Translational biomedicine最新文献

{"title":"A Translational Biomedical Approach to Structural Arrangement of Amino Acids Complexes: A Combined Theoretical and Computational Study","authors":"A. Heidari","doi":"10.21767/2172-0479.100072","DOIUrl":"https://doi.org/10.21767/2172-0479.100072","url":null,"abstract":"In this short communication, respectively bonding among Boron (B3+), Aluminum (Al3+), Gallium (Ga3+), Indium (In3+) and Thallium (Tl3+) cations and Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glutamine, Glycine, Proline, Selenocysteine, Serine, Tyrosine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan and Valine ligands and also structural arrangement of the present compounds were studied, theoretically and computationally","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68097584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cupriavidus pauculus Osteomyelitis and Secondary Septic Arthritis withHemodialysis Origins: A Case Study","authors":"N. Carayannopoulos","doi":"10.21767/2172-0479.100095","DOIUrl":"https://doi.org/10.21767/2172-0479.100095","url":null,"abstract":"Chronic osteomyelitis is a severe pathology that is often troublesome for physicians to manage. This condition requires both aggressive surgical and pharmacological approaches to eradicate the infection. Infrequently in adults, septic arthritis may manifest as a result of adjacent osteomyelitis. We present the first case of osteomyelitis along with secondary septic arthritis caused by Cupriavidus pauculus. A 28-year-old immunosuppressed female on hemodialysis presented with osteomyelitis of her right distal tibia and talar dome with subsequent septic arthritis of the tibiotalar joint. The distal tibia and superior talus were resected, antibiotic loaded cement was incorporated into the debrided area, and the spacer was internally fixed. Our patient is now undergoing a physical therapy regimen and has not experienced complications.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68100945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Wall Abscess Harbouring Gall Stones and Adenocarcinoma after Laparoscopic Cholecystectomy: A Rare Case Report","authors":"R. Chaudhary, Ramesh Bharti, Ankit Shukla","doi":"10.21767/2172-0479.100052","DOIUrl":"https://doi.org/10.21767/2172-0479.100052","url":null,"abstract":"Cholecystectomy is the most commonly performed operation worldwide. Laparoscopic cholecystectomy is the gold standard treatment of gall stones today. Over the decades the complications of laparoscopic cholecystectomy has decreased but gall bladder perforation and bile spillage is still a significant problem. The lost gall stones can lead to abscess formation both intra-abdominal and intraparietal. Rarely the port sites may harbor malignancy, which is the most feared of all complications. So gall bladder perforation and bile or gall stone spillage should be properly documented.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digestive Fistulas: The Challenge Continues","authors":"I. Filho, Amália Cinthia Menezes Rêgo, Francisco Irochima Pinheiro","doi":"10.21767/2172-0479.100069","DOIUrl":"https://doi.org/10.21767/2172-0479.100069","url":null,"abstract":"The digestive fistulas correspond to abnormal communications between the digestive system and between this and the body surface. Even after many years of study on the subject, digestive fistulas continue to challenge surgeons and patients suffering harm, consuming fortunes in their treatment, as well as causing serious damage affected people, its due to high morbidity and mortality. This review aims to review the literature on the gastrointestinal fistula subject, focusing on etiology, pathophysiology, classification, diagnosis, current therapy and prognosis in order to revisit a highly important topic and continue helping clinicians, general surgeons and device digestive in combating this challenge for doctors and patients.