to the introduction of orthotic undergarment as a part of individually tailored physical therapy interventions for the child with ASD.","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"14 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75082684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Similarities in Dyspraxia and Autism","authors":"Waleed Abdulkarim","doi":"10.4172/2165-7890.1000231","DOIUrl":"https://doi.org/10.4172/2165-7890.1000231","url":null,"abstract":"","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73835094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can Fortified Bifidobacterium with Mycosporin-like Amino Acid be a New Insight for Neurological Disease' s Treatment?","authors":"H. Bozkurt, B. Kara","doi":"10.4172/2165-7890.1000219","DOIUrl":"https://doi.org/10.4172/2165-7890.1000219","url":null,"abstract":"Gastrointestinal microbiota includes bacteria, archaea, viruses, fungi and other eukaryotes. The genus Bifidobacterium is considered the dominant once; it has an important role on immunologic, hormonal and metabolic homeostasis of the host. Recent studies demonstrated that the Mycosporin-like Amino Acids (MAAs) had prebiotic effects and they modulated host immunity by regulating the proliferation and differentiation of intestinal epithelial cells, macrophage and lymphocytes. Also MAAs modulate NF-κB and tryptophan metabolism. Modulation NF-κB and tryptophan metabolism induced a beneficial effect on central nervous cascade. The safety of Bifidobacterium species is known; although they do not produce MAAs, their presence is required for immunological response continuity of intestine. Thereby we hypothesize that if we could create Bifidobacteria species producing MAAs via genetic engineering; they might have stronger immuno-stimulatory properties and might be used as more potent pharmacological agents in neurological diseases secondary to impaired microbiota.","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"16 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84951684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Dunn, Jonah Elgart, Lisa Lokshina, Alexander Faisman, E. Khokhlovich, Y. Gankin, A. Vyshedskiy
{"title":"Children with Autism Appear to Benefit from Parent-Administered Computerized Cognitive and Language Exercises Independent of the Child’s Age or Autism Severity","authors":"R. Dunn, Jonah Elgart, Lisa Lokshina, Alexander Faisman, E. Khokhlovich, Y. Gankin, A. Vyshedskiy","doi":"10.4172/2165-7890.1000217","DOIUrl":"https://doi.org/10.4172/2165-7890.1000217","url":null,"abstract":"We describe data from 1,514 young children with ASD who over the course of 4 to 12 months used a parentadministered tablet-based therapeutic application designed by the authors. Older children and children with milder forms of ASD performed better and progressed faster in cognitive and language exercises. However, most children were able to engage with and learn from exercises independent of their age or ASD severity. These data suggest that tablet-based cognitive and language exercises can be successfully administered by parents to children as young as two years of age over the course of many months, relatively independent of ASD severity.","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"24 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75754922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Shakespeare and Autism: A Pilot Study Examining the Treatment Effects and Predictors of Treatment Response of the Hunter Heartbeat Method","authors":"Margaret H. Mehling, M. Tassé, R. Andridge","doi":"10.4172/2165-7890.1000222","DOIUrl":"https://doi.org/10.4172/2165-7890.1000222","url":null,"abstract":"This pilot study was designed to explore the potential impact of participation in the Hunter Heartbeat Method, a drama-based social skills intervention, on the core symptoms of autism spectrum disorder (ASD). A sample of 10 children with ASD participated in this study. Children were assessed at three time-points: before the start of the intervention (T1), after 14 weeks of participation (T2) and after 42 weeks of participation (T3). Findings from this pilot study indicated that the Hunter Heartbeat Method (HHM) is an intervention that shows promise in impacting social, communication and facial emotion recognition deficits associated with ASD. We also identified the individual characteristics of the participants who were responders and non-responders to the HHM intervention. The results of these findings are discussed.","PeriodicalId":89745,"journal":{"name":"Autism-open access","volume":"56 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85612059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}