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Igg4 Related Disease of the Pancreas Review of Imaging Findings 胰腺Igg4相关疾病影像学研究综述
Pancreatic disorders & therapy Pub Date : 2016-02-29 DOI: 10.4172/2165-7092.1000171
N. Nair, N. Gupta
{"title":"Igg4 Related Disease of the Pancreas Review of Imaging Findings","authors":"N. Nair, N. Gupta","doi":"10.4172/2165-7092.1000171","DOIUrl":"https://doi.org/10.4172/2165-7092.1000171","url":null,"abstract":"IgG4 related disease is a systemic fibro-inflammatory disorder which can affect any organ system in the body. Involvement of pancreas by IgG4 related disease is quite common. Imaging of the pancreas shows characteristic changes in IgG4 related disease. Imaging can also differentiate it from other mimics as pancreatic malignancy.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"26 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80207334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brief History of the Spread of Melanoma to the Pancreas 黑色素瘤向胰腺扩散的简史
Pancreatic disorders & therapy Pub Date : 2016-02-29 DOI: 10.4172/2165-7092.1000170
W. Onuigbo
{"title":"A Brief History of the Spread of Melanoma to the Pancreas","authors":"W. Onuigbo","doi":"10.4172/2165-7092.1000170","DOIUrl":"https://doi.org/10.4172/2165-7092.1000170","url":null,"abstract":"The informative Merriam-Webster’s Collegiate Dictionary not only defined melanoma as a tumor which forms pigment but also added that this name first appeared in 1838. In this context, a historical review of pigment cell biology did not mention the pancreas up to 1900. Therefore, this paper briefly documents its appearances before that year.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"366 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77202719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Pancreatic Cancer Exosomes: Shedding Off for a Meaningful Journey. 胰腺癌外泌体:为有意义的旅程而脱落。
Pancreatic disorders & therapy Pub Date : 2016-02-26 DOI: 10.4172/2165-7092.1000E148
G. Patel, Mary C. Patton, Seema Singh, M. Khushman, A. Singh
{"title":"Pancreatic Cancer Exosomes: Shedding Off for a Meaningful Journey.","authors":"G. Patel, Mary C. Patton, Seema Singh, M. Khushman, A. Singh","doi":"10.4172/2165-7092.1000E148","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E148","url":null,"abstract":"This year, pancreatic ductal adenocarcinoma (PDAC) is expected to overtake breast cancer to become the third leading cause of cancerrelated death in the United States [1]. Nearly 50,416 new cases and 41,780 deaths are estimated to occur in 2016. PDACs carry a notoriously poor prognosis due to advanced stage presentation in most patients and lack of effective therapies. Early diagnosis of PDAC continues to be a challenge in clinics along with early metastasis and resistance to available chemotherapy that together contributes to the poor prognosis [2]. These challenges have motivated researchers to define novel, reliable, and non-invasive or minimally invasive biomarkers for early detection, and understand the process of early metastasis and chemo resistance.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"22 1","pages":"e148"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80348034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Port Site Metastases after Minimally Invasive Gynaecologic Cancer Surgery Prevention is better than Cure 微创妇科肿瘤手术后肝部位转移预防胜于治疗
Pancreatic disorders & therapy Pub Date : 2016-02-26 DOI: 10.4172/2165-7092.1000E147
Swasti
{"title":"Port Site Metastases after Minimally Invasive Gynaecologic Cancer Surgery Prevention is better than Cure","authors":"Swasti","doi":"10.4172/2165-7092.1000E147","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E147","url":null,"abstract":"The last three decades have witnessed laparoscopy being used in cancer surgeries. Initial reports date back to 1970s [1-3]. The use of laparoscopy has been established in oncologic surgeries with innumerable advantages [4] such as being safe, less invasive, preservation of oncologic and immunologic functions and shorter intervals to start of adjuvant treatment if needed [5]. However, minimally invasive onco-surgeries may have complications like vascular injuries, bowel injuries, genitourinary injuries and port-site metastases (PSMs) [6,7]. PSM is a strong risk factor for peritoneal dissemination [8]. PSMs are associated with poor outcome of patients and represent significant patient morbidity and end-of-life care issues. PSMs can significantly increase patient morbidity and are associated with poor outcome.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"37 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86835999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Short Commentary on Acute Pancreatitis 浅谈急性胰腺炎
