Biological & pharmaceutical bulletin最新文献_第8页

Piperacillin Exacerbates Vancomycin-Induced Toxicity in Renal Proximal Tubular Cells. 哌拉西林加重万古霉素诱导的肾近端小管细胞毒性。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00726

Shingo Takada, Yuya Takashima, Riku Shinozaki, Mizuki Nishisato, Natsuko Takahashi-Suzuki, Akira Takaguri, Takehiro Yamada

{"title":"Piperacillin Exacerbates Vancomycin-Induced Toxicity in Renal Proximal Tubular Cells.","authors":"Shingo Takada, Yuya Takashima, Riku Shinozaki, Mizuki Nishisato, Natsuko Takahashi-Suzuki, Akira Takaguri, Takehiro Yamada","doi":"10.1248/bpb.b24-00726","DOIUrl":"https://doi.org/10.1248/bpb.b24-00726","url":null,"abstract":"Vancomycin (VCM) combined with piperacillin/tazobactam (PIPC/TAZ) is used as an empiric therapy in patients with severe infections, including sepsis. Recent research has found an increased incidence of acute kidney injury (AKI) in patients receiving combination therapy with these antibiotics. However, the pharmacological mechanism by which this combination worsens kidney function remains unclear. In this study, we investigated the direct cytotoxicity of VCM, PIPC, and TAZ on HK-2 cells and human renal proximal tubular epithelial cells (RPTEC). VCM, PIPC/TAZ, or PIPC significantly reduced cell viability in a concentration-dependent manner; the potency was in the order of VCM, PIPC/TAZ, and PIPC (IC50 values were 1717, 2491, and 3020 μg/mL, respectively). The combined treatment with PIPC/TAZ or PIPC significantly enhanced the VCM-induced decrease in cell viability. Furthermore, PIPC/TAZ or PIPC increased lactate dehydrogenase leakage, indicating membrane cytotoxicity, whereas no such effect was observed with VCM or TAZ. VCM increased caspase-3/-7 activity, whereas PIPC did not. The VCM-induced increase in neutrophil gelatinase-associated lipocalin (NGAL) production was amplified by concomitant PIPC treatment. Synergistic effects were detected for both the cell viability and NGAL production, suggesting that the direct toxicity of PIPC to RPTEC was responsible for the increased AKI incidence in patients treated with VCM. Our results may contribute to a better understanding of how AKI is exacerbated, as well as provide tips for preventing AKI after VCM and PIPC/TAZ combined therapy.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 4","pages":"363-371"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Enhanced Antimicrobial Stewardship Team Interventions for Patients Receiving Meropenem and Tazobactam/Piperacillin. 加强抗菌药物管理团队干预对接受美罗培南和他唑巴坦/哌拉西林治疗的患者的疗效。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00862

Kengo Ohashi, Yasutaka Shinoda, Tomoko Matsuoka, Kaori Arai, Nao Hotta, Takamasa Takahashi, Hiroaki Shikano, Michiko Kagajo, Tetsuya Yagi, Eiseki Usami

