The open inflammation journal最新文献

Effects of Antioxidant-rich Indo-mediterranean Foods on Pre-heart Failure: Results from the Meta-analysis of Randomized Controlled Trials. 富含抗氧化剂的印度地中海食物对心力衰竭前期的影响:来自随机对照试验的荟萃分析结果

The open inflammation journal Pub Date : 2020-04-20 DOI: 10.2174/1875041902008010001

Ram B Singh, Toru Takahashi, G. Fatima, Rie Horiuchi, J. Fedacko, Zuzana Hůzová, D. Gurín

引用次数: 9

Effect of Physical Activity on the Lesion Repair Process in the Gastrocnemius Muscle of Rats 运动对大鼠腓肠肌损伤修复过程的影响

The open inflammation journal Pub Date : 2014-05-16 DOI: 10.2174/1875041901407010001

E. Namba, Thiago Otávio Nawick, Mariele Jung Thome, P. Trevilatto, M. Machado, L. Azevedo-Alanis, Antonio Adilson Soares de Lima, A. Johann, E. A. Rosa, S. Ignácio, A. M. Grégio

{"title":"Effect of Physical Activity on the Lesion Repair Process in the Gastrocnemius Muscle of Rats","authors":"E. Namba, Thiago Otávio Nawick, Mariele Jung Thome, P. Trevilatto, M. Machado, L. Azevedo-Alanis, Antonio Adilson Soares de Lima, A. Johann, E. A. Rosa, S. Ignácio, A. M. Grégio","doi":"10.2174/1875041901407010001","DOIUrl":"https://doi.org/10.2174/1875041901407010001","url":null,"abstract":"The present study aimed to evaluate the effect of a progressive load of physical activity on a musculoskeletal injury in rats. Sixty-four rates were divided into two groups: experimental group (EG), which underwent physical activity (swimming) with a progressive load, and the control group (CG), which was not submitted to this program. The training was carried out according to an adapted version of the Goncalves (1999) swimming system. Injuries were caused to the gastrocnemic muscle by inducing 40% NaOH. On days 2, 7, 14, and 21 after inducing muscle injury, the animals from both EC and CG were sacrificed. The injured area was removed and processed. The neutrophils, macrophages, lymphocytes, and plasmocytes were quantified by hematoxylin and eosin (HE GC=2.48±1.00; p=0.006) and lymphocytes (GE=2.12±0.82; GC=0.06±0.82; p=0.037) after 2 days, and of macrophages (GE=15.74±3.00; GC=6.02±1.95; p=0.007) and lymphocytes (GE=2.01±0.78; GC=0.14±0.09; p=0.044) after 7 days, could be observed in the EG when compared to the CG; however, the opposite was true for neutrophils (GE=48.12±17.04; GC=105.54±12.25; p=0.005). After 14 days, a smaller quantity of neutrophils (GE= 32.70±10.26; GC= 90.96±17.62; p= 0.044) and a larger quantity of plasmocytes (GE=9.06±3.84; GC=0.68±0.53; p=0.028) could be observed in the EG as compared to the CG. A greater area of type III collagen could be observed in the EG when compared to the CG over a 14-day period (GE=44.90±16.15; GC=0.74±0.40; p=0.000) and a 21-day period (GE=13.19±9.09; GC=1.02±0.94; p=0.029), whereas the opposite could be observed for type I collagen. The physical activity promoted an increase in the deposition of type III collagen in the muscle injury. This activity accelerated the repair process after 14 days, possibly moderated by the larger number of inflammatory cells, while after 21 days, the lesion presented a lesser resistance.","PeriodicalId":89637,"journal":{"name":"The open inflammation journal","volume":"7 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2014-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of Kawasaki Disease in a Young Child 1例幼儿川崎病复发

The open inflammation journal Pub Date : 2013-08-21 DOI: 10.2174/1875041920130710001

J. Bangert, Georgios Meridis, E. Strehle

引用次数: 1

Kawasaki Disease: Time for Change 川崎病:是时候改变了

The open inflammation journal Pub Date : 2013-08-21 DOI: 10.2174/1875041920130710002

E. Strehle

引用次数: 1

Definition of Inflammation, Causes of Inflammation and PossibleAnti-inflammatory Strategies 炎症的定义，炎症的原因和可能的抗炎策略

The open inflammation journal Pub Date : 2012-07-27 DOI: 10.2174/1875041901205010001

S. Stankov

{"title":"Definition of Inflammation, Causes of Inflammation and PossibleAnti-inflammatory Strategies","authors":"S. Stankov","doi":"10.2174/1875041901205010001","DOIUrl":"https://doi.org/10.2174/1875041901205010001","url":null,"abstract":"Current definition of inflammation by its cardinal signs is obsolete and unsuitable for guiding adequate therapeutic strategies. Furthermore, present theory of the inflammatory process regarding vascular phenomena as essential for generation of cardinal signs is invalid and unable to explain well established empirical facts, particularly the extent of the osmotic pressure and temperature variations within the inflamed tissue. From five cardinal signs, there is actually just one specific macroscopic sign of inflammation, namely localized edema. Further, the driving force for tissue fluid accumulation is defined in biochemical terms and as such taken for the definition of the inflammatory process. Inflammation may be defined as a degenerative process which is intense enough to cause local accumulation of low molecular weight catabolic products, which in turn elevates tissue osmotic pressure that attracts extra fluid, with or without heat release sufficient for significant elevation of tissue temperature. This process is in a sharp contrast to the pathogenesis of burns, where externally applied heat causes a process that is in essence opposite to inflammation, bearing only some superficial similarities with the latter. The inflammatory process is itself a pathological process, whereas the natural anti-inflammatory response that ensues after acute inflammation tends to reverse tissue homeostasis towards normality and should therefore be regarded as a true defensive reaction of the affected tissue. Based on the therapeutic principle of reverse thermodynamics, heat application to the inflamed tissue is an obvious, yet non-exclusive therapeutic choice that follows from the given universal definition of inflammation.","PeriodicalId":89637,"journal":{"name":"The open inflammation journal","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2012-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Biomarkers in Pediatric Sepsis 儿童败血症的生物标志物