Pancreatic disorders & therapy Pub Date : 2016-02-26 DOI: 10.4172/2165-7092.1000E146
M. D'souza
{"title":"A Short Commentary on Acute Pancreatitis","authors":"M. D'souza","doi":"10.4172/2165-7092.1000E146","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E146","url":null,"abstract":"","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"29 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2016-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86193347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Systemic Inflammatory Response and Fat Necrosis of Perineal Soft Tissues: A Rare Complication of Bladder-Drained Transplanted Pancreas Leak 会阴软组织全身性炎症反应及脂肪坏死:膀胱引流移植胰腺渗漏的罕见并发症
Pancreatic disorders & therapy Pub Date : 2016-02-24 DOI: 10.4172/2165-7092.1000169
Sara A. Mansfield, W. J. Melvin, Brent E Carlyle, Steven Sun, J. Huntington, David C. Evans, A. Rushing
{"title":"Systemic Inflammatory Response and Fat Necrosis of Perineal Soft Tissues: A Rare Complication of Bladder-Drained Transplanted Pancreas Leak","authors":"Sara A. Mansfield, W. J. Melvin, Brent E Carlyle, Steven Sun, J. Huntington, David C. Evans, A. Rushing","doi":"10.4172/2165-7092.1000169","DOIUrl":"https://doi.org/10.4172/2165-7092.1000169","url":null,"abstract":"Pancreatic transplant is increasingly being performed for management of diabetes. There are known complications, specifically related to exocrine drainage of the pancreas, with enteric versus bladder drainage being options. Here we present a unique complication of leakage of the pancreaticocystostomy, likely secondary to severe urethritis and obliteration of the urethra. Accumulation of pancreatic enzymes in the subcutaneous tissues led to fat necrosis of the scrotum and groin with severe systemic inflammatory response syndrome. Presentation mimicked an infectious soft tissue infection that failed antibiotic management. This highlights a unique clinical entity mimicking infection. This patient required debridement, urinary diversion, and a multidisciplinary approach to treatment.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"17 2 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78259004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Endoscopic Ultrasound-Guided Pancreatic Cyst-Duodenostomy via a Distal Trans-Duodenal Approach 超声内镜引导下经十二指肠远端入路胰囊肿十二指肠切开术
Pancreatic disorders & therapy Pub Date : 2016-02-23 DOI: 10.4172/2165-7092.1000168
Dennis Yang, Donevan R. Westerveld, Christopher J DiMaio
{"title":"Endoscopic Ultrasound-Guided Pancreatic Cyst-Duodenostomy via a Distal Trans-Duodenal Approach","authors":"Dennis Yang, Donevan R. Westerveld, Christopher J DiMaio","doi":"10.4172/2165-7092.1000168","DOIUrl":"https://doi.org/10.4172/2165-7092.1000168","url":null,"abstract":"Dennis Yang1, Donevan Westerveld2 and Christopher J. DiMaio3* 1Division of Gastroenterology, University of Florida College of Medicine, Gainesville, FL, USA 2University of Florida College of Medicine, Gainesville, FL, USA 3Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA *Corresponding author: Christopher J. DiMaio, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA, Tel: 212-241-4299; E-mail: christopher.dimaio@mountsinai.org","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"13 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82009034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing Effective Salmonella-based Approaches to Treat Pancreatic Cancer 开发有效的沙门氏菌治疗胰腺癌的方法
Pancreatic disorders & therapy Pub Date : 2016-01-15 DOI: 10.4172/2165-7092.1000167
J. Chen, D. Diamond, E. Manuel