{"title":"Efficacy of Enhanced Antimicrobial Stewardship Team Interventions for Patients Receiving Meropenem and Tazobactam/Piperacillin.","authors":"Kengo Ohashi, Yasutaka Shinoda, Tomoko Matsuoka, Kaori Arai, Nao Hotta, Takamasa Takahashi, Hiroaki Shikano, Michiko Kagajo, Tetsuya Yagi, Eiseki Usami","doi":"10.1248/bpb.b24-00862","DOIUrl":"https://doi.org/10.1248/bpb.b24-00862","url":null,"abstract":"Multidrug-resistant bacteria pose a major challenge in healthcare, and antimicrobial stewardship teams (ASTs) play a crucial role in optimizing antimicrobial use, particularly for last-resort drugs like meropenem (MEPM) and tazobactam/piperacillin (TAZ/PIPC). This study evaluated the impact of enhanced interventions, which included a hospital-wide policy restricting MEPM and TAZ/PIPC use to 5 d and mandating pre-treatment culture testing. A before-and-after study was conducted at a public hospital in Japan, comparing the pre- (June 2021-May 2022) and post-enhanced intervention (June 2022-May 2023) periods. The primary outcome was days of therapy (DOT) per 1000 patient days for MEPM and TAZ/PIPC. Secondary outcomes included antimicrobial use density (AUD), monthly number of patients receiving MEPM and TAZ/PIPC, 30-d mortality, and AST intervention proposals. Overall, 1896 patients received MEPM (pre: 591; post: 527) or TAZ/PIPC (pre: 411; post: 367). As a result, MEPM DOT decreased from 19.4 to 17.2 per 1000 patient days (p = 0.019), and AUD from 14.4 to 11.7 defined daily doses per 1000 patient days (p = 0.017). TAZ/PIPC DOT remained unchanged (p = 0.219), while AUD decreased from 8.7 to 7.6 (p = 0.046). Furthermore, the monthly number of patients receiving MEPM and TAZ/PIPC and their 30-d mortality showed no significant change. AST proposals increased from 209 to 359 for MEPM and from 116 to 238 for TAZ/PIPC (both p < 0.001). In conclusion, enhanced interventions effectively reduced MEPM use without increasing TAZ/PIPC use or worsening 30-d mortality, suggesting that structured guidelines may enhance antimicrobial stewardship in resource-limited settings.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 5","pages":"571-576"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic GSTP1/2 Exhibits High Sensitivity to Testosterone-Mediated Regulation in Mice. 小鼠肝脏GSTP1/2对睾酮介导的调节具有高度敏感性。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b25-00082

Youngseo Park, Ki-Hoan Nam, Herin Hwang, Se-Yeong Jeon, Doug-Young Ryu

{"title":"Hepatic GSTP1/2 Exhibits High Sensitivity to Testosterone-Mediated Regulation in Mice.","authors":"Youngseo Park, Ki-Hoan Nam, Herin Hwang, Se-Yeong Jeon, Doug-Young Ryu","doi":"10.1248/bpb.b25-00082","DOIUrl":"https://doi.org/10.1248/bpb.b25-00082","url":null,"abstract":"Glutathione S-transferases (GSTs) are essential phase II detoxification enzymes encoded by a diverse gene superfamily. Among them, the pi class (GSTP) includes 2 isozymes, GSTP1 and GSTP2, which share a high degree of sequence similarity. In mice, hepatic GSTP1/2 expression is higher in males than in females. To investigate the regulatory mechanisms underlying this sex difference, we examined orchiectomized mice treated with testosterone. Orchiectomy reduced hepatic GSTP1/2 expression and associated enzyme activity, both of which were restored following testosterone administration. To assess the sensitivity of GSTP1/2 to testosterone fluctuations, we compared mice experiencing a serum testosterone surge with those maintaining baseline levels. Mice with elevated testosterone exhibited increased hepatic GSTP1/2 protein expression and enzyme activity, demonstrating the high responsiveness of GSTP1/2 to testosterone. To our knowledge, this is the first study to demonstrate that testosterone surges regulate both the expression and enzymatic function of a specific protein. These findings underscore testosterone's critical role in the male-dominant expression of GSTP1/2 and highlight its sensitivity to physiological fluctuations in testosterone levels. Further studies are warranted to elucidate the molecular mechanisms by which testosterone surges influence gene expression.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 6","pages":"830-834"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of Human Colorectal Cancer Cells in Tumor Spheroids by Sodium Butyrate. 丁酸钠调节人结直肠癌细胞在肿瘤球体中的作用。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b25-00043

Yuzuki Takahama, An Kadoi, Yuno Tauchi, Satsuki Kasahara, Kyota Ishii, Tomohiro Yano

