ISRN urology最新文献

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Sarcomatoid variant of urothelial carcinoma (carcinosarcoma, spindle cell carcinoma): a review of the literature. 尿路上皮癌的肉瘤样变异(癌肉瘤、梭形细胞癌):文献综述。
ISRN urology Pub Date : 2014-01-22 eCollection Date: 2014-01-01 DOI: 10.1155/2014/794563
Anthony Kodzo-Grey Venyo, Sami Titi
{"title":"Sarcomatoid variant of urothelial carcinoma (carcinosarcoma, spindle cell carcinoma): a review of the literature.","authors":"Anthony Kodzo-Grey Venyo,&nbsp;Sami Titi","doi":"10.1155/2014/794563","DOIUrl":"https://doi.org/10.1155/2014/794563","url":null,"abstract":"<p><p>Background. Sarcomatoid variant of urothelial carcinoma (SVUC) was added to the WHO classification in 2004. Aims. To review the literature. Materials and Method. Various internet databases were used. Result. SVUCs are rare biphasic malignant neoplasms exhibiting morphologic/immunohistochemical evidence of epithelial and mesenchymal differentiation with the presence or absence of heterologous elements. Some cases of SVUC have been associated with radiation therapy and cyclophosphamide treatment. Patients' ages range from 50 to 77 years (mean age 66). Patients tend to be younger and they more commonly presented with high-grade histology and advanced stage disease, in comparison with patients who had conventional urothelial carcinoma (CUC). Results of molecular/genetic studies strongly argue for a common monoclonal cell origin of both the epithelial and mesenchymal components in SUVC. The cancer specific survival of SVUC is poor in comparison with CUC. Radical surgical excision and chemoradiation may be associated with improved prognosis; chemoradiation as an organ preserving alternative to radical excision may be associated with improved outcome. There is no consensus opinion on the best treatment modalities for SUVC. Conclusions. SVUC is rare and is associated with inferior outcome compared with CUC. A multicentre trial of various treatment options is required. Cases of SVUC should be reported. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2014 ","pages":"794563"},"PeriodicalIF":0.0,"publicationDate":"2014-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/794563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32168286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Mini-arc for the treatment of female stress urinary incontinence: long-term prospective evaluation by patient reported outcomes. 治疗女性压力性尿失禁的迷你弧线:患者报告结果的长期前瞻性评估。
ISRN urology Pub Date : 2014-01-20 eCollection Date: 2014-01-01 DOI: 10.1155/2014/659383
Rui Oliveira, Alexandre Resende, Carlos Silva, Paulo Dinis, Francisco Cruz
{"title":"Mini-arc for the treatment of female stress urinary incontinence: long-term prospective evaluation by patient reported outcomes.","authors":"Rui Oliveira,&nbsp;Alexandre Resende,&nbsp;Carlos Silva,&nbsp;Paulo Dinis,&nbsp;Francisco Cruz","doi":"10.1155/2014/659383","DOIUrl":"https://doi.org/10.1155/2014/659383","url":null,"abstract":"<p><p>Single-incision slings were introduced in the surgical treatment of female stress urinary incontinence (SUI) to lessen the morbidity associated with traditional midurethral slings. However, long-term reports on patient satisfaction are still scarce. This study describes the outcome of women treated with Mini-Arc at a mean follow-up of 45 months. In a previous report on 105 women with 15-month mean follow-up, 84 (80%) were found cured and 12 (11%) improved. Now, with a mean follow-up of 45 months, cured/improved patients were reassessed by telephone and completed Patient Global Impression of Improvement (PGI-I), Patient Global Impression of Severity (PGI-S), rated their improvement in a 0-100 scale, and answered if they would recommend the procedure. At 45-month follow-up, 73 women cured/improved were available for evaluation. Over 80% of the cured patients rated the improvement of SUI by the PGI-I as \"very much better\" or \"much better,\" reported their urinary tract condition to be \"normal\" on PGI-S, and described their improvement >70%. Ninety percent would recommend this procedure to a friend. The improved-patient population is very small (n = 7). This study shows that the majority of patients cured/improved after Mini-Arc placement maintain a high degree of satisfaction at a long-term evaluation. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2014 ","pages":"659383"},"PeriodicalIF":0.0,"publicationDate":"2014-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/659383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32163139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Noninvasive electromagnetic detection of bladder cancer. 膀胱癌的无创电磁检测。