{"title":"Developing Effective Salmonella-based Approaches to Treat Pancreatic Cancer","authors":"J. Chen, D. Diamond, E. Manuel","doi":"10.4172/2165-7092.1000167","DOIUrl":"https://doi.org/10.4172/2165-7092.1000167","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is predicted to have the second highest incidence of fatalities among all solid tumor malignancies worldwide. Despite three decades of research focused on treating PDAC, the five-year survival rate is less than 6%, thus leaving much room for improvement. Historically, PDAC has been difficult to treat due to the absence of early detection methods resulting in clinical disease that is significantly advanced and characterized by immunosuppression, an extreme form of fibrosis known as desmoplasia, and metastasis to vital organs [1]. Current chemotherapeutic combinations, such as gemcitabine with Abraxane, have been shown to extend patient survival; however, they only do so by two to three months [2]. The newly released irinotecan liposome injection tested in pancreatic cancer patients is, at best, equal in efficacy to gemcitabine with Abraxane [3-5]. The low efficacy and high toxicity of chemotherapy has lead to innovative new strategies using immunotherapeutic approaches for treatment of PDAC. For example, the whole pancreatic cancer cell vaccine expressing human macrophage-colony stimulating factor (GM-CSF), known as GVAX, combined with a Listeriabased vaccine expressing the PDAC antigen mesothelian (CRS-207) shows promise in extending survival evidenced by both pre-clinical and preliminary clinical data [6]. Furthermore, antibody therapies targeting CTLA-4 and PD-1 have shown great benefit toward enhancing antitumor immunity resulting in tumor regression and extension of survival in other solid tumor models [7]. Despite these successes, there is a growing consensus that a “multipronged” approach to induce anti-tumor immunity and simultaneously targeting immune suppression and desmoplasia will have the greatest effect in eliminating PDAC. However, balancing such aggressive approaches with minimal toxicity to the patient will prove to be an incredibly daunting task.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"6 1","pages":"1 - 2"},"PeriodicalIF":0.0,"publicationDate":"2016-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87371406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cancer of the Pancreas (CaP) New Thoughts, New Approaches for the New Year 胰腺癌(CaP)新年新思路新方法
Pancreatic disorders & therapy Pub Date : 2016-01-11 DOI: 10.4172/2165-7092.1000E145
A. Cooperman
{"title":"Cancer of the Pancreas (CaP) New Thoughts, New Approaches for the New Year","authors":"A. Cooperman","doi":"10.4172/2165-7092.1000E145","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E145","url":null,"abstract":"","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"27 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74500199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
EUS-Guided Transmural Drainage of Pancreatic Fluid Collections: Keeping It Close eus引导下胰液收集的经壁引流:保持其紧密
Pancreatic disorders & therapy Pub Date : 2016-01-01 DOI: 10.4172/2165-7092.1000E144
Dennis Yang, P. Draganov
{"title":"EUS-Guided Transmural Drainage of Pancreatic Fluid Collections: Keeping It Close","authors":"Dennis Yang, P. Draganov","doi":"10.4172/2165-7092.1000E144","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E144","url":null,"abstract":"Pancreatic fluid collections (PFCs) can develop as a consequence of acute necrotizing pancreatitis, pancreatic duct (PD) disruption due to acute or chronic pancreatitis, pancreatic surgery, and trauma [1-3]. Based on the Revised Atlanta classification, PFCs are classified as acute peripancreatic fluid collections (APFC), pseudocysts, acute necrotic collection (ANC), and walled-off necrosis according to their morphology on imaging [1]. While most of these collections tend to resolve spontaneously, treatment is warranted for symptomatic PFCs. Symptoms, including abdominal pain, early satiety, jaundice, or weight loss, are often secondary to luminal (gastroduodenal) and/or biliary obstruction. Other indications for intervention include infection, bleeding and fistulization [4,5].","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"133 3 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79622983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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