{"title":"Regulation of Human Colorectal Cancer Cells in Tumor Spheroids by Sodium Butyrate.","authors":"Yuzuki Takahama, An Kadoi, Yuno Tauchi, Satsuki Kasahara, Kyota Ishii, Tomohiro Yano","doi":"10.1248/bpb.b25-00043","DOIUrl":"10.1248/bpb.b25-00043","url":null,"abstract":"Butyrate exerts strong anti-colorectal cancer effects via epigenetic regulation. However, whether butyrate has a negative impact on colorectal cancer in vivo remains unclear. Therefore, this study aimed to investigate whether butyric acid can regulate the growth of colorectal cancer cells using spheroids as an in vivo model. A three-dimensional (3D) culture system was used to form spheroids from the human colorectal cancer cell line HT-29. Spheroids formed in the 3D culture system exhibited some malignant cancer phenotypes (increased cancer stem cell marker levels, anticancer drug resistance, and G0/G1 phase accumulation in the cell cycle) compared with cells in the two-dimensional cell culture system. Sodium butyrate (SB) treatment suppressed cancer stem cell marker levels in spheroids and induced differentiation by increasing the alkaline phosphatase activity. Additionally, SB-induced changes in genes related to cell cycle control indicated that SB reactivated the cell cycle in spheroids, regulating the transition from the G0 to G1 phase. Furthermore, SB treatment induced cell death via apoptosis, which might be due to G1 arrest in the cell cycle. In conclusion, SB induced the differentiation and subsequent cell death of HT-29-derived cancer cells in spheroids, highlighting its potential as a novel anticancer agent for colorectal cancer.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 6","pages":"872-877"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Notice of Withdrawal. 撤回通知。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b25-e4803

引用次数: 0

Impact of Eye Contact on Communication during Online Medication Counseling: An Analysis Using the Roter Interaction Analysis System. 在线药物咨询中眼神接触对沟通的影响：基于Roter交互分析系统的分析

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00489

Ayako Mori, Izumi Kato, Katsuya Narumi, Yoh Takekuma, Shuhei Ishikawa, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Masaki Kobayashi

{"title":"Impact of Eye Contact on Communication during Online Medication Counseling: An Analysis Using the Roter Interaction Analysis System.","authors":"Ayako Mori, Izumi Kato, Katsuya Narumi, Yoh Takekuma, Shuhei Ishikawa, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Masaki Kobayashi","doi":"10.1248/bpb.b24-00489","DOIUrl":"10.1248/bpb.b24-00489","url":null,"abstract":"We have previously used the Roter Interaction Analysis System (RIAS) to analyze differences between online and face-to-face medication counseling. In our previous research, students have commented that the built-in camera on their laptops makes it difficult to make eye contact and communicate effectively. Furthermore, there is a lack of research on the impact of eye contact in online medical communication. Therefore, this study aimed to investigate the effects of eye contact on online medication counseling. Two simulated patients (SPs) and 10 pharmacy students acting as pharmacists were enrolled in this clinical study (ID:2022-001). Participants were divided into 2 groups: one using cameras designed to naturally align eye contact and another using standard device cameras. The dialogues were segmented into meaningful minimal units (utterances), categorized using RIAS according to their nature, and analyzed. Scenarios with aligned eye contact significantly increased the total number of SP utterances and the occurrence and proportion of \"Check\" utterances by students, confirming their understanding. The increase in the total utterance count of SPs was associated with a corresponding increase in the number of \"Agree\" utterances indicating agreement and understanding. Thus, eye contact enhances the clarity of patient responses and proactively confirms patient understanding, thereby mitigating the difficulty of assessing comprehension and conducting bidirectional communication online. This study's findings quantitatively suggested that eye contact in online medication counseling enhances proactive engagement in communication for pharmacy students and SPs.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 1","pages":"17-22"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resmetirom Is an Effective Thyromimetics for the Chemical Rescue of Thyroid Hormone Receptor Mutants. 雷司替龙是一种有效的促甲状腺药物，用于甲状腺激素受体突变体的化学救援。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00845

Mana Mitsutani, Mei Yokoyama, Hiromi Hano, Aoi Morita, Midori Matsushita, Tetsuya Tagami, Kenji Moriyama

