The open pathology journal最新文献

Fibrous Pseudotumor of Paratestis Mimicking a Testicular Tumor 模仿睾丸肿瘤的旁睾丸纤维性假瘤

The open pathology journal Pub Date : 2014-06-13 DOI: 10.2174/1874375701408010001

J. Singh, A. Hafiz, M. Rasool, Harbinder Singh, Shaveeta Sharma, S. Bashir

引用次数: 3

Are Areas of Isolated Atypical Cells or Residual Tumor Cartilage Prognostically Significant in Neoadjuvant Treated Osteosarcoma? An Analysis of 106 Consecutive Cases from a Single Institution 在新辅助治疗的骨肉瘤中，分离的非典型细胞区域或残留的肿瘤软骨是否具有预后意义?某机构106例连续病例分析

The open pathology journal Pub Date : 2013-09-06 DOI: 10.2174/1874375720130815002

Michael J. Cascio

{"title":"Are Areas of Isolated Atypical Cells or Residual Tumor Cartilage Prognostically Significant in Neoadjuvant Treated Osteosarcoma? An Analysis of 106 Consecutive Cases from a Single Institution","authors":"Michael J. Cascio","doi":"10.2174/1874375720130815002","DOIUrl":"https://doi.org/10.2174/1874375720130815002","url":null,"abstract":"Treatment of high-grade osteosarcoma consists of neoadjuvant chemotherapy then surgical resection. Generally, < 90% tumor necrosis predicts an unfavorable prognosis and can influence post-operative therapy. Thus, accurate, reproducible, microscopic measurement of tumor necrosis is imperative. Treated osteosarcomas contain a variety of morphologic patterns making quantitative assessment difficult. Whether residual tumor cartilage or widely dispersed atypical cells in fibrous stroma represent prognostically significant “viable” tumor is unknown and, to our knowledge, has not been formally tested. Full cross sections of the post-chemotherapy resection specimens of 106 osteosarcomas were evaluated for the presence and pattern of viable tumor using two methods. First, we counted as viable only dense areas of mitotically-active atypical cells (“stringent”). Second, we also included as viable rare (<25 / 400X field), atypical cells in fibrous stroma and/or tumor cartilage (“inclusive”). Treatment response was judged as good (>90% necrosis) or poor (<90% necrosis) and correlated with disease-free survival using the Kaplan-Meier method. Eleven tumors (10%) had no evidence of residual tumor after chemotherapy. The remainder contained different proportions of tightly-packed, atypical, mitotically-active cells (n=73, 69%), isolated atypical cells in fibrosis or necrosis (n=35, 33%) and/or tumor cartilage (n=10, 8%). Disease-free survival correlated significantly with chemotherapy response using the “stringent” method (p=0.008) but not the “inclusive” method (p=0.34). These data confirm that the percent tumor necrosis after chemotherapy is an important prognostic indicator, but areas of tumor cartilage or widely distributed, mitotically-inactive, atypical cells should not be measured as residual viable tumor.","PeriodicalId":89507,"journal":{"name":"The open pathology journal","volume":"18 1","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"2013-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77172719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Activation of Sterol-Responsive Element Binding Proteins in a Sucrose- Induced Model of Lysosomal Storage 蔗糖诱导的溶酶体储存模型中甾醇反应元件结合蛋白的激活

The open pathology journal Pub Date : 2013-08-15 DOI: 10.2174/1874375720130905003

Guillaume Van Beersel, M. Jadot, I. Hamer, T. Arnould

引用次数: 0

Variables Impacting Lymph Node Recovery in Colectomy Resection Specimens Removed for Colorectal Adenocarcinoma 影响结直肠腺癌结肠切除术标本中淋巴结恢复的因素

The open pathology journal Pub Date : 2013-08-02 DOI: 10.2174/1874375720130613001

Grant Schafer, B. Kimler, D. Mcgregor, Fang Fan, O. Tawfik

引用次数: 0

Interrogation of Chromosome 13q12-14 in Esophageal Squamous Cell Carcinoma 染色体13q12-14在食管鳞状细胞癌中的研究

