Pancreatic disorders & therapy最新文献_第10页

Pancreatic Carcinoma with the First Symptom of Acute Pancreatitis: MRI Findings and Clinical Features 以急性胰腺炎为首发症状的胰腺癌:MRI表现和临床特征

Pancreatic disorders & therapy Pub Date : 2014-04-27 DOI: 10.4172/2165-7092.1000132

Z. Xm, Y. Li, Jiao Yf, Bao Zg, Liu Xh, Chen Tw, H. Xh, L. Yang

{"title":"Pancreatic Carcinoma with the First Symptom of Acute Pancreatitis: MRI Findings and Clinical Features","authors":"Z. Xm, Y. Li, Jiao Yf, Bao Zg, Liu Xh, Chen Tw, H. Xh, L. Yang","doi":"10.4172/2165-7092.1000132","DOIUrl":"https://doi.org/10.4172/2165-7092.1000132","url":null,"abstract":"Purpose: To study the MRI findings and clinical features of pancreatic carcinoma with the first symptom of acute pancreatitis. \u0000Materials and Methods: Twelve patients with pancreatic carcinoma and the first symptom of acute pancreatitis were included in this study. Pancreatic carcinoma with acute pancreatitis was confirmed by pathology. The MRI findings and clinical features of pancreatic carcinoma combined with acute pancreatitis were noted. \u0000Results: In the 12 patients with acute pancreatitis, the pancreas appeared edematous and non-necrotic on MRI. The pancreatic carcinomas were mainly located in the head of the pancreas (83.33%, 10/12). Most patients showed a mass on T1-weighted and T2-weighted images. A dilated pancreatic duct and/or Common Bile Duct (CBD) was observed on MRI of 75% (9/12) of the patients. The results of laboratory tests demonstrated increased CA19-9 in 8 of the patients (66.67%), elevation of both ALP and AST in 11 of the patients (91.67%), and normal ALP and AST levels in 1 patient. \u0000Conclusions: Acute pancreatitis may be an indicator of pancreatic carcinoma. A pancreatic mass and a dilated pancreatic duct and/or CBD observed by MRI can provide evidence of the associated pancreatic carcinoma. Increased levels of ALT, AST or ALP and CA19-9 may aid the diagnosis of pancreatic carcinoma in cases of acute pancreatitis.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"16 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82455191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrapancreatic Solid Pseudopapillary Neoplasm in the Subhepatic Region: A Diagnostic Dilemma 肝下区胰腺外实性假乳头状肿瘤:诊断困境

Pancreatic disorders & therapy Pub Date : 2014-04-26 DOI: 10.4172/2165-7092.1000152

Rifat Mannan Aas, Songyang Yuan

{"title":"Extrapancreatic Solid Pseudopapillary Neoplasm in the Subhepatic Region: A Diagnostic Dilemma","authors":"Rifat Mannan Aas, Songyang Yuan","doi":"10.4172/2165-7092.1000152","DOIUrl":"https://doi.org/10.4172/2165-7092.1000152","url":null,"abstract":"Solid pseudopapillary neoplasm (SPN) is a rare but distinctive pancreatic neoplasm that typically affects young women. Rare cases of extrapancreatic SPN have been reported. Here; we present an unusual case of SPN in a 32- year-old woman who presented with vague abdominal pain. Computed tomography scan revealed a large solid mass in the subhepatic region; adjacent to the head of pancreas and second part of duodenum. The pancreatic gland parenchyma was not involved. Radiologic features were suggestive of a gastrointestinal stromal tumor. On microscopic examination, the lesion exhibited both solid and pseudopapillary pattern with prominent myxoid change in the stroma. Immunohistochemistry showed strong expression of vimentin, CD10, CD56 and alpha 1 antitrypsin. Synaptophysin was focally positive. β-catenin immunostain showed strong nuclear expression; while stain for Ecadherin was negative. Stains for cytokeratin;epithelial membrane antigen; chromogranin A; calretinin; carcinoembryonic antigen and S-100 protein were negative. These morphologic and immunohistochemical features were characteristic of SPN. We present this case to highlight the importance of recognizing SPN at an unusual location. Differentiation from neuroendocrine tumor can be particularly challenging due to their overlapping clinical; radiologic; morphologic and immunohistochemical features.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"102 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2014-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75806908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Hydatid Cysts of the Pancreas: A Literature First 胰腺多发性包囊:文献第一

Pancreatic disorders & therapy Pub Date : 2014-04-19 DOI: 10.4172/2165-7092.1000130

Senthil Kumar, S. Bramhall, I. Scalera

引用次数: 0

Peripancreatic Fluid Collections: A Review 胰周液收集综述

Pancreatic disorders & therapy Pub Date : 2014-04-19 DOI: 10.4172/2165-7092.1000131

J. Goyal

引用次数: 1

An IPMN Inside a Serous Cystadenoma: Is That Possible? 浆液性囊腺瘤内的IPMN:可能吗?

