ISRN urology最新文献

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The impact of financial interest in intensity-modulated radiation therapy on the utilization of radiation therapy for treatment of newly diagnosed prostate cancer: a single center experience. 调强放射治疗的经济利益对新诊断前列腺癌放射治疗利用的影响:单中心经验。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-03-11 DOI: 10.5402/2012/759258
Xiaolong S Liu, Joseph C Zola, David E McGinnis, Mehrdad Soroush, Leigh G Bergmann, David J Ellis, James F Squadrito, Ilia S Zeltser
{"title":"The impact of financial interest in intensity-modulated radiation therapy on the utilization of radiation therapy for treatment of newly diagnosed prostate cancer: a single center experience.","authors":"Xiaolong S Liu,&nbsp;Joseph C Zola,&nbsp;David E McGinnis,&nbsp;Mehrdad Soroush,&nbsp;Leigh G Bergmann,&nbsp;David J Ellis,&nbsp;James F Squadrito,&nbsp;Ilia S Zeltser","doi":"10.5402/2012/759258","DOIUrl":"https://doi.org/10.5402/2012/759258","url":null,"abstract":"<p><p>Objective. As recent participants in an integrated prostate cancer (PCa) care center, we sought to evaluate whether financial investment in an intensity-modulated radiation therapy (IMRT) center resulted in an increased utilization of radiation therapy in our patients with newly diagnosed PCa. Materials & Methods. Following institutional review board approval, we retrospectively reviewed the records of all consecutive patients who were diagnosed with prostate cancer in the 12 months prior to and after investment in IMRT. Primary treatment modalities included active surveillance (AS), brachytherapy (BT), radiation therapy (XRT), radical prostatectomy (RP), and androgen deprivation therapy (ADT). Treatment data were available for all patients and were compared between the two groups. Results. A total of 344 patients with newly diagnosed PCa were evaluated over the designated time period. The pre-investment group totaled 198 patients, while 146 patients constituted the post-investment group. Among all patients evaluated, there was a similar rate in the use of XRT (20.71% versus 20.55%, P = 1.000) pre- and post-investment in IMRT. Conclusions. Financial interest in IMRT by urologists does not impact overall utilization rates among patients with newly diagnosed PCa at our center.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"759258"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/759258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30601888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The inhibition of ureteral motility by periureteral adipose tissue. 输尿管周围脂肪组织对输尿管运动的抑制。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.5402/2012/312487
Lyndsey M Killian, Stuart J Bund
{"title":"The inhibition of ureteral motility by periureteral adipose tissue.","authors":"Lyndsey M Killian,&nbsp;Stuart J Bund","doi":"10.5402/2012/312487","DOIUrl":"https://doi.org/10.5402/2012/312487","url":null,"abstract":"<p><p>Perivascular adipose tissue exerts an anticontractile influence on vascular smooth muscle. This study was conducted to determine whether periureteral adipose tissue (PUAT) could exert a similar influence upon ureteral smooth muscle. Acetylcholine-stimulated (10(-7) M-10(-4) M) contractile responses of ureteral segments obtained from male Wistar rats were recorded in the presence and absence of PUAT. Ureters with PUAT generated phasic contractile responses with significantly lower frequencies (P < 0.001) and magnitudes (P < 0.001) compared with ureters cleared of their periureteral adipose tissue. Removal of PUAT significantly increased the frequency (P < 0.01) and magnitude (P < 0.01) of the contractile responses. Bioassay experiments demonstrated that ureters with PUAT released a transferable factor that significantly reduced frequencies (P < 0.05), but not magnitudes, of the contractile responses of ureters cleared of PUAT. The nitric oxide synthase inhibitor L-NNA (10(-4) M) did not significantly influence the anticontractile effect exerted by ureters with PUAT. This is the first study to demonstrate that ureteral motility is influenced by its surrounding adipose tissue. The PUAT has an anticontractile effect which is mediated by a transferable factor released from the PUAT. The identity of the factor is unknown but does not exert its effect through nitric oxide.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"312487"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/312487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30602004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Does 3D Ultrasound Enhance the Diagnosis of Bladder Tumours in Patients with Haematuria? 3D超声是否能提高血尿患者膀胱肿瘤的诊断?
