Milton V. Marshall, J. Rasmussen, I. Tan, M. Aldrich, K. Adams, Xue-juan Wang, C. Fife, E. Maus, L. Smith, E. Sevick-Muraca
{"title":"Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update~!2009-12-07~!2009-12-23~!2010-05-26~!","authors":"Milton V. Marshall, J. Rasmussen, I. Tan, M. Aldrich, K. Adams, Xue-juan Wang, C. Fife, E. Maus, L. Smith, E. Sevick-Muraca","doi":"10.2174/1876504101002020012","DOIUrl":"https://doi.org/10.2174/1876504101002020012","url":null,"abstract":"","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"12-25"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68143252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Application of Indocyanine Green Fluorescence Imaging for Detection of Sentinel Node in Gastric Cancer Surgery~!2009-11-11~!2009-12-23~!2010-05-26~!","authors":"I. Miyashiro","doi":"10.2174/1876504101002020062","DOIUrl":"https://doi.org/10.2174/1876504101002020062","url":null,"abstract":"The indocyanine green fluorescence imaging is a promising technique for sentinel node biopsy with advantages of dye-guided method, which is potentially safer, more convenient, and more cost-effective compared with the radioguided one. It could simplify the dye-guided method in both open and laparoscopic gastric cancer surgery, and possibly shortens the learning curve, which is one of the most crucial factors in the clinical application of SN concept.","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"62-64"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68143880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Tajima, M. Murakami, Kimiyasu Yamazaki, Takashi Kato, M. Kusano
{"title":"Indocyanine Green Fluorescence Imaging for Sentinel Node Mapping in Gastric Cancer~!2009-10-31~!2009-12-23~!2010-05-26~!","authors":"Y. Tajima, M. Murakami, Kimiyasu Yamazaki, Takashi Kato, M. Kusano","doi":"10.2174/1876504101002020065","DOIUrl":"https://doi.org/10.2174/1876504101002020065","url":null,"abstract":"Background: Indocyanine green (ICG) fluorescence imaging has recently been reported as a new method for sentinel node (SN) mapping in several types of cancers. In this study, we determined the feasibility and accuracy of SN mapping guided by ICG fluorescence imaging in gastric cancer. Methods: Our series consisted of 84 patients with gastric cancer who had undergone standard gastrectomy with lymphadenectomy. Intraoperative SN mapping guided by ICG fluorescence imaging was conducted using a chargecoupled device camera with a light-emitting diode as the light source and a cut filter as the detector. Results: The detection rate and mean number of SNs were 97.6% and 7.5, respectively. The accuracy and false-negative rates were 91.5% and 33.3%, respectively. The false-negative result was significantly associated with an intraoperative tracer injection, larger number of cT-stage and pT-stage (P = 0.0012, P = 0.0003, and P = 0.0062, respectively). Lymph node metastasis outside the lymphatic basins was never found in 59 patients with cT1-2 stage gastric cancer who had received preoperative ICG injection. Conclusions: ICG fluorescence imaging-guided SN mapping with preoperative ICG injection can be useful for predicting the metastatic status in the lymph nodes in gastric cancer.","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68143891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bio-Optical Devices in Indocyanine Green Fluorescence Guided Sentinel Node Biopsy for Breast Cancer~!2009-10-04~!2009-12-23~!2010-05-26~!","authors":"Toshiyuki Kitai, M. Kawashima, M. Toi","doi":"10.2174/1876504101002020078","DOIUrl":"https://doi.org/10.2174/1876504101002020078","url":null,"abstract":"Background: The indocyanine green (ICG) fluorescence method is a newly developed technology to facilitate the sentinel node biopsy with the guidance of ICG fluorescence images. However, the surgical technique is still difficult, since the sentinel node cannot be indentified before skin incision and careful dissection of the subcutaneous lymphatic vessels is necessary. In this paper, an axillary pressing technique is introduced. Materials and methods: The subcutaneous lymphatic vessels just under the skin were easily detectable, but the detection of the sentinel nodes deep under the skin was difficult by ordinary observation of the fluorescence images. By pressing the axillary skin against the chest wall, the sentinel node is close to the skin and the fluorescence signal becomes intense enough to be detected. The skin incision was made on the pressure-induced fluorescent spot, and the sentinel node was directly approached with the guidance of fluorescence without dissecting the subcutaneous lymphatic vessels. Results: Pressure-induced fluorescence signal in the axilla was observed in all of 36 cases. Direct approach to the axillary sentinel nodes without tracing the subcutaneous lymphatic vessels was successful in 33 cases. Conclusions: The