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68097445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Occurrence of a High Number of Lung Cancer Metastases is Consonant with the Proposed Theory of Erythrocyte Associated Necrosis Factor","authors":"W. Onuigbo","doi":"10.21767/2172-0479.100054","DOIUrl":"https://doi.org/10.21767/2172-0479.100054","url":null,"abstract":"In this journal, I argued that, concerning cancer necrosis itself, which was personally named as the Erythrocyte Associated Necrosis Factor (EANF), it plays a significant role. Accordingly, it is necessary to weigh repeatedly any evidence, which crops up or becomes recognized, in order to confirm or confute any such subsisting hypothesis. Elsewhere, it was hypothesized that EANF positively explains the anomalous lack of contralateral deposits in the cases of lung cancer. This emerged right from the experiences of the medical masters of yester years. In this context, another working hypothesis is being brought forward, namely, that when EANF production is low, the resulting metastases tend to be high in number. In conclusion, just as dangerous bleeding brought death in the days of yore, and the discovery of the Coagulation Factor brought relief, let EANF become the harbinger of the cure of cancer itself be it in the lung or elsewhere.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68095707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic Duct Opening into Right Hepatic Duct; a Disaster Waiting to Happen During Cholecystectomy: A Case Report","authors":"R. Chaudhary, Kulbhushan Sharma, Ankit Shukla, Atul Gupta, K. Saurabh, A. Parashar","doi":"10.21767/2172-0479.100059","DOIUrl":"https://doi.org/10.21767/2172-0479.100059","url":null,"abstract":"Cholecystectomy is the most commonly performed elective surgery worldwide. Variations in the normal anatomy of the biliary tree are common. Cystic duct variations are surgically most significant. Incidence of cystic duct opening into right hepatic duct is very low. In the case presented in this report cystic duct opened into the right hepatic duct. An abnormally wide cystic duct made us suspicious and after careful dissection we could trace the cystic duct entering into right hepatic duct. Various radiologic investigations like ERCP (endoscopic retrograde cholangiopancreatography), MRCP (magnetic resonance cholangiopancreatography), Helical CT (computerized tomography) can give us excellent picture of biliary tree but they are seldom used preoperatively. Hence the proper knowledge of normal anatomy and anomalies of the biliary tree can help to avoid disasters during cholecystectomy, especially for surgeons beginning their careers.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neuronal Mechanism of the Faith","authors":"R. Skopec","doi":"10.21767/2172-0479.100086","DOIUrl":"https://doi.org/10.21767/2172-0479.100086","url":null,"abstract":"Top-down processes overrode brain circuits devoted reading and detection conflict (the Stroop effect). Most of the time bottom-up information matches top-down expectations. If we imagine something different, so it is different. A number of recent brain imaging studies point to top-down brain mechanism under the influence of suggestion. By Kosslyn, brain scans show that the control mechanisms for detecting what to do in the face of conflict become uncoupled, when subjects are hypnotized. Top-down processes override sensory bottom-up information. Subjects think that sights, sounds, and touch from outside world constitute reality. But the brain constructs what it perceives based on past experience. We propose this process label as a neurobiological mechanism of the faith (in religious tradition “the Heart”).","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68099606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Drug Testing in Animals","authors":"Bhanu Prasad. Ch","doi":"10.21767/2172-0479.100099","DOIUrl":"https://doi.org/10.21767/2172-0479.100099","url":null,"abstract":"An estimated 26 million animals are used every year in the United States for scientific and commercial testing. Animals are used to develop medical treatments, determine the toxicity of medications, check the safety of products destined for human use, and other biomedical, commercial, and health care uses. Research on living animals has been practiced since Ancient times. Researchers will use animal testing to obtain clues to how the disease develops in the body. The purpose of this article is to raise some points for an understanding the ethics of using animals in scientific experiments. I present the various positions from scientific and moral perspectives establishing different ways of viewing animals; the paper aims to analyze the controversial topic i.e. Animal Testing. This paper represents the process of animal testing as well as Alternative Studies to animal Experiments.