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-03-07 DOI: 10.5402/2012/158437
Miguel Silva-Ramos, Nuno Louro, Rui Versos, Victor Cavadas, Filinto Marcelo
{"title":"Does 3D Ultrasound Enhance the Diagnosis of Bladder Tumours in Patients with Haematuria?","authors":"Miguel Silva-Ramos,&nbsp;Nuno Louro,&nbsp;Rui Versos,&nbsp;Victor Cavadas,&nbsp;Filinto Marcelo","doi":"10.5402/2012/158437","DOIUrl":"https://doi.org/10.5402/2012/158437","url":null,"abstract":"<p><p>Purpose. Bladder cancer is a frequent cause of haematuria in elderly patients, and bladder ultrasound (US) is a valuable tool in diagnosing these malignancies. We examined the accuracy of 3D bladder US in diagnosing bladder tumors in patients with haematuria. Patients and Methods. Twenty-one patients observed in the emergency department for haematuria underwent a kidney and bladder US. Patients with normal or uncertain bladder US findings underwent a 3D US and a cystoscopy. Results. In 5 (23.8%) patients, the 3D US detected bladder tumours not seen in 2D US. All these patients were found to have bladder tumours on cystoscopy. Another 5 (23.8%) patients with uncertain findings on 2D US had normal 3D US and cystoscopy. 3D US showed a sensitivity of 83.3% and a specificity of 100% with a positive predicted value and negative predictive values of 100% and 93.8%, respectively. Conclusion. 3D US was more sensitive than 2D US in diagnosing bladder tumours in patients with haematuria.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"158437"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/158437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30586357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
One-stage urethroplasty for strictures in maiduguri, north eastern Nigeria. 尼日利亚东北部迈杜古里一期尿道成形术治疗狭窄。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-03-04 DOI: 10.5402/2012/847870
Ahmed Gadam Ibrahim, Nuhu Ali, Sulieman Aliyu, Abubakar Alhaji Bakari
{"title":"One-stage urethroplasty for strictures in maiduguri, north eastern Nigeria.","authors":"Ahmed Gadam Ibrahim,&nbsp;Nuhu Ali,&nbsp;Sulieman Aliyu,&nbsp;Abubakar Alhaji Bakari","doi":"10.5402/2012/847870","DOIUrl":"https://doi.org/10.5402/2012/847870","url":null,"abstract":"<p><p>Background. Urethral stricture is a frequent cause of lower urinary tract obstruction worldwide. The aim of this study is to present our experience with one-stage urethroplasty. Methods. All males that underwent one-stage urethroplasty between January 2001 and December 2010 were retrospectively reviewed. Details of their biodata, clinical presentation, diagnostic investigations, operative treatment, postoperative complications, and other outcome of surgery were extracted and analyzed. Results. Ninety-one patients aged 8-76 years, (mean; 45.6 ± 19.7) with urethral stricture were studied. Postinfective strictures accounted for 58.2% and postprostatectomy strictures for 3.3%. Twenty-six (27.9%) of the strictures were in the posterior urethra of which 18 (59.2%) were posttraumatic. Fifty-seven strictures (61.3%) were in the anterior urethra of which 51 (54.8%) were postinfective. Thirty-nine (42.9%) patients had end to end anastomosis, 29 (31.9%) flap augmentation and 17 (18.7%) tabularized flap substitution, and 6 (6.6%) dorsal onlay grafts (5 with buccal mucosa and 1 with penile skin). There were 18 (19.8%) cases of wound infection, 12 (13.2%) of restricture and 6 (6.6%) cases of urethrocutaneous fistula. Satisfactory urinary stream was found in 77 (84.6%) patients. There was no mortality. Conclusion. Infection is the commonest cause of urethral stricture followed by trauma, and one-stage urethroplasty give excellent results.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"847870"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/847870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30601891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Use of procalcitonin in patients on chronic hemodialysis: procalcitonin is not related with increased serum calcitonin. 慢性血液透析患者使用降钙素原:降钙素原与血清降钙素升高无关。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-05-20 DOI: 10.5402/2012/431859
Ken-Ichi Mori, Mitsuru Noguchi, Yasuhiro Sumino, Fuminori Sato, Hiromitsu Mimata
