Journal of glycomics & lipidomics最新文献

{"title":"Lipidomics: Methods and Protocols","authors":"","doi":"10.1007/978-1-0716-2966-6","DOIUrl":"https://doi.org/10.1007/978-1-0716-2966-6","url":null,"abstract":"","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85926806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional Regulation of the Natural Cytotoxicity Receptor NKp44 Gene in Human NK Cell Leukemia","authors":"Kenichiro Ito, M. Kawana, T. Iwata, K. Higai","doi":"10.4172/2153-0637.1000144","DOIUrl":"https://doi.org/10.4172/2153-0637.1000144","url":null,"abstract":"The natural cytotoxicity receptor NKp44 is an important regulator of NK cell function. We have previously reported that NKp44 has binding affinity to heparin and the transferrin containing multimeric sialyl Lewis X produced by human hepatoma HepG2 cells (HepTF) is more highly expressed than the other natural cytotoxicity receptors. To further understand the differences between natural cytotoxicity receptors, we sought to understand the gene transcriptional regulation of NKp44 in KHYG-1 human NK leukemia cells. 5′-rapid amplification of cDNA ends revealed the location of the NKp44 transcription initiation sites allowing identification of the 5′ untranscribed region. The result of the dual luciferase assay suggested that regulation of NKp44 gene expression is affected by the -1963 to -1599 nt region and the -352 to -231 nt region relative to the transcription initiation sites. The -410 to +1 nt region contained potential binding sites for the transcription factors AP-1, Oct-1, HNF-4, and Pax-4. These results suggest that defined regions in the 5′-flanking region of NKp44 gene is important for NKp44 transcription and regulation.","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"7 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44649865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Acid-based Membrane Lipidomics: Why, What and When","authors":"C. Chatgilialoglu, C. Ferreri","doi":"10.4172/2153-0637.1000E127","DOIUrl":"https://doi.org/10.4172/2153-0637.1000E127","url":null,"abstract":"Lipidomics and nutrilipidomics are tools at the disposal of health professionals involved in the diagnosis and care of patients, as well as in the management of optimal conditions for prevention [1]. Functional lipidomics, divided into membrane lipidomics, mediator lipidomics and biomarker lipidomics, addresses the three main tasks involving lipids in living organisms, following-up their types and levels in correlation with physiological and pathological conditions. Research in these fields opened the way to a full understanding of the lipid roles in recognition and immunity, tissue development, signaling for cell reactivity and regeneration, giving a different, wider, meaning also to the fat balance that is required from a nutritional point of view. Research in membrane lipidomics carried out in the last decade individuated a crucial level of lipid diversity in living organisms: indeed, the quality and quantity of phospholipid structures found as components of cell membranes represent not only the availability of the nutritional and metabolic pathways, but fulfill the important task of maintenance of the overall of cell homeostasis [1]. This is realized in each tissue with the appropriate fatty acid balance [2], whose maintenance involves an active membrane remodeling process, known as Lands’s cycle [3].","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":" ","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2153-0637.1000E127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49657005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons Why Omega-3 Polyunsaturated Fatty Acids Produce Mixed Results in Alzheimer's Disease Prevention Studies","authors":"A. Fonteh","doi":"10.4172/2153-0637.1000143","DOIUrl":"https://doi.org/10.4172/2153-0637.1000143","url":null,"abstract":"Abnormal aging that epitomizes Alzheimer’s disease (AD) is accompanied by memory and cognitive deficits that interfere with daily activities. As scientists look for causes and means of treating AD, omega-3 (n-3) polyunsaturated fatty acids (PUFA) are gaining significance because of their importance in brain function and their depletion in AD [1]. A direct remedy is dietary supplementation studies that have unfortunately yielded mixed results. The perplexing question is why some studies have beneficial outcomes while others report no effects on AD-associated cognitive or memory problems. Factors that may account for these discrepancies include an incomplete understanding of PUFA metabolic pathways and inadequate study design. Most findings are based on epidemiological observations rather than placebo-controlled intervention studies. From examining these studies, it is evident that any improvement in the outcome must include a better understanding of omega-3 fatty acid metabolism, standardization of initial clinical observations, assurance of pharmaceutical quality of omega-3 supplements, and genetics based selection of study participants combined with quantifiable outcomes.","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"7 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47836416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Artemisia