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68101167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical Hodgkin Lymphoma Presenting as A Post-Transplant Lymphoproliferative Disorder after Organ Allograft Transplantation","authors":"J-M Li, Sakura Hosoba, Harris Ac Wayne, A. Box, J. Spivey, Kyle T. Bradley, E. Waller","doi":"10.21767/2172-0479.100056","DOIUrl":"https://doi.org/10.21767/2172-0479.100056","url":null,"abstract":"Background: Post-transplant lymphoproliferative disorders (PTLD) complicate 1%-8% of post-transplant patients receiving solid organ or allogeneic stem cell grafts. Classical Hodgkin lymphoma (cHL) PTLD is rare among PTLD, and its clinical course is not well described. Methods and findings: We reviewed the published literature of cases of cHL-PTLD from 1974-2015, and described the successful treatment of a patient who presented with cHL-PTLD 4 months post liver transplantation. We treated a 66-year-old female diagnosed with stage IV Epstein-Barr Virus positive cHLPTLD with reduced doses of pharmacological immunosuppression and 4 cycles of R-ChlVPP-AV (rituximab-chlorambucil, vinblastine, procarbazine, and prednisone-adriamycin and vincristine) on a 28-day cycle. The patient achieved complete remission complicated by grade 3 neutropenia (neutrophils 500-1,000/mm3), responsive to granulocyte colony stimulating factor. Conclusions: Although it is a rare entity among patients with PTLD, cHL-PTLD tends to respond well to combination regimens, leading to favorable outcomes.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenic Cytotoxic Factors and Formation of the Clinic Forms of Myasthenia","authors":"Klimova Em, Bozhkov Ai, Boyko Vv, Drozdova La, Lavinskaya Ðv, Skok Mv","doi":"10.21767/2172-0479.100084","DOIUrl":"https://doi.org/10.21767/2172-0479.100084","url":null,"abstract":"Background: Recently, increased incidence of autoimmune disorders, one of which is myasthenia gravis. The myasthenia is revealed at 3-30 patients out of 100 000 in a year. As it is considered by the most of specialists the central chain in myasthenia development is the formation of antibodies to the nicotinic acetylcholine receptors (nAChR), leading to the blockage of muscle fiber contraction and to the muscle dystrophy. Along with this, there is an assumption of the role of cytotoxic factors in the development of myasthenia gravis. The aim of the present article is to proof working hypothesis about specific role of cytotoxic factors in the formation of various clinical variants of myasthenia gravis. Method: Patients were divided according to the clinical phenotype of myasthenia gravis: myasthenia without thymus lesion (M), myasthenia with thymus hyperplasia (MH) and myasthenia with thymoma (MT). We used methods of light microscopy to determine the serum cytotoxicity using a cell bioindicator Dunaliella viridis. The determination of antibodies to nicotinic acetylcholine receptors (nAChR), thyroperoxidase (TPO) and antibodies to lungs, liver tissues and elastin was performed by ELISA. And fluorescence microscopy used for determination of expression of clusters differentiation of CD3+, CD4+, CD8+, CD16+, CD19+, CD45+. Results: The patients with different clinical phenotypes of myasthenia: myasthenia without thymus lesions (M), myasthenia with thymus hyperplasia (MH), and myasthenia with thymoma (MT), have been investigated. It was discovered that the amount of autoantibodies to the α1 and α7 acetylcholine receptor was different among patients with different clinical types of myasthenia. Drastic differences between forms of myasthenia were also identified using a blood serum thyroperoxidase activity. Additionally, we found that all clinical forms of myasthenia could be characterized by the differences in the amounts of IL4 and IL8, compositions of lymphocyte subpopulations, as well as patterns of autoantibodies to the lung tissue, liver, heart, and DNA. Test culture D. viridis responded differently to the cytotoxic components of the blood serum in different clinical types of myasthenia. Our results suggest that endogenous factors play a primary role in forming of clinical types of myasthenia. Conclusions: 1) development of myasthenia gravis occurs on the background of cytotoxic factors formed in the organism; 2) endogenous cytotoxic factors have nonspecific effects on the various functional systems of the organism, even the plant objects; 3) the organism of patients with myasthenia gravis produce various cytotoxic factors, which influence on different systems of the organism and can lead to the formation of a variety of clinical phenotypes.","PeriodicalId":89642,"journal":{"name":"Translational biomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2172-0479.100084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68098591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}