Influenza research and treatment最新文献_第4页

Influenza vaccination in the face of immune exhaustion: is herd immunity effective for protecting the elderly? 免疫力衰竭时接种流感疫苗：群体免疫对保护老年人有效吗？

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2012-01-29 DOI: 10.1155/2011/419216

Pierre Olivier Lang, Dimitrios Samaras, Nikolaos Samaras, Sheila Govind, Richard Aspinall

{"title":"Influenza vaccination in the face of immune exhaustion: is herd immunity effective for protecting the elderly?","authors":"Pierre Olivier Lang, Dimitrios Samaras, Nikolaos Samaras, Sheila Govind, Richard Aspinall","doi":"10.1155/2011/419216","DOIUrl":"10.1155/2011/419216","url":null,"abstract":"At the start of the 21st century, seasonal influenza virus infection is still a major public health concern across the world. The recent body of evidence confirms that trivalent inactivated influenza vaccines (TIVs) are not optimal within the population who account for approximately 90% of all influenza-related death: elderly and chronically ill individuals regardless of age. With the ever increasing aging of the world population and the recent fears of any pandemic influenza rife, great efforts and resources have been dedicated to developing more immunogenic vaccines and strategies for enhancing protection in these higher-risk groups. This paper describes the mechanisms that shape immune response at the extreme ages of life and how they have been taken into account to design more effective immunization strategies for these vulnerable populations. Furthermore, consideration will be given to how herd immunity may provide an effective strategy in preventing the burden of seasonal influenza infection within the aged population.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"419216"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30983895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The modes of evolutionary emergence of primal and late pandemic influenza virus strains from viral reservoir in animals: an interdisciplinary analysis. 动物病毒库中原始和晚期大流行流感病毒株的进化出现模式：跨学科分析。

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2011-11-15 DOI: 10.1155/2011/861792

Dany Shoham

{"title":"The modes of evolutionary emergence of primal and late pandemic influenza virus strains from viral reservoir in animals: an interdisciplinary analysis.","authors":"Dany Shoham","doi":"10.1155/2011/861792","DOIUrl":"10.1155/2011/861792","url":null,"abstract":"Based on a wealth of recent findings, in conjunction with earliest chronologies pertaining to evolutionary emergences of ancestral RNA viruses, ducks, Influenzavirus A (assumingly within ducks), and hominids, as well as to the initial domestication of mallard duck (Anas platyrhynchos), jungle fowl (Gallus gallus), wild turkey (Meleagris gallopavo), wild boar (Sus scrofa), and wild horse (Equus ferus), presumed genesis modes of primordial pandemic influenza strains have multidisciplinarily been configured. The virological fundamentality of domestication and farming of those various avian and mammalian species has thereby been demonstrated and broadly elucidated, within distinctive coevolutionary paradigms. The mentioned viral genesis modes were then analyzed, compatibly with common denominators and flexibility that mark the geographic profile of the last 18 pandemic strains, which reputedly emerged since 1510, the antigenic profile of the last 10 pandemic strains since 1847, and the genomic profile of the last 5 pandemic strains since 1918, until present. Related ecophylogenetic and biogeographic aspects have been enlightened, alongside with the crucial role of spatial virus gene dissemination by avian hosts. A fairly coherent picture of primary and late evolutionary and genomic courses of pandemic strains has thus been attained, tentatively. Specific patterns underlying complexes prone to generate past and future pandemic strains from viral reservoir in animals are consequentially derived.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"861792"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30984996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of a Low Pathogenic Avian Influenza Virus (H6N1) Isolated from Turkeys. 从火鸡中分离的低致病性禽流感病毒(H6N1)的特性分析。

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2010-12-30 DOI: 10.1155/2011/285218

