Influenza research and treatment最新文献_第3页

Pediatric influenza-associated deaths in new york state: death certificate coding and comparison to laboratory-confirmed deaths. 纽约州儿童流感相关死亡:死亡证明编码和与实验室确认死亡的比较

Influenza research and treatment Pub Date : 2012-01-01 Epub Date: 2012-09-25 DOI: 10.1155/2012/397890

Dina Hoefer, Bryan Cherry, Marilyn Kacica, Kristi McClamroch, Kimberly Kilby

{"title":"Pediatric influenza-associated deaths in new york state: death certificate coding and comparison to laboratory-confirmed deaths.","authors":"Dina Hoefer, Bryan Cherry, Marilyn Kacica, Kristi McClamroch, Kimberly Kilby","doi":"10.1155/2012/397890","DOIUrl":"https://doi.org/10.1155/2012/397890","url":null,"abstract":"Introduction. Surveillance for laboratory-confirmed influenza-associated deaths in children is used to monitor the severity of influenza at the population level and to inform influenza prevention and control policies. The goal of this study was to better estimate pediatric influenza mortality in New York state (NYS). Methods. Death certificate data were requested for all passively reported deaths and any pneumonia and influenza (P&I) coded pediatric deaths occurring between October 2004 and April 2010, excluding New York City (NYC) residents. A matching algorithm and capture-recapture analysis were used to estimate the total number of influenza-associated deaths among NYS children. Results. Thirty-four laboratory-confirmed influenza-associated pediatric deaths were reported and 67 death certificates had a P&I coded death; 16 deaths matched. No laboratory-confirmed influenza-associated death had a pneumonia code and no pneumonia coded deaths had laboratory evidence of influenza infection in their medical record. The capture-recapture analysis estimated between 38 and 126 influenza-associated pediatric deaths occurred in NYS during the study period. Conclusion. Passive surveillance for influenza-associated deaths continues to be the gold standard methodology for characterizing influenza mortality in children. Review of death certificates can complement but not replace passive reporting, by providing better estimates and detecting any missed laboratory-confirmed deaths.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2012 ","pages":"397890"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/397890","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30984998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Situation-based survey of avian influenza viruses in possible "bridge" species of wild and domestic birds in Nigeria. 在尼日利亚可能的野生和家禽“桥接”种中禽流感病毒的情况调查。

Influenza research and treatment Pub Date : 2012-01-01 Epub Date: 2012-09-02 DOI: 10.1155/2012/567601

Vakuru Columba Teru, Shiiwua A Manu, Gashash I Ahmed, Kabir Junaidu, Scott Newman, Joseph Nyager, Vivian N Iwar, Gideon M Mshelbwala, T Joannis, Junaidu A Maina, Paul T Apeverga

{"title":"Situation-based survey of avian influenza viruses in possible \"bridge\" species of wild and domestic birds in Nigeria.","authors":"Vakuru Columba Teru, Shiiwua A Manu, Gashash I Ahmed, Kabir Junaidu, Scott Newman, Joseph Nyager, Vivian N Iwar, Gideon M Mshelbwala, T Joannis, Junaidu A Maina, Paul T Apeverga","doi":"10.1155/2012/567601","DOIUrl":"https://doi.org/10.1155/2012/567601","url":null,"abstract":"The highly pathogenic avian influenza (H5N1 subtype) recurred in Nigeria after 9 months period of no reported case. A critical look at possible sources of the re-occurrence was desirable. The objective of this study was to determine whether avian influenza viruses were present at reasonably detectable levels (0.5%) in possible \"bridge\" species of wild and domestic birds. The study was conducted in 8 Nigerian states. A total of 403 birds from 40 species were sampled. Virus isolation was done in embryonated chicken eggs according to standard protocols. The test results were all negative for avian influenza viruses. The overall confidence interval (CI) calculated in R using the exact binomial confidence interval function was 0-0.007406. Tawny Eagle (Aquila rapax) was the lowest sampled 0.3% (1/403) and Red-billed Firefinch (Lagonosticta senegala) the highest 11.7% (47/403). The limitations of the sample size and possibly designing effects on the study, as to make concrete conclusions were acknowledged. Species of wild birds, so identified in the study could be useful in future surveys. Furthermore, multidisciplinary and community oriented approach, blending targeted and passive surveillances was suggested. This approach was envisaged to bring about wider coverage of \"bridge\" species and clearer insight of their possible roles in avian influenza re-occurrences and spread in Nigeria.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2012 ","pages":"567601"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/567601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30985000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Persistence of avian influenza viruses in various artificially frozen environmental water types. 禽流感病毒在各种人工冷冻环境水类型中持续存在。

Influenza research and treatment Pub Date : 2012-01-01 Epub Date: 2012-10-04 DOI: 10.1155/2012/912326