Genus: A Review on Traditional Uses, Phytochemical Constituents, Pharmacological Properties and Germplasm Conservation","authors":"B. Koul, Pooja Taak, Anil Kumar, Taslimahemad T. Khatri, I. Sanyal","doi":"10.4172/2153-0637.1000142","DOIUrl":"https://doi.org/10.4172/2153-0637.1000142","url":null,"abstract":"Artemisia, being the largest and widely distributed genus of the plant family Asteraceae encompasses more than 400 species. Some popular species are reported to possess several medicinal properties owing to the rich phytochemical diversity. Altogether, eight thirty-nine chemical constituents including volatile and non-volatile compounds in these species are listed together with their references. These have been categorized into phenylpropanoids, flavonoids, terpenes, sterols, lignans, phenolics, fatty acids, fatty esters hydrocarbons and miscellaneous compounds, many of which are responsible for various biological activities such as analgesic, anti-parasitic, anti-inflammatory, hypolipidemic, antinociceptive, anti-microbial, anti-oxidant, hepato-protective, antiulcerogenic, anti-malarial, anti-leishmanial, anti-cancer, anti-tumor, anti-diabetic, anticonvulsant, anti-promastigote, anti-convulsant, anxiolytic and anti-depressant. The traditional uses and recent advances in the field of phytochemistry of selected Artemisia species and their respective medicinal, insecticidal and nutritional properties, for the period up to 2017, are assessed and compiled in this paper. Meticulous phytochemical and pharmacological studies on Artemisia species and their sustainable conservation will yield reliable molecules of pharmacological importance, for better healthcare.","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"17 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2153-0637.1000142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70233010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Salt Obesity Exist","authors":"Lopez Rueda Fern, O. D. Jesús, Flores Anaya Luis Alberto, V. Nicolas, Ramirez Vazquez Jocelyn Montserrat, Rincon Gres Ana Lizbeth, del Toro Equihua Mario, Lopez Alcaraz Fatima, Palacios Fonseca Alin Jael, Virgen-Ortiz Adolfo, Carrasco Pena Karla Berenice, Jimenez Maldonado Alberto, M. Adrian, C. C. Francisco, J. Cortés","doi":"10.4172/2153-0637.1000141","DOIUrl":"https://doi.org/10.4172/2153-0637.1000141","url":null,"abstract":"Background: Glucose transport within the intestine is performed by the SGLT1 cotransporter if it is attached to two sodium ions. Salt provides one sodium ion per molecule consumed. In humans its ingestion is commonly ten times the amount needed and its consumption is generally accompanied by high carbohydrate diets. This project evaluates if a large salt intake in the diet leads to the development of obesity. This work was raised thinking that a simple strategy to reduce the weight would decrease the amount of salt in food. Methods: The effect of salt on the dynamics of glucose absorption in the gut was evaluated making glucose tolerance curves with salt (1.55 molar of glucose 3.1 molar of salt) and without salt. Salty tastes simulating increased food intake and promoting weight gain in Wistar rats were also analysed. Results: The experiments showed that excessive salt intake prevents the transport of glucose from the intestinal lumen into the bloodstream. Additionally, salty tastes favoured increased food intake and weight gain. Conclusion: Sodium that naturally flows from the cytoplasm of enterocytes into the intestinal lumen, maintains the glucose cotransporter SGLT1 saturated and ensures at all times the transport of glucose that has been ingested in the diet. Excessive salt intake prevents the absorption of glucose from the intestinal lumen. Moreover, salty taste favours increased food intake and weight gain in Wistar rats.","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"6 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70232575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins in the treatment and prevention of cardiovascular diseases: Current and emerging clinical and public health challenges","authors":"C. Hennekens","doi":"10.4172/2153-0637.C1.004","DOIUrl":"https://doi.org/10.4172/2153-0637.C1.004","url":null,"abstract":"","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70234253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does n-3 PUFAs lower the inflammation markers in type 2 diabetic mellitus populations? A systemic review and meta-analysis of randomized controlled trials","authors":"LiJun Tang","doi":"10.4172/2153-0637.C1.006","DOIUrl":"https://doi.org/10.4172/2153-0637.C1.006","url":null,"abstract":"","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70234516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of membrane phospholipids in development of male-specific cardiac hypertrophy and hypertension","authors":"Marica Bakovic Poulami Basu, Jasmine Ischpuniani","doi":"10.4172/2153-0637.C1.005","DOIUrl":"https://doi.org/10.4172/2153-0637.C1.005","url":null,"abstract":"Secretion of lipids in the form of very low-density lipoproteins (VLDL) by the liver plays an important role in maintaining overall body lipid homeostasis. Any abnormality associated with this