ISRN urology Pub Date : 2014-01-16 eCollection Date: 2014-01-01 DOI: 10.1155/2014/802328
Luigi Cormio, Clarbruno Vedruccio, Giorgio Leucci, Paolo Massenio, Giuseppe Di Fino, Vincenzo Cavaliere, Giuseppe Carrieri
{"title":"Noninvasive electromagnetic detection of bladder cancer.","authors":"Luigi Cormio,&nbsp;Clarbruno Vedruccio,&nbsp;Giorgio Leucci,&nbsp;Paolo Massenio,&nbsp;Giuseppe Di Fino,&nbsp;Vincenzo Cavaliere,&nbsp;Giuseppe Carrieri","doi":"10.1155/2014/802328","DOIUrl":"https://doi.org/10.1155/2014/802328","url":null,"abstract":"<p><p>Objectives. Normal and neoplastic human tissues have different electromagnetic properties. This study aimed to determine the diagnostic accuracy of noninvasive electromagnetic detection of bladder cancer (BC) by the tissue-resonance interaction method (TRIM-prob). Patients and Methods. Consecutive patients were referred for cystoscopy because of (i) microscopic or gross hematuria and/or irritative voiding symptoms and (ii) bladder ultrasounds and urinary cytology findings negative or just suspicious of malignancy. Patients were first submitted to TRIM-prob bladder scanning by a single investigator and then to cystoscopy by another investigator blind to TRIM-prob data. Results. In 125 evaluated patients cystoscopy was positive for BC in 47 and negative in the remaining 78; conversely, TRIM-prob bladder scanning was positive for BC in 53 and negative in 72. In particular, TRIM-prob scanning yielded 7 false positives and only one false negative; therefore, its overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 97.9%, 89.9%, 86.8%, 98.6%, and 93.6%, respectively. Conclusions. TRIM-prob bladder scanning was a simple and quite accurate method for non-invasive electromagnetic detection of BC. If the elevated positive and negative predictive values will be replicated in further well-designed studies, it could be used to screen asymptomatic patients at high risk of BC. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2014 ","pages":"802328"},"PeriodicalIF":0.0,"publicationDate":"2014-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/802328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32148060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Buried penis: evaluation of outcomes in children and adults, modification of a unified treatment algorithm, and review of the literature. 埋没阴茎:儿童和成人结局的评价,统一治疗算法的修改,文献回顾。
ISRN urology Pub Date : 2013-12-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/109349
I C C King, A Tahir, C Ramanathan, H Siddiqui
{"title":"Buried penis: evaluation of outcomes in children and adults, modification of a unified treatment algorithm, and review of the literature.","authors":"I C C King,&nbsp;A Tahir,&nbsp;C Ramanathan,&nbsp;H Siddiqui","doi":"10.1155/2013/109349","DOIUrl":"https://doi.org/10.1155/2013/109349","url":null,"abstract":"<p><p>Introduction. Buried penis is a difficult condition to manage in children and adults and conveys significant physical and psychological morbidity. Surgery is often declined due to morbid obesity, forcing patients to live in disharmony for years until the desired weight reduction is achieved. No single operative technique fits all. We present our experience and surgical approach resulting in an improved algorithm unifying the treatment of adults and children. Methods. We conducted a retrospective analysis of patients treated for buried penis between 2011 and 2012. All patients underwent penile degloving and basal anchoring. Penile shaft coverage was achieved with skin grafts. Suprapubic lipectomies were performed on adult patients. Results. Nine patients were identified: four children and five obese adults. Average postoperative stay was three days for children and five for adults. Three adults were readmitted with superficial wound problems. One child had minor skin breakdown. All patients were pleased with their outcomes. Conclusion. Buried penis is a complex condition, and treatment should be offered by services able to deal with all aspects of reconstruction. Obesity in itself should not delay surgical intervention. Local and regional awareness is essential to manage expectations in these challenging patients aspiring to both aesthetic and functional outcomes. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"109349"},"PeriodicalIF":0.0,"publicationDate":"2013-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/109349","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32083305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Protective Effects of Resveratrol against Chronic Immobilization Stress on Testis. 白藜芦醇对睾丸慢性固定应激的保护作用。