I Shkoda, E Lapin, E Rosenbluth, S Perk, Z Geva, A Inbar, I Davidson

引用次数: 1

Efficacy and Safety of CVT-E002, a Proprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza-Vaccinated Community-Dwelling Adults: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial. 西西参提取物CVT-E002预防流感疫苗接种社区居民呼吸道感染的有效性和安全性:一项多中心、随机、双盲和安慰剂对照试验

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2011-07-20 DOI: 10.1155/2011/759051

Janet E McElhaney, Andrew E Simor, Shelly McNeil, Gerald N Predy

{"title":"Efficacy and Safety of CVT-E002, a Proprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza-Vaccinated Community-Dwelling Adults: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Trial.","authors":"Janet E McElhaney, Andrew E Simor, Shelly McNeil, Gerald N Predy","doi":"10.1155/2011/759051","DOIUrl":"https://doi.org/10.1155/2011/759051","url":null,"abstract":"CVT-E002 (a proprietary extract) was found to be effective in the prevention of upper respiratory infections (URIs) in healthy adults, and institutionalized and community-dwelling seniors. A multicenter, randomized, double-blind, placebo-controlled trial was carried out to determine effects of CVT-E002 in the prevention of URIs in influenza-vaccinated community-dwelling adults. 783 community-dwelling adults were randomized to receive placebo, 400 mg or 800 mg treatment/d (1 : 1 : 1) for 6 months. Primary analysis on the incidence of laboratory-confirmed-clinical URIs (LCCUs), including influenza A and B, was performed on those receiving at least one dose. Secondary analysis was performed on study completers and included incidence, severity, and duration of URIs meeting a Jackson-based criteria and safety of CVT-E002. The incidence of LCCUs in the ITT group was 5.5%, 5.2%, and 4.6% in the placebo, 400 mg and 800 mg groups, respectively (P = 0.89). Jackson-confirmed URIs were significantly lower in the treated groups (P < 0.04). CVT-E002 supplementation reduced the severity and duration of Jackson-confirmed URIs. The results indicate that CVT-E002 can be safely used by similar groups and may prevent symptoms of URIs; larger sample size is warranted.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"759051"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/759051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30983900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

A Novel Vaccine Using Nanoparticle Platform to Present Immunogenic M2e against Avian Influenza Infection. 利用纳米颗粒平台制备抗禽流感免疫原性M2e疫苗

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2012-01-12 DOI: 10.1155/2011/126794

Sankhiros Babapoor, Tobias Neef, Christian Mittelholzer, Theodore Girshick, Antonio Garmendia, Hongwei Shang, Mazhar I Khan, Peter Burkhard

{"title":"A Novel Vaccine Using Nanoparticle Platform to Present Immunogenic M2e against Avian Influenza Infection.","authors":"Sankhiros Babapoor, Tobias Neef, Christian Mittelholzer, Theodore Girshick, Antonio Garmendia, Hongwei Shang, Mazhar I Khan, Peter Burkhard","doi":"10.1155/2011/126794","DOIUrl":"https://doi.org/10.1155/2011/126794","url":null,"abstract":"Using peptide nanoparticle technology, we have designed two novel vaccine constructs representing M2e in monomeric (Mono-M2e) and tetrameric (Tetra-M2e) forms. Groups of specific pathogen free (SPF) chickens were immunized intramuscularly with Mono-M2e or Tetra-M2e with and without an adjuvant. Two weeks after the second boost, chickens were challenged with 107.2 EID50 of H5N2 low pathogenicity avian influenza (LPAI) virus. M2e-specific antibody responses to each of the vaccine constructs were tested by ELISA. Vaccinated chickens exhibited increased M2e-specific IgG responses for each of the constructs as compared to a non-vaccinated group. However, the vaccine construct Tetra-M2e elicited a significantly higher antibody response when it was used with an adjuvant. On the other hand, virus neutralization assays indicated that immune protection is not by way of neutralizing antibodies. The level of protection was evaluated using quantitative real time PCR at 4, 6, and 8 days post-challenge with H5N2 LPAI by measuring virus shedding from trachea and cloaca. The Tetra-M2e with adjuvant offered statistically significant (P < 0.05) protection against subtype H5N2 LPAI by reduction of the AI virus shedding. The results suggest that the self-assembling polypeptide nanoparticle shows promise as a potential platform for a development of a vaccine against AI.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"126794"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/126794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30981720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72