{"title":"Use of procalcitonin in patients on chronic hemodialysis: procalcitonin is not related with increased serum calcitonin.","authors":"Ken-Ichi Mori,&nbsp;Mitsuru Noguchi,&nbsp;Yasuhiro Sumino,&nbsp;Fuminori Sato,&nbsp;Hiromitsu Mimata","doi":"10.5402/2012/431859","DOIUrl":"https://doi.org/10.5402/2012/431859","url":null,"abstract":"<p><p>Objectives. To investigate whether procalcitonin (PCT) could be useful for detecting bacterial infections in patients on hemodialysis (HD) and with increased calcitonin (CT). Methods. This prospective study included 42 males and 34 females on HD. The infection group consisted of 15 patients with proven bacterial infections; the other 61 patients were designated as the noninfection group. Serum C-reactive protein (CRP), interleukin (IL)-6, white blood cell (WBC) count, immature and total neutrophil (I/T) ratio, and CT were measured at the beginning of HD, and serum PCT levels at the beginning of HD and after HD. Results. The mean CT level in the both groups was apparently higher than that of nonchronic kidney disease. Significantly higher values between the infection and noninfection groups were seen for CRP, IL-6, WBC, I/T ratio, PCT, and CT. The PCT value of the area under the receiver operating characteristic curve was 0.921, which was significantly higher than the values for CRP (0.853; P < 0.01), IL-6 (0.739; P < 0.01), WBC (0.692; P < 0.01), and I/T ratio (0.584; P < 0.01). Conclusions. PCT was useful marker of bacterial infection in patients on HD and with increased CT. PCT levels should be determined before HD.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"431859"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/431859","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30679999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Current Strategies to Enhance Recovery following Radical Cystectomy: Single Centre Initial Experience. 提高根治性膀胱切除术后恢复的当前策略:单中心初步经验。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-03-08 DOI: 10.5402/2012/382843
Nikhil Vasdev, Praveen L Pillai, Christopher P Snowdon, Andrew C Thorpe
{"title":"Current Strategies to Enhance Recovery following Radical Cystectomy: Single Centre Initial Experience.","authors":"Nikhil Vasdev,&nbsp;Praveen L Pillai,&nbsp;Christopher P Snowdon,&nbsp;Andrew C Thorpe","doi":"10.5402/2012/382843","DOIUrl":"https://doi.org/10.5402/2012/382843","url":null,"abstract":"<p><p>A radical cystectomy (RC) with pelvic lymph node dissection is the gold standard treatment for muscle-invasive bladder carcinoma. The morbidity associated with RC is clearly lower than that in the previous decades; it still continues to remain higher than 30% in the early postoperative period associated with and remains the most effective method for local control. We present current strategies being developed to further enhance recovery in patients undergoing RC and stratifying these into pre, intra, and post operative. We present our current strategies to enhance revcovery in patients undergoing RC which includes a combination of a through preoperative assessment with cardiopulmonary exercise (CPX), preoperative carbohydrate loading drinks, and intraoperative fluid monitoring with the trans-oesophageal Doppler probe (TODP) that may enhance recovery following radical cystectomy. We conclude that using these strategies may not only help in reducing peri/post operative morbidity and the duration of inpatient stay but may also help in enhancing the patient's long-term recovery.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"382843"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/382843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30602005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The retrourethral transobturator sling suspension in the treatment of male urinary stress incontinence: results of a single institution experience. 经尿道气囊悬吊治疗男性压力性尿失禁:单一机构经验的结果。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-05-17 DOI: 10.5402/2012/304205
Johannes Mueller, Andres Jan Schrader, Thomas Schnoeller, Friedemann Zengerling, Ilija Damjanoski, Andreas Al Ghazal, Mark Schrader, Florian Jentzmik
