Seasonal Variations in Drug-Related Erythema Multiforme: A Time Series Analysis Using the JADER Database.

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Hideyuki Tanaka, Mika Maezawa, Sakiko Hirofuji, Koumi Miyasaka, Satoshi Nakao, Yuka Nokura, Moe Yamashita, Nanaka Ichihara, Kana Sugishita, Tomofumi Yamazaki, Kohei Shiota, Hirofumi Tamaki, Hiroyuki Tanaka, Kazuhiro Iguchi, Mitsuhiro Nakamura
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Abstract

Erythema multiforme (EM) is a rare, immune-mediated skin condition triggered primarily by infections, drugs, and autoimmune diseases. Although its seasonal variations have been reported, with peaks in spring and summer, comprehensive analyses remain limited. In this study, we aimed to investigate the seasonal patterns and drug associations of EM using the Japanese Adverse Drug Event Report database. A time series analysis was performed using EM-related adverse event onset dates reported between January 2005 and December 2019. The periodic patterns and residual autocorrelation were evaluated by applying seasonal and trend decomposition using loess (STL) and autocorrelation function (ACF) analyses to the time series data of monthly EM reports. A total of 3843 cases of EM were analyzed, with 43.1% being male and 56.3% female. STL decomposition identified June as the peak month for EM cases, with a higher incidence observed from spring to summer than in winter. Male patients exhibited greater seasonal variations, with a higher incidence in summer. Reports of anti-infective and antineoplastic drugs increased from spring to summer and declined in winter in male patients with EM, suggesting a potential seasonal trend. Female patients with EM also showed seasonal variations, albeit less pronounced than in male patients. The current study identified seasonal variations in drug-related EM, with reports peaking in June, which is consistent with previous observations of higher EM incidence in spring and summer. The findings indicated potential sex-related disparities in drug-related EM, underscoring the necessity for additional research to elucidate its mechanisms and patterns.

药物相关性多形性红斑的季节变化:使用JADER数据库的时间序列分析。
多形性红斑(EM)是一种罕见的、免疫介导的皮肤病,主要由感染、药物和自身免疫性疾病引发。尽管报告了其季节性变化,春季和夏季达到高峰,但综合分析仍然有限。在这项研究中,我们旨在利用日本不良药物事件报告数据库调查EM的季节性模式和药物关联。使用2005年1月至2019年12月报告的em相关不良事件发病日期进行时间序列分析。采用黄土季节分解(STL)和自相关函数分析(ACF)对月报告时间序列数据进行周期模式和残差自相关分析。共分析了3843例EM,其中男性43.1%,女性56.3%。STL分解发现6月是EM病例的高发月份,春夏季发病率高于冬季。男性患者表现出较大的季节变化,夏季发病率较高。男性EM患者抗感染和抗肿瘤药物的报告从春季到夏季增加,冬季减少,提示潜在的季节性趋势。女性EM患者也表现出季节性变化,尽管不像男性患者那么明显。目前的研究确定了与药物相关的EM的季节性变化,报告在6月达到高峰,这与之前观察到的春季和夏季较高的EM发病率一致。研究结果表明,在药物相关的EM中存在潜在的性别差异,强调了进一步研究阐明其机制和模式的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.50
自引率
5.00%
发文量
247
审稿时长
2 months
期刊介绍: Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.
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