The open inflammation journal Pub Date : 2011-10-07 DOI: 10.2174/1875041901104010024

Kristen A. Smith, M. Bigham

引用次数: 9

Negative Regulators of the Host Response in Sepsis 脓毒症中宿主反应的负性调节因子

The open inflammation journal Pub Date : 2011-10-07 DOI: 10.2174/1875041901104010061

Annia Maslash-Hubbard, Nidal El-wiher, T. Shanley, Timothy T. Cornell

引用次数: 1

Oxidative Stress in Critically Ill Children with Sepsis. 脓毒症危重患儿的氧化应激。

The open inflammation journal Pub Date : 2011-10-07 DOI: 10.2174/1875041901104010074

Derek S Wheeler

引用次数: 0

Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System. 小儿败血症--第五部分：细胞外热休克蛋白：宿主免疫系统的警报素。

The open inflammation journal Pub Date : 2011-10-07 DOI: 10.2174/1875041901104010049

John S Giuliano, Patrick M Lahni, Hector R Wong, Derek S Wheeler

{"title":"Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.","authors":"John S Giuliano, Patrick M Lahni, Hector R Wong, Derek S Wheeler","doi":"10.2174/1875041901104010049","DOIUrl":"10.2174/1875041901104010049","url":null,"abstract":"<p><p>Heat shock proteins (HSPs) are molecular chaperones that facilitate the proper folding and assembly of nascent polypeptides and assist in the refolding and stabilization of damaged polypeptides. Through these largely intracellular functions, the HSPs maintain homeostasis and assure cell survival. However, a growing body of literature suggests that HSPs have important effects in the extracellular environment as well. Extracellular HSPs are released from damaged or stressed cells and appear to act as local \"danger signals\" that activate stress response programs in surrounding cells. Importantly, extracellular HSPs have been shown to activate the host innate and adaptive immune response. With this in mind, extracellular HSPs are commonly included in a growing list of a family of proteins known as danger-associated molecular patterns (DAMPs) or alarmins, which trigger an immune response to tissue injury, such as may occur with trauma, ischemia-reperfusion injury, oxidative stress, etc. Extracellular HSPs, including Hsp72 (HSPA), Hsp27 (HSPB1), Hsp90 (HSPC), Hsp60 (HSPD), and Chaperonin/Hsp10 (HSPE) are especially attractrive candidates for DAMPs or alarmins which may be particularly relevant in the pathophysiology of the sepsis syndrome.</p>","PeriodicalId":89637,"journal":{"name":"The open inflammation journal","volume":"4 ","pages":"49-60"},"PeriodicalIF":0.0,"publicationDate":"2011-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995031/pdf/nihms-352211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32289230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sepsis-induced Innate and Adaptive Immune Suppression 败血症诱导的先天和适应性免疫抑制

The open inflammation journal Pub Date : 2011-10-07 DOI: 10.2174/1875041901104010067

Jennifer A. Muszynski, M. Hall

{"title":"Sepsis-induced Innate and Adaptive Immune Suppression","authors":"Jennifer A. Muszynski, M. Hall","doi":"10.2174/1875041901104010067","DOIUrl":"https://doi.org/10.2174/1875041901104010067","url":null,"abstract":"The inflammatory response to sepsis has classically been characterized by an overactive innate immune response. Recent adult and pediatric evidence suggests that the immune response is quite dynamic in this setting, often with endogenous innate and adaptive immunosuppression following the onset of sepsis. Sepsis-induced innate immune dysfunction can include reduction in antigen presenting capacity (as evidenced by decreased monocyte HLA-DR expression) and low pro-inflammatory cytokine production capacity (as evidenced by reduced ex vivo LPS-induced tumor necrosis factor-� production). The term immunoparalysis describes a state of severe reduction in these parameters and has been associated with increased risks for the development of nosocomial infection and death in septic adults and children. Intriguing evidence suggests that immunoparalysis may be reversible with beneficial effects on outcomes. Adaptive immune dysfunction has also been reported following the onset of sepsis. Lymphopenia, lymphocyte apoptosis, and skewing toward anti-inflammatory T cell subtypes (such as regulatory T cells) have all been associated with adverse outcomes from sepsis. Without specific testing, most aspects of sepsis-related immune dysfunction are occult. Accordingly, the development of robust immune monitoring and modulation protocols should be a high priority in the battle to improve outcomes from sepsis in critically ill adults and children.","PeriodicalId":89637,"journal":{"name":"The open inflammation journal","volume":"4 1","pages":"67-73"},"PeriodicalIF":0.0,"publicationDate":"2011-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68107705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3