ISRN urology Pub Date : 2013-11-06 eCollection Date: 2013-01-01 DOI: 10.1155/2013/278720
Gulsah Bitgul, Isil Tekmen, Didem Keles, Gulgun Oktay
{"title":"Protective Effects of Resveratrol against Chronic Immobilization Stress on Testis.","authors":"Gulsah Bitgul,&nbsp;Isil Tekmen,&nbsp;Didem Keles,&nbsp;Gulgun Oktay","doi":"10.1155/2013/278720","DOIUrl":"https://doi.org/10.1155/2013/278720","url":null,"abstract":"<p><p>Objective. The aim of this study was to investigate protective effects of resveratrol, a strong antioxidant, against possible negative effects of chronic immobilization stress on testes of male rats histochemically, immunohistochemically, ultrastructurally, and biochemically. Material and Methods. Male Wistar rats were divided into 4 groups (n = 7). Group I, control group (C), was not exposed to stress. Group II, stress group (S), was exposed to chronic immobilization stress. In Group III, low dose resveratrol + stress group (LRS), rats were given 10 mg/kg/day resveratrol just before the stress application. In Group IV, high dose resveratrol + stress group (HRS), rats were given 20 mg/kg/day resveratrol just before the stress application. For chronic immobilization stress application animals were put in the plastic tubes (6 cm in diameter, 15 cm in length) during 32 days for 6 hours. All animals were sacrificed 18 hours after the last stress application. Results. Histochemical and ultrastructural investigations showed that in stress group there was germ cell deprivation in seminiferous tubules and increase of connective tissue on interstitial area. No significant changes were seen in low and high dose resveratrol groups. After immunohistochemical investigations, TUNEL (+) and Active Caspase-3 (+) cells were increased in seminiferous tubules of stress group compared with those control group, but they were decreased in low and high dose resveratrol groups. According to biochemically results, MDA, GSH, and testosterone levels in stress group showed no significant difference when compared with those of the other groups. Conclusion. The chronic immobilization stress increases oxidative stress and apoptosis and causes histological tissue damages; resveratrol can minimize the histological damage in testes significantly. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"278720"},"PeriodicalIF":0.0,"publicationDate":"2013-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/278720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31927803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
The effect of varicocelectomy on sperm parameters in subfertile men with clinical varicoceles who have asthenozoospermia or teratozoospermia with normal sperm density. 精索静脉曲张切除术对临床精索静脉曲张伴弱精症或畸形精症精子密度正常的不育男性精子参数的影响。
ISRN urology Pub Date : 2013-10-21 eCollection Date: 2013-01-01 DOI: 10.1155/2013/698351
Basri Cakiroglu, Orhun Sinanoglu, Ramazan Gozukucuk
{"title":"The effect of varicocelectomy on sperm parameters in subfertile men with clinical varicoceles who have asthenozoospermia or teratozoospermia with normal sperm density.","authors":"Basri Cakiroglu,&nbsp;Orhun Sinanoglu,&nbsp;Ramazan Gozukucuk","doi":"10.1155/2013/698351","DOIUrl":"https://doi.org/10.1155/2013/698351","url":null,"abstract":"<p><p>Background. To compare preoperative and postoperative sperm parameters such as sperm count, motility, and morphology in patients with normal sperm concentration with teratozoospermia and asthenozoospermia. Materials and Methods. Hundred and six patients with varicocele associated with male infertility over a 5-year period were included into the study. Pre- and postvaricocelectomy seminal fluid parameters evaluation according to the World Health Organization (WHO) criteria was performed at 4-6-month intervals. Results. One hundred and six patients met the criteria. The mean age of patients was 24.53 ± 8.13. The mean duration of infertility was 3.6 years (range: 1.5-6.3). Only the sperm motility of patients with normospermia showed a significant improvement postoperatively. Conclusions. No significant improvement in sperm morphology may be obtained in patients with clinical varicocele and preoperative normospermia. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"698351"},"PeriodicalIF":0.0,"publicationDate":"2013-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/698351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31867162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat sertoli cells. 胰岛素剥夺减少培养大鼠支持细胞中caspase依赖性凋亡信号。
