The open nutraceuticals journal最新文献_第3页

Chronobiology and chronomics honor Douglas Wilson. neither calories nor anything else are equal at breakfast and dinner or along other time scales 时间生物学和时间学是为了纪念道格拉斯·威尔逊。在早餐和晚餐或其他时间尺度上，卡路里和其他任何东西都不相等

The open nutraceuticals journal Pub Date : 2013-09-20 DOI: 10.2174/1876396001306010089

Germaine G. Cornelissen-Guillaume, R. Singh, O. Schwartzkopff, F. Halberg

引用次数: 1

Biography - Some Background on Dr Douglas Wilson's Achievements 传记-道格拉斯·威尔逊博士成就的一些背景

The open nutraceuticals journal Pub Date : 2013-09-20 DOI: 10.2174/1876396001306010051

Douglas W. Wilson

引用次数: 0

Editorial - Impact of Research Conducted by Dr Douglas Wilson on World Science 社论- Douglas Wilson博士的研究对世界科学的影响

The open nutraceuticals journal Pub Date : 2013-09-20 DOI: 10.2174/1876396001306010049

R. Singh

引用次数: 0

Nutrition and Cancer: Dr. Douglas Wilson - Honoured 营养与癌症:道格拉斯·威尔逊博士-获奖

The open nutraceuticals journal Pub Date : 2013-09-20 DOI: 10.2174/1876396001306010076

K. Griffiths, A. Hungin, F. Meester, R. Singh, L. Juneja

引用次数: 1

Reversal of Immunogenicity of Hepatitis B Antigen by Treatment with Nutraceuticals (OMEGA QGEL) 保健品治疗逆转乙型肝炎抗原免疫原性(OMEGA QGEL)

The open nutraceuticals journal Pub Date : 2013-08-07 DOI: 10.2174/1876396001306010045

Ram B. Singh, Mikio Tokunaga, Toru Takahashi, Douglas W. Wilson, E. Gerasimova, F. Meester

引用次数: 2

Effect of Diet and Nutrients on Molecular Mechanism of Gene Expression Mediated by Nuclear Receptor and Epigenetic Modulation 日粮和营养物质对核受体介导的基因表达分子机制及表观遗传调控的影响

The open nutraceuticals journal Pub Date : 2013-05-03 DOI: 10.2174/1876396001306010027

Mahsa Jalili

{"title":"Effect of Diet and Nutrients on Molecular Mechanism of Gene Expression Mediated by Nuclear Receptor and Epigenetic Modulation","authors":"Mahsa Jalili","doi":"10.2174/1876396001306010027","DOIUrl":"https://doi.org/10.2174/1876396001306010027","url":null,"abstract":"Major research progress in the last few decades has elucidated the complex nexus between nutrition and health. Diet and lifestyle influence epigenetic changes that are heritable. However, a statement of reservation is needed here, viz. that it is often difficult to distinguish between epigenetic changes that are inherited from one generation to the next and true mutations, for instance in mitochondrial DNA. The last topic is a big one in its own right and will not be further dis- cussed in this article. Epigenetic changes induced by dietary nutrients ultimately culminate in changes of the expression of genes through transcription and translation. The interaction between dietary nutrients and nuclear receptors triggers the signaling pathway, leading to modulation of epigenetic change and gene expression. Knowledge about nuclear receptors is important for explaining dietary modulation of transcription via recruitment of large protein complexes. These proteins are capable of causing modification of chromosomal components, can influence chromatin proteins, and affect the binding of proteins to particular parts of the DNA molecules controlling the expression of individual genes. Chromatin complexes between DNA and proteins can be destabilized by recruitment of transcriptional coactivators by histone acetylation. How- ever, in the presence of hormone antagonists or in the absence of relevant ligands, recruitment of other cellular core pro- teins may stabilize chromatin by their influence on histone deacetylases, thus antagonizing the effect of enzymes causing histone acetylation. This article reviews the current knowledge on nutritional modulation of bioactive molecules by epige- netic changes, if they can regulate genetic expressions. The molecular mechanism of action of various dietary nutrients on gene expression mediated by nuclear receptors is also discussed.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"6 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2013-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68132968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Physiological and Biochemical Significance of Genetically Modified Foods: An Overview 转基因食品的生理生化意义综述

The open nutraceuticals journal Pub Date : 2013-04-30 DOI: 10.2174/1876396001306010018

S. Mishra, R. Singh

{"title":"Physiological and Biochemical Significance of Genetically Modified Foods: An Overview","authors":"S. Mishra, R. Singh","doi":"10.2174/1876396001306010018","DOIUrl":"https://doi.org/10.2174/1876396001306010018","url":null,"abstract":"Biotechnological discoveries and inventions have been observed to improve food production qualitatively as well as quantitatively. In certain specific cases, the improvement in the quality and nutrition of foods by altering their composition were also monitored. However, the practice of biotechnology has also upraised concerns about its potential risks to the environment as well as human being. Genetic Engineering provides resources to host genes into plants via mechanisms, different in some respects from classical breeding. A number of genetically engineered variety of foods have been developed, which have become important nutraceuticals; most notably canola, cotton, maize and soybean, were de- veloped employing this modern technology, and at present the traits introduced are herbicide and/or pest tolerance. Gene technology leads to increase the production in plants, as well as the elevation of resistance to pests, viruses, frost, etc. Gene transfer technology is employed to alter the physical and chemical composition with nutraceutical worth. The pre- sent review article is the compilation of various physiological and biochemical studies reflecting both positive and nega- tive ecological concerns of genetically modified foods.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"6 1","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2013-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68132957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Developing a commercially viable process for an Active Pharmaceutical Ingredient, Challenges, Myths and Reality in the Art of Process Chemistry 开发一种商业上可行的活性药物成分工艺，工艺化学艺术中的挑战、神话和现实

