The open nutraceuticals journal最新文献

{"title":"Influence of a D-aspartic Acid/Sodium Nitrate/Vitamin D3 Dietary Supplement on Physiological Parameters in Middle-aged Men: A Pilot Study","authors":"R. Bloomer, Trint A. Gunnels, Ryan G. Moran, J. Schriefer","doi":"10.2174/1876396001508010043","DOIUrl":"https://doi.org/10.2174/1876396001508010043","url":null,"abstract":"D-aspartic acid (DAA), nitrate, and vitamin D3 have received considerable attention in recent years for their potential health-enhancing properties. Using an open-label design, we evaluated the impact of a DAA/sodium nitrate/ vitamin D3 dietary supplement on blood testosterone and nitrate/nitrite, as well as subjective indicators of health, in middle-aged men. Methods: 10 overweight or obese men (mean age: 42 years) were assigned to ingest a DAA/sodium nitrate/ vitamin D3 supplement (either one or two servings per day) for 28 days. Blood total and free testosterone and nitrate/nitrite was measured before and after 14 and 28 days of supplementation. Subjective assessment of to health indicators (e.g., energy level, libido) was included at each collection time. Results: Total and free testosterone increased on average 5-10%, which was not of statistical significance (p>0.05). The response was highly variable; some men failed to respond to treatment, while men with relatively low basal testosterone values experienced increases exceeding 20%. Plasma nitrate/nitrite was increased approximately 6-10 fold after treatment with the supplement, with a trend noted for a time effect (p=0.07). Men reported a significantly better feeling following supplement use, as evidenced by a time effect for both vitality (p=0.02) and libido (p=0.04), with a trend noted for increased energy level (p=0.08) and mental outlook and mood (p=0.10). Conclusion: Twenty-eight days of treatment with a DAA/sodium nitrate/ vitamin D3 dietary supplement increased blood nitrate/nitrite and improved subjective feelings of vitality and libido in middle-aged men. In selected men with low basal testosterone values, the supplement increased circulating levels of this hormone.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"8 1","pages":"43-48"},"PeriodicalIF":0.0,"publicationDate":"2015-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Functional Foods Consumption Patterns Among Decedents Dying Due to Various Causes of Death","authors":"Ram B. Singh, P. Visen, Divyank Sharma, Sarthak Sharma, Ratin Mondo, J. Sharma, M. Sharma, Mikio Tokunaga, Toru Takahashi, S. Mishra, A. Sharma, Monika Jain, F. Marinho, R. Pal","doi":"10.2174/1876396001508010016","DOIUrl":"https://doi.org/10.2174/1876396001508010016","url":null,"abstract":"Background: Western diet appears to be a risk factor for non-communicable diseases (NCDs), cardiovascular diseases (CVDs), diabetes and cancer whereas dietary supplements of functional foods rich Mediterranean diets are inversely associated, among individuals and populations with underlying lack of general and health education. We have only scanty information about functional foods which may be considered as nutraceuticals. The prevalence of optimal functional food eating behavior pattern in the population is unknown. This study examines the prevalence of optimal functional foods eating behavior as a protective factor among victims dying due to NCDs to find out the accuracy of the verbal autopsy questionnaire. Subjects and Methods: Death records of 2,222 (1,385 men and 837 women) decedents, aged 25-64 years, out of 3,034 death records, were randomly selected and studied by verbal autopsy questionnaires. All the risk factors and protective factors were assessed by questionnaires which were completed with the help of the victim's spouse and a local treating doctor, by a trained scientist. The lack of knowledge on health education about the role of adverse effects of Western foods was assessed by the questionnaires. Functional food intake was considered in presence of fruit, vegetable and legume intake of minimum 250g/day (moderate) and ideally 400g/day consistent with WHO guidelines. Results: The prevalence of optimal prudent foods intake behavior; fruit, vegetable and legume (>250g/day) intake were observed among 51.4% (n=712) men and 50.4% (n=422) women. Western type food (>255g/day)intake was observed among 63.2% (n=875)men and 59.9% (n=502) women. The prevalence of optimal functional food intake was significantly greater among men compared to women (19.4 vs 14.6%, P<0.05). The consumption of functional food not fruits; grapes and apples, guava, stargoose berry and lemon and onion, garlic ginger was significantly greater among men as compared to women. Other functional foods such as soy products, mustard or olive oil, curd or yogurt, nuts and fish, tea and cocoa, spices; turmeric, cumin, coriander seeds and peppers intake showed no significant difference between two sexes. Multivariate logistic regression analysis revealed that after adjustment of age and body weight, total functional foods intakes and fruit, vegetable, legume and nuts intake were significantly inversely