ISRN urology Pub Date : 2013-10-09 eCollection Date: 2013-01-01 DOI: 10.1155/2013/970370
T R Dias, L Rato, A D Martins, V L Simões, T T Jesus, M G Alves, P F Oliveira
{"title":"Insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat sertoli cells.","authors":"T R Dias,&nbsp;L Rato,&nbsp;A D Martins,&nbsp;V L Simões,&nbsp;T T Jesus,&nbsp;M G Alves,&nbsp;P F Oliveira","doi":"10.1155/2013/970370","DOIUrl":"https://doi.org/10.1155/2013/970370","url":null,"abstract":"<p><p>Insulin is essential for the regulation of glucose homeostasis. Insulin dysfunction occurs in several pathologies, such as diabetes mellitus, which is associated with fertility problems. Somatic Sertoli cells (SCs) not only metabolize glucose to lactate, which is the central energy source used by developing germ cells, but also determine the germ cell population size. If a deregulation in SCs apoptosis occurs, it will affect germ cells, compromising spermatogenesis. As SCs apoptotic signaling is a hormonally regulated process, we hypothesized that the lack of insulin could lead to alterations in apoptotic signaling. Therefore, we examined the effect of insulin deprivation on several markers of apoptotic signaling in cultured rat SCs. We determined mRNA and protein expression of apoptotic markers as well as caspase-3 activity. SCs cultured in insulin deprivation demonstrated a significant decrease on mRNA levels of p53, Bax, caspase-9, and caspase-3 followed by a significant increase of Bax and decrease of caspase-9 protein levels relatively to the control. Caspase-3 activity was also decreased in SCs cultured in insulin deprivation conditions. Our results show that insulin deprivation decreases caspase-dependent apoptotic signaling in cultured rat SCs evidencing a possible mechanism by which lack of insulin can affect spermatogenesis and fertility. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"970370"},"PeriodicalIF":0.0,"publicationDate":"2013-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/970370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31863671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Efficacy of extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome: a randomized, controlled trial. 体外冲击波治疗慢性盆腔疼痛综合征的疗效:一项随机对照试验。
ISRN urology Pub Date : 2013-08-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/972601
Babak Vahdatpour, Farshid Alizadeh, Amir Moayednia, Masoud Emadi, Mohammad Hatef Khorami, Saeid Haghdani
{"title":"Efficacy of extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome: a randomized, controlled trial.","authors":"Babak Vahdatpour,&nbsp;Farshid Alizadeh,&nbsp;Amir Moayednia,&nbsp;Masoud Emadi,&nbsp;Mohammad Hatef Khorami,&nbsp;Saeid Haghdani","doi":"10.1155/2013/972601","DOIUrl":"https://doi.org/10.1155/2013/972601","url":null,"abstract":"<p><p>Objectives. To investigate the effectiveness of extracorporeal shock wave therapy (ESWT) for symptoms alleviation in chronic pelvic pain syndrome (CPPS). Materials and Methods. 40 patients with CPPS were randomly allocated into either the treatment or sham group. In the first group, patients were treated by ESWT once a week for 4 weeks by a defined protocol. In the sham group, the same protocol was applied but with the probe being turned off. The follow-up assessments were done at 1, 2, 3, and 12 weeks by Visual Analogue Scale (VAS) for pain and NIH-developed Chronic Prostatitis Symptom Index (NIH-CPSI). Results. Pain domain scores at follow-up points in both treatment and sham groups were reduced, more so in the treatment group, which were significant at weeks 2, 3, and 12. Urinary scores became significantly different at weeks 3 and 12. Also, quality of life (QOL) and total NIH-CPSI scores at all four follow-up time points reduced more significantly in the treatment group as compared to the sham group. Noticeably, at week 12 a slight deterioration in all variables was observed compared to the first 3 weeks of the treatment period. Conclusions. our findings confirmed ESWT therapy as a safe and effective method in CPPS in short term. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"972601"},"PeriodicalIF":0.0,"publicationDate":"2013-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/972601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31702903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
ERG Protein Expression Is of Limited Prognostic Value in Men with Localized Prostate Cancer. ERG蛋白表达对局限性前列腺癌患者的预后价值有限。
ISRN urology Pub Date : 2013-08-19 eCollection Date: 2013-01-01 DOI: 10.1155/2013/786545