Changing patterns of h6 influenza viruses in Hong Kong poultry markets. h6流感病毒在香港家禽市场的变化模式。

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2010-10-18 DOI: 10.1155/2011/702092

Hiroichi Ozaki, Yi Guan, Malik Peiris, Robert Webster, Richard Webby

{"title":"Changing patterns of h6 influenza viruses in Hong Kong poultry markets.","authors":"Hiroichi Ozaki, Yi Guan, Malik Peiris, Robert Webster, Richard Webby","doi":"10.1155/2011/702092","DOIUrl":"https://doi.org/10.1155/2011/702092","url":null,"abstract":"Until 2001, H6N1 influenza viruses in the Hong Kong bird markets were represented by a single stable A/teal/Hong Kong/W312/97-like lineage. Beginning in 2001, despite a reduction in overall prevalence, an increase was observed in the number of H6 viruses isolated from chickens and other hosts. To assess any changes in H6 viruses, we characterized 18 H6 viruses isolated in the Hong Kong bird markets from 2001 to 2003. Experimental data showed that the 2003 H6 viruses had similar infectivity for chickens as did A/teal/HK/W312/97, and they were unable to transmit. Although all hemagglutinin genes were closely related to A/teal/HK/W312/97, 7 isolates were reassortant viruses containing similar gene segments of co-circulating H9N2 or H5N1 viruses. The receptor specificity was different from that of A/teal/Hong Kong/W312/97. Interestingly, similar observations have been documented in H9N2 viruses in Hong Kong. This evolution strongly suggests that some change in the ecology of influenza in the region selected for these changes. Taken together, these findings suggest that the H6 influenza viruses isolated in the Hong Kong markets are not well adapted to chickens and that the likely continued source of these viruses are other \"minor\" poultry species in which they are undergoing genetic and biologic evolution.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"702092"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/702092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30983899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Ten-year (1999-2009) epidemiological and virological surveillance of influenza in South Italy (Apulia). 南意大利(阿普利亚)流感十年(1999-2009年)流行病学和病毒学监测。

Influenza research and treatment Pub Date : 2010-01-01 Epub Date: 2010-06-22 DOI: 10.1155/2010/642492

Annamaria Campa, Manuela Quattrocchi, Marcello Guido, Giovanni Gabutti, Cinzia Germinario, Antonella De Donno, The Influenza Collaborative Group

{"title":"Ten-year (1999-2009) epidemiological and virological surveillance of influenza in South Italy (Apulia).","authors":"Annamaria Campa, Manuela Quattrocchi, Marcello Guido, Giovanni Gabutti, Cinzia Germinario, Antonella De Donno, The Influenza Collaborative Group","doi":"10.1155/2010/642492","DOIUrl":"https://doi.org/10.1155/2010/642492","url":null,"abstract":"Clinical and epidemiological surveillance of influenza and other Acute Respiratory Infections (ARI) are currently a major objective of Public Health. The aim was to describe the epidemiology of influenza using the Italian surveillance system. Vaccination Coverage (VC) rates were calculated during 1999-2009 influenza seasons. Molecular studies of influenza virus isolated, from patients with ILI, living in Apulia, are described. 1269 nasal-pharyngeal swabs were taken from patients with ILI and ARI in order to isolate and identify viruses using PCR. Influenza isolates are typed as being types A and B and influenza A isolates are A/H1 and A/H3. The progression of the ILI cases registered in Apulia was similar to the data recorded on a national level. The VC data recorded in Apulia showed a progressive increase in the vaccine doses administered to subjects over 65 years old. The virological surveillance showed a major circulation of the type A/H3N2 influenza virus during the peak incidence of the illness in seasons 1999-2000, 2002-2003, 2004-2005 and 2008-2009. During the same period, the lowest incidence was registered when the type A/H1N1 and B viruses were in circulation. In contrast, during the other seasons the lowest incidence was reported with A/H3N2 and B viruses.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2010 ","pages":"642492"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/642492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30981717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus. 越南H5N1高致病性禽流感病毒攻毒鸭中H5亚单位疫苗和H5N2灭活禽流感标记疫苗的评价