ICG fluorescence method is reliable and little training is required. The axillary pressing technique is useful to make it more popular.","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"78-82"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Applications of ICG Fluorescence Imaging in Plastic and Reconstructive Surgery~!2009-12-01~!2009-12-23~!2010-05-26~!","authors":"C. Holm","doi":"10.2174/1876504101002020037","DOIUrl":"https://doi.org/10.2174/1876504101002020037","url":null,"abstract":"Aims and Background: Compromise in blood supply and failure in tissue transfer are associated with excessive resource costs in plastic surgery. The ability to detect impaired blood supply on the table would contribute to major cost savings for the health care system. Indocyanine green imaging (ICGA) holds promise as a simple method with a high sensitivity and specificity for assessing blood flow in the operating room. Methods: In this review, experimental and clinical studies concerning the use of ICGA in the field of plastic and reconstructive surgery are reviewed. Findings: Possible plastic surgical applications of ICGA range from assessment of flap perfusion in pedicle and free flap surgery to patency assessment of microvascular anastomoses, sentinel node detection, lymph vessel identification, and burn depth estimation. Conclusions: At present ICGA offers the best data-supported estimates of blood supply in reconstructive plastic surgery. Substantial evidence exists that intraoperative ICGA improves the quality of plastic surgical procedures and has the potential to reduce peri-and postoperative morbidity significantly.","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68144075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Indocyanine Green Fluorescence Navigation May be Useful to Personalize Lymph Nodes Dissection~!2009-10-30~!2009-12-23~!2010-05-26~!","authors":"M. Toi, T. Sugie, Toshiyuki Kitai","doi":"10.2174/1876504101002020029","DOIUrl":"https://doi.org/10.2174/1876504101002020029","url":null,"abstract":"The indocyanine green (ICG) fluorescence imaging is a tool to detect sentinel nodes and the associated lymphatic network including para-sentinel nodes. According to recent experiences in breast cancer treatment, a real-time lymphatic mapping with ICG fluorescence may provide a possibility of being able to personalize lymph node dissection. This novel concept needs to be investigated in various types of diseases.","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"29-30"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68142770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Tagaya, A. Nakagawa, A. Abe, Y. Iwasaki, K. Kubota
{"title":"Non-Invasive Identification of Sentinel Lymph Nodes Using Indocyanine Green Fluorescence Imaging in Patients with Breast Cancer~!2009-11-04~!2009-12-23~!2010-05-26~!","authors":"N. Tagaya, A. Nakagawa, A. Abe, Y. Iwasaki, K. Kubota","doi":"10.2174/1876504101002020071","DOIUrl":"https://doi.org/10.2174/1876504101002020071","url":null,"abstract":"Background: Recently, sentinel lymph node biopsy (SLNB) has been carried out routinely in patients with early breast cancer. Avoidance of axillary lymph node dissection is considerably desirable items of maximizing the quality of life of postoperative patients Here we report non-invasive identification of SLN using indocyanine green (ICG) fluorescence imaging, which provides a high detection rate and a low false-negativity rate. Patients and Methods: One hundred and fifty breast cancer patients with tumors less than 3 cm in diameter were enrolled in this study. ICG dye and indigo carmine were injected subdermally at the same time into the areola. Subcutaneous lymphatic channels draining from the areola to the axilla were immediately rendered visible by fluorescence imagings using a Photodynamic Eye (PDE). After incising the axillary skin over the location of the LN identified by ultrasonography, the SLN was dissected under fluorescence imaging guidance with adequate adjustment of sensitivity. Results: Lymphatic channels and SLN were successfully identified in all patients. The mean number of SLN and the operation time for SLNB were 3.2 and 15.2 min, respectively. Twenty-six patients (17.3%) were found to have lymph node metastases pathologically. Adjustment of the sensitivity of PDE facilitated a reduction in the operation time. There were no intra- or postoperative complications associated with SLN identification. Conclusions: This method is feasible, safe, and only minimally invasive for intraoperative detection of SLN, allowing real-time observation without any need for training.","PeriodicalId":89705,"journal":{"name":"Open surgical oncology journal (Online)","volume":"2 1","pages":"71-74"},"PeriodicalIF":0.0,"publicationDate":"2010-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68143980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}