Liang Hong Teng, Cheng Wang, Michael Dolph, Bryan Donnelly, Tarek A Bismar
{"title":"ERG Protein Expression Is of Limited Prognostic Value in Men with Localized Prostate Cancer.","authors":"Liang Hong Teng,&nbsp;Cheng Wang,&nbsp;Michael Dolph,&nbsp;Bryan Donnelly,&nbsp;Tarek A Bismar","doi":"10.1155/2013/786545","DOIUrl":"https://doi.org/10.1155/2013/786545","url":null,"abstract":"<p><p>Background. The prognostic significance of ERG expression in prostate cancer (PCA) has generated mixed results. We sought to investigate the prognostic significance of ERG expression in a localized cohort of men with PCA. Material and Methods. We investigated ERG protein expression in a cohort of 198 men with localized PCA. ERG expression was correlated with patients' clinical outcome and several pathological parameters, including Gleason score (GS), pathological stage, surgical margin, and extra-capsular extension. Results. ERG expression was detected in 86/198 (43.4%) patients exclusively in neoplastic epithelium. Overall, ERG mean expression intensity was 1.01 ± 1.27 versus 0.37 ± 0.83 in acinar PCA compared to foamy type PCA (P < 0.001). In HGPIN, ERG intensity levels were comparable to those in foamy type PCA (0.13 ± 0.56) but significantly lower than those in acinar PCA (P < 0.001). ERG expression was significantly associated with extra-prostatic extension and higher pathological stage and showed a trend toward seminal vesicle invasion. Herein, ERG expression was documented in 50/131 (38.1%) patients with pT2 versus 30/55 (54.5%) patients with pT3 (P = 0.04). ERG association with higher pathological stage was more pronounced in patients with GS > 7. Grouping patients into those with GS ≤ 7 versus >7, there was no significant association between ERG expression and GS. Similarly, no association was present in relation to either surgical margins or postsurgical serum PSA levels. Conclusion. We report significant association between ERG protein levels and extra-prostatic extension and higher pathological stage. ERG expression is not associated with adverse clinical outcome and is of limited prognostic value in localized PCA. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"786545"},"PeriodicalIF":0.0,"publicationDate":"2013-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/786545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31724992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Fournier's Gangrene as Seen in University of Maiduguri Teaching Hospital. 迈杜古里大学教学医院的富尼耶坏疽。
ISRN urology Pub Date : 2013-08-12 eCollection Date: 2013-01-01 DOI: 10.1155/2013/673121
S Aliyu, A G Ibrahim, N Ali, A M Waziri
{"title":"Fournier's Gangrene as Seen in University of Maiduguri Teaching Hospital.","authors":"S Aliyu,&nbsp;A G Ibrahim,&nbsp;N Ali,&nbsp;A M Waziri","doi":"10.1155/2013/673121","DOIUrl":"https://doi.org/10.1155/2013/673121","url":null,"abstract":"<p><p>Background. Fournier's gangrene is uncommon but increasingly being seen over the last two decades probably due to increasing socioeconomic problems including an upsurge in HIV infection especially in the tropics. Patients and Methods. The study retrospectively reviewed all patients with Fournier's gangrene managed in UMTH between January 2007 and December 2012. Results. Thirty-eight males aged 2 weeks to 80 years (mean 37.82) were reviewed, with most aged 30-39 years (13 (34.21%)). Clinical features were scrotal pain and swelling, 36 (94.74%), fever, 19 (50.00%), and discharging scrotal wound, 19 (50.00%). The predisposing conditions were UTI secondary to obstructive uropathy in 11 (28.95%), perianal suppuration, and HIV, in 8 (21.05%) patients each. Wound biopsy culture revealed mixed organisms in 27 (71.05%). Twenty-six (68.42%) had blood transfusions. Thirty-seven (97.37%) patients had wound debridement. Twenty (52.63%) had flap rotation for skin cover. There were 6 (15.79%) mortalities, of which 4 (10.53%) were HIV positive, 1 (2.63%) was diabetic, and 1 (2.63%) was both diabetic and HIV positive. Conclusion. Fournier's gangrene is a fulminant synergistic necrotising fasciitis of the perineum and genitalia with poor prognosis especially when associated with HIV and diabetes, requiringprompt and aggressive management for good outcome. </p>","PeriodicalId":89401,"journal":{"name":"ISRN urology","volume":"2013 ","pages":"673121"},"PeriodicalIF":0.0,"publicationDate":"2013-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/673121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31701399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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