Dany Shoham, Alam Jahangir, Sakchai Ruenphet, Kazuaki Takehara

{"title":"Persistence of avian influenza viruses in various artificially frozen environmental water types.","authors":"Dany Shoham, Alam Jahangir, Sakchai Ruenphet, Kazuaki Takehara","doi":"10.1155/2012/912326","DOIUrl":"10.1155/2012/912326","url":null,"abstract":"Background. This study investigates the viable persistence of avian influenza viruses (AIVs) in various types of artificially frozen environmental water and evaluates the feasibility of similar occurrence taking place in nature, and allowing for prolonged abiotic virus survival, with subsequent biotic viral recirculation. Methods. Fresh, brackish, and salty water, taken in Japan from aquatic biotopes regularly visited by migratory waterfowl, were seeded with AIVs. We monthly monitored the viability of the seeded viruses in the frozen state at -20°C and -30°C, for 12 months. We also monitored virus viability following repeatedly induced freezing and thawing. Results. The viruses exhibited considerable viable persistence all along that period of time, as well as during freezing-thawing cycles. Appreciable, yet noncrucial variances were observed in relation to some of the parameters examined. Conclusions. As typical waterborne pathogens of numerous northerly aquatic birds, AIVs are innately adapted to both the body temperature of their hosts (40°C to 42°C) and, presumably, to subzero temperatures of frozen lakes (down to -54°C in parts of Siberia) occupied and virus-seeded by subclinically infected birds, prior to freezing. Marked cryostability of AIVs appears to be evident. Preservation in environmental ice has significant ecophylogenetic and epidemiological implications, potentially, and could account for various unexplained phenomena.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2012 ","pages":"912326"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/912326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30995315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Myocarditis Associated with Influenza A H1N1pdm2009. 与甲型h1n1流感相关的心肌炎

Influenza research and treatment Pub Date : 2012-01-01 Epub Date: 2012-12-17 DOI: 10.1155/2012/351979

Akira Ukimura, Hidetoshi Satomi, Yukimasa Ooi, Yumiko Kanzaki

{"title":"Myocarditis Associated with Influenza A H1N1pdm2009.","authors":"Akira Ukimura, Hidetoshi Satomi, Yukimasa Ooi, Yumiko Kanzaki","doi":"10.1155/2012/351979","DOIUrl":"https://doi.org/10.1155/2012/351979","url":null,"abstract":"Acute myocarditis is a well-known complication of influenza infection. The frequency of myocardial involvement in influenza infection varies widely, with the clinical severity ranging from asymptomatic to fulminant varieties. The worst cases can result in death due to impaired cardiac function, although such fulminant myocarditis associated with influenza infection is rare, as shown by previous papers. Following the 2009 influenza pandemic, we reported on the clinical features of a cohort of 15 patients in Japan with H1N1pdm2009 myocarditis. In our subsequent survey of the literature for case reports or series of patients with myocarditis associated with H1N1pdm2009, we identified 58 detailed cases. We discuss here the high prevalence of fulminant myocarditis (36/58, 62%) among patients reported to have myocarditis associated with H1N1pdm2009. Mechanical circulatory support was required in 17 of the patients with fulminant myocarditis, 13 of whom recovered. We stress the need for increased awareness of influenza-associated myocarditis; such knowledge will facilitate earlier diagnosis and treatment of this fatal complication during future influenza pandemics.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2012 ","pages":"351979"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/351979","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86

A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model. 猪流感期间对金黄色葡萄球菌呼吸道感染敏感性的时间过程。

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2012-01-11 DOI: 10.1155/2011/846910

Elizabeth A Smith, Sandeep R P Kumar, Jagadeeswaran Deventhiran, Thomas E Cecere, Tanya Leroith, Mike McGilliard, Subbiah Elankumaran, Isis Kanevsky Mullarky

{"title":"A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model.","authors":"Elizabeth A Smith, Sandeep R P Kumar, Jagadeeswaran Deventhiran, Thomas E Cecere, Tanya Leroith, Mike McGilliard, Subbiah Elankumaran, Isis Kanevsky Mullarky","doi":"10.1155/2011/846910","DOIUrl":"https://doi.org/10.1155/2011/846910","url":null,"abstract":"Bacterial superinfections following influenza A virus (IAV) are predominant causes of morbidity in humans. The recent emergence of methicillin-resistant Staphylococcus aureus (MRSA) and highly virulent IAV strains has reduced treatment options. Development of an appropriate animal model to study secondary S. aureus infections may provide important information regarding disease pathogenesis. Pigs are natural hosts to both IAV and S. aureus and have respiratory physiology and immune response comparable to humans. To establish a time course of susceptibility to S. aureus after IAV infection, nursery pigs infected intranasally with IAV were challenged with MRSA at different time points. Lung pathology scores and MRSA CFU were evaluated in dual-infected animals after IAV infection. Flow cytometric analysis of bronchoalveolar lavage fluid indicated differences between treatments. These results demonstrate the appropriateness of an intranasal challenge model in nursery pigs for studying the pathogenesis of IAV and S. aureus coinfection and provide insights into the timeframe for susceptibility of IAV-infected pigs to secondary S. aureus infection.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"846910"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/846910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30984994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Impact of Infection with Pandemic Influenza (H1N1) 2009 Virus in Naïve Nucleus and Multiplier Pig Herds in Norway. 挪威Naïve核型和倍增型猪群感染2009年H1N1大流行性流感病毒的临床影响