associated with deaths due to NCDs, whereas Western type foods (red meat and eggs, refined foods ) were positively associated with these causes of deaths, in both sexes. Total spices intake, mustard/olive oil intake and curd or yogurt intake, were inversely but weakly associated with causes of deaths due to NCDs, among both men and women. The prevalence of protective behavior pattern was observed among half of the victims, dying due to injury and accidents where such behaviors were uncommon among decedents dying due to NCDs. Conclusions: It is possible that protective health beh","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"8 1","pages":"16-28"},"PeriodicalIF":0.0,"publicationDate":"2015-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies","authors":"S. Sibilla, M. Godfrey, S. Brewer, Anil Budh-Raja, L. Genovese","doi":"10.2174/1876396001508010029","DOIUrl":"https://doi.org/10.2174/1876396001508010029","url":null,"abstract":"Skin, the main barrier to the external environment, is subject to deterioration caused by dermatological disorders, environmental conditions and the intrinsic ageing process. This damage to both structure and function may be accelerated by smoking, alcohol consumption and chronic sun exposure (extrinsic components). All these factors may lead to the formation of wrinkles, the appearance of brown spots and skin thickening. One effective strategy to managing the skin ageing process is adopting a healthy nutritional approach to life, maintaining a balanced diet and a good supply of food supplements. This can restore the homeostasis of macro and micronutrients and support the physiology of cells and tissues in the skin. Hydrolysed collagen, an increasingly popular nutraceutical, is composed of low molecular weight small peptides, which are easily digestible, absorbed and distributed in the human body. Numerous clinical trials have now been performed showing the efficacy and benefits of collagen peptides on skin properties, such as hydration, elasticity and reduction of wrinkles. As a result, hydrolysed collagen can be considered an important weapon in the everyday fight against skin ageing.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"8 1","pages":"29-42"},"PeriodicalIF":0.0,"publicationDate":"2015-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Nutritional Modulators in Chronic Heart Failure","authors":"Ram B. Singh, K. Hristova, G. Elkilany, Takahashi Toru, A. Shehab, H. Chaves, Douglas W. Wilson, D. Rupini, N. Gupta, Rajeev Gupta","doi":"10.2174/1876396001508010001","DOIUrl":"https://doi.org/10.2174/1876396001508010001","url":null,"abstract":"Chronic Heart failure (HF) may be associated with cardiac cachexia characterized with weight loss as well as with nutritional deficiency [1-4]. The increased oxidative stress in chronic HF attempts to consume various nutrients present in the cardiomyocyte as well as endogenous antioxidants. Vitamin C, E and beta carotene, as well as coenzyme Q10 are potential antioxidants for protection against oxidative stress developed in HF patients [1-5]. The increase in homocysteine due to oxidative stress, is antagonized by vitamins; B6, B12 and folic acid. The decrease in magnesium and potassium due to long term diuretic therapy in HF which can predispose arrhythmiogenesis, leading to rhythm disturbances and sudden cardiac death [3-5]. L-carnitine, cysteins and taurine amino acids are also reduced in chronic HF and their supplementation may be protective [6-8]. It seems that these nutrients can be administered as nutraceuticals among these patients with chronic HF. Apart from above micronutrients, calcium, selenium, zinc, thiamine, vitamin D and omega-3 fatty acids may play a more important role than previously thought [1-9]. Increased concentration of aldosterone and chronic use of loop diuretics increase urinary excretion of calcium and magnesium, leading to arrhythmias and secondary hyperparathyroidism, which in turn depletes calcium from bone and drives calcium into cells, causing further increase in oxidative stress [8-12]. Vitamin D deficiency, can enhance the damage, which now appears ubiquitous in northern","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"8 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Nutraceutical Alpha Lipid ColostemTM Modulates Peripheral Bloodand Bone Marrow Stem Cell Subsets following Oral Supplementation","authors":"G. Webster, P. Lehrke","doi":"10.2174/1876396001407010058","DOIUrl":"https://doi.org/10.2174/1876396001407010058","url":null,"abstract":"Alpha Lipid Colostem TM is a proprietary blend of colostrum and other natural ingredients, designed to enhance stem cell activity following consumption. Previous animal feeding studies demonstrated that oral supplementation increased the frequency of hematopoietic stem cells in the bone marrow. To further characterise the steady-state effect of this supplement on stem cell activity, a feeding study was conducted in groups of mice (n=5 per group) to investigate circulating as well as bone marrow hematopoietic and mesenchymal/stromal stem cell subsets using