The open nutraceuticals journal Pub Date : 2013-04-19 DOI: 10.2174/1876396020130419001

A. Gill

{"title":"Developing a commercially viable process for an Active Pharmaceutical Ingredient, Challenges, Myths and Reality in the Art of Process Chemistry","authors":"A. Gill","doi":"10.2174/1876396020130419001","DOIUrl":"https://doi.org/10.2174/1876396020130419001","url":null,"abstract":"There is increasing interest in the use of functional foods to activate natural stem cell associated repair pathways resulting in improved health and well-being. Bovine Alpha Lipid colostrum, a proprietary formulation, induced stem cell associated cytokines and growth factor, GCSF, IL-6 and VEGF and also enhanced the differentiation of bone marrow stem cells in vitro. To boost colostrum activity, commercially available natural extracts of immune stimulatory carbohydrates were screened for their capacity to induce GCSF and IL-6. Combining selected extracts with colostrum, showed synergistic cytokine induction in vitro. In a mouse feeding study, a trial formulation of Alpha Lipid colostrum combined with selected carbohydrate extracts, was shown to increase the frequency of bone marrow hematopoietic stem cells to a greater extent that was seen with the colostrum alone, as assessed by CFU assay. Furthermore, a pilot human study showed there were alterations in circulating hematopoietic and mesenchymal/stromal stem cell numbers following consumption of the trial formulation compared to subjects receiving a placebo supplement. These data indicate that is possible to influence the endogenous stem cell niche by oral supplementation with a combination of colostrum and highly potent sources of immune stimulatory carbohydrates.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"6 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition in Transition from Homo sapiens to Homo economicus 从智人到经济人的营养过渡

The open nutraceuticals journal Pub Date : 2013-03-22 DOI: 10.2174/1876396001306010006

Ram B. Singh, Toru Takahashi, Takashi Nakaoka, K. Otsuka, E. Toda, H. Shin, Moon-Kyu Lee, Vicky Beeharry, Krisimira Hristova, J. Fedacko, D. Pella, F. Meester, Douglas W. Wilson, L. Juneja, D. Martirosyan

{"title":"Nutrition in Transition from Homo sapiens to Homo economicus","authors":"Ram B. Singh, Toru Takahashi, Takashi Nakaoka, K. Otsuka, E. Toda, H. Shin, Moon-Kyu Lee, Vicky Beeharry, Krisimira Hristova, J. Fedacko, D. Pella, F. Meester, Douglas W. Wilson, L. Juneja, D. Martirosyan","doi":"10.2174/1876396001306010006","DOIUrl":"https://doi.org/10.2174/1876396001306010006","url":null,"abstract":"The food and nutrient intake among Paleolithic Homo sapiens, hunter-gatherers and among Asian and Homo economicus Western populations shows marked variations. Economic development and affluence may be associated with a decrease in the consumption of omega-3 fatty acids, vitamins, antioxidants and amino acids and significant increase in the intakes of carbohydrates, (mainly refined), fat (saturated, trans fat and linoleic acid) and salt compared to the Paleo- lithic period. The protein or amino acid intake was 2.5 fold greater (33 vs. 13%) in the Paleolithic diet Homo sapiens compared to modern Western diet consumed by Homo economicus populations. Approximately 10,000 years ago, prior to the Agricultural Revolution, our diet was based on an enormous variety of wild plants. However, today about 17% of plant species provide 90% of the world's food supply which is mainly contributed by grains produced by fertilizer based on rapidly grown crops which may result in a decrease in nutrient density and increase in energy. Wheat, corn and rice ac- count for three fourths of the world's grain production on which humans are dependent for their food supply. Grains are high in omega-6 fatty acids and carbohydrates and low in omega-3 fatty acids and antioxidants compared to leafy green vegetables. It has been estimated that diet of Homo sapiens was characterized by higher intakes by essential and non- essential amino acids, calcium, potassium, magnesium, flavonoids and w-3 fatty acids whereas modern Western diet of Homo economicus has excess of energy-rich refined carbohydrates, w-6, trans fat and saturated fat and low in protective nutrients. The consumption of such diets in wealthy countries in conjunction with sedentary behavior is associated with increased prevalence of morbidity and mortality due to noncommunicable diseases (NCDs).","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"6 1","pages":"6-17"},"PeriodicalIF":0.0,"publicationDate":"2013-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68133507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

EDITORIAL Perspectives on Chocolate Consumption and Risk of Cardiovascular Dis- eases and Cognitive Function 巧克力消费与心血管疾病和认知功能风险的观点

The open nutraceuticals journal Pub Date : 2012-12-28 DOI: 10.2174/1876396001205010207

K. Hristova, Takashi Nakaoka, K. Otsuka, J. Fedacko, Reema Singh, R. Singh, F. Meester, A. Wilczynska, Douglas W. Wilson

引用次数: 10