physiological process can lead to severe metabolic disorders such as hyperlipidemia, hepatic steatosis, etc. The rate-limiting step in the secretion of VLDLs from the liver is their transport from the endoplasmic reticulum (ER) to the Golgi and represents a potential therapeutic target in controlling VLDL secretion. We have identified a distinct ER-derived vesicle, VLDL transport vesicle (VTV), which facilitates the targeted delivery of VLDLs from the ER to the Golgi. To find out the factors that regulate the biogenesis of these vesicles, we performed detailed proteomic and biochemical analyses. Our data revealed that two small MR proteins, cideB and SVIP are present in VTV but not in other ER-derived vesicles. Our morphological and co-immunoprecipitation data revealed that both cideB and SVIP specifically interact with VLDL structural protein, apolipoproteinB100. To examine the roles of these proteins in VTV-biogenesis, we carried out an in vitro ER-budding assay. We showed that either blocking or knockdown of cideB and SVIP abrogates VTV-budding and VLDL secretion from hepatocytes. We conclude that cideB and SVIP control VLDL/ lipid secretion from the liver by regulating VTV-formation and their identification is critical for the development of novel therapeutics for dyslipidemia. Cholesterol efflux from lipid-loaded cells is a key athero-protective event that counteracts cholesterol uptake. The imbalance between cholesterol efflux and uptake determines the prevention or development of atherosclerosis. Many proteins and factors participate in the cholesterol efflux event. However, there are currently no systematic models of reverse cholesterol transport (RCT) that include most RCT-related factors and events. On the basis of recent research findings from other and our laboratories, we propose a novel model of one center and four systems with coupling transportation and networking regulation. \u0000 \u0000  \u0000 \u0000This model represents a common way of cholesterol efflux; however, the systems in the model consist of different proteins/factors in different cells. In this review, we evaluate the novel model in vascular smooth muscle cells (VSMCs) and macrophages, which are the most important original cells of foam cells. This novel model consists of 1) a caveolae transport center, 2) an intracellular trafficking system of the caveolin-1 complex, 3) a transmembrane transport system of the ABC-A1 complex, 4) a transmembrane transport system of the SR-B1 complex, and 5) an extracelluar trafficking system of HDL/Apo-A1. In brief, the caveolin-1 system transports cholesterol from intracellular compartments to caveolae. Subsequently, both ABC-A1 and SR-B1 complex systems transfer cholesterol from caveolae to extracellular HDL/Apo-A1. The four systems are linked by a regulatory net","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70234402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case-control Study in an Orcadian Population Investigating the Relationship between Human Plasma N-glycans and Metabolic Syndrome","authors":"Fiona McLachlan, M. Timofeeva, M. Bermingham, S. Wild, I. Rudan, G. Lauc, Wei Wang, H. Campbell, James F. Wilson, E. Theodoratou","doi":"10.4172/2153-0637.1000139","DOIUrl":"https://doi.org/10.4172/2153-0637.1000139","url":null,"abstract":"Background: Alterations in glycosylation patterns have long been known to reflect changes in cell metabolism. In this study, we investigated the relationship between human N-glycan profiles and metabolic syndrome. Method: Between 2005 and 2011, 2,155 individuals from the Orkney Islands (UK) were recruited and biological material, alongside phenotypic measures were collected. Individual N-glycan profiles were measured in plasma using weak anion exchange high performance liquid chromatography and calibrated hydrophilic interaction liquid chromatography. Pre-specified criteria were used to identify 564 cases with metabolic syndrome and 1475 controls. We applied logistic regression to test for association between this binary outcome against measured plasma N-glycans. We also assessed the correlation between N-glycan traits and individual components of metabolic syndrome and compared this to results found in similar analyses based in Chinese and Croatian populations. Results: 21 N-glycan traits were found to be associated with either an increased or a decreased likelihood of participants having metabolic syndrome, including monosialylated plasma N-glycans (OR of 1.49 (95%CI 1.33, 1.67), q=1.26E-12) and core fucosylated plasma N-glycans (OR of 0.81(95% CI 0.72-0.90), q=7.75E-4). Notably, consistent results in both sections of this analysis demonstrated the protective association of higher levels of core fucosylated N-glycans. Conclusion: Our results demonstrate that metabolic syndrome is associated with an alteration in plasma N-glycosylation patterns. The metabolic role of core fucosylated N-glycans is of particular interest for future study.","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"6 1","pages":"139-148"},"PeriodicalIF":0.0,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2153-0637.1000139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70232451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}