{"title":"The retrourethral transobturator sling suspension in the treatment of male urinary stress incontinence: results of a single institution experience.","authors":"Johannes Mueller,&nbsp;Andres Jan Schrader,&nbsp;Thomas Schnoeller,&nbsp;Friedemann Zengerling,&nbsp;Ilija Damjanoski,&nbsp;Andreas Al Ghazal,&nbsp;Mark Schrader,&nbsp;Florian Jentzmik","doi":"10.5402/2012/304205","DOIUrl":"https://doi.org/10.5402/2012/304205","url":null,"abstract":"<p><p>Objective. To evaluate functional outcome of the retrourethral transobturator sling suspension (RTS) in the treatment of stress urinary incontinence (SUI) caused by prior prostate surgery. Methods. The RTS (AdVance male sling) was implanted in 32 patients who suffered from mild to severe postsurgical-treatment incontinence at the University Hospital Ulm from September 2010 to September 2011 including 10 patients with prior radiation therapy. Functional data (uroflowmetry, daily pad use, and postvoid residual urine) as well as quality of life with impact of urinary problems (ICIQ-UI SF) were prospectively assessed at baseline and during followup. Results. After a median followup of 9 months (range, 3-14) the incontinence cure rate (no pad usage) was 56.2% and the improvement rate (1-2 pads/day or ≥50% reduction) was 21.9%. No improvement was observed in 21.9%. Daily pad use and ICIQ-UI SF score improved significantly. No major perioperative complications occurred. Postoperatively, 15.6% of the patients exhibited transient acute urinary retention which resolved without further treatment after a maximum of 3 weeks. One patient underwent sling explantation due to dislocation and persistent perineal pain. Conclusions. The implantation of the RTS is a safe and effective procedure in selected patients with SUI resulting from prostate surgery.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"304205"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/304205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30672883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Nitrotyrosine Density of Rabbit Urinary Bladder Muscle and Mucosa Measured via Western Blotting and 96-Well Plate Analysis. Western Blotting和96孔板法测定兔膀胱肌肉和粘膜的硝基酪氨酸密度。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-02-29 DOI: 10.5402/2012/618247
Brittany Fitzpatrick, Catherine Schuler, Robert E Leggett, Robert M Levin
{"title":"Nitrotyrosine Density of Rabbit Urinary Bladder Muscle and Mucosa Measured via Western Blotting and 96-Well Plate Analysis.","authors":"Brittany Fitzpatrick,&nbsp;Catherine Schuler,&nbsp;Robert E Leggett,&nbsp;Robert M Levin","doi":"10.5402/2012/618247","DOIUrl":"https://doi.org/10.5402/2012/618247","url":null,"abstract":"<p><p>Purpose. Nitrotyrosine was quantitated in rabbit bladder muscle and mucosa using two analytical systems: Western blotting analyses and a 96-well plate quantitative analysis kit. Materials and Methods. Rabbit bladder muscle and mucosa were obtained from control rabbits. For the Western analysis, the samples were loaded into a SDS page gel and then transferred to a PVDF membrane. The optical density was measured using a Kodak Scanner. Using the 96-well plate, the samples and standards were loaded, incubated with primary and secondary antibody, washed and vacuumed with 10x wash buffer three times between each incubation period. Stop buffer was added to the plate and the results were quantified via the plate reader. Results. For both muscle and mucosa tissue, the optical density readings were linear with tissue concentration; the concentration of nitrotyrosine in the mucosa was significantly higher than in the muscle. However, whereas the Western blot analysis is based on relative optical densities, the 96-well plate kit provides a truly quantitative analysis. Discussion. Mucosa tissue displayed a higher density of nitrotyrosine than did detrusor muscle tissue. This may well be due to the significantly higher metabolic activity of the mucosa compared to the muscle.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"618247"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/618247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30602009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect of heamolysis on prostate-specific antigen. 溶血对前列腺特异性抗原的影响。