The open pathology journal Pub Date : 2012-08-23 DOI: 10.2174/1874375701206010008

H. Erickson, J. Rodriguez-Canales, P. Albert, Kris Yala, S. Mukherjee, N. Hu, A. Goldstein, R. Chuaqui, S. Hewitt, P. Taylor, M. Emmert-Buck

{"title":"Interrogation of Chromosome 13q12-14 in Esophageal Squamous Cell Carcinoma","authors":"H. Erickson, J. Rodriguez-Canales, P. Albert, Kris Yala, S. Mukherjee, N. Hu, A. Goldstein, R. Chuaqui, S. Hewitt, P. Taylor, M. Emmert-Buck","doi":"10.2174/1874375701206010008","DOIUrl":"https://doi.org/10.2174/1874375701206010008","url":null,"abstract":"Previous studies of esophageal squamous cell carcinoma (ESCC) suggested chromosome region 13q12-14 harbors a familial ESCC gene. DNA sequencing of the BRCA2 gene, located on 13q12, showed evidence of both germline and tumor specific alterations but the frequency of changes was low and did not fit the classic Knudsen two-hit gene inactivation model. To further investigate chromosome 13q12-14 in ESCC, quantitative expression measurements were performed on BRCA2 and 11 neighboring genes in matched normal epithelium and tumor from 17 cases. Transcript analysis showed normal levels of five genes, tumor down-regulation of two genes (TNFRS19 and TPT1), and tumor up- regulation of five genes, including BRCA2. No evidence of BRCA2 loss-of-function was detected based on reduced mRNA in tumor cells. Between 13q12.3 (KATNAL1) and 13q12.3-q13 (CCNA1) five adjacent genes showed increased mRNA expression raising the possibility of a DNA amplicon; however, qPCR analysis showed normal DNA amounts in this region. CCNA1 transcript was significantly up-regulated in tumors and was thus further interrogated at the protein level by immunohistochemistry. CCNA1 staining was restricted to normal basal epithelium and was not expressed in more superficial, differentiated regions. In contrast, the CCNA1 protein was ubiquitously and highly expressed throughout tumor foci. Overall, these data from a relatively small number of cases (17) suggest that TNFRS19 and TPT1 deserve further investigation as candidate tumor suppressor genes in esophageal cancer in a larger patient series; BRCA2 mRNA is increased in the tumors, likely as a compensatory response to the marked DNA damage that is present in these lesions; and, CCNA1 was identified as a novel up-regulated gene in ESCC.","PeriodicalId":89507,"journal":{"name":"The open pathology journal","volume":"8 1","pages":"8-16"},"PeriodicalIF":0.0,"publicationDate":"2012-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85689344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasopressin, Angiotensin II and Tyrosine-Hydroxylase Expression in the Hypothalamus of the Syndrome of Inappropriate ADH: A Case Report 垂体后叶加压素、血管紧张素II和酪氨酸羟化酶在不适当ADH综合征下丘脑的表达:1例报告

The open pathology journal Pub Date : 2012-05-11 DOI: 10.2174/1874375701206010001

E. Carmona-Calero, L. Castañeyra-Ruiz, Ibrahim González-Marrero, J. González-Toledo, H. D. Paz-Carmona, A. Castañeyra-Ruiz, M. L. Ruiz-Mayor, A. Castañeyra-Perdomo