{"title":"Resmetirom Is an Effective Thyromimetics for the Chemical Rescue of Thyroid Hormone Receptor Mutants.","authors":"Mana Mitsutani, Mei Yokoyama, Hiromi Hano, Aoi Morita, Midori Matsushita, Tetsuya Tagami, Kenji Moriyama","doi":"10.1248/bpb.b24-00845","DOIUrl":"https://doi.org/10.1248/bpb.b24-00845","url":null,"abstract":"Thyroid hormone receptors (TRs) predominantly consist of three isoforms: TRβ1, TRβ2, and TRα1. Mutations in TRs that reduce or eliminate their ligand-dependent functions lead to a condition known as resistance to thyroid hormone (RTH), which is a genetic disorder caused in an autosomal-dominant manner. Recently, resmetirom, a selective TRβ agonist, has showen significant promise and was approved by the United States Food and Drug Administration as the first drug for the treatment of metabolic dysfunction-associated steatohepatitis and liver fibrosis. In this study, we performed a series of assays to determine how different mutations retain the activity of resmetirom in presumed clinical practice to screen patients based on previously published 15 studies. We generated and examined the transcriptional activation of 57 mutant TRβs, to evaluate the therapeutic potential of resmetirom in treating these mutations. Resmetirom functions as a partial agonist for TRβ and has been found to recruit and interact with all cofactors, albeit significantly less effectively than T3. Consequently, our results suggest that some residues in helices 1, 3, 5, 6, 7, 10, and 11 of TRβ, are still susceptible to resmetirom binding. However, mutants of helix 12, which forms part of the dimerization interface used to bind transcriptional coactivators, are non-responsive to resmetirom. While certain mutants do not respond to lower concentrations of resmetirom, some can be rescued when higher concentrations are applied. In clinical applications, resmetirom can contribute to RTH without considering the syndrome of inappropriate secretion of thyroid-stimulating hormones by the negatively regulated gene.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 4","pages":"463-474"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N⁶-Methyladenosine Reader Protein YTHDC1 Supports Proper Mitotic Progression Partly through Regulation of TPX2-Aurora A Signaling. n6 -甲基腺苷解读蛋白YTHDC1通过调控TPX2-Aurora A信号支持有丝分裂的正常进行。

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00542

Rina Michimori, Ryuzaburo Yuki, Junna Tanaka, Youhei Saito, Yuji Nakayama

{"title":"N6-Methyladenosine Reader Protein YTHDC1 Supports Proper Mitotic Progression Partly through Regulation of TPX2-Aurora A Signaling.","authors":"Rina Michimori, Ryuzaburo Yuki, Junna Tanaka, Youhei Saito, Yuji Nakayama","doi":"10.1248/bpb.b24-00542","DOIUrl":"https://doi.org/10.1248/bpb.b24-00542","url":null,"abstract":"Chemical modification of mRNA regulates its stability and translation efficiency. The most prevalent modification is the N6-methyladenosine (m6A) modification. YT521-B homology domain-containing proteins (YTHDCs) are \"reader\" proteins of m6A modification and contribute to various cell functions by regulating their target m6A-containing mRNAs. Although m6A modification dynamically changes throughout the cell cycle, the role of the m6A pathway in cell division remains unclear. In this study, we found that YTHDC1, one of the YTHDCs, is important for cell division. Mitotic progression is delayed in YTHDC1-knockdown cells, and the mitotic delay is mitigated by the re-expression of wild-type YTHDC1, indicating the YTHDC1 function in mitotic progression. Time-lapse imaging analysis showed that prolonged mitotic duration caused by YTHDC1 knockdown is due to the retardation of chromosome alignment and segregation. Treatment of AZ3146, an inhibitor of the spindle assembly checkpoint (SAC), mitigates the mitotic delay in YTHDC1-knockdown cells, suggesting that YTHDC1 knockdown results in SAC activation, leading to a slowdown of mitotic progression. Furthermore, increased TPX2 protein expression and the subsequent overabundance of Aurora A at the centrosomes is partly involved in YTHDC1 knockdown-induced mitotic delay. Since YTHDC1 knockdown does not affect the TPX2 mRNA level and the inhibition of protein synthesis by cycloheximide treatment impairs the YTHDC1-knockdown effect on the TPX2 protein level, YTHDC1 may post-transcriptionally regulate the TPX2 expression. Considering that TPX2 or Aurora A overexpression causes mitotic failure, these results suggest that YTHDC1 contributes to mitotic progression partly through the precise regulation of TPX2-Aurora A signaling.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 5","pages":"613-621"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant Inventory in the Solomon Islands, with Special Reference to Medicinal Plant Resources (4). Comparison of Dendrobium (Orchidaceae) Plant Components Using Multivariate Analysis. 所罗门群岛植物目录，特别参考药用植物资源(4)。石斛（兰科）植物成分的多变量分析比较