multi-colour flow cytometry-based methodologies. The results demonstrated that supplementation increased the number and proportion of hematopoietic stem cells (HSC) in the blood, suggesting there was effective release of stem cells from the bone marrow niche into the circulation. Analysis of bone marrow cells showed a concomitant reduction in the proportion of total HSC, however within the HSC compartment there was a relative increase of CD34 + c-Kit + and reduction in CD34 + Sca-1 + HSC subsets. Mesenchymal/stromal stem cell (CD105 + CD29 + ) numbers showed a decrease in the peripheral blood, with an increased proportion detected in the bone marrow. Alpha Lipid Colostem supplementation also correlated with increased the number of blood granulocytes demonstrating enhancement of hematopoietic stem cell differentiation. These findings further strengthen the hypothesis that dietary supplementation with a synergistic combination of bovine colostrum and immune stimulatory carbohydrates promotes coherent activation of the stem cell niche.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"7 1","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2015-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schisandrin B Enhances Glutathione Redox Cycling and Protects Against β-amyloid-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: A Comparative Study of Various Phytochemicals","authors":"P. Leong, P. Lam, Na Chen, K. Ko","doi":"10.2174/1876396001407010049","DOIUrl":"https://doi.org/10.2174/1876396001407010049","url":null,"abstract":"In the present study, we aim to define the cytoprotective mechanism of ()schisandrin B (()Sch B) in comparison with other phytochemicals in SH-SY5Y cells. The effects of ()Sch B and curcumin (Cur), resveratrol (Rev) and epigallocatechin gallate (EGCG) on -amyloid (A)-induced apoptosis were investigated in SH-SY5Y cells. Cellular reduced glutathione (GSH) levels and peroxide-induced GSH depletion were measured. Activities of glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6DPH) in Aβ-challenged cells were also examined. All tested phytochemicals were investigated for the activation of nuclear factor erythroid-2 related factor 2 (Nrf2) in SH-SY5Y cells, using a luciferase-based assay. Finally, they were examined for the effect on the extent of phosphorylation of Tau in A- challenged cells. The results showed that only ()Sch B and EGCG protected against Aβ-induced apoptosis in SH-SY5Y cells. The cytoprotection afforded by ()Sch B and EGCG were associated with an increase in cellular GSH levels in Aβ- challenged cells and a reduction in peroxide-induced GSH depletion. However, only ()Sch B, but not EGCG, increased G6DPH and GR activities in Aβ-challenged cells and caused the activation of Nrf2 in unchallenged cells. Both ()Sch B and EGCG reduced the extent of Tau phosphorylayion in Aβ-challenged cells. In conclusion, ()Sch B may enhance cellular glutathione redox cycling, presumably by increasing G6PDH and GR activities, via activation of the Nrf2 signaling pathway, whereas EGCG likely acts as a radical scavenger. Both ()Sch B and EGCG suppressed the phosphorylation of Tau in Aβ-challenged cells, suggesting their potential in ameliorating the pathological condition of Alzheimer's disease.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"7 1","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tribute to Nutrio-Diabetologist; Shanti S. Rastogi MBBS, MD, FRCP, FICN, FICC","authors":"Ram B. Singh, Amrat K. Singh, L. Juneja, S. Kaur, M. Garg, Toru Takahashi, Adarsh Kumar, R. Garg, N. Neki, Riponjot Singh, S. Rastogi, H. Mori, D. Pella, T. Basu, L. Ozimek, S. K. Vajpeyee, Douglas W. Wilson, F. Meester, K. Hristova","doi":"10.2174/1876396001407010039","DOIUrl":"https://doi.org/10.2174/1876396001407010039","url":null,"abstract":"","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"7 1","pages":"39-43"},"PeriodicalIF":0.0,"publicationDate":"2014-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Wine and Moderate Alcohol Intake Work as Functional Food Nutraceuticals? A Tribute to Dr. Serge C. Renaud","authors":"Ram B. Singh, F. Meester, Agnieszka Wilkzynska, D. Wilson, D. Lanzmann, M. Abramova, S. Shastun, Chibisov Sergey, Pavel Khochunsky, P. Velangi, E. Awori, A. Sharma, Monika Jain, H. Buttar","doi":"10.2174/1876396001407010044","DOIUrl":"https://doi.org/10.2174/1876396001407010044","url":null,"abstract":"Alcohol appears to be a double-edged sword because moderate alcohol intake is protective whereas drinking more than 10 drinks in a week appears to have adverse effects on morbidity and mortality. Recently, the exponential nature of the relation between average alcohol consumption and mortality has been demonstrated in Russia. This study revealed that substantial numbers of people report drinking three or more half-litre bottles of vodka per week. However, the exponential curves for dose-response relations between average volume of alcohol consumption and the mortality risk of various diseases is not fully explained. The variation in mortality may be due to presence of confounders