{"title":"Vasopressin, Angiotensin II and Tyrosine-Hydroxylase Expression in the Hypothalamus of the Syndrome of Inappropriate ADH: A Case Report","authors":"E. Carmona-Calero, L. Castañeyra-Ruiz, Ibrahim González-Marrero, J. González-Toledo, H. D. Paz-Carmona, A. Castañeyra-Ruiz, M. L. Ruiz-Mayor, A. Castañeyra-Perdomo","doi":"10.2174/1874375701206010001","DOIUrl":"https://doi.org/10.2174/1874375701206010001","url":null,"abstract":"The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolality of urine, and where vasopressin, angiotensin II and catecholamines are implicated in salt water balance, cardiovascular and blood pressure regulation. Therefore, the aim of this study is to analyze the hypothalamic distribution of vasopressin (VAS) Angiotensin II (AGII) and tyrosine-hydroxylase (TH) in a case of SIADH and compare it with a case without SIADH. Two hypothalamus taken from a 66 year-old man with SIADH, and the other from a 63 year-old man without SIADH, were used. An immunohistochemical study was performed using anti-VAS, anti-AGII and anti-TH as primary antibodies. The vasopressin immunoreactive material was mainly found in the supraoptic nucleus (SON) and paraventricular nucleus (PVN), but VAS was also shown in the periventricular nucleus, preoptic medial area, perifornical nucleus and hypothalamic lateral area. The AGII was also mainly found in the SON and PVN. The TH was found in the SON, PVN, arcuate nucleus, periventricular nucleus, perifornical nucleus, preoptic medial and lateral area. VAS was less intensive and in a lesser number of cells and fibres in the case of SIADH, as opposed to the AGII and TH which were similar in both cases.","PeriodicalId":89507,"journal":{"name":"The open pathology journal","volume":"21 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2012-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79555786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial: Advances in the Diagnosis and Management of Oral Diseases 社论:口腔疾病的诊断和治疗进展

The open pathology journal Pub Date : 2011-03-31 DOI: 10.2174/1874375701105010001

I. Al-Hashimi

引用次数: 0

Hypersensitivity to Dental Cast Metals: A Clinical Study 牙科铸造金属过敏的临床研究

The open pathology journal Pub Date : 2011-03-31 DOI: 10.2174/1874375701105010013

T. Rees

引用次数: 7

Advances in Diagnostic Adjuncts for Oral Squamous Cell Carcinoma 口腔鳞状细胞癌诊断辅助手段的研究进展

The open pathology journal Pub Date : 2011-03-31 DOI: 10.2174/1874375701105010003

Y. Cheng, John M. Wright

引用次数: 31

Guided Bone Regeneration in the Oral Cavity: A Review 口腔引导骨再生:综述

The open pathology journal Pub Date : 2011-03-31 DOI: 10.2174/1874375701105010033

Rita A. Hitti, D. Kerns

{"title":"Guided Bone Regeneration in the Oral Cavity: A Review","authors":"Rita A. Hitti, D. Kerns","doi":"10.2174/1874375701105010033","DOIUrl":"https://doi.org/10.2174/1874375701105010033","url":null,"abstract":"Guided bone regeneration (GBR) in the oral cavity is defined according to the American Academy of Periodontology as \"procedures attempting to regenerate lost periodontal structures through different tissue responses... typically referring to ridge augmentation or bone regeneration procedures.\" GBR evolved from guided tissue regeneration (GTR) techniques directed toward regenerating tissues in osseous defects adjacent to natural teeth. One of the objectives of GBR is formation of new bone at sites deficient in bone volume. Another objective is to treat fenestrations and dehiscences at implant surfaces as well as defects associated with immediate implant placement into extraction sites. GBR has allowed for placement of restorations at a more ideal location in the oral cavity, thus improving esthetics and function. This paper is a review of current techniques of GBR for ridge preservation. Evaluation of cell proliferation kinetics revealed that both the PDL and perivascular cells from the bone proliferate and migrate into the osseous defect to form the early healing tissue (5). Melcher (6) amended his original hypothesis to include the contribution of the perivascular cells of the bone in periodontal regeneration concluding that cells from both the PDL and alveolar bone are important in formation of new bone, cementum, and functionally oriented PDL (regeneration). The mechanism of new attachment formation was described by a series of studies by Nyman, Karring, Lindhe and others (7-9), and based on this, guided tissue regeneration (GTR) was designated as a periodontal tissue regenerative procedure.","PeriodicalId":89507,"journal":{"name":"The open pathology journal","volume":"16 1","pages":"33-45"},"PeriodicalIF":0.0,"publicationDate":"2011-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75279615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41