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2011-12-22 DOI: 10.1155/2011/163745

Carl Andreas Grøntvedt, Chiek Er, Britt Gjerset, Anna Germundsson, Tore Framstad, Edgar Brun, Anne Jørgensen, Bjørn Lium

{"title":"Clinical Impact of Infection with Pandemic Influenza (H1N1) 2009 Virus in Naïve Nucleus and Multiplier Pig Herds in Norway.","authors":"Carl Andreas Grøntvedt, Chiek Er, Britt Gjerset, Anna Germundsson, Tore Framstad, Edgar Brun, Anne Jørgensen, Bjørn Lium","doi":"10.1155/2011/163745","DOIUrl":"https://doi.org/10.1155/2011/163745","url":null,"abstract":"The Norwegian pig population has been free from influenza viruses until 2009. The pandemic influenza outbreak during the autumn 2009 provided an opportunity to study the clinical impact of this infection in an entirely naïve pig population. This paper describes the results of a case-control study on the clinical impact of pandemic influenza (H1N1) 2009 infection in the nucleus and multiplier herds in Norway. The infection spread readily and led to seroconversion of 42% of the Norwegian nucleus and multiplier herds within a year. Positive and negative herds were identified based on surveillance data from the Norwegian Veterinary Institute. Telephone interviews were conducted with pig herd owners or managers between November 2010 and January 2011. Pigs with clinical signs were reported from 40% of the case herds with varying morbidity and duration of respiratory disease and reduced reproductive performance. Clinical signs were reported in all age groups.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"163745"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/163745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30981721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Experiences after Twenty Months with Pandemic Influenza A (H1N1) 2009 Infection in the Naïve Norwegian Pig Population. Naïve挪威猪群感染2009年甲型H1N1流感20个月后的经验

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2012-01-03 DOI: 10.1155/2011/206975

B Gjerset, C Er, S Løtvedt, A Jørgensen, O Hungnes, B Lium, A Germundsson

引用次数: 11

Pathological Findings and Distribution of Pandemic Influenza A (H1N1) 2009 Virus in Lungs from Naturally Infected Fattening Pigs in Norway. 2009年大流行性流感(H1N1)病毒在挪威自然感染的育肥猪肺部的病理发现和分布

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2011-12-20 DOI: 10.1155/2011/565787

Mette Valheim, Hans Gamlem, Britt Gjerset, Anna Germundsson, Bjørn Lium

{"title":"Pathological Findings and Distribution of Pandemic Influenza A (H1N1) 2009 Virus in Lungs from Naturally Infected Fattening Pigs in Norway.","authors":"Mette Valheim, Hans Gamlem, Britt Gjerset, Anna Germundsson, Bjørn Lium","doi":"10.1155/2011/565787","DOIUrl":"https://doi.org/10.1155/2011/565787","url":null,"abstract":"The Norwegian pig population was considered free from influenza A virus infections until the first case of porcine pandemic influenza A (H1N1) 2009 virus infection in October 2009. Human to pig transmission of virus was suspected. Unusual lung lesions were observed in fattening pigs, with red, lobular, multifocal to coalescing consolidation, most frequently in the cranial, middle, and accessory lobes. The main histopathological findings were epithelial degeneration and necrosis, lymphocyte infiltration in the epithelial lining and lamina propria of small bronchi and bronchioles, and peribronchial and peribronchiolar lymphocyte infiltrations. Infection with pandemic influenza A (H1N1) 2009 virus was confirmed by real-time RT-PCR and immunohistochemical detection of influenza A virus nucleoprotein in the lesions. This investigation shows that natural infection with the pandemic influenza A (H1N1) 2009 virus induces lung lesions similar to lesions described in experimental studies and natural infections with other swine-adapted subtypes of influenza A viruses.","PeriodicalId":89679,"journal":{"name":"Influenza research and treatment","volume":"2011 ","pages":"565787"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2011/565787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30983896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Predictive and Reactive Distribution of Vaccines and Antivirals during Cross-Regional Pandemic Outbreaks. 跨区域大流行爆发期间疫苗和抗病毒药物的预测和反应性分布。

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2011-06-05 DOI: 10.1155/2011/579597

Andrés Uribe-Sánchez, Alex Savachkin

引用次数: 0

Blow Flies Were One of the Possible Candidates for Transmission of Highly Pathogenic H5N1 Avian Influenza Virus during the 2004 Outbreaks in Japan. 在2004年日本爆发的高致病性H5N1禽流感疫情中，苍蝇是传播高致病性H5N1禽流感病毒的可能候选者之一。

Influenza research and treatment Pub Date : 2011-01-01 Epub Date: 2010-12-28 DOI: 10.1155/2011/652652

Kyoko Sawabe, Keita Hoshino, Haruhiko Isawa, Toshinori Sasaki, Kyeong Soon Kim, Toshihiko Hayashi, Yoshio Tsuda, Hiromu Kurahashi, Mutsuo Kobayashi

引用次数: 16