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-12-01 DOI: 10.5402/2012/729821
Hasan S Sağlam, Osman Köse, Fatma Ozdemir, Oztuğ Adsan
{"title":"Effect of heamolysis on prostate-specific antigen.","authors":"Hasan S Sağlam,&nbsp;Osman Köse,&nbsp;Fatma Ozdemir,&nbsp;Oztuğ Adsan","doi":"10.5402/2012/729821","DOIUrl":"https://doi.org/10.5402/2012/729821","url":null,"abstract":"<p><p>Purpose. We have investigated the effect of haemolysis on free and total prostate-specific antigen (PSA) in daily clinical practice. Materials and Methods. Thirty-nine consecutive men were enrolled in this study. With an 18 gauge (G) needle 4 cc of blood samples were drawn from the right arm and 2 cc of it was expelled gently in a Vacutainer for regular PSA assay and the remaining was emptied into a second tube for complete haemolysis. Simultaneously 2 cc of more blood were taken with a 26 G insulin needle from the left arm of the same patient and expelled into another Vacutainer with forcing. All three samples were assayed for free PSA (fPSA), total PSA (tPSA), and potassium (K). Results. The results of the first tube were fPSA 0,535 ng/mL; tPSA 2,493 ng/mL; K(+) 4,178 mmol/L. The results from the haemolysis tube were 0,170 ng/mL; 0,929 ng/mL; 39,545 mmol/L for fPSA, tPSA, K(+), respectively, (P value was 0,001 for all the changes). In the same order the third tube results were 0,518 ng/mL, 2,322 ng/mL, and 7,11 mmol/L. Conclusions. Haemolysis may result in interference by decreasing free and total PSA falsely in daily blood draw practice, that could lead to misinterpreting the case in which especially small amount of increase may be of value.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"729821"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/729821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31134006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Correlation between Diffusion-Weighted Imaging and Histopathological Evaluation of 356 Prostate Biopsy Sites in Patients with Prostatic Diseases. 前列腺疾病患者356个前列腺活检部位弥散加权成像与组织病理学评价的相关性
ISRN urology Pub Date : 2012-01-01 Epub Date: 2012-06-26 DOI: 10.5402/2012/252846
R Kilinç, O G Doluoglu, B Sakman, D S Ciliz, E Yüksel, O Adsan, M Cetinkaya
{"title":"The Correlation between Diffusion-Weighted Imaging and Histopathological Evaluation of 356 Prostate Biopsy Sites in Patients with Prostatic Diseases.","authors":"R Kilinç,&nbsp;O G Doluoglu,&nbsp;B Sakman,&nbsp;D S Ciliz,&nbsp;E Yüksel,&nbsp;O Adsan,&nbsp;M Cetinkaya","doi":"10.5402/2012/252846","DOIUrl":"https://doi.org/10.5402/2012/252846","url":null,"abstract":"<p><p>Purpose. The aim of this study is to investigate the reliability of diffusion MRI for detection of cancer foci by comparing diffusion-weighted imaging (DWI) results and pathology results of prostate biopsy sites. Methods. Of the patients who applied with lower urinary tract symptoms, 36 patients who had suspected DRE and/or PSA ≥2.5 ng/mL were included in the study. Patients underwent DWI prior to 10 cores-prostate biopsy. 356 biopsy cores were obtained from the patients. Foci from the patients with prostate cancer were labeled as malignant or benign foci, likewise foci from the patients with benign pathology were grouped as BPH and inflammation foci. Apparent diffusion coefficients (ADCs) of biopsy groups were compared with each other in order to measure the reliability of DWI in detection of PCa foci. Results. When ADC values of adenocarcinoma foci and BPH foci were compared, a statistically significant difference was found (P < 0.001). When ADC values obtained from adenocarcinoma foci and chronic inflammation foci are compared, the difference between two groups is statistically significant, too (P < 0.001). Conclusions. Biopsies focused on suspected regions after formation of ADC maps by means of DWI would provide to start definitive treatment immediately as well as being beneficial to prevent morbidity related to repeated prostate biopsies.</p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2012 ","pages":"252846"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/252846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30759994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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