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00413

Koji Sugimura, Akihiro Daikonya, Hiroyuki Fuchino, Nobuyuki Tanaka, Fred Pitisopa, Takashi Watanabe

{"title":"Plant Inventory in the Solomon Islands, with Special Reference to Medicinal Plant Resources (4). Comparison of Dendrobium (Orchidaceae) Plant Components Using Multivariate Analysis.","authors":"Koji Sugimura, Akihiro Daikonya, Hiroyuki Fuchino, Nobuyuki Tanaka, Fred Pitisopa, Takashi Watanabe","doi":"10.1248/bpb.b24-00413","DOIUrl":"https://doi.org/10.1248/bpb.b24-00413","url":null,"abstract":"Eight species of the genus Dendrobium were collected from the Solomon Islands. The morphological and compositional characteristics of their stems and leaves were studied and compared with two Japanese medicinal species of Dendrobium by using multivariate analysis of their components. As a result, we discovered that some types of Dendrobium plants from the Solomon Islands have a composition pattern comparable to that of the Japanese medicinal species, D. catenatum. Within the same species, distinct varieties with different compositions exist based on their locations in the Solomon Islands. Certain types also have different composition patterns depending on the stem and leaf sections. Our findings show that Dendrobium plants in the Solomon Islands have a distinct stem and leaf morphology and composition, while they also share similar compositional patterns with existing medicinal species. As a result, these plants are regarded as valuable medicinal resources with the potential to be used as novel crude drug ingredients.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 5","pages":"622-631"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Long Coronavirus Disease in Japan: A Nationwide Study of Symptom-Associated Drug Prescriptions. 日本长冠状病毒病的治疗：一项全国性的症状相关药物处方研究

IF 1.7 4区医学

Biological & pharmaceutical bulletin Pub Date : 2025-01-01 DOI: 10.1248/bpb.b24-00762

Yuka Kogure, Wataru Ando, Kyoka Sakamaki, Mitsuhiro Sugawara

{"title":"Treatment of Long Coronavirus Disease in Japan: A Nationwide Study of Symptom-Associated Drug Prescriptions.","authors":"Yuka Kogure, Wataru Ando, Kyoka Sakamaki, Mitsuhiro Sugawara","doi":"10.1248/bpb.b24-00762","DOIUrl":"https://doi.org/10.1248/bpb.b24-00762","url":null,"abstract":"Long coronavirus disease (COVID) is characterized by symptoms persisting or reappearing at least 2 months post-recovery from acute coronavirus disease 2019 (COVID-19). Although Long COVID symptoms have been widely studied, data on drug prescriptions for patients with Long COVID in Japan remain limited. Therefore, this study aimed to analyze drug utilization patterns for Long COVID treatment using a nationwide database in Japan, with the goal of providing basic data to support the establishment of standard treatments in the future. The Medical Data Vision COVID-19 dataset was used to identify patients diagnosed with Long COVID between January 15, 2020 and December 31, 2022. Symptoms and prescribed medications were extracted, and descriptive statistics were used to analyze the relationship between symptoms and drug prescriptions. Among 652016 patients with COVID-19, 3769 (0.6%) developed Long COVID. Common symptoms included fatigue, bronchial asthma-like symptoms, and insomnia. Acetaminophen was the most prescribed drug in the first month of diagnosis. Other frequently prescribed drugs included dextromethorphan, l-carbocisteine, and polaprezinc. From 3 months post-diagnosis, prescriptions for Hochu-ekki-to (a traditional Japanese herbal medicine; Kampo medicine) and polaprezinc increased, especially among patients aged 30-50 years. Long COVID in Japan is characterized by a wide range of symptoms, leading to symptom-based drug prescriptions, particularly fatigue, respiratory issues, and taste disturbances. These findings offer insights into the pharmacological management of Long COVID in Japan, highlighting the need for further research on optimal treatments in the future.","PeriodicalId":8955,"journal":{"name":"Biological & pharmaceutical bulletin","volume":"48 5","pages":"641-649"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0