such as physical activity, greater consumption of fish and salads which are rich sources of omega-3 fatty acids and polyphenolics. It is possible that patients with type 2 diabetes, moderate alcohol us-e, particularly wine consumption, is associated with reduced risks of cardiovascular events and all-cause mortality. Serge C. Renaud gave the definition of the French paradox and suggested that the inhibition of platelet reactivity by wine may be one explanation for protection from CAD in France. It is known that aging of alcohol also increases 1, 1-diphenyl-2-picrylhydrazyl radical scavenging activity and therefore moderate drinking of aged whisky and other alcoholic drinks in moderation may provide beneficial effects. Excess of alcohol intake causes decreases in vitamin B1, B6 and B12 as well as in folic acid, antioxidants vitamins A,E ,C and beta carotene, flavonoids, amino acids, coenzyme Q10, l-carnitine, omega-3 fatty acids as well as in minerals magnesium, potassium, calcium, copper, zinc, chromium and selenium. Alcoholism also has a direct adverse effects on cell membrane, mitochondria and genes. Alcoholic cirrhosis, fatty liver, cardiomyopathy, hypertriglyceridemia, hyperuricemia, oxidative stress and inflammation are well known adverse effects of alcoholism. It also damages the brain causing dementia, depression and psychosis. However, moderate alcohol intake up to 10 drinks per week may have beneficial effects on the risk of all these problems. Moderate alcohol intake increases HDL-C, and decreases C-reactive proteins, IL-6, TNF-alpha, Lp (a), plasminogen activator inhibiter-1, insulin resistance which are risk markers of CVDs, type 2 diabetes and cancer. These beneficial effects are enhanced by omega-3 fatty acids and polyphenolics that are rich in Mediterranean style diets. Vodka and spirits can be made healthly if enriched with fish oil or alpha- linolenic acid (rich source of w-3) and cocoa (flavanol) which can repair this deficiency. It is like a cleaning drink for the all the organs of the body. If standard Vodka is 40% alcohol, then we need +/- 1-g DHA per 500-ml bottle.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"7 1","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2014-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating Effect of Ferulic Acid on NF-kB, COX-2 and VEGF Expression Pattern During 7, 12-Dimethylbenz(a)anthracene Induced Oral Carcinogenesis","authors":"S. Manoharan, Tharmaraj Rejitharaji, M. M. Prabhakar, A. Manimaran, Ram B. Singh","doi":"10.2174/1876396001407010033","DOIUrl":"https://doi.org/10.2174/1876396001407010033","url":null,"abstract":"Ferulic acid, a natural antioxidant, has the potential to prevent inflammation and to modulate angiogenesis in both in vivo and in vitro models. The present study has investigated the modulating effect of ferulic acid on the expression pattern of COX-2, NF-B and VEGF during 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Over expression of COX-2, NF-B and VEGF was noticed in the oral tumor tissues of hamsters treated with DMBA. Oral administration of ferulic acid at a dose of 40 mg/kg body weight to hamsters treated with DMBA completely prevented the tumor formation and downregulated the expression of COX-2, NF-B and VEGF during DMBA induced oral carcinogenesis. The present results suggest that ferulic acid might have suppressed oral tumor formation by down regulating the expression of COX-2, NF-B and VEGF during DMBA induced oral carcinogenesis.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"7 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2014-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Euphorbia supina Extract on Antioxidant Activity","authors":"Hyangi Choi, Sun‐Young Lim","doi":"10.2174/1876396001407010028","DOIUrl":"https://doi.org/10.2174/1876396001407010028","url":null,"abstract":"We investigated the effect of Euphorbia supina extract on the production of cellular reactive oxygen species (ROS) in order to evaluate its antioxidative activity. The H2O2-induced ROS generation was measured with dichlorofluorescein-diacetate (DCFH-DA) assay. The acetone+methylene chloride (A+M) and methanol (MeOH) extracts dose-dependently decreased ROS production induced by H2O2 compared to the extract-free control during the 120 min assay. The MeOH extract showed a higher inhibitory effect on the A+M at all concentrations tested. All tested fractions showed a decrease in ROS production with increase in concentration. Treatments with n-hexane and 85% aqueous methanol (MeOH) fractions (0.5 mg/mL concentrations) showed 82% and 97% inhibition rate, respectively, suggesting that the 85% aqueous MeOH fraction had ROS scavenging effects. These results indicate that the 85% aqueous MeOH fraction inhibited cellular oxidation and may contain valuable active compounds.","PeriodicalId":89504,"journal":{"name":"The open nutraceuticals journal","volume":"7 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2014-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68134257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}