Pancreatic disorders & therapy Pub Date : 2014-03-27 DOI: 10.4172/2165-7092.1000129

M. Makris, Nikolaos M Kourkounakis, I. Karoumpalis, Konstantinos C Koumarelas, A. Mitrousias, M. Kornaropoulos, Dimitris Katsogiannos, E. Yettimis

引用次数: 0

A Meta-Analysis and Systematic Review of Pancreatic Duct Stent 胰管支架的荟萃分析和系统评价

Pancreatic disorders & therapy Pub Date : 2014-01-16 DOI: 10.4172/2165-7092.1000128

Sukharamwala Prashant, Thoens Jonathan, S. Mauricio, P. Neil, O. Dennis, Ghani N Abdul, D. Peter

{"title":"A Meta-Analysis and Systematic Review of Pancreatic Duct Stent","authors":"Sukharamwala Prashant, Thoens Jonathan, S. Mauricio, P. Neil, O. Dennis, Ghani N Abdul, D. Peter","doi":"10.4172/2165-7092.1000128","DOIUrl":"https://doi.org/10.4172/2165-7092.1000128","url":null,"abstract":"Abstract \u0000Background: Two methods of pancreatic duct decompression following pancreaticoduodenectomy (PD) are currently employed, the internal and external pancreatic duct stent. Previous analysis of the efficacy of ductal decompression following PD has been confounded by either including both the internal and external stent method or by small sample size. The aim of this meta-analysis was to analyze the efficacy of the external pancreatic duct stent method alone in preventing Post-Operative Pancreatic Fistula (POPF) formation and other complications in patients undergoing PD. \u0000Methods: A systematic literature search was conducted using the Medline, Cochrane Library, SCI, and EMBASE databases on all studies published from January 1970 to March 2012 reporting the peri-operative outcomes following PD. The primary end-point was the incidence of POPF formation in the presence of external pancreatic duct stent placement. Secondary outcomes considered included the incidence of post-operative mortality, Delayed Gastric Emptying (DGE), postoperative wound infection, operative time and blood loss, and length of hospital stay. \u0000Results: Four trials were included comprising 416 patients. There was a statistically significant decrease in the incidence of both any grade POPF formation (OR 0.37, 95% CI=0.23 to 0.58, P=0.0001) and clinically significant (grade B or C) POPF formation (OR 0.50, 95% CI=0.30 to 0.84, P=0.0009) in patients receiving an external pancreatic duct stent versus no stent following PD. Total length of hospital stay was also found to be shortened with the use of an external stent (SMD -0.39, 95% CI=-0.63 to -0.15, P=0.001). \u0000Conclusions: There is a decreased incidence of POPF formation following PD in patients receiving an external pancreatic duct stent versus patients receiving no stent. Total length of hospital stay was also found to be favorably affected by placement of an external pancreatic duct stent.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"91 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80498935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current Guidelines for the Management of Branch Duct Intraductal Papillary Mucinous Neoplasms 分支导管导管内乳头状黏液性肿瘤的现行治疗指南

Pancreatic disorders & therapy Pub Date : 2014-01-13 DOI: 10.4172/2165-7092.1000E134

B. Goh

{"title":"Current Guidelines for the Management of Branch Duct Intraductal Papillary Mucinous Neoplasms","authors":"B. Goh","doi":"10.4172/2165-7092.1000E134","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E134","url":null,"abstract":"The management of pancreatic cystic neoplasms has been constantly evolving and changing over the past 2 decades [1-3]. This is mainly due to the rapid advancement of knowledge in this field resulting in particular: 1) the improved understanding of the natural history and biological behavior of the different pathological entities which comprise pancreatic cystic neoplasms and 2) more accurate preoperative diagnosis of these neoplasms as a result of a better understanding of their individual morphological characteristics on imaging and the introduction of newer diagnostic modalities such as endoscopic ultrasonography with fine needle aspirate (EUS-FNA) [2-4]. In general, the management approach has trended from that of aggressive surgical resection [5] to a more selective approach whereby most cystic neoplasms are now managed via surveillance [1,6-8]. Since the landmark paper by Compagno and Oertel [9]; the general consensus was that all mucinous neoplasms were potentially malignant or malignant and should be surgically resected whereas serous cystic neoplasms were benign and could be managed conservatively [2,10,11]. Subsequently, investigators recognized that mucinous neoplasms were actually composed of 2 distinct pathological entities i.e. mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMNs) [10,12,13]. More recently, it was recognized that IPMNs could be classified into branch-duct (BD), main-duct (MD) and mixed-duct types (MT) [14,15]. BD-IPMNs were found to be associated with a less aggressive biological behavior when compared to MD/MT-IPMN and many investigators have since demonstrated that selected BD-IPMNs could be managed conservatively [1,6,8,14-16].","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"83 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2014-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91106053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Pharmacological Options for Acute Pancreatitis: An Overview 急性胰腺炎的药物选择:综述

Pancreatic disorders & therapy Pub Date : 2014-01-01 DOI: 10.4172/2165-7092.1000142

R. Pezzilli

引用次数: 0

Towards A New Surgical Standard for the Treatment of Chronic Pancreatitis 探讨治疗慢性胰腺炎的外科新标准

Pancreatic disorders & therapy Pub Date : 2013-12-11 DOI: 10.4172/2165-7092.1000E132

R. Gruessner

引用次数: 0

Curcumin: Ancient Drug, Modern Challenges, Malignant Pancreatitis 姜黄素:古代药物，现代挑战，恶性胰腺炎

Pancreatic disorders & therapy Pub Date : 2013-12-10 DOI: 10.4172/2165-7092.1000E131

A. Shehzad

引用次数: 1