Influenza research and treatment Pub Date : 2010-01-01 Epub Date: 2010-06-27 DOI: 10.1155/2010/489213

Tze-Hoong Chua, Connie Y H Leung, H E Fang, Chun-Kin Chow, Siu-Kit Ma, Sin-Fun Sia, Iris H Y Ng, Stanley G Fenwick, Cassandra M James, Sin Bin Chua, Siang Thai Chew, Jimmy Kwang, J S M Peiris, Trevor M Ellis

{"title":"Evaluation of a Subunit H5 Vaccine and an Inactivated H5N2 Avian Influenza Marker Vaccine in Ducks Challenged with Vietnamese H5N1 Highly Pathogenic Avian Influenza Virus.","authors":"Tze-Hoong Chua, Connie Y H Leung, H E Fang, Chun-Kin Chow, Siu-Kit Ma, Sin-Fun Sia, Iris H Y Ng, Stanley G Fenwick, Cassandra M James, Sin Bin Chua, Siang Thai Chew, Jimmy Kwang, J S M Peiris, Trevor M Ellis","doi":"10.1155/2010/489213","DOIUrl":"https://doi.org/10.1155/2010/489213","url":null,"abstract":"The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2010 ","pages":"489213"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/489213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30981716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration. 服用奥司他韦后猪源性甲型流感病毒(H1N1)的脱落。

Influenza research and treatment Pub Date : 2010-01-01 Epub Date: 2010-12-14 DOI: 10.1155/2010/976084

Leiyun Weng, Qiang Wang, Wei Wang, Peijun Ren, Vincent Deubel, Tetsuya Toyoda

引用次数: 0

Factors associated with increased risk perception of pandemic influenza in australia. 澳大利亚对大流行性流感风险认识增加的相关因素。

Influenza research and treatment Pub Date : 2010-01-01 Epub Date: 2010-07-20 DOI: 10.1155/2010/947906

Jennifer Jacobs, Melanie Taylor, Kingsley Agho, Garry Stevens, Margo Barr, Beverley Raphael

{"title":"Factors associated with increased risk perception of pandemic influenza in australia.","authors":"Jennifer Jacobs, Melanie Taylor, Kingsley Agho, Garry Stevens, Margo Barr, Beverley Raphael","doi":"10.1155/2010/947906","DOIUrl":"https://doi.org/10.1155/2010/947906","url":null,"abstract":"The aim of this study was to assess factors associated with increased risk perception of pandemic influenza in Australia. The sample consisted of 2081 Australian adults aged 16 years and older who completed a short three item pandemic influenza question module which was incorporated into the NSW Health Adult Population Health Survey during the first quarter of 2007. After adjusting for covariates, multivariate analysis indicated that those living in rural regions were significantly more likely to perceive a high risk that a pandemic influenza would occur, while those with poor self-rated health perceived both a high likelihood of pandemic and high concern that self/family would be directly affected were such an event to occur. Those who spoke a language other than English at home and those on low incomes and younger people (16-24 years) were significantly more likely to have changed the way they lived their lives due to the possibility of pandemic influenza, compared to those who spoke only English at home, middle-high income earners, and older age groups, respectively. This data provides an Australian population baseline against which the risk perceptions of demographic subgroups regarding the current, and potential future pandemics, can be compared and monitored.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2010 ","pages":"947906"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2010/947906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30981718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35